| أسهم المطلعين | ٧٨٦٬٢٦٦٬٤٧٤ shares |
| إجمالي المطلعين | 41 |
درجات مزاج المطلعين
تكشف نقاط مزاج المطلعين عن الشركات التي تم شراؤها من قبل المطلعين على الشركات.
إنه نتيجة لنموذج كمي متطور ومتعدد العوامل يحدد الشركات التي تتمتع بأعلى مستويات التراكم الداخلي. يستخدم نموذج التسجيل مزيجًا من صافي عدد المطلعين الذين اشتروا 90 يومًا السابقة، وإجمالي الأسهم المشتراة كنسبة مئوية من التعويم، وإجمالي الأسهم المملوكة من قبل المطلعين. ويتراوح الرقم من 0 إلى 100، وتشير الأرقام الأعلى إلى مستوى أعلى من التراكم لأقرانه، و50 هو المتوسط.
تكرار التحديث: يومياً
راجع أفضل اختيارات المطلعين، والتي توفر قائمة بالشركات التي تتمتع بأعلى تراكم من المطلعين.
درجة مزاج المسؤولين
تكشف درجة مزاج المسؤولين عن الشركات التي يتم شراؤها من قبل مسؤولي الشركات.
بحكم التعريف، فإن مسؤولي الشركة هم من المطلعين على الشركة، ولكن على عكس بعض المطلعين الآخرين (10% من المساهمين وأعضاء مجلس الإدارة)، يعمل المسؤولون في الشركة على أساس يومي، ويستخدمون أموالهم الخاصة عند التداول. (10% من المساهمين وأعضاء مجلس الإدارة غالبًا ما يكونون مديري صناديق يديرون أموال الآخرين.) وعلى هذا النحو، تكون الصفقات الداخلية التي يقوم بها المسؤولون أكثر أهمية ويجب التعامل معها بشكل مناسب.
مثل درجة مزاج المطلعين، فإن درجة مزاج الموظف هي نتيجة لنموذج كمي متطور ومتعدد العوامل يحدد الشركات التي تتمتع بأعلى مستويات تراكم الموظفين.
تكرار التحديث: يومياً
راجع أفضل خيارات المطلعين، والتي توفر قائمة بالشركات التي تتمتع بأعلى المزاجات الداخلية.
المقاييس الرئيسية من الداخل
توضح هذه البطاقة كيفية تصنيف الشركة وفقًا لمختلف المقاييس الداخلية. يوضح الترتيب المئوي كيفية مقارنة هذه الشركة بالشركات الأخرى في الأسواق الأمريكية. تشير التصنيفات الأعلى إلى أوضاع أفضل.
على سبيل المثال، من المقبول عمومًا أن الشراء من الداخل يعد مؤشرًا إيجابيًا، وبالتالي فإن الشركات التي لديها المزيد من الشراء من الداخل ستحتل مرتبة أعلى من الشركات التي لديها قدر أقل من الشراء من الداخل (أو حتى البيع من الداخل).
نسبة الأسهم العائمة المشتراة من قبل المطلعين (المرتبة)
N/A
النسبة المئوية للأسهم العائمة المشتراة من قبل المطلعين هي إجمالي عدد الأسهم المشتراة من قبل المطلعين مطروحًا منه إجمالي عدد الأسهم المباعة من قبل المطلعين في آخر 90 يومًا، مقسومًا على إجمالي الأسهم العائمة ومضروبًا في 100.
الرسم البياني للتداول من الداخل
Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock) يتم عرض الصفقات الداخلية في الرسم البياني التالي. المطلعون هم مسؤولين أو مدراء أو مستثمرين مهمون في الشركة. بشكل عام، من غير القانوني بشكل عام أن يقوم المطلعون بإجراء عمليات تداول في شركاتهم بناءً على معلومات مادية وغير عامة. وهذا لا يعني أنه من غير القانوني بالنسبة لهم إجراء أي صفقات تجارية في شركاتهم الخاصة. ومع ذلك، يجب عليهم الإبلاغ عن جميع الصفقات إلى هيئة الأوراق المالية والبورصات عبر النموذج 4.
قائمة المطلعين ومقاييس الربحية
يعرض هذا الجدول قائمة المطلعين المعروفين، ويتم إنشاؤه تلقائيًا من التصريحات التي تم الكشف عنها إلى هيئة الأوراق المالية والبورصات. بالإضافة إلى الأسماء، وأحدث منصب، والمدير، أو المسؤول، أو تعيين المالك بنسبة 10%، فإننا نقدم أحدث الممتلكات التي تم الكشف عنها. بالإضافة إلى ذلك، عندما يكون ذلك ممكنًا، فإننا نقدم الأداء التجاري التاريخي للمطلعين على بواطن الأمور. الأداء التجاري التاريخي هو المتوسط المرجح لأداء معاملات الشراء الفعلية في السوق المفتوحة التي أجراها المطلعون من الداخل. لمزيد من المعلومات حول كيفية حساب ذلك، شاهد هذا البرنامج التعليمي عبر الإنترنت على يوتيوب.
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| مطلع | متوسط الربح (%) | الأسهم مملوكة |
التقسيم المعدل |
|---|---|---|---|
| Lawrence M Alleva Director - [D] | ١٢٬٦٠٠ | ١٢٬٦٠٠ | |
| Rafael Amado President, R&D - [O] | ١٧٬٢٣٧ | ١٧٬٢٣٧ | |
|
M James Barrett
10% Owner -
|
٨٢٬٩٧٨٬٦٦٨ | ٨٢٬٩٧٨٬٦٦٨ | |
|
Peter J Barris
10% Owner -
|
١٢٬٠٠٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | |
|
Forest Baskett
10% Owner -
|
١٩٬٥٠٠٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | |
| Ali Behbahani Director - [D] | ٠ | ٠ | |
| William C JR Bertrand Chief Operating Officer - [O] | ٩٨٦٬٣٥٢ | ٩٨٦٬٣٥٢ | |
| Gwendolyn Knowlton Binder-Scholl Chief Technology Officer - [O] | ٢٬٤٨٧ | ٢٬٤٨٧ | |
| Joanna Elizabeth Brewer | ٢٢٣٬٥١٢ | ||
| Barbara Gayle Duncan | ١٤٤٬٠٠٠ | ||
|
EcoR1 Capital, LLC
10% Owner -
|
١٠٠٬٣٧١٬٨٨٢ | ١٠٠٬٣٧١٬٨٨٢ | |
|
Florence Anthony A. Jr.
10% Owner -
|
١٩٬٥٠٠٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | |
| John Furey | ١٩٦٬١٨٦ |
| مطلع | متوسط الربح (%) | الأسهم مملوكة |
التقسيم المعدل |
|---|---|---|---|
| Michael Garone | ٠ | ||
| Samuel D Isaly Director - [D] | ٦٬١٤٩٬٣٧٧ | ٦٬١٤٩٬٣٧٧ | |
|
Patrick J Kerins
10% Owner -
|
٨٢٬٩٧٨٬٦٦٨ | ٨٢٬٩٧٨٬٦٦٨ | |
|
Krishna Kittu Kolluri
10% Owner -
|
١١٨٬٥٣٨٬٠٠٠ | ١١٨٬٥٣٨٬٠٠٠ | |
| Giles Francis Bertram Kerr | ١٢٤٬٠٠٠ | ||
| Jonathan Kenneth Charles Knowles Director - [D] | ٧٬٢٠٨٬٧٦٨ | ٧٬٢٠٨٬٧٦٨ | |
| Ian Michael Laing Director - [D] | ٥٨٬٠٨٥٬٦٠٠ | ٥٨٬٠٨٥٬٦٠٠ | |
| John Lunger Chief Patient Supply Officer - [O] | ٧٬٥١٠ | ٧٬٥١٠ | |
|
David M Mott
Director, 10% Owner -
[D]
|
١٩٬٥٠٠٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | |
| Garry E Menzel Director - [D] | ٧٥٬٠٥٦ | ٧٥٬٠٥٦ | |
|
Nea 14 Gp, Ltd
10% Owner -
|
٨٢٬٩٧٨٬٦٦٨ | ٨٢٬٩٧٨٬٦٦٨ | |
|
NEA Partners 14, L.P.
10% Owner -
|
٨٢٬٩٧٨٬٦٦٨ | ٨٢٬٩٧٨٬٦٦٨ | |
|
New Enterprise Associates 14, L.P.
10% Owner -
|
٨٢٬٩٧٨٬٦٦٨ | ٨٢٬٩٧٨٬٦٦٨ | |
| James Noble Director - [D] | ٠ | ٠ |
| مطلع | متوسط الربح (%) | الأسهم مملوكة |
التقسيم المعدل |
|---|---|---|---|
| Elliot Norry Chief Medical Officer - [O] | ٧٬٥١٠ | ٧٬٥١٠ | |
| Orbimed Advisors Llc Director - [D] | ٤٬٩٠١٬٣١٠ | ٤٬٩٠١٬٣١٠ | |
| OrbiMed Capital GP V LLC Director - [D] | ٤٬٩٠١٬٣١٠ | ٤٬٩٠١٬٣١٠ | |
| Cintia Piccina Chief Commercial Officer - [O] | ١٨٬٤٢١ | ١٨٬٤٢١ | |
| Adrian Rawcliffe Chief Executive Officer, Director - [D] [O] | ٤٤٬٣٢٧ | ٤٤٬٣٢٧ | |
|
Scott D Sandell
10% Owner -
|
١٩٬٥٠٠٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | |
| Charles Elliott Sigal Director - [D] | ٣١٤٬١٠٠ | ٣١٤٬١٠٠ | |
|
Sonsini Peter W.
10% Owner -
|
١٩٬٥٠٠٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | |
| Helen Katrina Tayton-martin Chief Business Officer - [O] | ١٬٨٠٠٬٠٠٠ | ١٬٨٠٠٬٠٠٠ | |
| Thompson Peter A. Director - [D] | ٤٬٩٠١٬٣١٠ | ٤٬٩٠١٬٣١٠ | |
|
Ravi Viswanathan
10% Owner -
|
١٢٬٠٠٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | |
|
Harry R Weller
10% Owner -
|
١١٨٬٥٣٨٬٠٠٠ | ١١٨٬٥٣٨٬٠٠٠ | |
| Gavin Wood Chief Financial Officer - [O] | ٠ | ٠ | |
| Tal Zvi Zaks | ١٤٤٬٠٠٠ |
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تتبع سجلات المشتريات الداخلية - تحليل الأرباح على المدى القصير
في هذا القسم، نقوم بتحليل ربحية كل عملية شراء داخلية غير مخطط لها في السوق المفتوحة تم إجراؤها في ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). يساعد هذا التحليل على فهم ما إذا كان المطلعون على بواطن الأمور يحققون عوائد غير طبيعية باستمرار، ويستحق المتابعة. هذا التحليل لمدة سنة واحدة بعد كل تجارة، و النتائج نظرية .
يوضح الجدول التالي أحدث عمليات الشراء في السوق المفتوحة والتي لم تكن جزءًا من خطة التداول التلقائية.
السعر المعدل هو السعر المعدل حسب التقسيم. المشاركات المعدلة هي المشاركات المعدلة حسب التقسيم.
تتبع سجلات المبيعات الداخلية - تحليل الخسائر على المدى القصير
في هذا القسم، نقوم بتحليل تجنب الخسارة على المدى القصير لكل عملية بيع داخلية غير مخطط لها في السوق المفتوحة تم إجراؤها في ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock). قد يشير النمط الثابت لتجنب الخسارة إلى أن معاملات البيع المستقبلية قد تتنبأ بانخفاض الأسعار. هذا التحليل لمدة سنة واحدة بعد كل تجارة، و النتائج نظرية .
يوضح الجدول التالي أحدث مبيعات السوق المفتوحة التي لم تكن جزءًا من خطة التداول التلقائية.
السعر المعدل هو السعر المعدل حسب التقسيم. المشاركات المعدلة هي المشاركات المعدلة حسب التقسيم.
تاريخ المعاملات
انقر على أيقونة الرابط للاطلاع على سجل المعاملات الكامل. ستظهر علامة X في العمود 10b-5 للمعاملات المُبلّغ عنها ضمن خطة التداول الآلي 10b5-1.
| تاريخ الملف |
تاريخ التبادل |
النموذج | المطلع | المؤشر | التغيير في القيمة | الرمز | مباشر | سعر التمرين |
سعر الوحدة |
الوحدة المتغيرة |
القيمة المتغيرة (1 ألف) |
الخيارات المتبقية |
الأسهم المتبقية |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-09-03 | 2025-09-02 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫٠٠٩٩ | ٩٦٬٠٠٠ | ١ | ٠ | ||||
| 2025-08-29 | 2025-08-28 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫٠١٠١ | ٢٠٧٬٠٠٠ | ٢ | ٩٨٦٬٣٥٢ | ||||
| 2025-08-19 | 2025-08-18 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٠١٢٠ | ١٤٬٦٧١٬٧٩٤ | ١٧٦ | ٠ | ||||
| 2025-08-19 | 2025-08-15 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٠١١٠ | ٤٬٨٢٨٬٢٠٦ | ٥٣ | ١٤٬٦٧١٬٧٩٤ | ||||
| 2025-07-30 | 2025-07-30 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | ٠٫١٠٢١ | ٢٧٬٤٣٣٬٣٣٨ | ٢٬٨٠١ | ١٠٠٬٣٧١٬٨٨٢ | ||||
| 2025-07-30 | 2025-07-29 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | ٠٫١٠١٢ | ٢٬٦٨٧٬٤٦٠ | ٢٧٢ | ١٢٧٬٨٠٥٬٢٢٠ | ||||
| 2025-07-30 | 2025-07-28 | 4 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | ٠٫١١٢٥ | ٣٣٬٩٣١٬٧٤٠ | ٣٬٨١٧ | ١٣٠٬٤٩٢٬٦٨٠ | ||||
| 2025-01-17 | 2025-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٠٨ | ٥٬٥٨٤ | ٣ | ٧٬٥١٠ | ||||
| 2025-01-17 | 2025-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٠٨ | ٥٬٥٨٤ | ٣ | ٧٬٥١٠ | ||||
| 2025-01-17 | 2025-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٠٨ | ٥٬٥٨٤ | ٣ | ٧٬٥١٠ | ||||
| 2025-01-17 | 2025-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٠٨ | ٣٠٬٦٠١ | ١٨ | ٤٤٬٣٢٧ | ||||
| 2025-01-15 | 2025-01-15 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٧٤٨ | ١٢٬٩٩١ | ٧ | ١٨٬٤٢١ | ||||
| 2025-01-15 | 2025-01-15 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٧٤٨ | ٢٩٬٠٩٦ | ١٧ | ٤١٬٥٨٢ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ١٧٬٩٣٤ | ١١ | ٢٥٬٧١١ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ١٢٬٥٣٩ | ٧ | ١٧٬٨٠١ | ||||
| 2025-01-15 | 2025-01-15 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٧٤٨ | ٩٬٨٠٣ | ٦ | ١٣٬٧٥٦ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٨٬١٢٤ | ٥ | ١١٬٥١٦ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٤٬٢٦٨ | ٣ | ٥٬٨٤٥ | ||||
| 2025-01-15 | 2025-01-15 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٧٤٨ | ٩٬٨٠٣ | ٦ | ١٣٬٧٥٦ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٥٬٤٧١ | ٣ | ٧٬٦٢٣ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٤٬٢٦٨ | ٣ | ٥٬٨٤٥ | ||||
| 2025-01-15 | 2025-01-15 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٧٤٨ | ٩٬٨٠٣ | ٦ | ١٣٬٧٥٦ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٥٬٤٧١ | ٣ | ٧٬٦٢٣ | ||||
| 2025-01-15 | 2025-01-13 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٥٨٧٩ | ٤٬٢٦٨ | ٣ | ٥٬٨٤٥ | ||||
| 2024-06-18 | 2024-06-18 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٩٣٠٠ | ٢٤٬٥٣١ | ٢٣ | ٣٨٬٢٩٣ | ||||
| 2024-03-26 | 3 | EcoR1 Capital, LLC See Note | ADAP | Ordinary Shares | I | ١٦٤٬٤٢٤٬٤٢٠ | ||||||||
| 2024-01-17 | 2024-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ٣٠٬٠٨٠ | ٢٠ | ٤٤٬٨٤٨ | ||||
| 2024-01-17 | 2024-01-16 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٧٩٠٠ | ٩٬٣٠٤ | ٧ | ١٤٬١٠٤ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ١٢٬٩٦٧ | ٩ | ١٩٬٢٥٧ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ٥٬٣٠٩ | ٤ | ٧٬٧٨٥ | ||||
| 2024-01-17 | 2024-01-16 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٧٩٠٠ | ٢٬٢٨٧ | ٢ | ٣٬٣٦٣ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ١٢٬٨٠٥ | ٩ | ١٩٬٠١٥ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ٥٬٣٠٩ | ٤ | ٧٬٧٨٥ | ||||
| 2024-01-17 | 2024-01-16 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٧٩٠٠ | ٤٬٦٨١ | ٤ | ٧٬٠٢٣ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ١٣٬٥٩٩ | ٩ | ٢٠٬٢٠١ | ||||
| 2024-01-17 | 2024-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٦٧٣٠ | ٥٬٣٠٩ | ٤ | ٧٬٧٨٥ | ||||
| 2024-01-17 | 2024-01-16 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٧٩٠٠ | ٤٬٦٨١ | ٤ | ٧٬٠٢٣ | ||||
| 2024-01-12 | 2024-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٥٤١ | ٥٬٢٢٠ | ٤ | ٧٬٨٧٤ | ||||
| 2024-01-12 | 2024-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٣٦٧ | ٤٬٠٠٩ | ٣ | ٦٬١٠٤ | ||||
| 2024-01-12 | 2024-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٥٤١ | ١٧٬٢٥٧ | ١٥ | ٢٦٬٣٨٨ | ||||
| 2024-01-12 | 2024-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٣٦٧ | ١١٬٩٤٥ | ١٠ | ١٨٬٣٩٥ | ||||
| 2024-01-12 | 2024-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٥٤١ | ٥٬٢٢٠ | ٤ | ٧٬٨٧٤ | ||||
| 2024-01-12 | 2024-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٣٦٧ | ٤٬٠٠٩ | ٣ | ٦٬١٠٤ | ||||
| 2024-01-12 | 2024-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٥٤١ | ٧٬٧٩٩ | ٧ | ١١٬٨٤١ | ||||
| 2024-01-12 | 2024-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٨٣٦٧ | ٤٬٠٠٩ | ٣ | ٦٬١٠٤ | ||||
| 2023-09-01 | 2023-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٧٨٠٠ | ٢٬٤٠٣ | ٢ | ٣٬٤٤٩ | ||||
| 2023-08-01 | 2023-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٩٠٥٦ | ٣٬٠٩٦ | ٣ | ٤٬٧١٨ | ||||
| 2023-07-10 | 2023-07-10 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٩١٠٨ | ٤٧٬٧٠٢ | ٤٣ | ٧٥٬٠٥٦ | ||||
| 2023-06-27 | 2023-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٠٫٩٢٠٠ | ٢٬٣٣٣ | ٢ | ٣٬٥١٩ | ||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | D | ٢٠٩٬٩٣١ | ٢٠٩٬٩٣١ | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | ٢٠٠٬٦٤٧ | ٢٠٠٬٦٤٧ | ||||||
| 2023-06-01 | 2023-06-01 | 4 | Menzel Garry E | ADAP | American Depositary Shares representing Ordinary Shares | I | ٢٠٠٬٦٤٦ | ٢٠٠٬٦٤٦ | ||||||
| 2023-01-31 | 2023-01-31 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٨٦٩٦ | ١١٬٨٩٠ | ٢٢ | ١٩٬٥٣٥ | ||||
| 2023-01-17 | 2023-01-17 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٨٥٨٠ | ٤٬٤٤٠ | ٨ | ٧٬٢٦٤ | ||||
| 2023-01-17 | 2023-01-17 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٨٥٨٠ | ١٠٬٠٥٧ | ١٩ | ١٣٬٣٥١ | ||||
| 2023-01-17 | 2023-01-17 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٨٥٨٠ | ٤٬٤٤٠ | ٨ | ٧٬٢٦٤ | ||||
| 2023-01-17 | 2023-01-17 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٨٥٨٠ | ٢٬١٥٩ | ٤ | ٣٬٤٩١ | ||||
| 2023-01-12 | 2023-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٠٦٠ | ٤٬٩٧٣ | ٨ | ٨٬١٢١ | ||||
| 2023-01-12 | 2023-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٤٦٨ | ٣٬٨٤٣ | ٧ | ٦٬٢٧٠ | ||||
| 2023-01-12 | 2023-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٠٦٠ | ٤٬٩٧٣ | ٨ | ٨٬١٢١ | ||||
| 2023-01-12 | 2023-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٤٦٨ | ٣٬٨٤٣ | ٧ | ٦٬٢٧٠ | ||||
| 2023-01-12 | 2023-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٠٦٠ | ٧٬٤٤٩ | ١٣ | ١٢٬١٩١ | ||||
| 2023-01-12 | 2023-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٤٦٨ | ٣٬٨٤٣ | ٧ | ٦٬٢٧٠ | ||||
| 2023-01-12 | 2023-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٠٦٠ | ١٨٬٧٦٣ | ٣٢ | ٢٤٬٨٨٢ | ||||
| 2023-01-12 | 2023-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٤٦٨ | ١٣٬٠٤٢ | ٢٣ | ١٧٬٢٩٨ | ||||
| 2023-01-04 | 2023-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٩٤٠ | ٣٬٥٨٤ | ٦ | ٥٬٧٨١ | ||||
| 2023-01-04 | 2023-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٩٤٠ | ٥٬٠٧٣ | ٩ | ٦٬٦٣١ | ||||
| 2023-01-04 | 2023-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٩٤٠ | ٨٧٦ | ١ | ١٬٣٦١ | ||||
| 2023-01-04 | 2023-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٩٤٠ | ١٬١٠٠ | ٢ | ١٬٧٢٥ | ||||
| 2022-09-01 | 2022-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٩٦٨٩ | ٢٬٥٣٦ | ٥ | ٣٬٣١٦ | ||||
| 2022-08-01 | 2022-08-01 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٧٣٥ | ٢٬٩٨٣ | ٥ | ٤٬٨٢٩ | ||||
| 2022-08-01 | 2022-08-01 | 4 | Piccina Cintia | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٧٧٣٥ | ٢١٬٠٤٠ | ٣٧ | ٣٤٬٨٢٤ | ||||
| 2022-07-05 | 2022-07-05 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٧٨١ | ١٬٩٧٣ | ٣ | ٣٬١٠٤ | ||||
| 2022-06-27 | 2022-06-27 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٦٣٠٠ | ٢٬٥٦٢ | ٤ | ٣٬٢٩٠ | ||||
| 2022-05-23 | 2022-05-20 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫٢٩٠٤ | ٣٩٬٠٠٠ | ١١ | ٩٦٬٠٠٠ | ||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٢٣٬٥١٢ | ٢٢٣٬٥١٢ | |||||
| 2022-05-04 | 2022-05-04 | 4 | Brewer Joanna Elizabeth | ADAP | Option to purchase Ordinary Shares | D | ٠٫٣٠ | ٣٣٣٬٧٩٢ | ٣٣٣٬٧٩٢ | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣٣٥٬١٨٤ | ٣٣٥٬١٨٤ | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٧٥٤٬٢٠٠ | ٧٥٤٬٢٠٠ | |||||
| 2022-01-31 | 2022-01-31 | 4 | Piccina Cintia | ADAP | Option to purchase Ordinary Shares | D | ٠٫٤٥ | ٣٬٣٧٦٬٩٩٢ | ٣٬٣٧٦٬٩٩٢ | |||||
| 2022-01-18 | 2022-01-18 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫١٩١٨ | ٤٬٣٦٨ | ١٤ | ٧٬٣٣٦ | ||||
| 2022-01-18 | 2022-01-18 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫١٩١٨ | ٤٬٣٦٨ | ١٤ | ٧٬٣٣٦ | ||||
| 2022-01-18 | 2022-01-18 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫١٩١٨ | ٢٬١٢١ | ٧ | ٣٬٥٢٩ | ||||
| 2022-01-18 | 2022-01-18 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫١٩١٨ | ١١٬٠٩٦ | ٣٥ | ١٢٬٣١٢ | ||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣١٤٬٢٥٦ | ٣١٤٬٢٥٦ | |||||
| 2022-01-13 | 2022-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ١٬٤٠٧٬٠٧٢ | ١٬٤٠٧٬٠٧٢ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣١٤٬٢٥٦ | ٣١٤٬٢٥٦ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ١٬٤٠٧٬٠٧٢ | ١٬٤٠٧٬٠٧٢ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٤٤١ | ٢٬٢٤٨ | ٨ | ٣٬٧٥٤ | ||||
| 2022-01-13 | 2022-01-11 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٥٦٧ | ٣٬٧٧٠ | ١٣ | ٦٬٣٤٣ | ||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣١٤٬٢٥٦ | ٣١٤٬٢٥٦ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ١٬٤٠٧٬٠٧٢ | ١٬٤٠٧٬٠٧٢ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٤٤١ | ١٬٠٧٦ | ٤ | ١٬٧٤٩ | ||||
| 2022-01-13 | 2022-01-11 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٥٦٧ | ٣٬٧٧٠ | ١٣ | ٦٬٣٤٣ | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٤٤١ | ٨٥٤ | ٣ | ١٬٣٨٣ | ||||
| 2022-01-13 | 2022-01-11 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٥٦٧ | ٣٬٧٧٠ | ١٣ | ٦٬٣٤٣ | ||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٤٤١ | ٣٬٠٤٦ | ١١ | ٣٬٣٥٦ | ||||
| 2022-01-13 | 2022-01-11 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٥٦٧ | ١٤٬٣٦٢ | ٥١ | ١٥٬٩٧٨ | ||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٤٧١٬٣٦٠ | ٤٧١٬٣٦٠ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ٢٬١١٠٬٦٠٨ | ٢٬١١٠٬٦٠٨ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٬٠٤٧٬٤٨٠ | ١٬٠٤٧٬٤٨٠ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ٤٬٦٩٠٬٢٢٤ | ٤٬٦٩٠٬٢٢٤ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣١٤٬٢٥٦ | ٣١٤٬٢٥٦ | |||||
| 2022-01-13 | 2022-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٠ | ١٬٤٠٧٬٠٧٢ | ١٬٤٠٧٬٠٧٢ | |||||
| 2022-01-05 | 2022-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٠٦٤٢ | ٣٬٤٩٠ | ١٤ | ٥٬٨٧٣ | ||||
| 2022-01-05 | 2022-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٠٦٤٢ | ١٬٠٧٠ | ٤ | ١٬٧٥٥ | ||||
| 2022-01-05 | 2022-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٠٦٤٢ | ٨٤٩ | ٣ | ١٬٣٨٨ | ||||
| 2022-01-05 | 2022-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٠٦٤٢ | ٥٬٥٣٢ | ٢٢ | ٦٬١٧٢ | ||||
| 2021-09-01 | 2021-09-01 | 4 | Rawcliffe Adrian | ADAP] | American Depositary Shares representing Ordinary Shares | D | ٥٫١٩٥٠ | ٢٬٧٨٢ | ١٤ | ٣٬٠٧٠ | ||||
| 2021-08-02 | 2021-08-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٣٫٥٨٤٨ | ٢٬٩٣٩ | ١١ | ٤٬٨٧٣ | ||||
| 2021-07-02 | 2021-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٣٧٩٬٧٨٨ | ٣٧٩٬٧٨٨ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٥٠٥٬٩١٨ | ٥٠٥٬٩١٨ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٤٧٤٬٣٨٥ | ٤٧٤٬٣٨٥ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٤٧٤٬٣٨٥ | ٤٧٤٬٣٨٥ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٣٧٩٬٧٨٨ | ٣٧٩٬٧٨٨ | |||||
| 2021-07-02 | 2021-07-02 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٢٦٤٩ | ٤٬٣٧٥ | ١٩ | ٧٬٣٢٩ | ||||
| 2021-07-02 | 2021-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٥٧٩٬٤٩٤ | ٥٧٩٬٤٩٤ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٣٧٩٬٧٨٨ | ٣٧٩٬٧٨٨ | |||||
| 2021-07-02 | 2021-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧١ | ٣٧٩٬٧٨٨ | ٣٧٩٬٧٨٨ | |||||
| 2021-07-02 | 2021-07-02 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٢٦٤٩ | ١٬٩٠٧ | ٨ | ٣٬١٧٠ | ||||
| 2021-06-28 | 2021-06-28 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٤٫٣٧٠٠ | ٢٬٧٩٤ | ١٢ | ٣٬٠٥٨ | ||||
| 2021-06-03 | 2021-06-01 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٠٫٧٩٠٠ | ١٢٬٦٠٠ | ١٠ | ١٢٬٦٠٠ | ||||
| 2021-03-03 | 2021-03-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫١٥٧٠ | ١٬٧٨٥٬٠٠٠ | ٢٨٠ | ١٬٨٠٠٬٠٠٠ | ||||
| 2021-01-19 | 2021-01-19 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٦٦٩٥ | ٢٬١١١ | ١٢ | ٣٬٥٣٩ | ||||
| 2021-01-19 | 2021-01-19 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٦٦٩٥ | ٤٬٣٥٨ | ٢٥ | ٧٬٣٤٦ | ||||
| 2021-01-19 | 2021-01-19 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٦٦٩٥ | ٩٬٨٧٩ | ٥٦ | ١٣٬٥٢٩ | ||||
| 2021-01-12 | 2021-01-12 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٦٫١٥٢٢ | ٢٬٢٣٤ | ١٤ | ٣٬٧٦٨ | ||||
| 2021-01-12 | 2021-01-12 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٦٫١٥٢٢ | ١٬٠٥٨ | ٧ | ١٬٧٦٧ | ||||
| 2021-01-12 | 2021-01-12 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٦٫١٥٢٢ | ٨٤١ | ٥ | ١٬٣٩٦ | ||||
| 2021-01-12 | 2021-01-12 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٦٫١٥٢٢ | ٢٬٧٠٧ | ١٧ | ٣٬٦٩٥ | ||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٤٢٬٧١٢ | ٢٤٢٬٧١٢ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ١٬٠٨٦٬٨١٦ | ١٬٠٨٦٬٨١٦ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٤٢٬٧١٢ | ٢٤٢٬٧١٢ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ١٬٠٨٦٬٨١٦ | ١٬٠٨٦٬٨١٦ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٧٢٨٬١٦٠ | ٧٢٨٬١٦٠ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ٣٬٢٦٠٬٤٠٠ | ٣٬٢٦٠٬٤٠٠ | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٤٢٬٧١٢ | ٢٤٢٬٧١٢ | |||||
| 2021-01-11 | 2021-01-11 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ١٬٠٨٦٬٨١٦ | ١٬٠٨٦٬٨١٦ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٤٢٬٧١٢ | ٢٤٢٬٧١٢ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ١٬٠٨٦٬٨١٦ | ١٬٠٨٦٬٨١٦ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٤٢٬٧١٢ | ٢٤٢٬٧١٢ | |||||
| 2021-01-11 | 2021-01-11 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ١٫٠٣ | ١٬٠٨٦٬٨١٦ | ١٬٠٨٦٬٨١٦ | |||||
| 2021-01-05 | 2021-01-04 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٢٧٩ | ١٬٠٦٥ | ٦ | ١٬٧٦٠ | ||||
| 2021-01-05 | 2021-01-04 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٢٧٩ | ٨٤٥ | ٥ | ١٬٣٩٢ | ||||
| 2021-01-05 | 2021-01-04 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٢٧٩ | ٣٬٤٩٩ | ١٩ | ٥٬٨٦٤ | ||||
| 2021-01-05 | 2021-01-04 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٢٧٩ | ٤٬٩٦٧ | ٢٦ | ٦٬٧٣٧ | ||||
| 2020-12-16 | 2020-12-14 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫٦٨٩٦ | ٢٤٬٠٠٠ | ١٧ | ٥٧٬٠٠٠ | ||||
| 2020-12-15 | 2020-12-14 | 4 | Bertrand William C JR | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫٦٩٤٨ | ٢٠٧٬٠٠٠ | ١٤٤ | ٢٨٤٬٨٠٨ | ||||
| 2020-09-02 | 2020-09-01 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٨٫٥١٤٩ | ٢٬٧٧٦ | ٢٤ | ٣٬٠٧٦ | ||||
| 2020-08-04 | 2020-08-03 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٩٫٢٥٠٠ | ٢٬٧٨٨ | ٢٦ | ٣٬٠٦٤ | ||||
| 2020-08-04 | 2020-08-03 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | ٨٫٧٤٠٩ | ٢٠٠٬٠٠٠ | ١٬٧٤٨ | ٠ | ||||
| 2020-08-04 | 2020-08-03 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٩٫٢٥٠٠ | ٤٬٨٢٣ | ٤٥ | ٨٬٠٦٦ | ||||
| 2020-07-01 | 2020-07-01 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٨٤٬٢٥٨ | ١٨٤٬٢٥٨ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٩٦٬١٨٦ | ١٩٦٬١٨٦ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٩٧٬٦٧٨ | ١٩٧٬٦٧٨ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٤٤٬٠٠٠ | ١٤٤٬٠٠٠ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٤٤٬٠٠٠ | ١٤٤٬٠٠٠ | |||||
| 2020-07-01 | 2020-07-01 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ٢٢٦٬٧٥٣ | ٢٢٦٬٧٥٣ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٨٤٬٢٥٨ | ١٨٤٬٢٥٨ | |||||
| 2020-07-01 | 2020-07-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ١٫٦٧ | ١٧٩٬٧٨٥ | ١٧٩٬٧٨٥ | |||||
| 2020-06-30 | 2020-06-29 | 4 | Wood Gavin | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٫٦٢٠٠ | ٣٣٬٠٠٠ | ٥٣ | ٣٣٬٠٠٠ | ||||
| 2020-06-11 | 2020-06-09 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٫٨٩٠٠ | ١٢٬٩٠٠ | ٢٤ | ١٢٬٩٠٠ | ||||
| 2020-06-02 | 2020-05-29 | 4 | Noble James | ADAP | American Depositary Shares | D | ٩٫٣٣٢٠ | ٥٠٠٬٠٠٠ | ٤٬٦٦٦ | ٠ | ||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٥٦٥٬٠٠٠ | ٥٦٥٬٠٠٠ | |||||
| 2020-04-01 | 2020-04-01 | 4 | Wood Gavin | ADAP | Option to purchase Ordinary Shares | D | ٠٫٤٥ | ٢٬٥٠٠٬٠٠٠ | ٢٬٥٠٠٬٠٠٠ | |||||
| 2020-04-01 | 2020-04-01 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٤٥ | ٣١٬٠٠٠ | ٣١٬٠٠٠ | |||||
| 2020-01-28 | 2020-01-24 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-28 | 2020-01-24 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-28 | 2020-01-24 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-28 | 2020-01-24 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-28 | 2020-01-24 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-28 | 2020-01-24 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٦٦٦٧ | ٧٬٥٠٠٬٠٠٠ | ٥٬٠٠٠ | ١٩٬٥٠٠٬٠٠٠ | ||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٣٥٬٦٠٠ | ١٣٥٬٦٠٠ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Norry Elliot | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٤ | ٢٠١٬٦٠٠ | ٢٠١٬٦٠٠ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٨٠٬٨٩٦ | ٢٨٠٬٨٩٦ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٤ | ١٬٢٥٧٬٧٤٤ | ١٬٢٥٧٬٧٤٤ | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٨٠٬٨٩٦ | ٢٨٠٬٨٩٦ | |||||
| 2020-01-17 | 2020-01-16 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٤ | ١٬٢٥٧٬٧٤٤ | ١٬٢٥٧٬٧٤٤ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٥٦١٬٧٩٢ | ٥٦١٬٧٩٢ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٤ | ٢٬٥١٥٬٥٣٦ | ٢٬٥١٥٬٥٣٦ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٨٠٬٨٩٦ | ٢٨٠٬٨٩٦ | |||||
| 2020-01-17 | 2020-01-16 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٤ | ١٬٢٥٧٬٧٤٤ | ١٬٢٥٧٬٧٤٤ | |||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | ٥٫٠٠٠٠ | ٢٠٠٬٠٠٠ | ١٬٠٠٠ | ٠ | ||||
| 2020-01-15 | 2020-01-13 | 4 | Noble James | ADAP | American Depositary Shares | D | ٤٫٠٠٠٠ | ١٠٠٬٠٠٠ | ٤٠٠ | ٠ | ||||
| 2020-01-15 | 2020-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫١٣٤٧ | ٣٬٢٣٦ | ١٧ | ٣٬١٦٦ | ||||
| 2020-01-15 | 2020-01-14 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫١٣٤٧ | ١٬١٤٤ | ٦ | ١٬٦٨١ | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | ٥٫٠٠٠٠ | ٥٠٬٠٠٠ | ٢٥٠ | ٠ | ||||
| 2020-01-15 | 2020-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | American Depositary Shares | D | ٤٫٠٠٠٠ | ٥٠٬٠٠٠ | ٢٠٠ | ٠ | ||||
| 2020-01-15 | 2020-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫١٣٤٧ | ٢٬٣٩٧ | ١٢ | ٣٬٦٠٥ | ||||
| 2020-01-15 | 2020-01-14 | 4 | Norry Elliot | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫١٣٤٧ | ٩١١ | ٥ | ١٬٣٢٦ | ||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٬٣٥٨ | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٬٣٥٨ | ||||||||
| 2020-01-13 | 3 | Norry Elliot | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٬٣٥٨ | ||||||||
| 2020-01-07 | 2020-01-06 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٢٠٠٠ | ٥٬٩٠٠ | ٧ | ٥٬٨٠٤ | ||||
| 2020-01-07 | 2020-01-06 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٢٠٠٠ | ٣٬٧٣١ | ٤ | ٥٬٦٣٢ | ||||
| 2020-01-07 | 2020-01-06 | 4 | Lunger John | ADAP | American Depositary Shares representing Ordinary Shares | D | ١٫٢٠٠٠ | ١٬١٤٨ | ١ | ١٬٦٧٧ | ||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٤٠٬٤٤٨ | ١٤٠٬٤٤٨ | |||||
| 2019-09-03 | 2019-09-01 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٢٧ | ٦٢٨٬٨٧٢ | ٦٢٨٬٨٧٢ | |||||
| 2019-08-07 | 2019-08-06 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | ٢٫٠٦٠٠ | ١١٬٠٤٣ | ٢٣ | ١٧٬٢٣٧ | ||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٧٬٦١٢ | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٧٬٦١٢ | ||||||||
| 2019-08-05 | 3 | Lunger John | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٧٬٦١٢ | ||||||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٨٧٬٥٠٠ | ١٨٧٬٥٠٠ | |||||
| 2019-08-05 | 2019-08-01 | 4 | Lunger John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٥٥ | ٨٣٩٬٥٦٨ | ٨٣٩٬٥٦٨ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ٢٣٤٬٤٠٧ | ٢٣٤٬٤٠٧ | |||||
| 2019-07-03 | 2019-07-02 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ٣٥٠٬٩٤٧ | ٣٥٠٬٩٤٧ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ٢٧١٬٢٠٩ | ٢٧١٬٢٠٩ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ٢٣٤٬٤٠٧ | ٢٣٤٬٤٠٧ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Furey John | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ٢٤٠٬٥٤١ | ٢٤٠٬٥٤١ | |||||
| 2019-07-03 | 2019-07-02 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦١ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٤٠٬٤٤٨ | ١٤٠٬٤٤٨ | |||||
| 2019-06-27 | 2019-06-27 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٦٨ | ٦٢٨٬٨٧٢ | ٦٢٨٬٨٧٢ | |||||
| 2019-05-17 | 2019-05-16 | 4 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٠٫١٤٣٠ | ١٬٧٧٣٬١٠٠ | ٢٥٤ | ١٬٧٧٣٬١٠٠ | ||||
| 2019-01-16 | 2019-01-14 | 4 | Rawcliffe Adrian | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٦٩٤ | ٣٬٠٨٤ | ١٧ | ٣٬٣١٨ | ||||
| 2019-01-16 | 2019-01-14 | 4 | Amado Rafael | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٦٩٤ | ٣٬٠٢٨ | ١٦ | ٤٬٩٧٤ | ||||
| 2019-01-16 | 2019-01-14 | 4 | Bertrand William C JR | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٦٩٤ | ٢٬٢٧١ | ١٢ | ٣٬٧٣١ | ||||
| 2019-01-16 | 2019-01-14 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares representing Ordinary Shares | D | ٥٫٣٦٩٤ | ١٬٥١٤ | ٨ | ٢٬٤٨٧ | ||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٥٦١٬٧٩٢ | ٥٦١٬٧٩٢ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨٩ | ٢٬٥١٥٬٥٣٦ | ٢٬٥١٥٬٥٣٦ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٢٤٬٧٢٤ | ٢٢٤٬٧٢٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨٩ | ١٬٠٠٦٬٢٢٤ | ١٬٠٠٦٬٢٢٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٨٠٬٨٩٦ | ٢٨٠٬٨٩٦ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨٩ | ١٬٢٥٧٬٧٤٤ | ١٬٢٥٧٬٧٤٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٢٤٬٧٢٤ | ٢٢٤٬٧٢٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨٩ | ١٬٠٠٦٬٢٢٤ | ١٬٠٠٦٬٢٢٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٢٢٤٬٧٢٤ | ٢٢٤٬٧٢٤ | |||||
| 2019-01-08 | 2019-01-04 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨٩ | ١٬٠٠٦٬٢٢٤ | ١٬٠٠٦٬٢٢٤ | |||||
| 2018-12-19 | 2018-12-17 | 4 | Alleva Lawrence M Held by Trust | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٠٫٨٤٠٠ | ٤٧٬٢٨٠ | ٤٠ | ٤٧٬٢٨٠ | ||||
| 2018-10-02 | 2018-10-01 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | ١٣٫٧٩٠٠ | ٢٥٬٠٠٠ | ٣٤٥ | ٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Behbahani Ali See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 5 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ١٢٬٠٠٠٬٠٠٠ | ٢٠٬٠٠٠ | ١٢٬٠٠٠٬٠٠٠ | ||||
| 2018-09-10 | 2018-09-07 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٦٦٦٧ | ٣٬٠٠٠٬٠٠٠ | ٥٬٠٠٠ | ٨٢٬٩٧٨٬٦٦٨ | ||||
| 2018-08-31 | 2018-08-29 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | American Depositary Shares | D | ١٠٫٢٥٠٠ | ٢٥٬٠٠٠ | ٢٥٦ | ٠ | ||||
| 2018-08-07 | 2018-08-06 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٦٧٨٬٧٢٠ | ٦٧٨٬٧٢٠ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٥٤٬٨٠٩ | ١٥٤٬٨٠٩ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٥٨٬٢٣٣ | ١٥٨٬٢٣٣ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٢٤٬٠٠٠ | ١٢٤٬٠٠٠ | |||||
| 2018-06-26 | 2018-06-22 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٥٤٬٨٠٩ | ١٥٤٬٨٠٩ | |||||
| 2018-06-26 | 2018-06-22 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ٢٫١٨ | ١٨٧٬٣٣٠ | ١٨٧٬٣٣٠ | |||||
| 2018-06-06 | 2018-06-06 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٤٩٠٠ | ١٬٦٠٠ | ٢٢ | ٤٬٩٠١٬٣١٠ | ||||
| 2018-06-06 | 2018-06-04 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٧٠٠ | ١٧٬١٠٠ | ٢٣٢ | ٤٬٩٠٢٬٩١٠ | ||||
| 2018-06-06 | 2018-06-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٤٩٠٠ | ١٬٦٠٠ | ٢٢ | ٤٬٩٠١٬٣١٠ | ||||
| 2018-06-06 | 2018-06-04 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٧٠٠ | ١٧٬١٠٠ | ٢٣٢ | ٤٬٩٠٢٬٩١٠ | ||||
| 2018-06-01 | 2018-06-01 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٤٩٠٠ | ٥٠٬٠٠٠ | ٦٧٤ | ٤٬٩٢٠٬٠١٠ | ||||
| 2018-06-01 | 2018-05-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٢٠٠ | ١٢١٬٠٠٠ | ١٬٦٣٦ | ٤٬٩٧٠٬٠١٠ | ||||
| 2018-06-01 | 2018-06-01 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٤٩٠٠ | ٥٠٬٠٠٠ | ٦٧٤ | ٤٬٩٢٠٬٠١٠ | ||||
| 2018-06-01 | 2018-05-30 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٢٠٠ | ١٢١٬٠٠٠ | ١٬٦٣٦ | ٤٬٩٧٠٬٠١٠ | ||||
| 2018-05-16 | 2018-05-14 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٠٠٠ | ١٠٬٣٠٠ | ١٣٩ | ٥٬٠٩١٬٠١٠ | ||||
| 2018-05-16 | 2018-05-14 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١٣٫٥٠٠٠ | ١٠٬٣٠٠ | ١٣٩ | ٥٬٠٩١٬٠١٠ | ||||
| 2018-03-29 | 2018-03-29 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١١٫٥٣٠٠ | ٣١٬٩٨٣ | ٣٦٩ | ٥٬١٠١٬٣١٠ | ||||
| 2018-03-29 | 2018-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١١٫٥٠٠٠ | ١٬٠١٦٬٠٨٤ | ١١٬٦٨٥ | ٥٬١٣٣٬٢٩٣ | ||||
| 2018-03-29 | 2018-03-29 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١١٫٥٣٠٠ | ٣١٬٩٨٣ | ٣٦٩ | ٥٬١٠١٬٣١٠ | ||||
| 2018-03-29 | 2018-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ١١٫٥٠٠٠ | ١٬٠١٦٬٠٨٤ | ١١٬٦٨٥ | ٥٬١٣٣٬٢٩٣ | ||||
| 2018-03-28 | 2018-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩١٦٧ | ٦٬٠٠٠٬٠٠٠ | ١١٬٥٠٠ | ٧٩٬٩٧٨٬٦٧٢ | ||||
| 2018-03-28 | 2018-03-26 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤١ | ٥٧١٬١٦٤ | ١٬٠٨٨ | ٧٣٬٩٧٨٬٦٧٢ | ||||
| 2018-03-23 | 2018-03-23 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-23 | 2018-03-23 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٤٦٢ | ٢٩٤٬٠٩٠ | ٥٧٢ | ٧٣٬٤٠٧٬٥٠٨ | ||||
| 2018-03-23 | 2018-03-22 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٩٠٤٠ | ٨٦٩٬٥٧٤ | ١٬٦٥٦ | ٧٣٬١١٣٬٤١٨ | ||||
| 2018-03-23 | 2018-03-21 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١٫٨١٠٥ | ١٠٤٬٨٤٤ | ١٩٠ | ٧٢٬٢٤٣٬٨٤٤ | ||||
| 2018-03-22 | 2018-03-20 | 4 | Rawcliffe Adrian | ADAP | Ordinary Shares | D | ١٫٧١٠٠ | ٦٠٠٬٠٠٠ | ١٬٠٢٦ | ٠ | ||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٣٨٤٬١٢٠ | ٣٨٤٬١٢٠ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ١٬٧١٩٬٩٣٦ | ١٬٧١٩٬٩٣٦ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٩٢٬٠٦٠ | ١٩٢٬٠٦٠ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ٨٥٩٬٩٦٨ | ٨٥٩٬٩٦٨ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٤٤٬٠٤٨ | ١٤٤٬٠٤٨ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Bertrand William C JR | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ٦٤٤٬٩٧٦ | ٦٤٤٬٩٧٦ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ٩٦٬٠٣٦ | ٩٦٬٠٣٦ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ٤٢٩٬٩٨٤ | ٤٢٩٬٩٨٤ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٥٣٬٦٤٨ | ١٥٣٬٦٤٨ | |||||
| 2018-01-17 | 2018-01-12 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ٦٨٧٬٩٨٤ | ٦٨٧٬٩٨٤ | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٠٠ | ١٥٣٬٦٤٨ | ١٥٣٬٦٤٨ | |||||
| 2018-01-17 | 2018-01-12 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ١٫٣٠ | ٦٨٧٬٩٨٤ | ٦٨٧٬٩٨٤ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ١٤٤٬٠٠٠ | ١٤٤٬٠٠٠ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Duncan Barbara Gayle | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٢٢٨٬٧٦٥ | ٢٢٨٬٧٦٥ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٢٢٠٬٧٨٨ | ٢٢٠٬٧٨٨ | |||||
| 2017-07-03 | 2017-07-03 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٣٠٢٬٥٦١ | ٣٠٢٬٥٦١ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٢٤٣٬٧٢٤ | ٢٤٣٬٧٢٤ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ١٤٤٬٠٠٠ | ١٤٤٬٠٠٠ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٢٢٠٬٧٨٨ | ٢٢٠٬٧٨٨ | |||||
| 2017-07-03 | 2017-07-03 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٥ | ٢٢٣٬٧٧٩ | ٢٢٣٬٧٧٩ | |||||
| 2017-03-28 | 2017-03-27 | 4 | Thompson Peter A. See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ٤٫٢٠٠٠ | ١٬١٩٠٬٤٧٦ | ٥٬٠٠٠ | ٦٬١٤٩٬٣٧٧ | ||||
| 2017-03-28 | 2017-03-27 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | American Depositary Shares representing Ordinary Shares | I | ٤٫٢٠٠٠ | ١٬١٩٠٬٤٧٦ | ٥٬٠٠٠ | ٦٬١٤٩٬٣٧٧ | ||||
| 2017-03-28 | 2017-03-27 | 4 | KERINS PATRICK J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | MOTT DAVID M See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | SANDELL SCOTT D See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | Sonsini Peter W. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | Viswanathan Ravi See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | New Enterprise Associates 14, L.P. | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRETT M JAMES See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | BARRIS PETER J See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | BASKETT FOREST See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-03-28 | 2017-03-27 | 4 | Florence Anthony A. Jr. See Note 3 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ٠٫٧٠٠٠ | ١٢٬٨٧٠٬٠٠٠ | ٩٬٠٠٩ | ٧٢٬١٣٩٬٠٠٠ | ||||
| 2017-01-18 | 2017-01-13 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٢ | ٢٬٠٧٢٬٩٧٦ | ٢٬٠٧٢٬٩٧٦ | |||||
| 2017-01-18 | 2017-01-13 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٢ | ٢٬٠٧٢٬٩٧٦ | ٢٬٠٧٢٬٩٧٦ | |||||
| 2017-01-18 | 2017-01-13 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٢ | ٢٬٠٧٢٬٩٧٦ | ٢٬٠٧٢٬٩٧٦ | |||||
| 2017-01-18 | 2017-01-13 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٢ | ٢٬٠٧٢٬٩٧٦ | ٢٬٠٧٢٬٩٧٦ | |||||
| 2017-01-18 | 2017-01-13 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ٠٫٧٢ | ٢٬٠٧٢٬٩٧٦ | ٢٬٠٧٢٬٩٧٦ | |||||
| 2016-12-01 | 2016-11-29 | 4 | Kerr Giles Francis Bertram | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨١ | ٢٨٨٬٠٠٠ | ٢٨٨٬٠٠٠ | |||||
| 2016-12-01 | 2016-11-29 | 4 | Zaks Tal Zvi | ADAP | Option to purchase Ordinary Shares | D | ٠٫٨١ | ٢٨٨٬٠٠٠ | ٢٨٨٬٠٠٠ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Thompson Peter A. | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٨٦٬١٤٢ | ١٨٦٬١٤٢ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Alleva Lawrence M | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٩٦٬٦٧٨ | ١٩٦٬٦٧٨ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Behbahani Ali | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٨٤٬٥٦٢ | ١٨٤٬٥٦٢ | |||||
| 2016-08-12 | 2016-08-11 | 4 | MOTT DAVID M | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٩١٬٤١٠ | ١٩١٬٤١٠ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Laing Ian Michael | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٤٤٬٠٠٠ | ١٤٤٬٠٠٠ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Sigal Charles Elliott | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٨٤٬٥٦٢ | ١٨٤٬٥٦٢ | |||||
| 2016-08-12 | 2016-08-11 | 4 | Knowles Jonathan Kenneth Charles | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ٢١٧٬٢٢٢ | ٢١٧٬٢٢٢ | |||||
| 2016-05-25 | 2016-05-24 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٤٨٠٠ | ٥١٨٬٤٠٠ | ٥٬٤٣٣ | ٢٩٬٧٥٣٬٤٠٤ | ||||
| 2016-05-25 | 2016-05-23 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٤٠٠٠ | ١٬١٩١٬٦٠٠ | ١٢٬٣٩٣ | ٢٩٬٢٣٥٬٠٠٤ | ||||
| 2016-05-25 | 2016-05-20 | 4 | ORBIMED ADVISORS LLC See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٠٤٠٠ | ٢٬٤٠٠ | ٢٤ | ٢٨٬٠٤٣٬٤٠٤ | ||||
| 2016-05-25 | 2016-05-24 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٤٨٠٠ | ٥١٨٬٤٠٠ | ٥٬٤٣٣ | ٢٩٬٧٥٣٬٤٠٤ | ||||
| 2016-05-25 | 2016-05-23 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٤٠٠٠ | ١٬١٩١٬٦٠٠ | ١٢٬٣٩٣ | ٢٩٬٢٣٥٬٠٠٤ | ||||
| 2016-05-25 | 2016-05-20 | 4 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٠٫٠٤٠٠ | ٢٬٤٠٠ | ٢٤ | ٢٨٬٠٤٣٬٤٠٤ | ||||
| 2016-05-19 | 2016-05-19 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٫٥٦٠٠ | ١٥٬٠٠٠ | ٢٣ | ٣١٤٬١٠٠ | ||||
| 2016-05-18 | 2016-05-18 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٫٥٥٠٠ | ١٥٬٠٠٠ | ٢٣ | ٢٩٩٬١٠٠ | ||||
| 2016-05-18 | 2016-05-17 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٫٥٣٠٠ | ١٥٬٠٠٠ | ٢٣ | ٢٨٤٬١٠٠ | ||||
| 2016-05-18 | 2016-05-16 | 4 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ١٫٥٠٠٠ | ١٥٬٠٠٠ | ٢٢ | ٢٦٩٬١٠٠ | ||||
| 2016-01-20 | 2016-01-18 | 4 | Rawcliffe Adrian | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ٩٣٩٬٩٤٨ | ٩٣٩٬٩٤٨ | |||||
| 2016-01-20 | 2016-01-18 | 4 | Binder-Scholl Gwendolyn Knowlton | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ٧٠٤٬٩٦١ | ٧٠٤٬٩٦١ | |||||
| 2016-01-20 | 2016-01-18 | 4 | TAYTON-MARTIN HELEN KATRINA | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ٩٣٩٬٩٤٨ | ٩٣٩٬٩٤٨ | |||||
| 2016-01-20 | 2016-01-18 | 4 | Noble James | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ١٬٩٦٨٬٠١٦ | ١٬٩٦٨٬٠١٦ | |||||
| 2016-01-20 | 2016-01-18 | 4 | Amado Rafael | ADAP | Option to purchase Ordinary Shares | D | ١٫٢٧ | ٩٣٩٬٩٤٨ | ٩٣٩٬٩٤٨ | |||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Weller Harry R See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Sonsini Peter W. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | KOLLURI KRISHNA KITTU See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Florence Anthony A. Jr. See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | BARRIS PETER J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | NEA 14 GP, LTD | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | D | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٦١٬١٣٨ | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott Shares held by Sigal Family Investments, LLC | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٦١٬١٣٨ | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٣٥٩٬٩٧٦ | ||||||||
| 2016-01-04 | 3 | Sigal Charles Elliott | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٣٥٩٬٩٧٦ | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٨٬٠٨٥٬٦٠٠ | ||||||||
| 2016-01-04 | 3 | Laing Ian Michael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٥٨٬٠٨٥٬٦٠٠ | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٤١٬١٦٨ | ||||||||
| 2016-01-04 | 3 | Alleva Lawrence M | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٤١٬١٦٨ | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٧٬٢٠٨٬٧٦٨ | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٤٬٢٠٥٬٧٨٤ | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٧٬٢٠٨٬٧٦٨ | ||||||||
| 2016-01-04 | 3 | Knowles Jonathan Kenneth Charles | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٤٬٢٠٥٬٧٨٤ | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٩٢٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Amado Rafael | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٩٢٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٣٬٦٣٠٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | TAYTON-MARTIN HELEN KATRINA | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٣٬٦٣٠٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٢١٬١٤٥٬٢٠٠ | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٢٬٣٧٢٬٦٠٠ | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ٢١٬١٤٥٬٢٠٠ | ||||||||
| 2016-01-04 | 3 | Noble James | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | D | ١٢٬٣٧٢٬٦٠٠ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | ISALY SAMUEL D See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | BASKETT FOREST See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | BARRETT M JAMES See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | MOTT DAVID M See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | KERINS PATRICK J See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | SANDELL SCOTT D See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٥٣٬٤٤٩٬٣٠٤ | ||||||||
| 2016-01-04 | 3 | Thompson Peter A. See Footnotes | ADAP | Ordinary Shares with a nominal value of GBP0.001 per share | I | ٣٠٬٦٧٣٬٧٠٨ | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ | ||||||||
| 2016-01-04 | 3 | Viswanathan Ravi See Note 1 | ADAP | Ordinary Shares with a nominal value of 0.001 GBP per share | I | ١١٨٬٥٣٨٬٠٠٠ |
P
السوق المفتوحة أو الشراء الخاص للأوراق المالية غير المشتقة أو المشتقة
S
السوق المفتوحة أو البيع الخاص للأوراق المالية غير المشتقة أو المشتقة
A
المنح أو المكافأة أو الاستحواذ على الأوراق المالية من الشركة (مثل الخيار)
C
تحويل المشتقات
D
بيع أو نقل الأوراق المالية مرة أخرى إلى الشركة
F
دفع سعر التمرين أو الالتزام الضريبي باستخدام جزء من الأوراق المالية المستلمة من الشركة
G
هدية الأوراق المالية من قبل أو إلى المطلعين
K
مقايضات الأسهم ومعاملات التحوط المماثلة
M
التمرين أو تحويل الأوراق المالية المشتقة المستلمة من الشركة (مثل الخيار)
V
معاملة تم الإبلاغ عنها طوعًا في النموذج 4
J
أخرى (مصحوبة بحاشية تصف المعاملة)
