ZYME / Zymeworks Inc. - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

شركة زايميوركس
US ˙ NasdaqGS ˙ US98985Y1082

الإحصائيات الأساسية
LEI 894500AHOYAGYLYZJL67
CIK 1403752
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Zymeworks Inc.
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
February 14, 2023 SC 13G/A

ZYME / Zymeworks Inc / BANK OF AMERICA CORP /DE/ Passive Investment

SC 13G/A 1 doc1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 01)* Zymeworks Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 98985W102 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

February 14, 2023 EX-99

BANK OF AMERICA CORPORATION LIMITED POWER OF ATTORNEY BANK OF AMERICA CORPORATION

EX-99 2 boa-poa2.htm BANK OF AMERICA CORPORATION LIMITED POWER OF ATTORNEY BANK OF AMERICA CORPORATION, a Delaware corporation (the "Corporation"), does hereby make, constitute, and appoint each of Kelvin Kwok, Tolu Tade, Andres Ortiz Custodio, Frank Lui, James Todd, Zainab Tarteel, Hannah Chae and Monica Yako as an attorney-in-fact for the Corporation acting for the Corporation and in the Corpora

February 6, 2023 SC 13G/A

ZYME / Zymeworks Inc / WELLINGTON MANAGEMENT GROUP LLP - SEC SCHEDULE 13G Passive Investment

SC 13G/A 1 SEC13GFiling.htm SEC SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Zymeworks Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 98985W102 (CUSIP Number) December 30, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desi

October 24, 2022 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

tx15-12G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-38068 Zymeworks BC Inc.* (Exact name of registrant as specified

October 21, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 21, 2022 Zymeworks BC Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 21, 2022 Zymeworks BC Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation)

October 21, 2022 EX-1.1

Open Market Sale AgreementSM, dated October 21, 2022, by and between Zymeworks Inc. and Jefferies LLC.

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM October 21, 2022 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Zymeworks Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), its common stock, par value $0.00001 pe

October 19, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 Zymeworks BC Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 Zymeworks BC Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation)

October 19, 2022 EX-99.2

Zymeworks To Host Conference Call on Exclusive Licensing Agreement of Zanidatamab

Exhibit 99.2 Zymeworks To Host Conference Call on Exclusive Licensing Agreement of Zanidatamab ? Jazz Pharmaceuticals to obtain exclusive development and commercialization rights in key markets including the U.S., Europe and Japan ? Zymeworks to receive $50 million upfront payment, a second payment of $325 million, at Jazz?s option, and further potential regulatory and commercial milestones for to

October 19, 2022 EX-99.1

Jazz Pharmaceuticals and Zymeworks Announce Exclusive License Agreement to Develop and Commercialize Zanidatamab, a HER2-Targeted Bispecific Antibody Jazz to obtain exclusive development and commercialization rights in key markets including the U.S.,

Exhibit 99.1 Jazz Pharmaceuticals and Zymeworks Announce Exclusive License Agreement to Develop and Commercialize Zanidatamab, a HER2-Targeted Bispecific Antibody Jazz to obtain exclusive development and commercialization rights in key markets including the U.S., Europe and Japan Zymeworks to receive $50 million upfront payment, a second payment of $325 million, at Jazz?s option, and further poten

October 18, 2022 EX-3.1

Notice of Alteration.

Exhibit 3.1 Date and Time: October 13, 2022 09:28 AM Pacific Time Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 Notice of Alteration FORM 11 BUSINESS CORPORATIONS ACT Section 257 Filed Date and Time: October 13, 2022 09:28 AM Pacific Time Alteration Date and Time: Notice of Articles

October 18, 2022 EX-3.2

Notice of Articles.

Exhibit 3.2 Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies Notice of Articles BUSINESS CORPORATIONS ACT T.K. SPARKS This Notice of Articles was issued by the Registrar on: October 13, 2022

October 18, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2022 Zymeworks BC Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation)

October 13, 2022 EX-99.25

EX-99.25

NOTIFICATION OF THE REMOVAL FROM LISTING AND REGISTRATION OF THE STATED SECURITIES The New York Stock Exchange hereby notifies the SEC of its intention to remove the entire class of the stated securities from listing and registration on the Exchange at the opening of business on October 24, 2022, pursuant to the provisions of Rule 12d2-2 (a).

October 13, 2022 S-8 POS

As filed with the Securities and Exchange Commission on October 13, 2022

As filed with the Securities and Exchange Commission on October 13, 2022 Registration No.

October 13, 2022 POSASR

As filed with the Securities and Exchange Commission on October 13, 2022

As filed with the Securities and Exchange Commission on October 13, 2022 Registration No.

October 13, 2022 S-8 POS

As filed with the Securities and Exchange Commission on October 13, 2022

As filed with the Securities and Exchange Commission on October 13, 2022 Registration No.

October 13, 2022 S-8 POS

As filed with the Securities and Exchange Commission on October 13, 2022

As filed with the Securities and Exchange Commission on October 13, 2022 Registration No.

October 13, 2022 S-8 POS

As filed with the Securities and Exchange Commission on October 13, 2022

S-8 POS 1 d369120ds8pos.htm S-8 POS As filed with the Securities and Exchange Commission on October 13, 2022 Registration No. 333-263042 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ZYMEWORKS INC. (Exact name of registrant as specified in its charter) Delaware 88-3099146 (J

October 13, 2022 EX-99.25

EX-99.25

NOTIFICATION OF THE REMOVAL FROM LISTING AND REGISTRATION OF THE STATED SECURITIES The New York Stock Exchange hereby notifies the SEC of its intention to remove the entire class of the stated securities from listing and registration on the Exchange at the opening of business on October 24, 2022, pursuant to the provisions of Rule 12d2-2 (a).

October 12, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 Zymeworks Inc. (

425 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation)

October 12, 2022 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

October 11, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2022 Zymeworks Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 11, 2022 EX-99.1

ZYMEWORKS INC. (the “Company”) Special Meeting of Securityholders October 7, 2022 REPORT OF VOTING RESULTS Section 11.3 of National Instrument 51-102 – Continuous Disclosure Obligations

EX-99.1 Exhibit 99.1 ZYMEWORKS INC. (the “Company”) Special Meeting of Securityholders October 7, 2022 REPORT OF VOTING RESULTS Section 11.3 of National Instrument 51-102 – Continuous Disclosure Obligations On October 7, 2022, the Company held a special meeting (the “Special Meeting”) of holders of: (i) common shares of the Company (each, a “Common Share” and the holders thereof, the “Zymeworks Sh

October 11, 2022 EX-99.2

Zymeworks Announces Results of Special Meeting

EX-99.2 Exhibit 99.2 Zymeworks Announces Results of Special Meeting VANCOUVER, British Columbia & SEATTLE – October 7, 2022 — Zymeworks Inc. (“Zymeworks” or the “Company”) (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, is pleased to announce that the Company’s securityholders have approved its plan to become a Delaware corporation (the “Redomic

October 11, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2022 Zymeworks Inc. (E

425 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 7, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation)

October 4, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2022 Zymeworks Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 4, 2022 EX-99.1

Zymeworks Reminds Shareholders to Vote FOR its Redomicile

Exhibit 99.1 Zymeworks Reminds Shareholders to Vote FOR its Redomicile ? The Redomicile is anticipated to provide greater opportunities to enhance long-term value for securityholders, simplify commercialization efforts and monetization opportunities for our product candidates, and provide greater comparability to our peers. ? Leading independent proxy advisory firms, Institutional Shareholder Serv

October 4, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 3, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 3, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 3, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences and Early Research & Development Day

Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences and Early Research & Development Day Vancouver, British Columbia and Seattle, Washington (October 03, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in upcoming investor conferen

September 26, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2022 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 26, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 26, 2022 EX-99.1

Independent Proxy Advisory Firm ISS Recommends a Vote FOR the Zymeworks Redomicile

Exhibit 99.1 Independent Proxy Advisory Firm ISS Recommends a Vote FOR the Zymeworks Redomicile ? Institutional Shareholder Services joins Glass Lewis in recommending a vote FOR the Redomicile resolution ? ISS cites potential for improved capital raising ability and commercialization efficiencies for the Company?s lead product candidate, zanidatamab ? To vote, contact Kingsdale Advisors at 1-855-4

September 22, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 22, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2022 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 16, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2022 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 16, 2022 EX-99.1

Independent Proxy Advisory Firm Glass Lewis Recommends Zymeworks Shareholders Vote FOR Redomicile

Exhibit 99.1 Independent Proxy Advisory Firm Glass Lewis Recommends Zymeworks Shareholders Vote FOR Redomicile ? Independent proxy advisory firm Glass Lewis recommends that Zymeworks shareholders vote FOR the Redomicile resolution ? Glass Lewis notes Zymeworks has made a compelling case that the Redomicile will favor the Company on the basis of more favorable corporate law ? To vote, contact Kings

September 16, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 12, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 12, 2022 EX-99.1

Zymeworks Reports Preliminary Phase 1 Trial Results for Zanidatamab Zovodotin (ZW49) at European Society for Medical Oncology Annual Congress • Company to hold conference call and webcast on Monday, September 12th at 4:30 PM Eastern Standard Time (ES

Exhibit 99.1 Zymeworks Reports Preliminary Phase 1 Trial Results for Zanidatamab Zovodotin (ZW49) at European Society for Medical Oncology Annual Congress ? Company to hold conference call and webcast on Monday, September 12th at 4:30 PM Eastern Standard Time (EST) VANCOUVER, British Columbia & SEATTLE - SEPTEMBER 12, 2022?Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company dev

September 8, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2022 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

September 8, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

September 8, 2022 EX-99.1

Zymeworks Announces Filing and Mailing of Materials for the Special Meeting to Approve Redomicile to Delaware

Exhibit 99.1 Zymeworks Announces Filing and Mailing of Materials for the Special Meeting to Approve Redomicile to Delaware ? Redomicile anticipated to enhance long-term value for securityholders, provide opportunities for increased value of Zymeworks common shares, and better position the Company for future growth ? Zymeworks Board recommends that Zymeworks securityholders vote FOR the Redomicile

September 6, 2022 EX-99.1

Zymeworks Announces Release of ESMO Abstract for Phase 1 Study of Zanidatamab Zovodotin (ZW49) in Solid Cancers

Exhibit 99.1 Zymeworks Announces Release of ESMO Abstract for Phase 1 Study of Zanidatamab Zovodotin (ZW49) in Solid Cancers ? Zanidatamab zovodotin shown to have manageable safety profile with encouraging, single-agent anti-tumor activity in patients with HER2+ cancers ? Results to be reviewed in an oral presentation at European Society for Medical Oncology (ESMO) Congress 2022 in Paris Monday, S

September 6, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

September 2, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

September 2, 2022 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defi

September 2, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2022 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

August 26, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 23, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

August 19, 2022 EX-2.1

Restated and Amended Transaction Agreement, dated August 18, 2022, by and among Zymeworks, Parent, Callco, and ExchangeCo.

Exhibit 2.1 RESTATED AND AMENDED TRANSACTION AGREEMENT BY AND AMONG ZYMEWORKS DELAWARE INC. ZYMEWORKS CALLCO ULC ZYMEWORKS EXCHANGECO LTD. AND ZYMEWORKS INC. DATED AS OF AUGUST 18, 2022 B-1 TABLE OF CONTENTS ARTICLE 1 INTERPRETATION B-5 1.1 Original Agreement B-5 1.2 Defined Terms B-5 1.3 Headings and References B-9 1.4 Time Periods B-9 1.5 Currency B-9 1.6 Time B-10 1.7 Construction B-10 1.8 Gove

August 19, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 18, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

August 19, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 18, 2022 Zymeworks Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 18, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

August 12, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada (State or other jurisdiction of incorporation) 001-38068 (Commission Fil

August 8, 2022 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the ?Exchange Act?), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the ?Schedule 13G?) relating to the Common Stock of Zymeworks Inc., which may be deemed necessary pursu

August 8, 2022 SC 13G

ZYME / Zymeworks Inc / Redmile Group, LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number) July 29, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

August 5, 2022 EX-99.1

FORM 51-102F3 MATERIAL CHANGE REPORT

Exhibit 99.1 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (?Zymeworks? or the ?Company?) 114 East 4th Avenue?Suite 800 Vancouver, BC, Canada V5T 1G4 Item 2: Date of Material Change August 4, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wire on August 4, 2022, and a copy was fil

August 5, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

August 4, 2022 EX-3.2

Articles of the

TABLE OF CONTENTS BUSINESS CORPORATIONS ACT ARTICLES of ZYMEWORKS INC. Pafie 3.1 3.2 51021069.7 4.1 4.2 5.1 5.2 5.3 5.4 1.1 1.2 Central Securities Register Closing Register ARTICLE 5 SHARE TRANSFERS ARTICLE 3 ISSUE OF SHARES 1 1 Definitions Business Corporations Act and Interpretation Act Definitions Applicable Registering Transfers Form of Instrument of Transfer.... Transferor Remains Shareholder

August 4, 2022 EX-10.4

Employment Agreement by and between Zymeworks BC Inc., Zymeworks Biopharmaceuticals Inc. and Paul Moore, dated July 18, 2022 (incorporated by reference to Exhibit 10.4 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2022).

Exhibit 10.4 EMPLOYMENT AGREEMENT THIS AGREEMENT is made and effective as of July 18, 2022 (the ?Effective Date?). BETWEEN: PAUL MOORE, an individual having a residence at [?***?]1. (the ?Employee?), on the one hand AND, on the other hand: ZYMEWORKS BIOPHARMACEUTICALS INC., a corporation registered in the State of Washington and having its principal place of business at 2100-1215 Fourth Avenue, Se

August 4, 2022 EX-10.2

Notice of Assignment of Lease, dated January 1, 2022 from 5th & Main Partnership, 2000 Main Holdings Inc. and Mount Pixel Projects Limited Partnership to Zymeworks BC Inc. (incorporated by reference to Exhibit 10.2 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2022).

Exhibit 10.2 NOTICE OF ASSIGNMENT OF LEASE DATE: January 1, 2022 TO: Zymeworks Inc. (the "Tenant") FROM: 5th & Main Partnership (the "Assignor"); 2000 Main Holdings Inc. and Mount Pixel Projects Limited Partnership (together, the "Interim Owner"); and 130 E 4th Partnership (the "Assignee") RE: Lease dated for reference January 25, 2019, as amended and modified from time to time (collectively, the

August 4, 2022 EX-10.3

Third Amendment to Collaboration and Cross License Agreement, effective June 6, 2022, by and between Zymeworks BC Inc. and Daiichi Sankyo Co., Ltd (incorporated by reference to Exhibit 10.3 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2022).

Exhibit 10.3 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK ?[?***?]?. CONFIDENTIAL EXECUTION COPY THIRD AMENDMENT TO COLLABORATION AND CROS

August 4, 2022 EX-10.1

Lease Amending Agreement, dated April 1, 2022, by and between Zymeworks BC Inc. and 130 E 4th Partnership (incorporated by reference to Exhibit 10.1 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2022).

Exhibit 10.1 LEASE AMENDING AGREEMENT THIS AGREEMENT dated for reference April 1, 2022, BETWEEN: 130 E 4TH PARTNERSHIP (the "Landlord") AND: ZYMEWORKS INC. (the "Tenant") WITNESSES THAT WHEREAS: A.Pursuant to a lease dated for reference January 25, 2019 (the "Original Lease") between 5th & Main Partnership (the "Original Landlord"), as landlord, and the Tenant, as tenant, the Original Landlord lea

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 4, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

August 4, 2022 EX-99.1

Zymeworks Provides Corporate Update and Reports Second Quarter 2022 Financial Results

Zymeworks Provides Corporate Update and Reports Second Quarter 2022 Financial Results ?Zanidatamab zovodotin (ZW49) accepted for oral presentation of Phase 1 clinical data at European Society for Medical Oncology (ESMO) Congress in September ?Announced Early Research and Development (eR&D) day presentation and webcast for October 20th, 2022 with focus on TOPO1i antibody-drug conjugate and multi-sp

August 4, 2022 EX-3.1

Notice of Articles of the

Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 Notice of Articles BUSINESS CORPORATIONS ACT CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies T.K. SPARKS This Notice of Articles was issued by the Registrar on: June 10, 2022 01:32 PM Pacif

August 2, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences

Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences Vancouver, British Columbia and Seattle, Washington (August 1, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in an upcoming investor conference: ? Citi?s 17th Annual BioPharma C

August 2, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

July 25, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 25, 2022 EX-99.1

Zymeworks Announces Oral Presentation of Data from Phase 1 Study of Zanidatamab Zovodotin (ZW49) in Solid Cancers at European Society for Medical Oncology (ESMO) Congress 2022 in Paris

Exhibit 99.1 Zymeworks Announces Oral Presentation of Data from Phase 1 Study of Zanidatamab Zovodotin (ZW49) in Solid Cancers at European Society for Medical Oncology (ESMO) Congress 2022 in Paris • Oral presentation will take place on Monday, September 12 at 5:25 pm Central European Summer Time (CEST) VANCOUVER, British Columbia & SEATTLE—(BUSINESS WIRE)—July 25, 2022 — Zymeworks Inc. (NYSE: ZYM

July 22, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 22, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 22, 2022 EX-99.1

Zymeworks Reports Inducement Grant to New Chief Scientific Officer

Exhibit 99.1 Zymeworks Reports Inducement Grant to New Chief Scientific Officer Vancouver, Canada and Seattle, Washington (July 22, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today reported, as required by the New York Stock Exchange Listed Company Manual Rule 303A.08 (the “NYSE Rule”), an equity inducement award to D

July 21, 2022 EX-99.1

Zymeworks to Host Second Quarter Results Conference Call

Exhibit 99.1 Zymeworks to Host Second Quarter Results Conference Call Vancouver, Canada and Seattle, Washington (July 21, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will report its second quarter 2022 financial results after market close on August 4th, 2022. Following the announcement,

July 21, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 15, 2022 EX-99.1

Zymeworks Announces Plan to Become a Delaware Corporation • Enhances alignment with US shareholder base and other peer biotechnology companies • Positions company for growth while helping to reduce complexity and certain administrative costs • The Co

EX-99.1 3 d373368dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Plan to Become a Delaware Corporation • Enhances alignment with US shareholder base and other peer biotechnology companies • Positions company for growth while helping to reduce complexity and certain administrative costs • The Company’s name, brand, and ticker symbol to remain unchanged Vancouver, Canada and Seattle, Washington

July 15, 2022 425

Filed by Zymeworks Inc.

Filed by Zymeworks Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File: 001-38068 On July 15, 2022, Zymeworks Inc. made the following materials available to employees. Redomicile On July 15, we issued a press release announcing our plans to become a Delaware Cor

July 15, 2022 425

Filed by Zymeworks Delaware Inc.

425 1 d346220d425.htm 425 Filed by Zymeworks Delaware Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File No. for Registration Statement on Form S-4 filed by Zymeworks Delaware Inc.: 333-266160 On July 15, 2022, Kenneth Galbraith, Chair and CEO of Zymeworks Inc.

July 15, 2022 EX-2.1

ransaction Agreement by and among the Company, Zymeworks Delaware Inc., Zymeworks CallCo ULC and Zymeworks ExchangeCo Ltd., dated July 14, 2022 (incorporated by reference to Exhibit 2.1 to the Company’s Current Report on Form 8-K originally filed with the SEC on July 15, 2022)

EX-2.1 2 d373368dex21.htm EX-2.1 Exhibit 2.1 TRANSACTION AGREEMENT BY AND AMONG ZYMEWORKS DELAWARE INC. ZYMEWORKS CALLCO ULC ZYMEWORKS EXCHANGECO LTD. AND ZYMEWORKS INC. DATED AS OF July 14, 2022 1 TABLE OF CONTENTS ARTICLE 1 INTERPRETATION 5 1.1 Defined Terms 5 1.2 Headings and References 9 1.3 Time Periods 9 1.4 Currency 9 1.5 Time 10 1.6 Construction 10 1.7 Governing Law 10 ARTICLE 2 THE ARRANG

July 15, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.2 4 d373368dex992.htm EX-99.2 Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (“Zymeworks” or the “Company”) 114 East 4th Avenue - Suite 800 Vancouver, BC, Canada V5T 1G4 Item 2: Date of Material Change July 14, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wire

July 15, 2022 425

-2-

Filed by Zymeworks Delaware Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File No. for Registration Statement on Form S-4 filed by Zymeworks Delaware Inc.: 333-266160 On July 15, 2022, Zymeworks Inc. made available to investors and the public a pre-recorded web

July 15, 2022 425

Filed by Zymeworks Inc.

Filed by Zymeworks Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File: 001-38068 On July 15, 2022, Kenneth Galbraith, Chair and CEO of Zymeworks Inc. (the ?Company?), sent the following email to employees of the Company. Everyone, Today ahead of market open we

July 15, 2022 425

Filed by Zymeworks Inc.

Filed by Zymeworks Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File: 001-38068 On July 15, 2022, Zymeworks Inc. made available to investors and the public a pre-recorded webcast presentation. The transcript of the presentation is included below, and the slide

July 15, 2022 425

Filed by Zymeworks Delaware Inc.

Filed by Zymeworks Delaware Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File No. for Registration Statement on Form S-4 filed by Zymeworks Delaware Inc.: 333-266160 On July 15, 2022, Zymeworks Inc. made the following materials available to employees. Redomici

July 15, 2022 425

Zymeworks Announces Plan to Become a Delaware Corporation ● Enhances alignment with US shareholder base and other peer biotechnology companies ● Positions company for growth while helping to reduce complexity and certain administrative costs ● The Co

Filed by Zymeworks Delaware Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File No. for Registration Statement on Form S-4 filed by Zymeworks Delaware Inc.: 333-266160 On July 15, 2022, Zymeworks Inc. issued the following press release. Zymeworks Announces Plan

July 15, 2022 425

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 14, 2022 Zymeworks Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 14, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 15, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 14, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 15, 2022 425

-2-

Filed by Zymeworks Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File: 001-38068 On July 15, 2022, Zymeworks Inc. made available to investors and the public a pre-recorded webcast presentation. The slides used in the presentation are reproduced below, and the t

July 15, 2022 425

Filed by Zymeworks Delaware Inc.

Filed by Zymeworks Delaware Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Exchange Act of 1934 Subject Company: Zymeworks Inc. Commission File No. for Registration Statement on Form S-4 filed by Zymeworks Delaware Inc.: 333-266160 On July 15, 2022, Zymeworks Inc. made available to investors and the public a pre-recorded web

June 27, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (?Zymeworks? or the ?Company?) 114 East 4th Avenue?Suite 800 Vancouver, BC, Canada V5T 1G4 Item 2: Date of Material Change June 27, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wire on June 27, 2022, and a copy was filed

June 27, 2022 EX-99.1

Zymeworks Appoints Dr. Paul Moore as Chief Scientific Officer Dr. Moore will lead Zymeworks’ Early Research & Development Group responsible for advancing the Company’s next-generation of multispecific antibody programs and antibody drug conjugate (AD

Exhibit 99.1 Zymeworks Appoints Dr. Paul Moore as Chief Scientific Officer Dr. Moore will lead Zymeworks? Early Research & Development Group responsible for advancing the Company?s next-generation of multispecific antibody programs and antibody drug conjugate (ADC) programs into clinical studies Vancouver, Canada and Seattle, Washington (June 27, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-sta

June 27, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

June 10, 2022 EX-99.1

Zymeworks Adopts Limited-Duration Shareholder Rights Plan, Enabling All Shareholders to Realize Full Value of Company

Exhibit 99.1 Zymeworks Adopts Limited-Duration Shareholder Rights Plan, Enabling All Shareholders to Realize Full Value of Company ? Plan ensures shareholders are protected and treated equitably ? Does not prevent the Zymeworks Board from engaging on future acquisition proposal that is in the best interests of all shareholders Vancouver, Canada and Seattle, Washington (June 10, 2022) ? Zymeworks I

June 10, 2022 EX-4.1

Preferred Shares Rights Agreement, dated as of June 9, 2022, by and between Zymeworks and Computershare Trust Company, N.A., as rights agent (incorporated by reference to Exhibit 4.1 to Zymeworks’s Current Report on Form 8-K filed with the SEC on June 10, 2022).

EX-4.1 2 d319186dex41.htm EX-4.1 Exhibit 4.1 PREFERRED SHARES RIGHTS AGREEMENT Dated as of June 9, 2022 between ZYMEWORKS INC. and COMPUTERSHARE TRUST COMPANY, N.A., as Rights Agent TABLE OF CONTENTS Page Section 1. Certain Definitions 1 Section 2. Appointment of Rights Agent 12 Section 3. Issuance of Rights Certificates 12 Section 4. Form of Rights Certificates 14 Section 5. Countersignature and

June 10, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.2 4 d319186dex992.htm EX-99.2 Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (“Zymeworks” or the “Company”) 114 East 4th Avenue - Suite 800 Vancouver, BC, Canada V5T 1G4 Item 2: Date of Material Change June 9, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wire o

June 10, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

June 10, 2022 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Zymeworks Inc. (Exact name of registrant as spe

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 98-1398788 (State of incorporation or organization) (I.R.S. Employer Identification No.) Suite 800, 11

May 27, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conference

Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conference Vancouver, Canada and Seattle, Washington (May 27, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in an upcoming investor conference: ? Jefferies Healthcare Conference. Zymeworks

May 27, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 27, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

May 26, 2022 SC 13D/A

ZYME / Zymeworks Inc / All Blue Falcons FZE - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D. C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number of Class of Securities) Daniel Cookson All Blue Falcons FZE Office 2301 23rd Floor API Trio Tower Al Barsha 1 Dubai, United Arab

May 26, 2022 EX-99.1

Clinical Data Demonstrating Promising Antitumor Activity with Zanidatamab in 1L Setting of HER2-Positive Breast and Gastroesophageal Cancers to be Presented at ASCO 2022

Exhibit 99.1 Clinical Data Demonstrating Promising Antitumor Activity with Zanidatamab in 1L Setting of HER2-Positive Breast and Gastroesophageal Cancers to be Presented at ASCO 2022 ? Study of zanidatamab in combination with docetaxel results in 90.5% confirmed objective response rate (cORR) in first-line treatment of advanced HER2-positive breast cancer ? Zanidatamab in combination with chemothe

May 26, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

May 20, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 20, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

May 20, 2022 EX-99.1

Zymeworks’ Board of Directors Unanimously Rejects Unsolicited, Non-Binding Proposal

EX-99.1 2 d244477dex991.htm EX-99.1 Exhibit 99.1 Zymeworks’ Board of Directors Unanimously Rejects Unsolicited, Non-Binding Proposal • Opportunistic proposal from activist shareholder substantially undervalues Zymeworks and is not in the best interests of shareholders • Shareholders are right to question the motive behind an activist proposal that was concurrently released to the media and sent to

May 20, 2022 EX-99.3

ALL BLUE CAPITAL EXPANDS ITS LEADERSHIP TEAM TO SUPPORT PROPOSED ACQUISITION OF ZYMEWORKS INC. Siddhartha Mukherjee, MD, Hematology and Oncology Medical Expert, Rhodes Scholar and Pulitzer Prize Winning Author, Recently Joined All Blue as Medical Adv

EX-99.3 2 tm2216134d1ex99-3.htm EXHIBIT 99.3 Exhibit 99.3 ALL BLUE CAPITAL EXPANDS ITS LEADERSHIP TEAM TO SUPPORT PROPOSED ACQUISITION OF ZYMEWORKS INC. Siddhartha Mukherjee, MD, Hematology and Oncology Medical Expert, Rhodes Scholar and Pulitzer Prize Winning Author, Recently Joined All Blue as Medical Advisor All Blue Urges Zymeworks Board to Engage with All Blue on Its Compelling $10.50 Per Sha

May 20, 2022 SC 13D/A

ZYME / Zymeworks Inc / All Blue Falcons FZE - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D. C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number of Class of Securities) Daniel Cookson All Blue Falcons FZE Office 2301 23rd Floor API Trio Tower Al Barsha 1 Dubai, United Arab

May 4, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commiss

May 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

May 4, 2022 EX-99.1

Zymeworks Provides Corporate Update and Reports First Quarter 2022 Financial Results

EX-99.1 2 exhibit991q12022xpressxre.htm EX-99.1 Zymeworks Provides Corporate Update and Reports First Quarter 2022 Financial Results •Last patient enrolled ahead of expectations in pivotal trial evaluating zanidatamab as monotherapy in 2L biliary tract cancers (BTC) •Two zanidatamab data presentations at ASCO in June: 1L breast cancer and 1L gastroesophageal adenocarcinoma (GEA) •Presented topoiso

May 2, 2022 EX-10.70

Separation Agreement and Release by and between Zymeworks and Kathryn O’Driscoll, dated March 4, 2022 (incorporated by reference to Exhibit 10.70 to Zymeworks’s Amendment No. 1 to Annual Report on Form 10-K/A originally filed with the SEC on May 2, 2022).

EX-10.70 4 d357655dex1070.htm EX-10.70 Exhibit 10.70 SEPARATION AGREEMENT AND RELEASE This Separation Agreement and Release (“Agreement”) is made by and between Kathryn O’Driscoll (“Employee”) and Zymeworks Biopharmaceuticals Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). WHEREAS, Employee was employed at-will by the Company; WHEREAS, Emp

May 2, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences

EX-99.1 2 d260432dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences Vancouver, Canada and Seattle, Washington (May 02, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in an upcoming investor conference: • H.C. W

May 2, 2022 8-K/A

Costs Associated with Exit or Disposal Activities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2022 (Original Report) April 28, 2022 (Amended Report) Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-139878

May 2, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commiss

May 2, 2022 EX-3.1

Notice of Articles of the Company.

EX-3.1 2 d357655dex31.htm EX-3.1 Exhibit 3.1 Mailing Address: Location: PO Box 9431 Stn Prov Govt 2nd Floor - 940 Blanshard Street Victoria BC V8W 9V3 Victoria BC www.corporateonline.gov.bc.ca 1 877 526-1526 CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies Notice of Articles BUSINESS CORPORATIONS ACT CAROL PREST This Notice of Articles was issued by t

May 2, 2022 EX-10.69

Separation Agreement and Release by and between Zymeworks and Anthony Polverino, dated March 14, 2022 (incorporated by reference to Exhibit 10.69 to Zymeworks’s Amendment No. 1 to Annual Report on Form 10-K originally filed with the SEC on May 2, 2022).

EX-10.69 3 d357655dex1069.htm EX-10.69 Exhibit 10.69 SEPARATION AGREEMENT AND RELEASE This Separation Agreement and Release (“Agreement”) is made by and between Anthony Polverino (“Employee”) and Zymeworks Biopharmaceuticals Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). WHEREAS, Employee was employed at-will by the Company; WHEREAS, Empl

May 2, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ☐ TRA

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission f

April 29, 2022 EX-99.1

Zymeworks Confirms Receipt of Unsolicited, Non-Binding Proposal from All Blue Falcons

EX-99.1 2 d266209dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Confirms Receipt of Unsolicited, Non-Binding Proposal from All Blue Falcons Vancouver, Canada and Seattle, Washington (April 28, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today confirmed it has received an unsolicited, non-binding proposal fro

April 29, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 28, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

April 28, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 28, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

April 28, 2022 EX-99.1

Zymeworks Reports Last Patient Enrolled in Pivotal Study of Zanidatamab in Treatment of HER2-Expressing Late-Line Biliary Tract Cancer

Exhibit 99.1 Zymeworks Reports Last Patient Enrolled in Pivotal Study of Zanidatamab in Treatment of HER2-Expressing Late-Line Biliary Tract Cancer Vancouver, Canada and Seattle, Washington (April 28, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that it has completed enrollment in its glo

April 28, 2022 SC 13D/A

ZYME / Zymeworks Inc / All Blue Falcons FZE - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D. C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number of Class of Securities) Daniel Cookson All Blue Falcons FZE Office 2301 23rd Floor API Trio Tower Al Barsha 1 Dubai, United Arab

April 28, 2022 EX-99.2

VIA EMAIL AND HAND DELIVERY

Exhibit 99.2 Office 2301 API Trio Tower Al Barsha, Dubai, United Arab Emirates Email: [email protected] Tel: +44 7502 018701 VIA EMAIL AND HAND DELIVERY April 28, 2022 Board of Directors Zymeworks Inc. 540-1385 West 8th Avenue Vancouver, BC V6H 3V9 Dear Members of the Board of Directors: On behalf of All Blue Falcons FZE (?All Blue?), and its respective affiliated investment funds that, di

April 27, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

April 27, 2022 EX-99.1

Zymeworks Announces Presentations at 2022 American Society of Clinical Oncology (ASCO) Annual Meeting

Exhibit 99.1 Zymeworks Announces Presentations at 2022 American Society of Clinical Oncology (ASCO) Annual Meeting Vancouver, Canada and Seattle, Washington (April 27, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced, in conjunction with its Asia Pacific partner BeiGene, the acceptance of two abstracts for p

April 22, 2022 SC 13D

ZYME / Zymeworks Inc / All Blue Falcons FZE - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D. C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number of Class of Securities) Daniel Cookson All Blue Falcons FZE Office 2301 23rd Floor API Trio Tower Al Barsha 1 Dubai, United Arab

April 22, 2022 EX-99.1

99.1 Joint Filing Agreement, dated as of April 22, 2022, by and among the Reporting Persons.

EX-99.1 2 tm2213368d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) THIS JOINT FILING AGREEMENT is entered into as April 22, 2022, by and among the parties hereto. The undersigned hereby agree that the Statement on Schedule 13D with respect to the common shares, no par value, of Zymeworks Inc. and any amendment thereafter signed by each of the undersigned

April 19, 2022 EX-99.1

Zymeworks to Host First Quarter 2022 Results Conference Call

Exhibit 99.1 Zymeworks to Host First Quarter 2022 Results Conference Call Vancouver, Canada and Seattle, Washington (April 19, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will report its first quarter 2022 financial results after market close on May 4th, 2022. Following the announcement,

April 19, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 19, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

April 1, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences

Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences Vancouver, Canada and Seattle, Washington (April 01, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in upcoming investor conferences: ? Wells Fargo 2022 Biotech Forum. Zymeworks

April 1, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

March 9, 2022 EX-10.1

Executive Incentive Compensation Plan (incorporated by reference to Exhibit 10.1 to Zymeworks’s Current Report on Form 8-K originally filed with the SEC on March 9, 2022).

EX-10.1 2 d497055dex101.htm EX-10.1 Exhibit 10.1 ZYMEWORKS INC. EXECUTIVE INCENTIVE COMPENSATION PLAN 1. Purposes of the Plan. The Plan is intended to increase stockholder value and the success of the Company by motivating Employees to (a) perform to the best of their abilities and (b) achieve the Company’s objectives. 2. Definitions. 2.1 “Actual Award” means as to any Performance Period, the actu

March 9, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 8, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

March 3, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences

Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences Vancouver, Canada and Seattle, Washington (March 03, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing next-generation multifunctional biotherapeutics, today announced that management will participate in upcoming investor conferences during March: ? Barclays Global Healthcare Co

March 3, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

February 25, 2022 S-8

Power of Attorney (included on page II-5 of this Registration Statement).

As filed with the Securities and Exchange Commission on February 25, 2022 Registration No.

February 25, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Zymeworks Inc. (Exact name of registrant as specified in its charter) Table 1 ? Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Shares, no par value per

February 25, 2022 S-8

As filed with the Securities and Exchange Commission on February 25, 2022

As filed with the Securities and Exchange Commission on February 25, 2022 Registration No.

February 25, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Zymeworks Inc. (Exact name of registrant as specified in its charter) Table 1 - Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Shares, no par value per

February 25, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

February 25, 2022 EX-10.1

Amended and Restated Employment Agreement by and between Zymeworks BC Inc. and Christopher Astle, dated February 24, 2022 (incorporated by reference to Exhibit 10.1 to Zymeworks BC Inc.’s Current Report on Form 8-K filed with the SEC on February 25, 2022).

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT THIS AGREEMENT is made and effective as of February 24, 2022 (the ?Effective Date?). BETWEEN: Dr. Christopher Astle, having a residence at [?***?]1 (the ?Employee?) AND: ZYMEWORKS INC., a corporation registered in the Province of British Columbia and having its principal place of business at 800-114 East 4th Avenue, Vancouver, BC, V5T 1G4, Can

February 25, 2022 EX-99.1

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.1 3 d295460dex991.htm EX-99.1 Exhibit 99.1 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (“Zymeworks” or the “Company”) 114 East 4th Avenue - Suite 800 Vancouver, BC, Canada V5T 1G4 Item 2: Date of Material Change February 24, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business W

February 24, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

February 24, 2022 EX-3.1

Notice of Articles of the Registrant.

Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 Notice of Articles BUSINESS CORPORATIONS ACT CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies CAROL PREST This Notice of Articles was issued by the Registrar on: January 26, 2022 11:16 AM Pa

February 24, 2022 EX-10.63

Separation and Release Agreement by and between Zymeworks and James Priour, dated February 4, 2022 (incorporated by reference to Exhibit 10.63 to Zymeworks’ Annual Report on Form 10-K, originally filed with the SEC on February 24, 2022).

EX-10.63 4 zyme-20211231xex1063.htm EX-10.63 Exhibit 10.63 SEPARATION AGREEMENT AND RELEASE This Separation Agreement and Release (“Agreement”) is made by and between James Priour (“Employee”) and Zymeworks Biopharmaceuticals Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). WHEREAS, Employee was employed at-will by the Company; WHEREAS, Emp

February 24, 2022 EX-10.66

Letter, dated November 9, 2021, from Zymeworks to Neil Josephson (incorporated by reference to Exhibit 10.66 to Zymeworks’ Annual Report on Form 10-K, originally filed with the SEC on February 24, 2022).

Exhibit 10.66 9 November 2021 Mr. Neil Josephson Interim Chief Medical Officer Promotion to Chief Medical Officer Dear Neil, On behalf of the Board of Directors of Zymeworks Inc. (?Zymeworks?), I am pleased to confirm your promotion to the position of Chief Medical Officer, effective 15 November 2021, and the following changes to your compensation: Current New Base Salary (USD) $453,200 $480,000 B

February 24, 2022 EX-4.1

Specimen common share certificate (incorporated by reference to Exhibit 4.1 to the Company’s Annual Report on Form 10-K, originally filed with the SEC on February 24, 2022).

EX-4.1 3 a41specimencommonsharece.htm EX-4.1 A COMPANY INCORPORATED UNDER THE LAWS OF BRITISH COLUMBIA SEE REVERSE FOR CERTAIN DEFINITIONS in the Authorized share structure of the above named Company subject to the Articles of the Company transferable on the Central Securities Register of the Company by the registered holder in person or by attorney duly authorized in writing upon surrender of thi

February 24, 2022 EX-99.1

Zymeworks Provides Corporate Update and Reports Year-End 2021 Financial Results

Zymeworks Provides Corporate Update and Reports Year-End 2021 Financial Results ?Enrollment on track for both pivotal trials of zanidatamab in 1L gastroesophageal adenocarcinoma (GEA) and 2L biliary tract cancer (BTC).

February 24, 2022 EX-21.1

Subsidiaries of the

Exhibit 21.1 Subsidiaries of the Company As of December 31, 2021 Name of Subsidiary State of Incorporation Zymeworks Biopharmaceuticals Inc. Washington

February 24, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-38

February 15, 2022 SC 13G/A

ZYME / Zymeworks Inc / PERCEPTIVE ADVISORS LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* Zymeworks Inc.. (Name of Issuer) Common Shares, no par value (Title of Class of Securities) 98985W 102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

February 15, 2022 EX-99.1

AGREEMENT

EX-99.1 EXHIBIT 1 AGREEMENT The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Date: February 14, 2022 PERCEPTIVE ADVISORS LLC

February 14, 2022 SC 13G

ZYME / Zymeworks Inc / EVENTIDE ASSET MANAGEMENT, LLC - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Zymeworks Inc. (Name of Issuer ? as specified in its charter) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

February 14, 2022 EX-99.1

In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they conduct business as the

EX-99.1 2 ex991.htm EX-99.1 In accordance with Securities and Exchange Commission Release No. 34-39538 (January 12, 1998), this Statement is being filed by Credit Suisse AG (the "Bank"), a Swiss bank, on behalf of its subsidiaries to the extent that they conduct business as the Swiss Universal Bank, Asia Pacific, International Wealth Management, Global Markets, Investment Banking & Capital Markets

February 14, 2022 SC 13G/A

ZYME / Zymeworks Inc / BAKER BROS. ADVISORS LP - SC 13G/A Passive Investment

SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2022 SC 13G

ZYME / Zymeworks Inc / CREDIT SUISSE AG/ - NONE Passive Investment

SC 13G 1 doc1.htm NONE UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Zymeworks Inc. (Name of Issuer) Common Shares, no par value per share (Title of Class of Securities) 98985W102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to

February 10, 2022 SC 13G

ZYME / Zymeworks Inc / MILLENNIUM MANAGEMENT LLC Passive Investment

SC 13G 1 ZYMESC13G.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ZYMEWORKS INC. (Name of Issuer) COMMON SHARES, NO PAR VALUE PER SHARE (Title of Class of Securities) 98985W102 (CUSIP Number) FEBRUARY 2, 2022 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pur

February 8, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 8, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

February 8, 2022 EX-99.1

Zymeworks to Host Fourth Quarter and Full Year 2021 Results Conference Call

EX-99.1 2 d244869dex991.htm EX-99.1 Exhibit 99.1 Zymeworks to Host Fourth Quarter and Full Year 2021 Results Conference Call Vancouver, Canada and Seattle, Washington (February 08, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will report its fourth quarter and full year 2021 financial res

February 4, 2022 SC 13G

ZYME / Zymeworks Inc / WELLINGTON MANAGEMENT GROUP LLP - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Zymeworks Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 98985W102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 3, 2022 EX-99.1

Zymeworks Announces Participation in Upcoming Investor Conferences

EX-99.1 2 d304104dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Participation in Upcoming Investor Conferences Vancouver, Canada and Seattle, Washington (February 03, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will participate in upcoming investor conferences. • Guggenheim Oncology

February 3, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 3, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

January 31, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 31, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

January 31, 2022 SC 13G

ZYME / Zymeworks Inc / BANK OF AMERICA CORP /DE/ - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Zymeworks Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 98985W102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whi

January 31, 2022 EX-99.1

Zymeworks Announces Closing of Public Offering and Exercise in Full of the Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 Zymeworks Announces Closing of Public Offering and Exercise in Full of the Underwriters? Option to Purchase Additional Shares Vancouver, Canada and Seattle, Washington (January 31, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced the closing of its previously announced underwritten public offeri

January 31, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (?Zymeworks? or the ?Company?) 1385 West 8th Avenue, Suite 540 Vancouver, BC, Canada V6H 3V9 Item 2: Date of Material Change January 26, 2022 and January 31, 2022 Item 3: News Release News releases dated January 26, 2022 and January 31, 2022 were disseminated through the facilities of Business Wire

January 27, 2022 EX-99.2

Zymeworks Announces Pricing of $100.0 Million Public Offering

Exhibit 99.2 Zymeworks Announces Pricing of $100.0 Million Public Offering Vancouver, Canada and Seattle, Washington (January 26, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced the pricing of its underwritten public offering of 9,160,000 common shares and, in lieu of common shares to certain investors, pre

January 27, 2022 424B5

CALCULATION OF REGISTRATION FEE Title Of Each Class of Securities to be Registered Number of Securities to be Registered Maximum Offering Price Per Security Maximum Aggregate Offering Price Amount of Registration Fee Common Shares, no par value 14,37

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-259970 CALCULATION OF REGISTRATION FEE Title Of Each Class of Securities to be Registered Number of Securities to be Registered Maximum Offering Price Per Security Maximum Aggregate Offering Price Amount of Registration Fee Common Shares, no par value 14,375,000(1) $8.00 $115,000,000.00 $10,660.50 Pre-Funded Warrants to Purcha

January 27, 2022 EX-1.1

Underwriting Agreement dated January 26, 2022

EX-1.1 2 d302094dex11.htm EX-1.1 Exhibit 1.1 Zymeworks Inc. 9,160,000 Common Shares and Pre-Funded Warrants to Purchase 3,340,000 Common Shares Underwriting Agreement New York, New York January 26, 2022 Jefferies LLC Evercore Group L.L.C. As Representatives of the several Underwriters c/o Jefferies LLC 520 Madison Avenue New York, New York 10022 c/o Evercore Group L.L.C. 55 East 52nd Street, 35th

January 27, 2022 EX-4.1

Form of Pre-Funded Warrant to Purchase Common Shares (incorporated by reference to Exhibit 4.1 to Zymeworks’s Current Report on Form 8-K filed with the SEC on January 27, 2022).

EX-4.1 3 d302094dex41.htm EX-4.1 Exhibit 4.1 [FORM OF PRE-FUNDED] WARRANT TO PURCHASE COMMON SHARES Number of Shares: [ ] (subject to adjustment) Warrant No. Original Issue Date: [ ] Zymeworks Inc., a company continued under the Business Corporations Act (British Columbia) (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby a

January 27, 2022 EX-99.1

Zymeworks Announces Proposed Public Offering

EX-99.1 5 d302094dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Proposed Public Offering Vancouver, Canada and Seattle, Washington (January 26, 2022) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that it has commenced an underwritten public offering of its common shares and, in lieu of common shares to cer

January 27, 2022 8-K

Entry into a Material Definitive Agreement, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 26, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

January 26, 2022 424B5

SUBJECT TO COMPLETION, DATED JANUARY 26, 2022

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-259970 This preliminary prospectus supplement and the accompanying prospectus relate to an effective registration statement under the Securities Act of 1933, as amended, but the information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying

January 19, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.2 3 d461277dex992.htm EX-99.2 Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (“Zymeworks” or the “Company”) 1385 West 8th Avenue, Suite 540 Vancouver, BC, Canada V6H 3V9 Item 2: Date of Material Change January 19, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wi

January 19, 2022 8-K

Costs Associated with Exit or Disposal Activities, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

January 19, 2022 EX-99.1

Zymeworks Provides Corporate Update on Key Strategic Priorities and Outlook for 2022

EX-99.1 2 d461277dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Provides Corporate Update on Key Strategic Priorities and Outlook for 2022 • New Chair and CEO, Mr. Kenneth Galbraith, outlines strategic priorities for 2022 and 2023 across key clinical development activities for zanidatamab and ZW49, preclinical R&D pipeline, collaborations and partnerships • Further changes to leadership team announced

January 18, 2022 EX-99.1

Zymeworks Reports Inducement Grant Under New York Stock Exchange Listed Company Manual Rule

Exhibit 99.1 Zymeworks Reports Inducement Grant Under New York Stock Exchange Listed Company Manual Rule Vancouver, Canada and Seattle, Washington (January 15, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today reported, as required by the New York Stock Exchange Listed Company Manual Rule 303A.08 (the ?NYSE Rule?), an

January 18, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 15, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

January 6, 2022 EX-99.1

Zymeworks to Present at 40th Annual J.P. Morgan Healthcare Conference

Exhibit 99.1 Zymeworks to Present at 40th Annual J.P. Morgan Healthcare Conference Vancouver, Canada and Seattle, Washington (January 6, 2022) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that Neil Klompas, Zymeworks? Chief Operating Officer and Chief Financial Officer, will present at the upcoming 40th Annual

January 6, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

January 5, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2022 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

January 5, 2022 EX-10.3

Promotion Letter from the Company to Neil Klompas, dated January 5, 2022 (incorporated by reference to Exhibit 10.3 to the Company’s Current Report on Form 8-K originally filed with the SEC on January 5, 2022).

Exhibit 10.3 5 January 2022 Mr. Neil Klompas Executive Vice President, Business Operations and Chief Financial Officer Promotion to Chief Operating Officer Dear Neil, On behalf of the Board of Directors of Zymeworks Inc. (?Zymeworks?), I am pleased to confirm your promotion to the position of Chief Operating Officer, effective 5 January 2022 (you will remain as Chief Financial Officer as well), an

January 5, 2022 EX-10.4

Inducement Stock Option and Equity Compensation Plan (incorporated by reference to Exhibit 10.4 to the Company’s Current Report on Form 8-K originally filed with the SEC on January 5, 2022).

Exhibit 10.4 ZYMEWORKS INC. INDUCEMENT STOCK OPTION AND EQUITY COMPENSATION PLAN TABLE OF CONTENTS ARTICLE I INTERPRETATION 1 Section 1.1 Definitions 1 Section 1.2 Interpretation 5 ARTICLE II GENERAL PROVISIONS 5 Section 2.1 Administration 5 Section 2.2 Shares Reserved 6 Section 2.3 Amendment and Termination 7 Section 2.4 Compliance with Legislation 8 Section 2.5 Effective Time and Termination 8 S

January 5, 2022 EX-99.1

Zymeworks Names Biotechnology Industry Leader Kenneth Galbraith as Chair and CEO to Succeed Dr. Ali Tehrani

EX-99.1 6 d207208dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Names Biotechnology Industry Leader Kenneth Galbraith as Chair and CEO to Succeed Dr. Ali Tehrani • Co-founder Dr. Ali Tehrani to remain as an advisor to the Company to assist in the transition expected to occur on or before February 1, 2022 • Chief Financial Officer (CFO) Neil Klompas also promoted to the dual position of Chief Operating

January 5, 2022 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (?Zymeworks? or the ?Company?) 1385 West 8th Avenue, Suite 540 Vancouver, BC, Canada V6H 3V9 Item 2: Date of Material Change January 5, 2022 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business Wire on January 5, 2022 and a copy was

January 5, 2022 EX-10.2

Separation Agreement and Release by and between the Company and Ali Tehrani, dated January 5, 2022 (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K originally filed with the SEC on January 5, 2022).

EX-10.2 3 d207208dex102.htm EX-10.2 Exhibit 10.2 SEPARATION AGREEMENT AND RELEASE THIS SEPARATION AGREEMENT AND RELEASE is made on January 5, 2022. BETWEEN: ZYMEWORKS INC. (“Zymeworks” or the “Company”) AND: DR. ALI TEHRANI (the “Executive”) WHEREAS: A. The Executive was employed by Zymeworks since September 8, 2003, pursuant to an amended and restated employment agreement dated January 17, 2017 (

January 5, 2022 EX-10.1

Employment Agreement by and between the Company and Kenneth Galbraith, dated January 5, 2022 (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K originally filed with the SEC on January 5, 2022).

EX-10.1 2 d207208dex101.htm EX-10.1 Exhibit 10.1 EMPLOYMENT AGREEMENT THIS AGREEMENT is made and effective as of the date the Employee commences employment with the Company, which date is expected to be on or before February 1, 2022 (the actual first day of employment with the Company, the “Effective Date”, BETWEEN: Mr. Kenneth Galbraith, having a residence at Corners, Moules Lane, Hadstock, Cambr

December 9, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

December 9, 2021 EX-99.1

Zanidatamab Data Presented at the San Antonio Breast Cancer Symposium (SABCS) Demonstrate Encouraging Antitumor Activity in Heavily Pretreated Patients with HER2-Positive Breast Cancer

EX-99.1 2 d260676dex991.htm EX-99.1 Exhibit 99.1 Zanidatamab Data Presented at the San Antonio Breast Cancer Symposium (SABCS) Demonstrate Encouraging Antitumor Activity in Heavily Pretreated Patients with HER2-Positive Breast Cancer • Overall confirmed objective response rate (cORR) of 36.4% and disease control rate (DCR) of 86.4% • Median progression-free survival (mPFS) of 7.3 months overall •

December 9, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 9, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

December 9, 2021 EX-99.1

Zymeworks Announces Expansion of Zanidatamab Pivotal Trial in Asia in Collaboration with BeiGene and Associated Milestone Payment

EX-99.1 2 d10637dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Expansion of Zanidatamab Pivotal Trial in Asia in Collaboration with BeiGene and Associated Milestone Payment • First patient dosed in South Korea under Zymeworks and BeiGene collaboration agreement • HERIZON-GEA-01 enrollment progresses with multiple active sites and continued global recruitment • Zymeworks to receive US$8MM deve

December 1, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

December 1, 2021 EX-99.1

Zymeworks Announces Second Janssen Bispecific Antibody to Begin Clinical Development Utilizing Azymetric™ and EFECT™ Therapeutic Platforms

Exhibit 99.1 Zymeworks Announces Second Janssen Bispecific Antibody to Begin Clinical Development Utilizing Azymetric? and EFECT? Therapeutic Platforms Vancouver, Canada (December 1, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that Janssen Biotech, Inc. (?Janssen?) dosed the first patient with JNJ-78306

November 19, 2021 EX-99.1

Zymeworks Announces Abstract for Zanidatamab in Late-Line HER2-Positive Breast Cancer at the San Antonio Breast Cancer Symposium (SABCS)

EX-99.1 2 d208558dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Abstract for Zanidatamab in Late-Line HER2-Positive Breast Cancer at the San Antonio Breast Cancer Symposium (SABCS) • Full presentation available December 8 at 5:00 pm Central Time (CT) Vancouver, Canada (November 19, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional bioth

November 19, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 19, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (C

November 9, 2021 EX-99.2

Zymeworks Names Neil Josephson, M.D., Chief Medical Officer

EX-99.2 3 d217459dex992.htm EX-99.2 Exhibit 99.2 Zymeworks Names Neil Josephson, M.D., Chief Medical Officer Vancouver, British Columbia (November 9, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that Neil Josephson, M.D., who has been serving as the company’s interim Chief Medical Officer (CMO) since May

November 9, 2021 EX-99.1

Zymeworks Launches Global Phase 3 Zanidatamab Trial in First-Line HER2-Positive Gastroesophageal Adenocarcinoma (GEA)

EX-99.1 2 d217459dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Launches Global Phase 3 Zanidatamab Trial in First-Line HER2-Positive Gastroesophageal Adenocarcinoma (GEA) • HERIZON-GEA-01 study is now open and enrolling patients to evaluate zanidatamab and chemotherapy with or without tislelizumab, versus standard of care • Phase 2 data demonstrate potential benefit of zanidatamab in first-line GEA, w

November 9, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

November 8, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

November 8, 2021 EX-99.1

Zymeworks to Present at Upcoming Investor Conferences

Exhibit 99.1 Zymeworks to Present at Upcoming Investor Conferences Vancouver, British Columbia (November 08, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will participate in three upcoming investor conferences. ? Stifel 2021 Virtual Healthcare Conference, November 16th ? 17th. Zymeworks i

November 3, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file numbe

November 3, 2021 EX-99.2

Second Amendment to License and Collaboration Agreement, dated August 10, 2021, by and between Zymeworks and BeiGene Ltd. (incorporated by reference to Exhibit 99.2 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on November 3, 2021).

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC.

November 3, 2021 EX-99.1

Fourth Amendment to Collaboration Agreement, dated August 4, 2021, by and between Zymeworks BC Inc., Celgene Corporation and Celgene Alpine Investment Co. LLC (incorporated by reference to Exhibit 99.1 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on November 3, 2021).

EX-99.1 6 zyme-20210930xex991.htm EX-99.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[…***…]”. CONFIDENTIAL FOURTH AMENDMENT TO COLLABO

November 3, 2021 EX-99.1

Zymeworks Reports 2021 Third Quarter Financial Results

Zymeworks Reports 2021 Third Quarter Financial Results Vancouver, Canada (November 3, 2021) ? Zymeworks Inc.

November 3, 2021 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

October 26, 2021 EX-99.1

Zymeworks Announces Webcast to Present HERIZON-GEA-01 Pivotal Trial Design and Zanidatamab Commercial Strategy in Gastrointestinal Cancers

EX-99.1 2 d247827dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Webcast to Present HERIZON-GEA-01 Pivotal Trial Design and Zanidatamab Commercial Strategy in Gastrointestinal Cancers Vancouver, British Columbia (October 26, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that management will host a con

October 26, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 26, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Co

October 5, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 5, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 5, 2021 EX-99.1

Zymeworks and ALX Oncology Announce First Patient Dosed in Phase 1b/2 Clinical Trial of Zanidatamab and Evorpacept (ALX148) in Patients with Advanced HER2-Expressing Breast Cancer and Other Solid Tumors

EX-99.1 2 d204577dex991.htm EX-99.1 Exhibit 99.1 Zymeworks and ALX Oncology Announce First Patient Dosed in Phase 1b/2 Clinical Trial of Zanidatamab and Evorpacept (ALX148) in Patients with Advanced HER2-Expressing Breast Cancer and Other Solid Tumors Vancouver, Canada and South San Francisco, California (October 5, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company de

October 1, 2021 EX-1.1

Amendment No. 1 to the Open Market Sale AgreementSM, dated October 1, 2021, by and between Zymeworks and Jefferies LLC (incorporated by reference to Exhibit 1.1 to Zymeworks’s Current Report on Form 8-K filed with the SEC on October 1, 2021).

EX-1.1 2 d237389dex11.htm EX-1.1 Exhibit 1.1 AMENDMENT NO. 1 TO THE OPEN MARKET SALE AGREEMENTSM October 1, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: This Amendment No. 1 to the Open Market Sale AgreementSM (this “Amendment”) is entered into as of the date first written above by Zymeworks Inc., a corporation continued under the Business Corporations Act (

October 1, 2021 S-3ASR

As filed with the Securities and Exchange Commission on October 1, 2021

Table of Contents As filed with the Securities and Exchange Commission on October 1, 2021 Registration No.

October 1, 2021 424B5

CALCULATION OF REGISTRATION FEE Title of each class of securities to be registered Proposed maximum aggregate offering price Amount of registration fee(1) Common Shares, no par value $150,000,000 $13,905(2)

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-259970 CALCULATION OF REGISTRATION FEE Title of each class of securities to be registered Proposed maximum aggregate offering price Amount of registration fee(1) Common Shares, no par value $150,000,000 $13,905(2) (1) Calculated in accordance with Rule 457(o) under the Securities Act of 1933, as amended, or the Securities Act,

October 1, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 1, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Com

October 1, 2021 EX-4.4

Form of Indenture

Exhibit 4.4 ZYMEWORKS INC. INDENTURE Dated as of Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1 Definitions 1 Section 1.2 Other Definitions 4 Section 1.3 Incorporation by Reference of Trust Indenture Act 5 Section 1.4 Rules of Construction 5 ARTICLE II THE SECURITIES 5 Section 2.1 Issuable in Series 5 Section 2.2 Establishment of Terms of Series o

September 16, 2021 EX-99.2

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.2 3 d195420dex992.htm EX-99.2 Exhibit 99.2 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Zymeworks Inc. (“Zymeworks” or the “Company”) 1385 West 8th Avenue, Suite 540 Vancouver, BC, Canada V6H 3V9 Item 2: Date of Material Change September 16, 2021 Item 3: News Release A news release announcing the material change was disseminated through the facilities of Business

September 16, 2021 EX-99.1

Zanidatamab Phase 2 Clinical Trial Demonstrates Promising Response Rate and Durability in First-Line HER2-Positive Gastroesophageal Adenocarcinoma (GEA) at the European Society for Medical Oncology (ESMO) Annual Congress

Exhibit 99.1 Zanidatamab Phase 2 Clinical Trial Demonstrates Promising Response Rate and Durability in First-Line HER2-Positive Gastroesophageal Adenocarcinoma (GEA) at the European Society for Medical Oncology (ESMO) Annual Congress ? Confirmed objective response rate (cORR) of 75% overall and 93% for the proposed Phase 3 regimen (zanidatamab + CAPOX/FP) ? Median duration of response (mDOR) of 16

September 16, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 13, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2021 Zymeworks Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (

September 13, 2021 EX-99.1

Zymeworks Announces Abstract for Zanidatamab in First-line HER2-Expressing Gastroesophageal Cancers (GEA) at the European Society for Medical Oncology (ESMO) Annual Congress

EX-99.1 2 d202904dex991.htm EX-99.1 Exhibit 99.1 Zymeworks Announces Abstract for Zanidatamab in First-line HER2-Expressing Gastroesophageal Cancers (GEA) at the European Society for Medical Oncology (ESMO) Annual Congress • Abstract data demonstrate encouraging antitumor activity in first-line GEA • Full ESMO presentation available September 16 at 8:30 am CEST, 2:30 am ET • Conference call and we

August 4, 2021 EX-99.5

Fourth Lease Modification Agreement, dated May 7, 2021, by and between Zymeworks and 5th and Main Partnership (incorporated by reference to Exhibit 99.5 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

EX-99.5 12 zyme-20210630xex995.htm EX-99.5 Exhibit 99.5 FOURTH LEASE MODIFICATION AGREEMENT THIS AGREEMENT (this “Agreement”) dated for reference the 7th day of May, 2021. BETWEEN: 5th & MAIN PARTNERSHIP (the “Landlord”) AND: ZYMEWORKS INC. (the “Tenant”) WHEREAS: A.By a lease dated January 25, 2019 (the “Original Lease”), as modified and expanded by a letter agreement dated June 27, 2019 (the “Fi

August 4, 2021 EX-99.7

Letter Agreement, effective June 4, 2021, by and between Zymeworks BC Inc. and GlaxoSmithKline Intellectual Property Development Limited (incorporated by reference to Exhibit 99.7 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 99.7 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK ?[?***?]?. May 18, 2021 VIA E-MAIL GSK 980 Great West Road Brentford, Middlesex

August 4, 2021 EX-99.2

Letter Agreement, effective October 7, 2020, by and between Zymeworks and BeiGene, Ltd. (incorporated by reference to Exhibit 99.2 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 99.2 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK ?[?***?]?. September 17, 2020 VIA E-MAIL BeiGene, Ltd. c/o Mourant Ozannes Corpo

August 4, 2021 EX-10.2

Letter, dated May 16, 2021, from Zymeworks to Neil Josephson (incorporated by reference to Exhibit 10.2 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

May 16, 2021 Exhibit 10.2 Neil Josephson Zymeworks Biopharmaceuticals Inc. Dear Neil, Re: Interim Chief Medical Officer On behalf of the senior leadership team and the Board of Directors, I am pleased to confirm your position as Interim Chief Medical Officer. Your acceptance of this assignment will Include the following changes to your compensation package, effective May 16, 2021. Your base compen

August 4, 2021 EX-99.3

Letter Agreement, effective October 7, 2020, by and between Zymeworks and BeiGene, Ltd. (incorporated by reference to Exhibit 99.3 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 99.3 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[…***…]”. September 17, 2020 VIA E-MAIL BeiGene, Ltd. c/o Mourant Ozannes Corpo

August 4, 2021 EX-99.1

Zymeworks Reports 2021 Second Quarter Financial Results

EX-99.1 2 exhibit991q22021xpressxre.htm EX-99.1 Zymeworks Reports 2021 Second Quarter Financial Results Vancouver, Canada (August 4, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today reported financial results for the second quarter ended June 30, 2021. “The second half of 2021 is an exciting time at Zymeworks as we pr

August 4, 2021 EX-99.8

Second Amendment to Collaboration and Cross License Agreement, effective July 2, 2021, by and between Zymeworks and Daiichi Sankyo Company, Limited (incorporated by reference to Exhibit 99.8 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

EX-99.8 15 zyme-20210630xex998.htm EX-99.8 Exhibit 99.8 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[…***…]”. Confidential Execution Ver

August 4, 2021 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

August 4, 2021 EX-99.6

Second Amendment to License and Collaboration Agreement, effective June 2, 2021, by and between Zymeworks and BeiGene, Ltd. (incorporated by reference to Exhibit 99.6 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 99.6 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK ?[?***?]?. CONFIDENTIAL ZYME MAY 13, 2021 SECOND AMENDMENT TO COLLABORATION AGRE

August 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 00

August 4, 2021 EX-99.4

Letter Agreement, effective April 20, 2021, by and between Zymeworks BC Inc. and Celgene Corporation and Celgene Alpine Investment Co. LLC. (incorporated by reference to Exhibit 99.4 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

EX-99.4 11 zyme-20210630xex994.htm EX-99.4 Exhibit 99.4 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK “[…***…]”. April 20, 2021 VIA E-MAIL

August 4, 2021 EX-99.1

Letter Agreement, effective October 7, 2020, by and between Zymeworks BC Inc. and BeiGene, Ltd. (incorporated by reference to Exhibit 99.1 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

Exhibit 99.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ZYMEWORKS INC. IF PUBLICLY DISCLOSED. INFORMATION THAT HAS BEEN OMITTED HAS BEEN NOTED IN THIS DOCUMENT WITH A PLACEHOLDER IDENTIFIED BY THE MARK ?[?***?]?. September 17, 2020 VIA E-MAIL BeiGene, Ltd. c/o Mourant Ozannes Corpo

August 4, 2021 EX-10.1

Employment Agreement, effective April 29, 2019, by and between Zymeworks and Neil Josephson (incorporated by reference to Exhibit 10.1 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on August 4, 2021).

EX-10.1 2 zyme-20210630xex101.htm EX-10.1 Exhibit 10.1 EMPLOYMENT AGREEMENT THIS AGREEMENT is made and effective as of the April 29, 2019 (the “Effective Date”). BETWEEN: Dr. Neil Josephson, having a residence […***…]1. (the “Employee”) AND: ZYMEWORKS BIOPHARMACEUTIALS INC., a corporation registered in the State of Washington and having its principal place of business at 350-2400 3rd Avenue, Seatt

August 3, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Comm

August 3, 2021 EX-99.1

Zymeworks Announces Milestone Payment as Janssen Achieves First Patient Dosed for its Bispecific Antibody Utilizing Zymeworks’ Azymetric™ and EFECT™ Therapeutic Platforms

Exhibit 99.1 Zymeworks Announces Milestone Payment as Janssen Achieves First Patient Dosed for its Bispecific Antibody Utilizing Zymeworks? Azymetric? and EFECT? Therapeutic Platforms Vancouver, Canada (August 3, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that Janssen Biotech, Inc. (Janssen) dosed the

July 28, 2021 EX-99.1

Zymeworks Announces First Patient with Advanced HER2-Positive Breast Cancer Dosed with Zanidatamab in Combination with Tukysa® (Tucatinib) and Chemotherapy

Exhibit 99.1 Zymeworks Announces First Patient with Advanced HER2-Positive Breast Cancer Dosed with Zanidatamab in Combination with Tukysa? (Tucatinib) and Chemotherapy Vancouver, Canada (July 28, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced the first patient has been dosed with zanidatamab in combinatio

July 28, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 28, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commi

July 9, 2021 S-8

Notice of Articles of Registrant (incorporated by reference to Exhibit 4.2 to the Company's Registration Statement on Form S-8 (File No. 333-257819), originally filed with the SEC on July 9, 2021.

As filed with the Securities and Exchange Commission on July 9, 2021 Registration No.

July 9, 2021 EX-4.2

Form of Notice of Articles of the Registrant (incorporated by reference to Exhibit 4.2 to the Company’s Registration Statement on Form S-8 (File No. 333-257819), originally filed with the SEC on July 9, 2021)

EX-4.2 2 d166021dex42.htm EX-4.2 Exhibit 4.2 Mailing Address: Location: PO Box 9431 Stn Prov Govt 2nd Floor—940 Blanshard Street Victoria BC V8W 9V3 Victoria BC www.corporateonline.gov.bc.ca 1 877 526-1526 CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies Notice of Articles BUSINESS CORPORATIONS ACT CAROL PREST This Notice of Articles was issued by the

July 8, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 8, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

July 8, 2021 EX-99.1

Zymeworks to Present at Ladenburg Thalmann Healthcare Conference

Exhibit 99.1 Zymeworks to Present at Ladenburg Thalmann Healthcare Conference Vancouver, British Columbia (July 08, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that the Company will present at the upcoming Ladenburg Thalmann Healthcare Conference on July 14, 2021 at 4:00 p.m. ET. The presentation will b

May 26, 2021 EX-99.1

Zymeworks to Present at Jefferies Virtual Healthcare Conference

EX-99.1 2 d162461dex991.htm EX-99.1 Exhibit 99.1 Zymeworks to Present at Jefferies Virtual Healthcare Conference Vancouver, British Columbia (May 26, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today announced that the Company will present at the upcoming Jefferies Virtual Healthcare Conference taking place June 1-4, 2

May 26, 2021 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commis

May 18, 2021 8-K/A

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2020 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of inc

May 6, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commiss

May 6, 2021 EX-99.2

Outcome of the Vote

Exhibit 99.2 Zymeworks Announces Election of Directors and Voting Results from Shareholder Meeting Vancouver, Canada (May 6, 2021) ? Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, is pleased to announce the detailed voting results on the items of business considered at its Annual General Meeting of Shareholders held on May 5, 202

May 6, 2021 EX-99.1

ZYMEWORKS INC. (the “Company”) Annual General Meeting of Shareholders May 5, 2021 REPORT OF VOTING RESULTS Section 11.3 of National Instrument 51-102 – Continuous Disclosure Obligations

Exhibit 99.1 ZYMEWORKS INC. (the ?Company?) Annual General Meeting of Shareholders May 5, 2021 REPORT OF VOTING RESULTS Section 11.3 of National Instrument 51-102 ? Continuous Disclosure Obligations Common Shares represented at the Meeting: 29,226,661 Total issued and outstanding Common Shares as at record date: 46,164,051 Percentage of issued and outstanding Common Shares represented: 63.31% Busi

May 5, 2021 EX-99.1

Zymeworks Reports 2021 First Quarter Financial Results

EX-99.1 2 exhibit991q12021xpressxre.htm EX-99.1 Zymeworks Reports 2021 First Quarter Financial Results Vancouver, Canada (May 5, 2021) – Zymeworks Inc. (NYSE: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, today reported financial results for the first quarter ended March 31, 2021. “As we look ahead over the next 12 months, Zymeworks is focused on del

May 5, 2021 EX-10.1

Employment Agreement, effective April 1, 2020, by and between Zymeworks and James Priour (incorporated by reference to Exhibit 10.1 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on May 5, 2021).

EX-10.1 2 zyme-20210331xex101.htm EX-10.1 Exhibit 10.1 EMPLOYMENT AGREEMENT THIS AGREEMENT is made and effective as of April 1, 2020 (the “Effective Date”). BETWEEN: Mr. James Priour, having a residence at […***…]1. (the “Employee”) AND: ZYMEWORKS BIOPHARMACEUTICALS INC., a corporation registered in the State of Washington and having its principal place of business at 2100-1215 Fourth Avenue, Seat

May 5, 2021 EX-10.2

Letter, dated March 3, 2021, from Zymeworks to James Priour (incorporated by reference to Exhibit 10.2 to Zymeworks’s Quarterly Report on Form 10-Q filed with the SEC on May 5, 2021).

EX-10.2 3 zyme-20210331xex102.htm EX-10.2 Priour, James Exhibit 10.2 March 3, 2021 Mr. James Priour Senior Vice President, Commercial Dear James, Re: Annual Compensation Review Our Compensation Review Process for the 2020 performance year is now complete. On behalf of the Zymeworks’ Board of Directors, I am pleased to confirm your promotion to the position of Chief Commercial Officer, in addition

May 5, 2021 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2021 Zymeworks Inc. (Exact name of registrant as specified in its charter) British Columbia, Canada 001-38068 98-1398788 (State or other jurisdiction of incorporation) (Commiss

May 5, 2021 EX-99.1

Third Lease Modification Agreement, dated February 17, 2021, by and between Zymeworks BC Inc. and 5th & Main Partnership (incorporated by reference to Exhibit 99.1 to Zymeworks BC Inc.’s Quarterly Report on Form 10-Q filed with the SEC on May 5, 2021).

Exhibit 99.1 THIRD LEASE MODIFICATION AGREEMENT THIS AGREEMENT (this ?Agreement?) dated for reference the 17 day of February, 2021, BETWEEN: 5th & MAIN PARTNERSHIP (the ?Landlord?) AND: ZYMEWORKS INC. (the ?Tenant?) WHEREAS: A.By a lease dated January 25, 2019 (the ?Original Lease?), between the Landlord and the Tenant, as modified and expanded by a letter agreement dated June 27, 2019 and by a Le

May 5, 2021 10-Q

Quarterly Report - 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 0

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