PLSE / Pulse Biosciences, Inc. - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

نبض العلوم البيولوجية، وشركة
US ˙ NasdaqCM ˙ US74587B1017

الإحصائيات الأساسية
LEI 529900NJUBI06118FM73
CIK 1625101
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Pulse Biosciences, Inc.
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
September 3, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☒ Definitive

September 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 2, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 2, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

September 2, 2025 EX-99.1

Pulse Biosciences Announces First Successful Procedures in PRECISE Benign Thyroid Nodule (BTN) Study

Exhibit 99.1 Pulse Biosciences Announces First Successful Procedures in PRECISE Benign Thyroid Nodule (BTN) Study HAYWARD, Calif. [Business Wire]– September 2, 2025, Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nanosecond PFA or nsPFA™) technology, today announced the first successful procedures in a multicenter IRB-appro

August 26, 2025 EX-99.1

Pulse Biosciences Announces Publication of First-In-Human Data for Treatment of Benign Thyroid Nodules in the Journal

Exhibit 99.1 Pulse Biosciences Announces Publication of First-In-Human Data for Treatment of Benign Thyroid Nodules in the Journal Thyroid First-in-Human Clinical Feasibility Study Demonstrates Effectiveness of Ablation of Benign Thyroid Nodules Using Nanosecond Pulsed Field Ablation HAYWARD, Calif.-(BUSINESS WIRE) August 26, 2025- Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its n

August 26, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

August 18, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☐ Definitive

August 12, 2025 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Second Quarter 2025 Financial Results HAYWARD, California. [Business Wire] – August 12, 2025. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nanosecond PFA or nsPFA™) technology, today announced business updates and financial results for the second quarter ended Ju

August 12, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 12, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 12, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

August 12, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 00

July 14, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 14, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission F

May 30, 2025 SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc.

May 30, 2025 EX-1.01

Conflict Minerals Report of Pulse Biosciences, Inc. as required by Items 1.01 and 1.02 of this Form SD for the period January 1 - December 31, 2024.

Exhibit 1.01 Conflict Minerals Report of Pulse Biosciences, Inc. in Accordance with Rule 13p-1 under the Securities Exchange Act of 1934  This is the Conflict Minerals Report (“CMR”) of Pulse Biosciences, Inc. (“Pulse Biosciences” or the “Company”) for the reporting period January 1, 2024 to December 31, 2024 in accordance with Rule 13p-1 (“Rule 13p-1”) under the Securities Exchange Act of 1934,

May 8, 2025 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and First Quarter 2025 Financial Results HAYWARD, California. [Business Wire] – May 8, 2025. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nanosecond PFA or nsPFA™) technology, today announced business updates and financial results for the first quarter ended March 31

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 8, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 0

April 30, 2025 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K/A (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-34899 Pulse Bioscie

April 30, 2025 EX-10.27

December 5, 2024

Exhibit 10.27 December 5, 2024 VIA HAND DELIVERY Burke Barrett Dear Burke: The purpose of this letter is to inform you that Pulse Biosciences, Inc. (the “Company”) is accepting your resignation and consequently terminating your employment effective Friday, December 6, 2024 (your “Separation Date”). On your Separation Date, you will receive your final paycheck, which will include payment for all of

April 30, 2025 EX-19.1

INSIDER TRADING POLICY As Amended and Approved by the Board of Directors Effective May 11, 2022

Exhibit 19.1 INSIDER TRADING POLICY As Amended and Approved by the Board of Directors Effective May 11, 2022 INTRODUCTION Federal and state securities laws prohibit any person who is aware of material nonpublic information about a company from trading in securities of that company. These laws also prohibit a person from disclosing material nonpublic information to other persons who may trade on th

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUA

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-348

March 31, 2025 EX-21.1

List of Subsidiaries

Exhibit 21.1 List of Subsidiaries  Subsidiary Jurisdiction of Incorporation Ownership Position NanoBlate Corp., a Delaware Corporation Delaware 100% BioElectroMed Corp., a California Corporation California 100% Pulse Biosciences BV Netherlands 100% 2783162 Ontario Inc. Ontario 100% 

March 28, 2025 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Third Quarter 2024 Financial Results MIAMI, Florida. [Business Wire] – Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nanosecond PFA or nsPFA™) technology, today announced business updates and financial results for the fourth quarter and full year ended December 31

March 28, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 27, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

February 27, 2025 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 Pulse Biosciences, Inc. (Exact name of Registrant as specified in its charter) Delaware 46-5696597 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number)  601 Brickell Key Drive, Suite 1080 Mi

February 27, 2025 EX-FILING FEES

Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

EXHIBIT 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc.

February 27, 2025 EX-4.4

PULSE BIOSCIENCES, INC. AMENDED AND RESTATED 2017 INDUCEMENT EQUITY INCENTIVE PLAN

Exhibit 4.4 PULSE BIOSCIENCES, INC. AMENDED AND RESTATED 2017 INDUCEMENT EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel for positions of substantial responsibility by providing an inducement material to individuals’ entering into employment with the Company or any Parent or Subsidiary of the Company. The Plan permits

February 27, 2025 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 Pulse Biosciences, Inc. (Exact name of Registrant as specified in its charter) Delaware 46-5696597 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number)  601 Brickell Key Drive, Suite 1080 Mi

February 27, 2025 EX-FILING FEES

Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

EXHIBIT 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc.

February 4, 2025 EX-10.1

Employment Agreement

Exhibit 10.1 PULSE BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is made and entered into by and between Jon Skinner (“Executive”) and Pulse Biosciences, Inc. (the “Company”), as of January 31, 2025. 1. Duties and Scope of Employment. (a) Position and Duties. As of February 3, 2025 (the “Start Date”), Executive will serve as the Company’s Chief Financial Office

February 4, 2025 EX-99.1

Pulse Biosciences, Inc. Appoints Jon Skinner as Chief Financial Officer Expanded executive team to support operational excellence and commercialization of the CellFX nanosecond PFA Platform

Exhibit 99.1 Pulse Biosciences, Inc. Appoints Jon Skinner as Chief Financial Officer Expanded executive team to support operational excellence and commercialization of the CellFX nanosecond PFA Platform MIAMI, Florida, February 4, 2025 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (n

February 4, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 31, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 31, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissio

January 23, 2025 EX-99.1

Pulse Biosciences Announces Late-Breaking Data from its Nanosecond PFA 360

Exhibit 99.1 Pulse Biosciences Announces Late-Breaking Data from its Nanosecond PFA 360° Cardiac Catheter System First-In-Human Feasibility Study Presented at the AF Symposium Successfully treated atrial fibrillation (AF) in initial 30 patients with the Nanosecond PFA 360° Cardiac Catheter MIAMI, Florida. [Business Wire]– January 21, 2025. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveragi

January 23, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 21, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 21, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissio

January 14, 2025 EX-99.1

Investor Deck, dated January 2025

Exhibit 99.1

January 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 14, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 14, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissio

January 13, 2025 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 9, 2025 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

January 13, 2025 EX-99.1

Pulse Biosciences, Inc. Appoints Paul LaViolette as Chief Executive Officer Current Co-Chairman of the Board will now also serve as Chief Executive Officer

Exhibit 99.1 Pulse Biosciences, Inc. Appoints Paul LaViolette as Chief Executive Officer Current Co-Chairman of the Board will now also serve as Chief Executive Officer MIAMI, Florida, January 10, 2025 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nano-PFA or nsPFA™) technology, tod

January 13, 2025 EX-10.1

Employment Agreement

Exhibit 10.1 PULSE BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is made and entered into by and between Paul LaViolette (“Executive”) and Pulse Biosciences, Inc. (the “Company”), as of January 9, 2025. 1. Duties and Scope of Employment. (a) Position and Duties. As of January 9, 2025 (the “Start Date”), Executive will serve as the Company’s President and Chief

December 26, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 23, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

December 26, 2024 EX-99.1

PULSE BIOSCIENCES, INC. ANNOUNCES PLANNED REDEMPTION OF WARRANTS

Exhibit 99.1 PULSE BIOSCIENCES, INC. ANNOUNCES PLANNED REDEMPTION OF WARRANTS HAYWARD, Calif. — (BUSINESS WIRE) — December 23, 2024 — Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nano-PFA or nsPFA™) technology, today announced that it intends to deliver an irrevocable notice of redemption, on or about December 27, 2024, t

December 6, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 2, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissio

November 26, 2024 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 26, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

October 31, 2024 EX-99.1

Pulse Biosciences Announces Positive Clinical Data Presented at the American Thyroid Association

Exhibit 99.1 Pulse Biosciences Announces Positive Clinical Data Presented at the American Thyroid Association European feasibility study demonstrates using nano-PFA in benign thyroid nodules reduces nodule volume by greater than 50% and provides symptomatic relief within the first month of treatment MIAMI, Florida. [Business Wire] – October 31, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a compa

October 31, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 31, 2024 Pulse Biosciences, Inc.

October 30, 2024 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Third Quarter 2024 Financial Results MIAMI, Florida. [Business Wire] – October 30, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nsPFA or nano-PFA) technology, today announced business updates and financial results for

October 30, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Numbe

October 30, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): October 30, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissio

October 30, 2024 EX-99.2

Pulse Biosciences Announces Appointment of David Kenigsberg, M.D. as Chief Medical Officer of Electrophysiology

Exhibit 99.2 Pulse Biosciences Announces Appointment of David Kenigsberg, M.D. as Chief Medical Officer of Electrophysiology Adds Andrea Natale, M.D. as a medical advisor, joining existing advisors Vivek Reddy, M.D. and Jacob Koruth, M.D. MIAMI, Florida. [Business Wire] – October 30, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary Nanosecond Pulsed Fiel

August 19, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 00

August 15, 2024 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 12b-25 NOTIFICATION OF LATE FILING SEC File Number: 001-37744 CUSIP Number: 74587B101 (Check One): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: June 30, 2024 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Period Ended: Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.

August 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 12, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 12, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

August 12, 2024 EX-99.1

Pulse Biosciences Reports Business Updates and Preliminary Second Quarter 2024 Financial Results

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Preliminary Second Quarter 2024 Financial Results HAYWARD, Calif. [Business Wire] – August 12, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary Nanosecond Pulsed Field Ablation™ (nano-PFA) technology, today announced business updates and preliminary financi

August 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 9, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 9, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

August 12, 2024 EX-99.2

Pulse Biosciences, Inc. Appoints Paul LaViolette to its Board of Directors Paul LaViolette to serve as Co-Chairman alongside Robert W. Duggan, adding 40 years of medical technology development, operating and leadership expertise

Exhibit 99.2 Pulse Biosciences, Inc. Appoints Paul LaViolette to its Board of Directors Paul LaViolette to serve as Co-Chairman alongside Robert W. Duggan, adding 40 years of medical technology development, operating and leadership expertise MIAMI, Florida, August 12, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietar

August 12, 2024 EX-99.1

Investor Deck, dated August 2024

EX-99.1 2 ex712662.htm INVESTOR DECK, DATED AUGUST 2024 Exhibit 99.1

August 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 8, 2024 Pulse Biosciences, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 8, 2024 Pulse Biosciences, Inc.

August 8, 2024 EX-99.1

Pulse Biosciences, Inc. Announces Successful Treatment of Patients in First-in-Human Study with its Nano-PFA Cardiac Surgery System Company’s proprietary system used in study for patients with atrial fibrillation Cardiac Surgery System enrolled in th

Exhibit 99.1 Pulse Biosciences, Inc. Announces Successful Treatment of Patients in First-in-Human Study with its Nano-PFA Cardiac Surgery System Company’s proprietary system used in study for patients with atrial fibrillation Cardiac Surgery System enrolled in the FDA’s Total Product Life Cycle (TPLC) Advisory Program (TAP)* MIAMI, Florida, August 8, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (

July 15, 2024 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 15, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission F

July 15, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pulse Biosciences, Inc.

July 15, 2024 S-3MEF

As filed with the Securities and Exchange Commission on July 15, 2024

S-3MEF As filed with the Securities and Exchange Commission on July 15, 2024 Registration No.

July 15, 2024 EX-1.1

At-the-Market Equity Offering Sales Agreement

Exhibit 1.1 PULSE BIOSCIENCES, INC. Common Stock ($0.001 par value per share) EQUITY DISTRIBUTION AGREEMENT July 15, 2024 CANACCORD GENUITY LLC 1 Post Office Square Suite 3000 Boston, Massachusetts 02109 NEEDHAM & COMPANY, LLC 250 Park Avenue New York, New York 10177 Ladies and Gentlemen: Pulse Biosciences, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions

July 15, 2024 424B5

Up to $60,000,000 Pulse Biosciences, Inc. Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-278322 and 333-280805 PROSPECTUS SUPPLEMENT (To Prospectus dated April 8, 2024) Up to $60,000,000 Pulse Biosciences, Inc. Common Stock We have entered into an equity distribution agreement (the “Equity Distribution Agreement”) with Canaccord Genuity LLC and Needham & Company, LLC (jointly and severally, the “Agents”), r

July 8, 2024 SC 13D/A

PLSE / Pulse Biosciences, Inc. / DUGGAN ROBERT W - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 15)1 Pulse Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 74587B 10 1 (CUSIP Number) ADAM W. FI

July 8, 2024 EX-99.1

Pulse Biosciences, Inc. Announces Receipt of FDA Breakthrough Device Designation for CellFX® nsPFA Cardiac Surgery System for the Treatment of Atrial Fibrillation Provides expanded access to FDA and prioritized review of submission

Exhibit 99.1 Pulse Biosciences, Inc. Announces Receipt of FDA Breakthrough Device Designation for CellFX® nsPFA Cardiac Surgery System for the Treatment of Atrial Fibrillation Provides expanded access to FDA and prioritized review of submission MIAMI, Florida, July 8, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietar

July 8, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 8, 2024 Pulse Biosciences, Inc.

July 3, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 3, 2024 Pulse Biosciences, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) July 3, 2024 Pulse Biosciences, Inc.

July 3, 2024 EX-99.1

Pulse Biosciences, Inc. Announces the Closing of its Rights Offering

Exhibit 99.1 Pulse Biosciences, Inc. Announces the Closing of its Rights Offering HAYWARD, Calif., July 3, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, announced today the closing of its rights offering and the final results thereof. The Company rec

June 28, 2024 EX-99.1

Pulse Biosciences, Inc. Announces Preliminary Results for its Rights Offering Oversubscribed offering expected to generate $60 million in immediate gross proceeds for the Company Warrants issued in the offering could generate up to an additional $66M

Exhibit 99.1 Pulse Biosciences, Inc. Announces Preliminary Results for its Rights Offering Oversubscribed offering expected to generate $60 million in immediate gross proceeds for the Company Warrants issued in the offering could generate up to an additional $66MM HAYWARD, Calif., June 28, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging it

June 28, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 28, 2024 Pulse Biosciences, Inc.

June 7, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 6, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

June 4, 2024 424B2

Pulse Biosciences, Inc. Subscription Rights to Purchase Up to 6,000,000 Units at the Initial Price Each Unit Consisting of One Share of Common Stock and Two Warrants, Each Being a Warrant to Purchase One-Half of One Share of Common Stock (and Up to 6

Filed Pursuant to Rule 424(b)(2) Registration Statement No. 333-278494 PROSPECTUS Pulse Biosciences, Inc. Subscription Rights to Purchase Up to 6,000,000 Units at the Initial Price Each Unit Consisting of One Share of Common Stock and Two Warrants, Each Being a Warrant to Purchase One-Half of One Share of Common Stock (and Up to 6,000,000 Shares of Common Stock Underlying the Warrants at 110% of t

June 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 4, 2024 Pulse Biosciences, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 4, 2024 Pulse Biosciences, Inc.

June 4, 2024 EX-99.1

Pulse Biosciences, Inc. Announces Commencement of Rights Offering

Exhibit 99.1 Pulse Biosciences, Inc. Announces Commencement of Rights Offering HAYWARD, Calif., June 4, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the “Company” or “Pulse Biosciences”), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced that it has commenced its previously announced rights offering of up to $60,000,000

May 31, 2024 SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc.

May 31, 2024 EX-1.01

Conflict Minerals Report of Pulse Biosciences, Inc. as required by Items 1.01 and 1.02 of this Form SD for the period January 1 - December 31, 2023.

Exhibit 1.01 Conflict Minerals Report of Pulse Biosciences, Inc. in Accordance with Rule 13p-1 under the Securities Exchange Act of 1934  This is the Conflict Minerals Report (“CMR”) of Pulse Biosciences, Inc. (“Pulse Biosciences” or the “Company”) for the reporting period January 1, 2023 to December 31, 2023 in accordance with Rule 13p-1 (“Rule 13p-1”) under the Securities Exchange Act of 1934,

May 28, 2024 POS AM

As filed with the Securities and Exchange Commission on May 28, 2024

As filed with the Securities and Exchange Commission on May 28, 2024 Registration No.

May 20, 2024 EX-99.1

Pulse Biosciences Announces Updated Timing of Rights Offering for Up to $60,000,000

Exhibit 99.1 Pulse Biosciences Announces Updated Timing of Rights Offering for Up to $60,000,000 HAYWARD, Calif. – (BUSINESS WIRE) – May 20, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (“Pulse” or the “Company”), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced that the Company’s Board of Directors has determined a new

May 20, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 20, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 20, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 15, 2024 EX-99.1

Pulse Biosciences Enhances Executive Leadership Team Appoints proven atrial fibrillation medical technology leader Burke T. Barrett as President and Chief Executive Officer Former President and Chief Executive Officer Kevin Danahy appointed as Chief

Exhibit 99.1 Pulse Biosciences Enhances Executive Leadership Team Appoints proven atrial fibrillation medical technology leader Burke T. Barrett as President and Chief Executive Officer Former President and Chief Executive Officer Kevin Danahy appointed as Chief Commercial Officer HAYWARD, Calif. [Business Wire] – May 14, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its nove

May 15, 2024 EX-10.4

Fourth Amendment to Employment Agreement, dated May 12, 2024, by and between Pulse Biosciences, Inc. and Kevin Danahy

Exhibit 10.4 PULSE BIOSCIENCES, INC. FOURTH AMENDMENT TO EMPLOYMENT AGREEMENT This fourth amendment (this “Amendment”) is entered into effective as of May 12, 2024, by and between Kevin Danahy (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Executive, the “Parties”). WHEREAS, the Parties entered into an employment agreement dated February 9, 2022 (as previously amended,

May 15, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 12, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 15, 2024 EX-10.2

Pulse Biosciences, 2017 Inducement Equity Incentive Plan

Exhibit 10.2 PULSE BIOSCIENCES, INC. AMENDED AND RESTATED 2017 INDUCEMENT EQUITY INCENTIVE PLAN 1. Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel for positions of substantial responsibility by providing an inducement material to individuals’ entering into employment with the Company or any Parent or Subsidiary of the Company. The Plan permits

May 15, 2024 EX-10.5

Fifth Amendment to Employment Agreement, dated May 12, 2024, by and between Pulse Biosciences, Inc. and Darrin Uecker

Exhibit 10.5 PULSE BIOSCIENCES, INC. FIFTH AMENDMENT TO EMPLOYMENT AGREEMENT This fifth amendment (this “Amendment”) is entered into effective as of May 12, 2024, by and between Darrin Uecker (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Executive, the “Parties”). WHEREAS, the Company and Executive entered into an employment agreement dated September 8, 2015 (as amend

May 15, 2024 EX-10.3

Form of Stock Option Grant Notice and Stock Option Agreement under 2017 Inducement Equity Incentive Plan

Exhibit 10.3 PULSE BIOSCIENCES, INC. 2017 INDUCEMENT EQUITY INCENTIVE PLAN STOCK OPTION AGREEMENT NOTICE OF STOCK OPTION GRANT Unless otherwise defined herein, the terms defined in the Pulse Biosciences, Inc. Amended and Restated 2017 Inducement Equity Incentive Plan (the “Plan” of the “2017 Inducement Equity Incentive Plan”)) will have the same defined meanings in this Stock Option Agreement incl

May 15, 2024 EX-10.1

Employment Agreement

Exhibit 10.1 PULSE BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is made and entered into by and between Burke T. Barrett (“Executive”) and Pulse Biosciences, Inc. (the “Company”), as of May 12, 2024. Certain capitalized terms used herein shall have the meanings assigned to them in Section 10 of this Agreement. 1. Duties and Scope of Employment. (a) Position an

May 9, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 9, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 9, 2024 EX-99.1

Pulse Biosciences Announces First U.S. Procedure with the CellFX nsPFA Percutaneous Electrode System

Exhibit 99.1 Pulse Biosciences Announces First U.S. Procedure with the CellFX nsPFA Percutaneous Electrode System HAYWARD, Calif. [Business Wire] – May 9, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced the first procedure with the CellFX nsPFA Percutaneous Electrode System i

May 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 7, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 0

May 7, 2024 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and First Quarter 2024 Financial Results HAYWARD, Calif. [Business Wire] – May 7, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced business updates and financial results for the first quarter ended March 31, 2024. Recent

May 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 2, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 2, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 2, 2024 EX-99.1

Pulse Biosciences Announces Timing of Rights Offering for Up to $60,000,000

Exhibit 99.1 Pulse Biosciences Announces Timing of Rights Offering for Up to $60,000,000 HAYWARD, Calif. – (BUSINESS WIRE) – May 2, 2024 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (“Pulse” or the “Company”), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced that the Company’s Board of Directors has set the record date for th

May 1, 2024 CORRESP

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545 (510) 906-4600

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545 (510) 906-4600 May 1, 2024 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Pulse Biosciences, Inc. Registration Statement on Form S-3 File No. 333-278494 Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities

April 30, 2024 CORRESP

April 30, 2024

April 30, 2024 VIA EDGAR Division of Corporation Finance United States Securities and Exchange Commission 100 F Street, N.

April 30, 2024 S-3/A

As filed with the Securities and Exchange Commission on April 30, 2024

As filed with the Securities and Exchange Commission on April 30, 2024 Registration No.

April 25, 2024 CORRESP

April 25, 2024

April 25, 2024 VIA EDGAR Division of Corporate Finance United States Securities and Exchange Commission 100 F Street, N.

April 25, 2024 S-3/A

As filed with the Securities and Exchange Commission on April 25, 2024

As filed with the Securities and Exchange Commission on April 25, 2024 Registration No.

April 23, 2024 S-3/A

As filed with the Securities and Exchange Commission on April 23, 2024

As filed with the Securities and Exchange Commission on April 23, 2024 Registration No.

April 23, 2024 CORRESP

April 23, 2024

April 23, 2024 VIA EDGAR Division of Corporate Finance United States Securities and Exchange Commission 100 F Street, N.

April 23, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEFA14A 1 plse20240418defa14a.htm FORM DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitte

April 23, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☒ Definitive Proxy State

April 15, 2024 S-3/A

As filed with the Securities and Exchange Commission on April 15, 2024

As filed with the Securities and Exchange Commission on April 15, 2024 Registration No.

April 15, 2024 CORRESP

April 15, 2024

April 15, 2024 Office of Industrial Applications and Services Division of Corporate Finance Securities and Exchange Commission 100 F Street, N.

April 15, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pulse Biosciences, Inc.

April 4, 2024 CORRESP

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545 (510) 906-4600

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545 (510) 906-4600 April 4, 2024 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Pulse Biosciences, Inc. Registration Statement on Form S-3 File No. 333-278322 Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securitie

April 3, 2024 EX-99.2

Form of Letter to Stockholders who are Record Holders

EXHIBIT 99.2 FORM OF LETTER TO STOCKHOLDERS WHO ARE RECORD HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. [ [●], 2024] Dear Stockholder: Enclosed are materials relating to a rights offering by Pulse Biosciences, Inc., a Delaware corporation (“we,” “us,” “our,” or the “Company”), including the prospectus dated [ [

April 3, 2024 EX-99.6

Form of Beneficial Owner Election Form

EXHIBIT 99.6 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY’S PROSPECTUS DATED [ [●], 2024] (THE “PROSPECTUS”), AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, LLC, THE SUBSCRIPTION AGENT, BY CALLING (888) 789-8409. PULSE BIOSCIENCES, INC. BENEFICIAL OWNER ELECTION FORM I (We), t

April 3, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pulse Biosciences, Inc.

April 3, 2024 EX-99.1

Form of Instructions As To Use of Non-Transferable Subscription Rights Certificates

EXHIBIT 99.1 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY’S PROSPECTUS DATED [ [●], 2024] (THE “PROSPECTUS”), AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, LLC, THE SUBSCRIPTION AGENT, BY CALLING (888) 789-8409. FORM OF INSTRUCTIONS AS TO USE OF PULSE BIOSCIENCES, INC. NON-TR

April 3, 2024 EX-99.4

Form of Letter to Clients of Brokers and other Nominee Holders

EXHIBIT 99.4 FORM OF LETTER TO CLIENTS OF BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. [ [●], 2024] To Our Clients: Enclosed for your consideration are the prospectus, dated [ [●], 2024] (the “Prospectus”), and the “Instructions as to Use of Pulse Biosciences, Inc. Non-Transferable Sub

April 3, 2024 S-3

As filed with the Securities and Exchange Commission on April 3, 2024

As filed with the Securities and Exchange Commission on April 3, 2024 Registration No.

April 3, 2024 EX-4.4

Warrant Agency Agreement, dated April 3, 2024

EXHIBIT 4.4 WARRANT AGENCY AGREEMENT WARRANT AGENCY AGREEMENT made as of April 3, 2024, between Pulse Biosciences, Inc., a Delaware corporation (“Company”), with offices at 3957 Point Eden Way, Hayward, California 94545, and Broadridge Corporate Issuer Solutions, LLC (“Warrant Agent”), with offices at 51 Mercedes Way, Edgewood, NY 11717 (the “Warrant Agreement”). WHEREAS, the Company is engaged in

April 3, 2024 EX-99.3

Form of Letter to Brokers and other Nominee Holders

EXHIBIT 99.3 FORM OF LETTER TO BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. [ [●], 2024] To Securities Dealers, Commercial Banks, Trust Companies, and Other Nominees: This letter is being distributed to securities dealers, commercial banks, trust companies, and other nominees in connec

April 3, 2024 EX-4.2

Form of Subscription Rights Certificate

Exhibit 4.2 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY’S PROSPECTUS DATED [ [●], 2024] (THE “PROSPECTUS”) AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, LLC, THE SUBSCRIPTION AGENT, BY CALLING (888) 789-8409. PULSE BIOSCIENCES, INC. Incorporated under the laws of the State o

April 3, 2024 EX-4.3

Form of Warrant Certificate

EXHIBIT 4.3 PULSE BIOSCIENCES, INC. Warrant To Purchase Common Stock Warrant Shares: Initial Exercise Date: , 2024 THIS WARRANT TO PURCHASE COMMON STOCK (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initia

April 3, 2024 EX-99.5

Form of Nominee Holder Certification

EXHIBIT 99.5 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY’S PROSPECTUS DATED [ [●], 2024 (THE “PROSPECTUS”) AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, LLC, THE SUBSCRIPTION AGENT, BY CALLING (888) 789-8409. PULSE BIOSCIENCES, INC. UNITS SUBSCRIBED FOR UPON EXERCISE OF SUBS

March 28, 2024 EX-99.2

Pulse Biosciences Announces Plans to Initiate a Rights Offering

Exhibit 99.2 Pulse Biosciences Announces Plans to Initiate a Rights Offering HAYWARD, Calif. [Business Wire] – March 28, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced that its Board of Directors has unanimously approved plans to initiate a rights offering. The rights offeri

March 28, 2024 EX-10.26

Third Amendment to Employment Agreement, between Kevin Danahy and Pulse Biosciences, Inc., dated March 2024

Exhibit 10.26 PULSE BIOSCIENCES, INC. THIRD AMENDMENT TO EMPLOYMENT AGREEMENT This third amendment (this “Amendment”) is entered into effective as of March 26, 2024, by and between Kevin Danahy (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Executive, the “Parties”). WHEREAS, the Parties entered into an employment agreement dated February 9, 2022 (as previously amended

March 28, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUA

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-348

March 28, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 28, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

March 28, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pulse Biosciences, Inc.

March 28, 2024 EX-4.2

Form of Indenture

Exhibit 4.2 PULSE BIOSCIENCES, INC. INDENTURE Dated as of , 20 [], As Trustee TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 6 1.1 Definitions 6 1.2 Other Definitions 8 1.3 Incorporation by Reference of Trust Indenture Act 8 1.4 Rules of Construction 9 ARTICLE II THE SECURITIES 9 2.1 Issuable in Series 9 2.2 Establishment of Terms of Series of Securities 9 2.3 Executio

March 28, 2024 EX-10.27

Fourth Amendment to Employment Agreement, between Darrin Uecker and Pulse Biosciences, Inc., dated March 2024

Exhibit 10.27 PULSE BIOSCIENCES, INC. FOURTH AMENDMENT TO EMPLOYMENT AGREEMENT This fourth amendment (this “Amendment”) is entered into effective as of March 26, 2024, by and between Darrin Uecker (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Executive, the “Parties”). WHEREAS, the Company and Executive entered into an employment agreement dated September 8, 2015 (as

March 28, 2024 EX-97.1

Section 10D Clawback Policy

Exhibit 97.1 Incentive-Based Compensation Clawback Policy Effective November 2023 Pulse Biosciences, Inc. (“Company”) has adopted this clawback policy (the “Policy”) as a supplement to any other clawback policies in effect now or in the future at the Company. To the extent this Policy applies to compensation payable to a covered person, it shall be the only clawback policy applicable to such compe

March 28, 2024 S-3

As filed with the Securities and Exchange Commission on March 28,2023

As filed with the Securities and Exchange Commission on March 28,2023 Registration No.

March 28, 2024 EX-21.1

List of Subsidiaries

Exhibit 21.1 List of Subsidiaries  Subsidiary Jurisdiction of Incorporation Ownership Position NanoBlate Corp., a Delaware Corporation Delaware 100% BioElectroMed Corp., a California Corporation California 100% Pulse Biosciences BV Netherlands 100% 2783162 Ontario Inc. Ontario 100% 

March 28, 2024 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Fourth Quarter & Full Year 2023 Financial Results HAYWARD, Calif. [Business Wire] – March 28, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary CellFX® Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced business updates and financial results for the fourth quarter and full yea

March 11, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 8, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission F

March 11, 2024 EX-99.1

Pulse Biosciences Announces FDA 510(k) Clearance for its CellFX

Exhibit 99.1 Pulse Biosciences Announces FDA 510(k) Clearance for its CellFX® nsPFA™ Percutaneous Electrode System HAYWARD, Calif. [Business Wire] – March 8, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary CellFX Nanosecond Pulsed Field Ablation™ (nsPFA™) technology, today announced receipt of U.S. Food and Drug Administration (FDA) 510(k) clearance for

February 14, 2024 EX-99.1

Pulse Biosciences Announces Positive 60-Day Follow-Up Evaluations for Initial Patients treated in the CellFX

Exhibit 99.1 Pulse Biosciences Announces Positive 60-Day Follow-Up Evaluations for Initial Patients treated in the CellFX® nsPFA™ 360° Cardiac Catheter First-in-Human Feasibility Study HAYWARD, Calif. [Business Wire] – February 14, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company with a primary focus on leveraging its novel and proprietary CellFX Nanosecond Pulsed Field Ablation (nsPFA) tec

February 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): February 14, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): February 14, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

January 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 9, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 9, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

January 9, 2024 EX-99.1

Investor Deck, dated January 2024

Exhibit 99.1

January 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 2, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): January 2, 2024 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

January 2, 2024 EX-99.1

Pulse Biosciences Files 510(k) Submission with U.S. FDA for its CellFX

Exhibit 99.1 Pulse Biosciences Files 510(k) Submission with U.S. FDA for its CellFX® nsPFA™ Cardiac Clamp HAYWARD, Calif. [Business Wire] – January 02, 2024. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company primarily focused on leveraging its novel and proprietary CellFX Nanosecond Pulsed Field Ablation (nsPFA) technology for the treatment of atrial fibrillation, today announced the filing of a p

December 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 19, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 19, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

December 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 20, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): December 20, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

December 20, 2023 EX-99.1

Pulse Biosciences Announces First-in-Human Procedures with its Novel CellFX

Exhibit 99.1 Pulse Biosciences Announces First-in-Human Procedures with its Novel CellFX™ Nanosecond Pulsed Field Ablation (nsPFA™) Cardiac Catheter Company’s proprietary system used to treat initial five patients in first-in-human feasibility study for patients with atrial fibrillation HAYWARD, Calif. [Business Wire] – December 20, 2023. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company primarily

December 15, 2023 SC 13D/A

PLSE / Pulse Biosciences Inc / DUGGAN ROBERT W - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 14)1 Pulse Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 74587B 10 1 (CUSIP Number) ADAM W. FI

December 4, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm2332044d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including additional amendments thereto) with respect to the shares of Common Stock, $0.001 par value, of Pulse Bio

December 4, 2023 SC 13D/A

PLSE / Pulse Biosciences Inc / DUGGAN ROBERT W - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 13)1 Pulse Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 74587B 10 1 (CUSIP Number) ADAM W. FI

November 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)

November 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 27, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 27, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

November 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 21, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 21, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

November 21, 2023 EX-99.1

Pulse Biosciences Files 510(k) Submission with U.S. FDA for its CellFX nsPFA Percutaneous Electrode

Exhibit 99.1 Pulse Biosciences Files 510(k) Submission with U.S. FDA for its CellFX nsPFA Percutaneous Electrode HAYWARD, Calif. [Business Wire] – November 21, 2023. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company primarily focused on leveraging its novel and proprietary CellFX Nanosecond Pulsed Field Ablation (nsPFA) technology for the treatment of atrial fibrillation, today announced the filin

November 13, 2023 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Third Quarter 2023 Financial Results Pulse Biosciences will host Third Quarter 2023 Financial Results conference call at 9:00 am PT / 12:00 pm ET on Monday, November 13, 2023 HAYWARD, Calif. [Business Wire] – November 13, 2023. Pulse Biosciences, Inc. (Nasdaq: PLSE), a company primarily focused on leveraging its novel and proprietary Cell

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Numbe

November 13, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): November 13, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commissi

September 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 10, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 10, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commiss

August 29, 2023 CORRESP

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, CA 94545 (510) 906-4600

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, CA 94545 (510) 906-4600 August 29, 2023 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Pulse Biosciences, Inc. Registration Statement on Form S-3 File No. 333-273944 Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securities Act

August 11, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Pulse Biosciences, Inc.

August 11, 2023 S-3

As filed with the Securities and Exchange Commission on August 11,2023

As filed with the Securities and Exchange Commission on August 11,2023 Registration No.

August 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 00

August 10, 2023 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and Second Quarter 2023 Financial Results HAYWARD, Calif. [Business Wire] – August 10, 2023 – Pulse Biosciences, Inc. (Nasdaq: PLSE), a company primarily focused on leveraging its novel and proprietary Nanosecond Pulsed Field Ablation (nsPFA) technology for the treatment of atrial fibrillation, today announced financial results for the second

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 10, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 10, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

July 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 20, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): July 20, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission F

July 20, 2023 EX-99.1

Investor Deck, dated July 20, 2023

Exhibit 99.1

May 31, 2023 SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc.

May 31, 2023 EX-1.01

2022 Conflict Minerals Report of Pulse Biosciences, Inc. as required by Items 1.01 and 1.02 of this Form SD.

Exhibit 1.01 Conflict Minerals Report of Pulse Biosciences, Inc. in Accordance with Rule 13p-1 under the Securities Exchange Act of 1934  This is the Conflict Minerals Report (“CMR”) of Pulse Biosciences, Inc. (“Pulse Biosciences” or the “Company”) for the reporting period January 1, 2022 to December 31, 2022 in accordance with Rule 13p-1 (“Rule 13p-1”) under the Securities Exchange Act of 1934,

May 30, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 25, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 11, 2023 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Exhibit 99.1 Pulse Biosciences Reports Business Updates and First Quarter 2023 Financial Results HAYWARD, Calif. [Business Wire] – May 11, 2023 – Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary nanosecond pulsed field ablation (nsPFA™) technology for the treatment of atrial fibrillation, today announced financial results for the first quarter ended March 31,

May 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 11, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 11, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 11, 2023 SC 13D/A

PLSE / Pulse Biosciences Inc / DUGGAN ROBERT W - AMENDMENT TO FORM SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 12)1 Pulse Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 74587B 10 1 (CUSIP Number) ADAM W. FI

May 11, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 0

May 10, 2023 EX-FILING FEES

Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Pulse Biosciences, Inc. S-8 Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equ

May 10, 2023 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 Pulse Biosciences, Inc. (Exact name of Registrant as specified in its charter) Delaware 46-5696597 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number)  3957 Point Eden Way Hayward, Californ

May 10, 2023 EX-99.1

PULSE BIOSCIENCES, INC. ANNOUNCES PLANNED REDEMPTION OF WARRANTS

Exhibit 99.1 PULSE BIOSCIENCES, INC. ANNOUNCES PLANNED REDEMPTION OF WARRANTS HAYWARD, Calif.-(BUSINESS WIRE)—May 10, 2023—Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary nanosecond pulsed field ablation (nsPFA™) technology for the treatment of atrial fibrillation, today announced that it intends to deliver an irrevocable notice of redemption, on or about May

May 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 10, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 10, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fi

May 9, 2023 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 9, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 5, 2023 EX-10.2

Amendment to Employment Agreement, between Darrin Uecker and Pulse Biosciences, Inc., dated May 5, 2023

EX-10.2 3 ex514883.htm AMENDMENT TO EMPLOYMENT AGREEMENT, BETWEEN DARRIN UECKER AND PULSE BIOSCIENCES, INC., DATED MAY 5, 2023. Exhibit 10.2 PULSE BIOSCIENCES, INC. THIRD AMENDMENT TO EMPLOYMENT AGREEMENT This third amendment (this “Amendment”) is entered into effective as of April 29, 2023 by and between Darrin Uecker (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Exe

May 5, 2023 EX-10.1

Amendment to Employment Agreement, between Kevin Danahy and Pulse Biosciences, Inc., dated May 4, 2023

Exhibit 10.1 PULSE BIOSCIENCES, INC. SECOND AMENDMENT TO EMPLOYMENT AGREEMENT This second amendment (this “Amendment”) is entered into effective as of April 29, 2023 (the “Amendment Date”) by and between Kevin Danahy (“Executive”) and Pulse Biosciences, Inc. (the “Company,” and together with Executive, the “Parties”). WHEREAS, the Parties entered into an employment agreement dated February 9, 2022

May 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 4, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): May 4, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 1, 2023 EX-10.1

Securities Purchase Agreement, dated as of April 30, 2023, by and between Pulse Biosciences, Inc. and Robert W. Duggan

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of April 30, 2023, between Pulse Biosciences, Inc., a Delaware corporation (the “Company”), and the purchaser identified on Exhibit A hereto (the “Purchaser”). RECITALS WHEREAS, on the terms and subject to the conditions set forth in this Agreement and pursuant to Section 4(a)(2) of the Sec

May 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 30, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): April 30, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

May 1, 2023 EX-99.1

PULSE BIOSCIENCES ANNOUNCES $65 MILLION PRIVATE PLACEMENT

Exhibit 99.1 PULSE BIOSCIENCES ANNOUNCES $65 MILLION PRIVATE PLACEMENT HAYWARD, Calif. [Business Wire] – May 1, 2023 – Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary nanosecond pulsed field ablation (nsPFA™) technology and proprietary CellFX System® for the treatment of atrial fibrillation, today announced that it has entered into a stock purchase agreement

April 14, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☐ Definitive Proxy State

April 14, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☒ Definitive Proxy State

March 31, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUA

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-348

March 31, 2023 EX-21.1

List of Subsidiaries

Exhibit 21.1 List of Subsidiaries  Subsidiary Jurisdiction of Incorporation Ownership Position NanoBlate Corp., a Delaware Corporation Delaware 100% BioElectroMed Corp., a California Corporation California 100% Pulse Biosciences BV Netherlands 100% 2783162 Ontario Inc. Ontario 100% 

March 30, 2023 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

EX-99.1 2 ex494874.htm PRESS RELEASE ISSUED BY PULSE BIOSCIENCES, INC. DATED MARCH 30, 2023 Exhibit 99.1 Pulse Biosciences Reports Fourth Quarter & Full Year 2022 Financial Results HAYWARD, Calif. [Business Wire] – March 30, 2023 – Pulse Biosciences, Inc. (Nasdaq: PLSE), a company leveraging its novel and proprietary nanosecond pulsed field ablation (nsPFA™) technology for electrophysiology and th

March 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 28, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 28, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

March 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 17, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): March 17, 2023 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commission

March 21, 2023 EX-10.1

First Amendment to Loan Agreement, between Pulse Biosciences, Inc. and Robert W. Duggan, dated March 17, 2023

Exhibit 10.1 FIRST AMENDMENT TO LOAN AGREEMENT This FIRST AMENDMENT TO LOAN AGREEMENT (this “Amendment”) dated as of March 17, 2023 (the “First Amendment Effective Date”) is entered into by and among PULSE BIOSCINECES, INC., a Delaware corporation (the “Borrower”) and ROBERT DUGGAN (the “Lender”). W I T N E S E T H: WHEREAS, the Borrower and the Lender are parties to that certain Loan Agreement da

December 6, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 30, 2022 Pulse Bioscience

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 30, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commissio

November 10, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 10, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commissio

November 10, 2022 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Pulse Biosciences Reports Third Quarter 2022 Financial Results ? HAYWARD, Calif. [Business Wire] ? November 10, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company and creator of the unique CellFX? System which harnesses and effectively controls the application of Nano-Pulse Stimulation? (NPS?) to human cells and tissue for ablation in multiple therapeutic condition

November 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 Or ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-34899 Pulse

September 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 23, 2022 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commiss

September 28, 2022 EX-10.1

Amendment to Employment Agreement, between Kevin Danahy and Pulse Biosciences, Inc., dated September 23, 2022

Pulse Biosciences, Inc. 8-K Exhibit 10.1 PULSE BIOSCIENCES, INC. AMENDMENT TO EMPLOYMENT AGREEMENT This amendment (the ?Amendment?) is entered into effective as September 20, 2022 (the ?Amendment Date?) by and between Kevin Danahy (?Executive?) and Pulse Biosciences, Inc. (the ?Company,? and together with Executive, the ?Parties?). WHEREAS, the Parties entered into an employment agreement dated Fe

September 23, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Costs Associated with Exit or Disposal Activities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 20, 2022 Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 001-37744 46-5696597 (State or Other Jurisdiction of Incorporation) (Commiss

September 23, 2022 EX-10.1

Loan Agreement, dated as of September 20, 2022, by and between Pulse Biosciences, Inc. and Robert W. Duggan

Pulse Biosciences, Inc. 8-K Exhibit 10.1 ******************************* LOAN AGREEMENT Dated as of September 20, 2022 by and among PULSE BIOSCIENCES, INC. as the Borrower, and ROBERT DUGGAN, as the Lender ******************************* TABLE OF CONTENTS Section Page ARTICLE I. DEFINITIONS AND ACCOUNTING TERMS 1 SECTION 1.1. Certain Defined Terms 1 SECTION 1.2. Terms Generally 5 SECTION 1.3. Comp

September 23, 2022 EX-10.2

Amendment to Employment Agreement, between Darrin Uecker and Pulse Biosciences, Inc., dated September 20, 2022

Pulse Biosciences, Inc. 8-K Exhibit 10.2 PULSE BIOSCIENCES, INC. AMENDMENT TO EMPLOYMENT AGREEMENT This amendment (the ?Amendment?) is entered into effective as September 20, 2022 by and between Darrin Uecker (?Executive?) and Pulse Biosciences, Inc. (the ?Company,? and together with Executive, the ?Parties?). WHEREAS, the Company and Executive entered into an employment agreement dated September

September 23, 2022 EX-99.1

Pulse Biosciences Announces Strategic Change of Focus in Support of Significant Additional Opportunities for medicinal related Nano-Pulse Stimulation Strategic focus shifting to advance core NPS™ technology in cardiac and oncology sectors activate ad

Pulse Biosciences, Inc. 8-K Exhibit 99.1 Pulse Biosciences Announces Strategic Change of Focus in Support of Significant Additional Opportunities for medicinal related Nano-Pulse Stimulation Strategic focus shifting to advance core NPS? technology in cardiac and oncology sectors activate additional executive leadership and reduce dermatologic footprint. Former Chief Commercial Officer, Kevin Danah

August 10, 2022 EX-10.1

Indemnification Letter, dated May 27, 2022, by and between Pulse Biosciences, Inc. and Robert W. Duggan

Robert W. Duggan 611 S Fort Harrison Avenue, Suite 306 Clearwater, FL 33756 ? May 27, 2022 ? ? Pulse Biosciences 3957 Point Eden Way Hayward, California 94545 Attn: Board of Directors ? Re: Indemnification of Board of Directors ? Dear Directors: ? This letter serves as formal agreement as between Robert Duggan (sometimes referred to herein as ?Indemnitor?), on one hand, and Pulse Biosciences, Inc.

August 10, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 10, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission

August 10, 2022 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except per share amounts)

Pulse Biosciences Reports Second Quarter 2022 Financial Results ? HAYWARD, Calif. [Business Wire] ? August 10, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company commercializing the CellFX? System powered by Nano-Pulse Stimulation? (NPS?) technology, today announced financial results for the second quarter ended June 30, 2022. ? Company Updates ? Continued active e

August 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-34899 Pulse Bios

July 14, 2022 CORRESP

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545   July 14, 2022 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549  Attention: Frank Wyman Mary Mast     Re: Form 10-K for the Fiscal Year Ended December 31, 2021 Filed March 31, 2022 File No. 001-37744  Dear Ladies and Gentlemen: This letter sets forth responses on behalf o

June 13, 2022 SC 13D/A

PLSE / Pulse Biosciences Inc / DUGGAN ROBERT W - AMENDMENT TO FORM SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO ? 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO ? 240.13d-2(a) (Amendment No. 11)1 Pulse Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 74587B 10 1 (CUSIP Number) ADAM W. FI

June 9, 2022 EX-99.1

Pulse Biosciences, Inc. Announces the Closing of its Rights Offering

Pulse Biosciences, Inc. Announces the Closing of its Rights Offering ? HAYWARD, Calif. [Business Wire] ? June 9, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE) (the ?Company? or ?Pulse Biosciences?), a novel bioelectric medicine company commercializing the CellFX? System powered by Nano-Pulse Stimulation? (NPS?) technology, announced today the closing of its rights offering and the final results th

June 9, 2022 CORRESP

PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545

CORRESP 1 filename1.htm PULSE BIOSCIENCES, INC. 3957 Point Eden Way Hayward, California 94545   June 9, 2022 VIA EDGAR United States Securities and Exchange Commission 100 F. Street, NE Washington, DC 20549  Attention: Frank Wyman Mary Mast    Re: Pulse Biosciences, Inc. Form 10-K for the Fiscal Year Ended December 31, 2021 Filed March 31, 2022 File No. 001-37744  Dear Ladies and Gentlemen:

June 9, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) June 9, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission Fil

June 3, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 31, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission Fil

June 3, 2022 EX-99.1

Pulse Biosciences, Inc. Announces Preliminary Results for its Rights Offering

Pulse Biosciences, Inc. Announces Preliminary Results for its Rights Offering ? HAYWARD, Calif. [Business Wire] ? June 3, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE) (the ?Company? or ?Pulse Biosciences?), a novel bioelectric medicine company commercializing the CellFX? System powered by Nano-Pulse Stimulation? (NPS?) technology, announced today preliminary results of its rights offering, which

May 31, 2022 SD

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter)

SD 1 plse-20220531corresp.htm FORM SD  UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM SD Specialized Disclosure Report Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter)  Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission File Number) (IRS Employer Identification No.) 3957 Point Eden Way Hayward, Califo

May 31, 2022 EX-1.01

2021 Conflict Minerals Report of Pulse Biosciences, Inc. as required by Items 1.01 and 1.02 of this Form SD.

EX-1.01 2 plse-20220531xex101.htm EXHIBIT 1.01 Exhibit 1.01   Conflict Minerals Report of Pulse Biosciences, Inc. in Accordance with Rule 13p-1 under the Securities Exchange Act of 1934  This is the Conflict Minerals Report (“CMR”) of Pulse Biosciences, Inc. (“Pulse Biosciences” or the “Company”) for the reporting period January 1, 2021 to December 31, 2021 in accordance with Rule 13p-1 (“Rule

May 23, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 19, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission Fil

May 19, 2022 EX-99.1

Pulse Biosciences, Inc. Announces Changes to its Rights Offering

Pulse Biosciences, Inc. Announces Changes to its Rights Offering ? HAYWARD, Calif. [Business Wire] ? May 19, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE) (the ?Company? or ?Pulse Biosciences?), a novel bioelectric medicine company commercializing the CellFX? System Powered by Nano-Pulse Stimulation? (NPS?) technology, announced today two changes to its current rights offering. First, the Company

May 19, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 19, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission Fil

May 19, 2022 424B3

PROSPECTUS SUPPLEMENT NO. 2 PULSE BIOSCIENCES, INC. Subscription Rights to Purchase Up to 4,032,258 of Units at the Initial Price Each Unit Consisting of 1 Share of Common Stock and a Warrant to Purchase 1 Share of Common Stock (and Up to 4,032,258 o

424B3 1 ny20003901x4424b3.htm 424B3 Filed Pursuant to Rule 424(b)(3) Registration No. 333-246346 Prospectus Supplement No. 2 (to Prospectus dated August 14, 2020, as supplemented on May 4, 2022) PROSPECTUS SUPPLEMENT NO. 2 PULSE BIOSCIENCES, INC. Subscription Rights to Purchase Up to 4,032,258 of Units at the Initial Price Each Unit Consisting of 1 Share of Common Stock and a Warrant to Purchase 1

May 13, 2022 S-8

As filed with the Securities and Exchange Commission on May 13, 2022

As filed with the Securities and Exchange Commission on May 13, 2022 Registration No.

May 13, 2022 EX-FILING FEES

Filing Fee Table

Calculation of Filing Fee Tables ? S-8 (Form Type) ? Pulse Biosciences, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities ? ? Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock 457(c) 1,188,657(2)

May 11, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 11, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission Fil

May 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-34899 Pulse Bio

May 11, 2022 EX-99.1

PULSE BIOSCIENCES, INC.

Pulse Biosciences Reports First Quarter 2022 Financial Results ? HAYWARD, Calif. [Business Wire] ? May 11, 2022 ? Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company commercializing the CellFX? System powered by Nano-Pulse Stimulation? (NPS?) technology, today announced financial results for the first quarter of 2022. ? Company Updates ? Increased the average CellFX System

May 4, 2022 EX-4.2

PULSE BIOSCIENCES, INC. Warrant To Purchase Common Stock

Exhibit 4.2 PULSE BIOSCIENCES, INC. Warrant To Purchase Common Stock Warrant Shares: Initial Exercise Date: , 2022 THIS WARRANT TO PURCHASE COMMON STOCK (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the ?Initia

May 4, 2022 EX-99.4

FORM OF LETTER TO CLIENTS OF BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc.

Exhibit 99.4 FORM OF LETTER TO CLIENTS OF BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. May 4, 2022 To Our Clients: Enclosed for your consideration are the prospectus, dated August 21, 2020, as supplemented by the prospectus supplement dated May 4, 2022 (collectively, the ?Prospectus?),

May 4, 2022 EX-99.6

PULSE BIOSCIENCES, INC. BENEFICIAL OWNER ELECTION FORM

Exhibit 99.6 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY?S PROSPECTUS DATED AUGUST 21, 2020, AS SUPPLEMENTED BY THE PROSPECTUS SUPPLEMENT DATED MAY 4, 2022 (COLLECTIVELY, THE ?PROSPECTUS?), AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, INC., THE SUBSCRIPTION AGENT, BY CALLIN

May 4, 2022 EX-99.3

FORM OF LETTER TO BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc.

Exhibit 99.3 FORM OF LETTER TO BROKERS AND OTHER NOMINEE HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. May 4, 2022 To Securities Dealers, Commercial Banks, Trust Companies, and Other Nominees: This letter is being distributed to securities dealers, commercial banks, trust companies, and other nominees in connect

May 4, 2022 EX-4.3

WARRANT AGENCY AGREEMENT

Exhibit 4.3 WARRANT AGENCY AGREEMENT WARRANT AGENCY AGREEMENT made as of April 25, 2022, between Pulse Biosciences, Inc., a Delaware corporation (?Company?), with offices at 3957 Point Eden Way, Hayward, California 94545, and Broadridge Corporate Issuer Solutions, Inc. (?Warrant Agent?), with offices at 51 Mercedes Way, Edgewood, NY 11717 (the ?Warrant Agreement?). WHEREAS, the Company is engaged

May 4, 2022 424B5

Pulse Biosciences, Inc. Subscription Rights to Purchase Up to 4,032,258 of Units at the Initial Price Each Unit Consisting of 1 Share of Common Stock and a Warrant to Purchase 1 Share of Common Stock (and Up to 4,032,258 of Shares of Common Stock Und

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration Statement No. 333-246346 PROSPECTUS SUPPLEMENT (to prospectus dated August 21, 2020) $15,000,000 ? Pulse Biosciences, Inc. Subscription Rights to Purchase Up to 4,032,258 of Units at the Initial Price Each Unit Consisting of 1 Share of Common Stock and a Warrant to Purchase 1 Share of Common Stock (and Up to 4,032,258 of Shares of Com

May 4, 2022 EX-99.2

FORM OF LETTER TO STOCKHOLDERS WHO ARE RECORD HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc.

Exhibit 99.2 FORM OF LETTER TO STOCKHOLDERS WHO ARE RECORD HOLDERS PULSE BIOSCIENCES, INC. Units Offered Pursuant to Subscription Rights Distributed to Stockholders of Pulse Biosciences, Inc. May 4, 2022 Dear Stockholder: Enclosed are materials relating to a rights offering by Pulse Biosciences, Inc., a Delaware corporation (?we,? ?us,? ?our,? or the ?Company?), including the prospectus dated Augu

May 4, 2022 EX-99.1

FORM OF INSTRUCTIONS AS TO USE OF PULSE BIOSCIENCES, INC. NON-TRANSFERABLE SUBSCRIPTION RIGHTS CERTIFICATES PLEASE CONSULT THE SUBSCRIPTION AND INFORMATION AGENT, YOUR BANK OR BROKER FOR ANY QUESTIONS

Exhibit 99.1 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY?S PROSPECTUS DATED AUGUST 21, 2020, AS SUPPLEMENTED BY THE PROSPECTUS SUPPLEMENT DATED MAY 4, 2022 (COLLECTIVELY, THE ?PROSPECTUS?), AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, INC., THE SUBSCRIPTION AGENT, BY CALLIN

May 4, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 4, 2022 Pulse Biosciences, Inc.

May 4, 2022 EX-4.1

PULSE BIOSCIENCES, INC. Incorporated under the laws of the State of Delaware NON-TRANSFERABLE SUBSCRIPTION RIGHTS CERTIFICATE Evidencing Non-Transferable Subscription Rights to Purchase Units of Pulse Biosciences, Inc. Subscription Price: To be deter

Exhibit 4.1 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY?S PROSPECTUS DATED AUGUST 21, 2020, AS SUPPLEMENTED BY THE PROSPECTUS SUPPLEMENT DATED MAY 4, 2022 (COLLECTIVELY, THE ?PROSPECTUS?) AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, INC., THE SUBSCRIPTION AGENT, BY CALLING

May 4, 2022 EX-99.7

Pulse Biosciences, Inc. Announces Commencement of Rights Offering

Exhibit 99.7 Pulse Biosciences, Inc. Announces Commencement of Rights Offering HAYWARD, Calif., May 4, 2022 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the ?Company? or ?Pulse Biosciences?), a novel bioelectric medicine company, today announced that it has commenced its previously announced rights offering of up to $15,000,000 of units (the ?Units,? and each, a ?Unit?) at the Initial Price (as defin

May 4, 2022 EX-99.5

PULSE BIOSCIENCES, INC. UNITS SUBSCRIBED FOR UPON EXERCISE OF SUBSCRIPTION RIGHTS NOMINEE HOLDER CERTIFICATION

Exhibit 99.5 THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY?S PROSPECTUS DATED AUGUST 21, 2020, AS SUPPLEMENTED BY THE PROSPECTUS SUPPLEMENT DATED MAY 4, 2022 (COLLECTIVELY, THE ?PROSPECTUS?) AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE AVAILABLE UPON REQUEST FROM BROADRIDGE CORPORATE ISSUER SOLUTIONS, INC., THE SUBSCRIPTION AGENT, BY CALLING

April 14, 2022 EX-99.1

Pulse Biosciences, Inc. Announces Rights Offering

Pulse Biosciences, Inc. Announces Rights Offering HAYWARD, Calif. [Business Wire] - April 14, 2022 - Pulse Biosciences, Inc. (Nasdaq: PLSE) (the ?Company? or ?Pulse Biosciences?), a novel bioelectric medicine company, today announced that the Company?s Board of Directors has approved a rights offering available to all holders of record of the Company?s common stock, par value $0.001 per share (the

April 14, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 14, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission F

April 1, 2022 DEF 14A

 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEF 14A 1 plse-20220519xdef14a.htm DEF 14A  UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by

April 1, 2022 DEFA14A

 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934

DEFA14A 1 plse-20220401xdefa14a.htm DEFA14A  UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted b

March 31, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) March 31, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission F

March 31, 2022 EX-10.4

Employment Agreement between Mitchell E. Levinson and the Registrant

PULSE BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is made and entered into by and between Mitch Levinson (?Executive?) and Pulse Biosciences, Inc. (the ?Company?), as of August 17, 2021. 1. Duties and Scope of Employment. (a) Position and Duties. As of August 19, 2021 (the ?Start Date?), Executive will serve as the Company?s Chief Strategy Officer operating f

March 31, 2022 EX-10.5

Employment Agreement between Kevin Danahy and the Registrant

? PULSE BIOSCIENCES, INC. EMPLOYMENT AGREEMENT This Employment Agreement (the ?Agreement?) is made and entered into by and between Kevin Danahy (?Executive?) and Pulse Biosciences, Inc. (the ?Company?), as of February 9, 2022. 1. Duties and Scope of Employment. (a) Position and Duties. As of February 14, 2022 (the ?Start Date?), Executive will serve as the Company?s Chief Commercial Officer operat

March 31, 2022 EX-21.1

List of Subsidiaries

Exhibit 21.1 List of Subsidiaries ? ? Subsidiary Jurisdiction of Incorporation Ownership Position NanoBlate Corp., a Delaware Corporation Delaware 100% BioElectroMed Corp., a California Corporation California 100% Pulse Biosciences BV Netherlands 100% 2783162 Ontario Inc. Ontario 100% ?

March 31, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ¨ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-34899 Pulse Bioscienc

March 31, 2022 EX-99.1

PULSE BIOSCIENCES, INC.

Pulse Biosciences Reports Fourth Quarter & Full Year 2021 Financial Results ? HAYWARD, Calif.

March 21, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) March 18, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission F

February 15, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 9, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission

February 15, 2022 EX-99.1

Pulse Biosciences Announces the Appointment of Kevin Danahy as Chief Commercial Officer

EX-99.1 2 plse-20220209xex991.htm EX-99.1 Pulse Biosciences Announces the Appointment of Kevin Danahy as Chief Commercial Officer HAYWARD, Calif. [Business Wire] – February 9, 2022. Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company commercializing the CellFX® System powered by Nano-Pulse Stimulation™ (NPS™) technology, today announced the appointment of Kevin Danahy to t

February 8, 2022 EX-99.1

Pulse Biosciences Provides an Update on Recent FDA 510(k) Submission

Pulse Biosciences Provides an Update on Recent FDA 510(k) Submission HAYWARD, Calif.

February 8, 2022 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 8, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission

January 11, 2022 EX-99.1

Pulse Biosciences Announces Preliminary Fourth Quarter and Full Year 2021 Financial and Operational Results

Pulse Biosciences Announces Preliminary Fourth Quarter and Full Year 2021 Financial and Operational Results HAYWARD, Calif.

January 11, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) January 11, 2022 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission

November 24, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 18, 2021 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commissio

November 15, 2021 EX-99.1

PULSE BIOSCIENCES, INC. Condensed Consolidated Balance Sheets (In thousands, except par value)

Pulse Biosciences Reports Third Quarter 2021 Financial Results ? HAYWARD, Calif. [Business Wire] ? November 15, 2021 ? Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company commercializing the CellFX? System powered by Nano-Pulse Stimulation? (NPS?) technology, today announced financial results for the third quarter of 2021. ? Recent Highlights ? Achieved third quarter 2021

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-34899 Pulse

November 15, 2021 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 15, 2021 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commissio

October 6, 2021 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 4, 2021 Pulse Biosciences, Inc. (Exact name of registrant as specified in its charter) Delaware 001-37744 46-5696597 (State or other jurisdiction of incorporation) (Commission

October 6, 2021 EX-99.1

Pulse Biosciences

? ? Pulse Biosciences Appoints Laureen DeBuono to Its Board of Directors ? HAYWARD, Calif.

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