CMRX / Chimerix, Inc. - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

شركة تشيمريكس
US ˙ NasdaqGM ˙ US16934W1062
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الإحصائيات الأساسية
LEI 5299002IR2GXUBEPKS66
CIK 1117480
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Chimerix, Inc.
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
May 1, 2025 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

15-12G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-35867 Chimerix, Inc. (Exact name of registrant as specified in it

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION CHIMERIX, INC. ARTICLE I

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF CHIMERIX, INC. ARTICLE I The name of the corporation is Chimerix , Inc. (the “Corporation”). ARTICLE II The address, including street, number, city, and county, of the registered office of the Corporation in the State of Delaware is the Corporation Trust Center, 1209 Orange Street, Wilmington, DE 19801 and County of New Castle

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 21, 2025 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 21, 2025 Chimerix, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number)

April 21, 2025 POS AM

As filed with the Securities and Exchange Commission on April 21, 2025

POS AM As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 EX-3.2

BY-LAWS CHIMERIX, INC. dated as of April 21, 2025

EX-3.2 Exhibit 3.2 BY-LAWS of CHIMERIX, INC. dated as of April 21, 2025 TABLE OF CONTENTS ARTICLE I OFFICES SECTION 1. REGISTERED OFFICE 1 SECTION 2. OTHER OFFICES 1 ARTICLE II MEETINGS OF STOCKHOLDERS SECTION 1. ANNUAL MEETINGS 1 SECTION 2. SPECIAL MEETINGS 1 SECTION 3. VOTING 1 SECTION 4. QUORUM 2 SECTION 5. NOTICE OF MEETINGS 2 SECTION 6. ACTION WITHOUT MEETING 2 ARTICLE III DIRECTORS SECTION 1

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on April 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on April 21, 2025 Registration No.

April 18, 2025 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 3) Chimerix, Inc. (Name of Subject Company) (Nam

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 3) Chimerix, Inc. (Name of Subject Company) (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities)

April 18, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 9) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 9) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

April 16, 2025 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-K/A (Amendment No.

April 14, 2025 EX-99.(A)(1)(K)

Our Jazz High Performance Culture Renée Galá President and Chief Operating Officer

Exhibit (a)(1)(K) Our Jazz High Performance Culture Renée Galá President and Chief Operating Officer Chimerix Team, As we move closer to bringing our organizations together, I want to highlight an important aspect of our culture at Jazz: High Performance.

April 14, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 8) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 8) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

April 11, 2025 EX-99.(A)(1)(K)

Employee Communication from April 11, 2025

Exhibit (a)(1)(K) Chimerix Pre-Integration FAQ We are thrilled that, subject to close, you will be joining Jazz Pharmaceuticals on our mission to innovate to transform the lives of patients and their families.

April 11, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 7) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 7) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

April 10, 2025 EX-99.(A)(1)(K)

Needham Conference Fireside Chat Transcript from April 9, 2025

EX-99.(a)(1)(K) Exhibit (A)(1)(K) Forward-Looking Statements This communication contains forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Jazz Pharmaceuticals Public Limited Company, an Irish public limited company plc (“Parent”) and Chimerix, Inc., a Delaware corporation (“Chimerix”), including statements regarding Parent’s pr

April 10, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 6) CHIMERIX, INC. (Name of Subject Company) PI

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 6) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stoc

April 9, 2025 EX-99.(A)(1)(J)

Employee Communication from April 9, 2025

Exhibit (a)(1)(J) More About Jazz – United by Our Purpose Bruce C. Cozadd Chairperson and Chief Executive Officer Chimerix Team, At Jazz, everything we do is driven by a singular purpose: to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options — so they

April 9, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 5) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 5) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

April 7, 2025 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) Chimerix, Inc. (Name of Subject Company) (Nam

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) Chimerix, Inc. (Name of Subject Company) (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities)

April 7, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 4) CHIMERIX, INC. (Name of Subject Company) PI

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 4) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stoc

April 4, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 3) CHIMERIX, INC. (Name of Subject Company) PI

SC TO-T/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 3) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stoc

April 2, 2025 EX-99.1

Employee and Director FAQ, first used on April 2, 2025.

Exhibit 99.1 Employee and Director FAQ 1. What is a tender offer? On March 4, 2025, Chimerix and Jazz announced an agreement for the acquisition of Chimerix for $8.55 per share, payable in cash without interest and subject to reduction for any applicable withholding taxes, representing a total consideration of approximately $935 million. The acquisition is structured as a tender offer. All Chimeri

April 2, 2025 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name o

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities) Mic

April 1, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 2) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 2) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

April 1, 2025 SC 14D9/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) Chimerix, Inc. (Name of Subject Company) (Nam

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) Chimerix, Inc. (Name of Subject Company) (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities)

March 28, 2025 EX-99.(A)(1)(I)

Employee Communication from March 28, 2025

Exhibit (a)(1)(I) A Message from Jazz’s Chief People Officer Heidi Manna Executive Vice President and Chief People Officer Dear Chimerix Team, It’s been a few weeks since the announcement of our transaction and outreach through the short welcome video from CEO Bruce Cozadd and the Jazz Global Leadership team.

March 28, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) CHIMERIX, INC. (Name of Subject Company) PI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO/A Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 (Amendment No. 1) CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par val

March 21, 2025 EX-10.24

arrant to Purchase Stock, dated December 23, 2024, by and between the Registrant and Si

Exhibit 10.24 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET

March 21, 2025 EX-99.(A)(1)(D)

Letter to Clients for Use by Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.

Exhibit (a)(1)(D) Offer To Purchase All Outstanding Shares of Common Stock of CHIMERIX, INC.

March 21, 2025 EX-99.(A)(1)(A)

Offer to Purchase, dated March 21, 2025.

Exhibit (a)(1)(A) Offer to Purchase All Outstanding Shares of Common Stock of Chimerix, Inc.

March 21, 2025 EX-21.1

Subsidiaries of Chimerix, Inc.

Exhibit 21.1 Subsidiaries of Chimerix, Inc. Oncoceutics, Inc., a Delaware corporation

March 21, 2025 EX-99.1

Chimerix Reports Fourth Quarter and Year End 2024 Financial Results New Drug Application (NDA) for Dordaviprone as Treatment for Recurrent H3 K27M-Mutant Diffuse Glioma Under Review with Prescription Drug User Fee Act (PDUFA) Action Date of August 18

Chimerix Reports Fourth Quarter and Year End 2024 Financial Results New Drug Application (NDA) for Dordaviprone as Treatment for Recurrent H3 K27M-Mutant Diffuse Glioma Under Review with Prescription Drug User Fee Act (PDUFA) Action Date of August 18, 2025 Acquisition of Chimerix by Jazz Pharmaceuticals (Jazz) Expected to Close in Second Quarter of 2025 DURHAM, N.

March 21, 2025 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE TO Tender Offer Statement Pursuant to Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 CHIMERIX, INC. (Name of Subject Company) PINETREE ACQUISITION SUB, INC. (Offeror) JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY (Parent of Offeror) (Names of Filing Persons) Common stock, par value $0.001 per share

March 21, 2025 EX-99.(A)(1)(B)

Letter of Transmittal.

Exhibit (a)(1)(B) LETTER OF TRANSMITTAL To Tender Shares of Common Stock of CHIMERIX, INC.

March 21, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 Chimerix, Inc.

March 21, 2025 SC 14D9

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) (Name of Person Filing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities) Michael T. Andriol

March 21, 2025 EX-19.1

Chimerix, Inc. Insider Trading Policy and Window Period Policy.

Chimerix, Inc. Insider Trading Policy April 2013 Persons Covered This Insider Trading Policy of Chimerix, Inc. (the “Company”) applies to all directors, officers, other employees and consultants of the Company and its subsidiaries. It also applies to their family members who reside with them, anyone else who lives in their households and any family members who do not live in their households but w

March 21, 2025 EX-99.(D)(3)

Exclusivity Agreement, dated as of March 4, 2025, by and between Jazz Pharmaceuticals Public Company Limited and Chimerix, Inc.

Exhibit (d)(3) STRICTLY PRIVATE & CONFIDENTIAL March 4, 2025 Michael T. Andriole Chief Executive Officer Chimerix, Inc. 2505 Meridian Parkway, Suite 100 Durham, NC 27713 Dear Mr. Andriole, Reference is made to our discussions regarding the proposed acquisition (the “Proposed Transaction”) of all of the issued and outstanding equity interests of Chimerix, Inc. (the “Company”) by Jazz Pharmaceutical

March 21, 2025 EX-99.(D)(2)

Confidentiality Agreement, dated as of December 19, 2024, between Chimerix, Inc. and Jazz Pharmaceuticals Public Company Limited.

Exhibit (d)(2) MUTUAL CONFIDENTIAL DISCLOSURE AND NON-USE AGREEMENT THIS MUTUAL NON-DISCLOSURE AGREEMENT (“Agreement”) is made effective as of December 19, 2024 (the “Effective Date”), by and between CHIMERIX, INC.

March 21, 2025 EX-10.11

Chimerix, Inc. Amended and Restated Officer Severance Benefit Plan (incorporated by reference to Chimerix, Inc.’s Annual Report on Form 10-K (No. 001-35867) filed with the SEC on March 21, 2025).

Exhibit 10.11 Chimerix, Inc. Amended and Restated Officer Severance Benefit Plan Section 1.Introduction. The Chimerix, Inc. Amended and Restated Officer Severance Benefit Plan (the “Plan”) is hereby established effective November 12, 2024 (the “Effective Date”). The purpose of the Plan is to provide for the payment of severance benefits to eligible officers of Chimerix, Inc. (the “Company” as furt

March 21, 2025 EX-10.23

Amended and Restated Loan and Security Agreement, dated December 23, 2024, by and between the Registrant and Silicon Valley Bank, a division of First-Citizens Bank & Trust Company.

Exhibit 10.23 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of the Effective Date between SILICON VALLEY BANK,

March 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2025 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2025 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Employ

March 21, 2025 EX-FILING FEES

Filing fee table

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) CHIMERIX, INC.

March 21, 2025 EX-99.(A)(1)(C)

Letter to Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees.

Exhibit (a)(1)(C) Offer To Purchase All Outstanding Shares of Common Stock of CHIMERIX, INC.

March 21, 2025 EX-99.(A)(1)(E)

Summary Advertisement as published in The New York Times on March 21, 2025

Exhibit (a)(1)(E) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below), and the provisions herein are subject in their entirety to the provisions of the Offer (as defined below).

March 6, 2025 EX-99.1

Infographic from March 6, 2025 (incorporated by reference to Exhibit 99.1 to the Schedule TO-C filed by Jazz Pharmaceuticals Public Limited Company with the U.S. Securities and Exchange Commission on March 6, 2025).

Exhibit 99.1 Jazz’s Proposed Acquisition of Chimerix to Further Diversify Oncology Portfolio Reinforces commitment to bringing medicines to patients with significant unmet needs Significant Anticipated Strategic and Financial Benefits Transaction Terms Strong strategic fit: Will strengthen Jazz’s presence in the rare oncology space ~$935 million total consideration Anticipated near-term launch: Ex

March 6, 2025 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (RULE 14d-100) Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Pinetree Acqu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (RULE 14d-100) Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Pinetree Acquisition Sub, Inc. (Offeror) Jazz Pharmaceuticals plc (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, $0.001 PAR VALUE PER SHARE (Title of

March 5, 2025 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (RULE 14d-100) Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Pinetree Acqu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (RULE 14d-100) Tender Offer Statement under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Pinetree Acquisition Sub, Inc. (Offeror) Jazz Pharmaceuticals plc (Parent of Offeror) (Names of Filing Persons) COMMON STOCK, $0.001 PAR VALUE PER SHARE (Title of

March 5, 2025 EX-99.1

Jazz Pharmaceuticals to Acquire Chimerix, Further Diversifying Oncology Portfolio -Dordaviprone addresses a significant unmet patient need for patients with rare, high-grade brain tumors- -Transaction to add near-term commercial opportunity to Jazz’s

Exhibit 99.1 Jazz Pharmaceuticals to Acquire Chimerix, Further Diversifying Oncology Portfolio -Dordaviprone addresses a significant unmet patient need for patients with rare, high-grade brain tumors- -Transaction to add near-term commercial opportunity to Jazz’s pipeline- -Transaction represents total cash consideration of approximately $935 million, or $8.55 per share- DUBLIN and DURHAM, March 5

March 5, 2025 EX-99.3

Employee FAQ, first used on March 5, 2025.

Exhibit 99.3 CMRX Employee FAQ 1. Why is Chimerix entering into a transaction with Jazz Pharmaceuticals? · The transaction will accelerate development of our pipeline, expand our commercial footprint, and eventually enable us to reach more patients globally while also delivering significant and certain cash value to our shareholders. · Jazz shares our commitment to advancing first-in-class medicin

March 5, 2025 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name o

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities) Mic

March 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2025 Chimerix, Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2025 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Numbe

March 5, 2025 EX-99.1

Corporate LinkedIn and Corporate X Post, each first used on March 5, 2025.

Exhibit 99.1

March 5, 2025 EX-99.4

Form of E-Mail Response to Investor Inquiry, first used on March 5, 2025.

Exhibit 99.4 Subject: Chimerix and Jazz Pharmaceuticals Transaction Good morning, We are very pleased to announce that Chimerix has entered into a definitive agreement to be acquired by Jazz Pharmaceuticals. This is an exciting transaction that provides Chimerix with the capital and global scale to advance our pipeline, expand our commercial footprint, and reach more patients with our innovative t

March 5, 2025 EX-99.1

Employee Communication from March 5, 2025 (incorporated by reference to Exhibit 99.1 to Pinetree Acquisition Sub, Inc. and Jazz Pharmaceuticals plc’s Schedule TO-C, filed March 5, 2025).

Exhibit 99.1 I am excited to share that we’ve just issued a press release announcing our intention to acquire Chimerix, a biopharmaceutical company with a current focus in oncology on a mission to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases. You can read the full press release here. I’d like to talk about what we expect this transaction will

March 5, 2025 EX-2.1

Agreement and Plan of Merger, dated as of March 4, 2025, by and among Chimerix, Inc., Jazz Pharmaceuticals Public Limited Company and Pinetree Acquisition Sub, Inc.

Exhibit 2.1 EXECUTION VERSION AGREEMENT AND PLAN OF MERGER among: Chimerix, Inc., a Delaware corporation; Jazz Pharmaceuticals Public Limited Company, an Irish public limited company; and Pinetree Acquisition Sub, Inc., a Delaware corporation Dated as of March 4, 2025 Table of Contents Section 1 THE OFFER 1.1 The Offer 2 1.2 Company Actions 5 Section 2 MERGER TRANSACTION 2.1 Merger of Purchaser in

March 5, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2025 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (C

March 5, 2025 EX-99.2

Social Media Post from March 5, 2025 (incorporated by reference to Exhibit 99.2 to Pinetree Acquisition Sub, Inc. and Jazz Pharmaceuticals plc’s Schedule TO-C, filed March 5, 2025).

Exhibit 99.2 Jazz Pharmaceuticals 182,033 followers 1h . We’re pleased to announce that we have entered into a definitive agreement for Jazz to acquire Chimerix, Inc. to further diversify our #oncology pipeline, reinforcing our commitment to delivering novel #cancer treatments to people who need them. The acquisition is subject to successful completion of the tender offer and customary closing con

March 5, 2025 EX-2.1

Agreement and Plan of Merger, dated as of March 4, 2025, by and among Chimerix, Inc., Jazz Pharmaceuticals Public Limited Company and Pinetree Acquisition Sub, Inc.

Exhibit 2.1 EXECUTION VERSION AGREEMENT AND PLAN OF MERGER among: Chimerix, Inc., a Delaware corporation; Jazz Pharmaceuticals Public Limited Company, an Irish public limited company; and Pinetree Acquisition Sub, Inc., a Delaware corporation Dated as of March 4, 2025 Table of Contents Section 1 THE OFFER 1.1 The Offer 2 1.2 Company Actions 5 Section 2 MERGER TRANSACTION 2.1 Merger of Purchaser in

March 5, 2025 EX-99.2

Transcript of Voicemail to Employees from Michael T. Andriole, President and Chief Executive Officer, first used on March 5, 2025.

Exhibit 99.2 Good morning everyone, Just minutes ago we issued a press release announcing that Chimerix has agreed to be acquired by Jazz Pharmaceuticals for $8.55 per share in cash, that’’s a 72% premium to yesterday’’s closing price. This transaction is a significant step forward that will further accelerate the development of our pipeline, expand our commercial footprint both domestically and,

March 5, 2025 SC14D9C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name o

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 Chimerix, Inc. (Name of Subject Company) Chimerix, Inc. (Name of Person Filing Statement) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number of Class of Securities) Mic

March 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2025 Chimerix, Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2025 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Numbe

December 30, 2024 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 23, 2024 Chimerix, Inc.

December 10, 2024 EX-99.1

Chimerix Corporate Presentation December 10, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertaintie

Chimerix Corporate Presentation December 10, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

December 10, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 9, 2024 Chimerix, Inc.

November 14, 2024 EX-10.1

Chimerix, Inc. Amended and Restated Officer and Severance Benefit Plan.

Exhibit 10.1 Chimerix, Inc. Amended and Restated Officer Severance Benefit Plan Section 1.Introduction. The Chimerix, Inc. Amended and Restated Officer Severance Benefit Plan (the “Plan”) is hereby established effective November 12, 2024 (the “Effective Date”). The purpose of the Plan is to provide for the payment of severance benefits to eligible officers of Chimerix, Inc. (the “Company” as furth

November 14, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 November 12, 2024 Date of Report (Date of earliest event reported) Chimerix, Inc.

November 7, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2024 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Empl

November 7, 2024 EX-99.2

Chimerix Corporate Presentation November 7, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties

Chimerix Corporate Presentation November 7, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIME

November 7, 2024 EX-10.1

Chimerix, Inc. Non-Employee Director Compensation Policy, as amended, dated June 20, 2024.

Chimerix, Inc. Non-Employee Director Compensation Policy Last Modified Effective as of June 20, 2024 Each member of the Board of Directors (the “Board”) who is not also serving as an employee of Chimerix, Inc. (“Chimerix”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy for his or her Bo

November 7, 2024 EX-99.1

Chimerix Reports Third Quarter 2024 Financial Results and Provides Operational Update – Phase 3 ACTION Study On-Track with First Interim Overall Survival Data Expected Third Quarter 2025 – – IDMC Recommends Continuing Conduct of ACTION Study As-Is Fo

Chimerix Reports Third Quarter 2024 Financial Results and Provides Operational Update – Phase 3 ACTION Study On-Track with First Interim Overall Survival Data Expected Third Quarter 2025 – – IDMC Recommends Continuing Conduct of ACTION Study As-Is Following Preplanned Safety Review – – Alignment with TGA to Submit Dordaviprone for Provisional Approval in Australia – – Conference Call at 8:30 a.

August 13, 2024 S-8

As filed with the Securities and Exchange Commission on August 13, 2024

As filed with the Securities and Exchange Commission on August 13, 2024 Registration No.

August 13, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Emplo

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

August 13, 2024 EX-99.2

Chimerix Corporate Presentation Aug 13, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties tha

Chimerix Corporate Presentation Aug 13, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

August 13, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-8 (Form Type) Chimerix, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock (par value $0.001 pe

August 13, 2024 EX-10.2

Form of Stock Option Grant Notice and Option Agreement and Form of Restricted Stock Unit Award Agreement and Form of Restricted Stock Unit Awar

Chimerix, Inc. Stock Option Grant Notice (2024 Equity Incentive Plan) Chimerix, Inc. (the “Company”) has granted to you (the “Participant”) an option to purchase the number of shares of Common Stock set forth below (the “Option”) under the Chimerix, Inc. 2024 Equity Incentive Plan (“Plan”). The Option is subject to all of the terms and conditions set forth in this Stock Option Grant Notice (the “G

August 13, 2024 EX-10.1

Chimerix, Inc. 2024 Equity Incentive Plan

Chimerix, Inc. 2024 Equity Incentive Plan Adopted by the Compensation Committee: April 10, 2024 Approved by the Stockholders: June 20, 2024 1.General. (a)Successor to and Continuation of Prior Plan. The Plan is the successor to and continuation of the Prior Plan. As of 12:01 a.m. Eastern Standard Time on the Effective Date, (i) no additional awards may be granted under the Prior Plan; (ii) the Pri

August 13, 2024 EX-99.1

Chimerix Reports Second Quarter 2024 Financial Results and Provides Operational Update – Phase 3 ACTION Study On-Track; First Interim Overall Survival Data Expected Third Quarter 2025 – – ONC206 Phase 1 PK and Safety Data Demonstrate Dose Proportiona

Chimerix Reports Second Quarter 2024 Financial Results and Provides Operational Update – Phase 3 ACTION Study On-Track; First Interim Overall Survival Data Expected Third Quarter 2025 – – ONC206 Phase 1 PK and Safety Data Demonstrate Dose Proportional Exposure with No Dose Limiting Toxicity to Date – – Dordaviprone Filed for Provisional Determination with Therapeutic Goods Administration in Australia – – Conference Call at 8:30 a.

August 13, 2024 EX-99.3

Form of Stock Option Grant Notice and Option Agreement for Inducement Grant Outside of 2024 Equity Incentive Plan.

Exhibit 99.3 Chimerix, Inc. Stock Option Grant Notice (Inducement Grant Outside of the 2024 Equity Incentive Plan) Chimerix, Inc. (the “Company”) has granted to you (the “Participant”) an option to purchase the number of shares of Common Stock set forth below (the “Option”). The Option is granted outside of the Chimerix, Inc. 2024 Equity Incentive Plan (“Plan”), and is subject to all of the terms

July 3, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 27, 2024 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number

June 21, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 20, 2024 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 20, 2024 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number

May 1, 2024 CORRESP

Chimerix, Inc. 2505 Meridian Parkway, Suite 100 Durham, NC 27713 (919) 806-1074

Chimerix, Inc. 2505 Meridian Parkway, Suite 100 Durham, NC 27713 (919) 806-1074 May 1, 2024 Via Edgar United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Chris Edwards Re: Chimerix, Inc. Registration Statement on Form S-3 File No. 333-277505 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as a

May 1, 2024 EX-10.1

Directorship Offer Letter to Marc D. Kozin, dated March 20, 2024.

CHIMERIX.COM March 20, 2024 Marc Kozin Re: Member of the Board of Directors of Chimerix, Inc. Dear Mr. Kozin: It is my sincere pleasure, on behalf of Chimerix, Inc. (“Chimerix”), to offer you a position as a member of the Board of Directors (the “Board”) of Chimerix. Your appointment to the Board is contingent and effective upon your formal acceptance of this offer, which shall be evidenced by you

May 1, 2024 EX-99.1

Chimerix Reports First Quarter 2024 Financial Results and Provides Operational Update – Dordaviprone (ONC201) ACTION Study Progressing; Reiterates Expectations for Interim Overall Survival (OS) Data in 2025 and Final OS Data in 2026 – – No Dose Limit

Chimerix Reports First Quarter 2024 Financial Results and Provides Operational Update – Dordaviprone (ONC201) ACTION Study Progressing; Reiterates Expectations for Interim Overall Survival (OS) Data in 2025 and Final OS Data in 2026 – – No Dose Limiting Toxicity in ONC206 Phase 1 Studies to Date, Preliminary Phase 1 Safety and Pharmacokinetic (PK) Data Expected This Summer – – Company to Advance Dordaviprone in Provisional Registration Process Following Positive Interaction with Therapeutic Goods Administration (TGA) in Australia – – Conference Call at 8:30 a.

May 1, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

May 1, 2024 EX-99.2

Chimerix Corporate Presentation May 1, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that

cmrx2q24corporatepresent Chimerix Corporate Presentation May 1, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

May 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2024 Chimerix, Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2024 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Employer

April 26, 2024 DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 26, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.__)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(

March 21, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 March 20, 2024 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Numbe

March 21, 2024 EX-99.1

Chimerix Appoints Marc D. Kozin to Board of Directors Veteran Industry Executive Brings More Than 35 Years of Corporate Strategy Experience

Exhibit 99.1 Chimerix Appoints Marc D. Kozin to Board of Directors Veteran Industry Executive Brings More Than 35 Years of Corporate Strategy Experience DURHAM, N.C., March 21, 2024 (GLOBE NEWSWIRE) - Chimerix (NASDAQ:CMRX), a biopharmaceutical company whose mission is to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases, today announced the appoin

February 29, 2024 EX-99.2

Chimerix Corporate Presentation February 29, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertaintie

Chimerix Corporate Presentation February 29, 2024 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

February 29, 2024 EX-4.7

Form of Debt Securities Warrant Agreement and Warrant Certificate.

Exhibit 4.7 CHIMERIX, INC. and , As Warrant Agent Form of Debt Securities Warrant Agreement Dated As Of CHIMERIX, INC. Form of Debt Securities Warrant Agreement This Debt Securities Warrant Agreement (this “Agreement”), dated as of [●], between Chimerix, Inc., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association] organized and existing under the laws of [●

February 29, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 Chimerix, Inc.

February 29, 2024 EX-97.1

Chimerix, Inc. Incentive Compensation Recoupment Policy, adopted on November 14, 2023.

288853836 v4 CHIMERIX, INC. INCENTIVE COMPENSATION RECOUPMENT POLICY 1. INTRODUCTION The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of CHIMERIX, INC., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Policy (this “Policy”) pro

February 29, 2024 EX-4.5

Form of Common Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.5 CHIMERIX, INC. AND , As Warrant Agent Form of Common Stock Warrant Agreement Dated as of CHIMERIX, INC. Form of Common Stock Warrant Agreement This Common Stock Warrant Agreement (this “Agreement”), dated as of [●], between Chimerix, Inc., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association] organized and existing under the laws of [●] and hav

February 29, 2024 EX-99.1

Chimerix Reports Fourth Quarter and Year End 2023 Financial Results and Provides Operational Update – ONC201 ACTION Study Progressing; Reiterate Interim OS Data Expected in 2025, Final OS Data Expected in 2026 – – Phase 2 ONC201 Data Published in Pee

Chimerix Reports Fourth Quarter and Year End 2023 Financial Results and Provides Operational Update – ONC201 ACTION Study Progressing; Reiterate Interim OS Data Expected in 2025, Final OS Data Expected in 2026 – – Phase 2 ONC201 Data Published in Peer-Reviewed Journal of Clinical Oncology – – $204 Million in Cash and Equivalents at December 31, 2023 – – Conference Call at 8:30 a.

February 29, 2024 EX-21.1

Subsidiaries of Chimerix, Inc.

Exhibit 21.1 Subsidiaries of Chimerix, Inc. Oncoceutics, Inc., a Delaware corporation

February 29, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Chimerix, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Re

February 29, 2024 EX-10.28

Directorship Offer Letter to Lisa L. Decker, PhD, dated December 28, 2023.

CHIMERIX.COM December 27, 2023 Re: Member of the Board of Directors of Chimerix, Inc. Dear Ms. Decker: It is my sincere pleasure, on behalf of Chimerix, Inc. (“Chimerix”), to offer you a position as a member of the Board of Directors (the “Board”) of Chimerix. Your appointment to the Board is contingent and effective upon your formal acceptance of this offer, which shall be evidenced by you signin

February 29, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 Chimerix, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Emp

February 29, 2024 EX-4.2

Form of Indenture, between the Registrant and one or more trustees to be named.

Exhibit 4.2 CHIMERIX, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities Table of Contents Page Article 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 Article 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certificate 6 Section 2.03

February 29, 2024 EX-10.27

dated February 29, 2024, by and between the Company and Jefferies LLC.

Exhibit 10.27 OPEN MARKET SALE AGREEMENT1 February 29, 2024 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Chimerix, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stock,

February 29, 2024 EX-10.22

irst Amendment to Loan and Security Agreement, dated November 21, 2

Exhibit 10.22 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed. FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIRST AMENDMENT to Loan and Security Agreement (this “Agreement”) is entered into as of November 21, 2023, by and between Silicon V

February 29, 2024 EX-4.6

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.6 CHIMERIX, INC. and , As Warrant Agent Form of Preferred Stock Warrant Agreement Dated As Of CHIMERIX, INC. Form of Preferred Stock Warrant Agreement This Preferred Stock Warrant Agreement (this “Agreement”), dated as of [·], between Chimerix, Inc., a Delaware corporation (the “Company”), and [·], a [corporation] [national banking association] organized and existing under the laws of [·

February 29, 2024 S-3

As filed with the Securities and Exchange Commission on February 29, 2024

As filed with the Securities and Exchange Commission on February 29, 2024 Registration No.

February 14, 2024 SC 13G/A

CMRX / Chimerix, Inc. / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* CHIMERIX, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule p

February 14, 2024 EX-1

Joint Filing Agreement

EX-1 2 tm246065d6ex1.htm EXHIBIT 1 EXHIBIT 1 AGREEMENT This Joint Filing Agreement, dated as of February 14, 2024, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchange Commission a

February 12, 2024 SC 13G/A

CMRX / Chimerix, Inc. / Rubric Capital Management LP - SC 13G/A Passive Investment

SC 13G/A 1 tm245464d4sc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Chimerix, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) December 31, 2023 (Date of event which requires filing of this statement) Check the appropriate

December 29, 2023 EX-99.1

Chimerix Appoints Lisa Decker to Board of Directors Seasoned Industry Executive Brings More Than 25 Years of Leadership and Business Development Experience

Exhibit 99.1 Chimerix Appoints Lisa Decker to Board of Directors Seasoned Industry Executive Brings More Than 25 Years of Leadership and Business Development Experience DURHAM, N.C., December 29, 2023 (GLOBE NEWSWIRE) - Chimerix (NASDAQ:CMRX), a biopharmaceutical company whose mission is to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases, today a

December 29, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 December 28, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 December 28, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Nu

December 4, 2023 EX-99.2

Employment Offer Letter to Michelle LaSpaluto, dated November 30, 2023.

December 4, 2023 EX-99.1

Chimerix Promotes Michelle LaSpaluto to Chief Financial Officer Proven Leader Brings More Than 25 Years of Financial Experience

Exhibit 99.1 Chimerix Promotes Michelle LaSpaluto to Chief Financial Officer Proven Leader Brings More Than 25 Years of Financial Experience DURHAM, N.C., December 4, 2023 (GLOBE NEWSWIRE) - Chimerix (NASDAQ:CMRX), a biopharmaceutical company whose mission is to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases, today announced the promotion of Mic

December 4, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 29, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Empl

November 16, 2023 EX-99.2

2505 Meridian Pkwy, Suite 100 I Durham, NC 27713

Exhibit 99.2 CHIMERIX.COM September 27, 2023 Thomas J. Riga 1608 Lookout Circle Waxhaw, NC 28173 Dear Tom, Chimerix is pleased to extend an offer of employment to you for the position of Chief Operating Officer and Chief Commercial Officer. This position reports to Michael Andriole, Chief Executive Officer. Our offer of employment is contingent on successful completion of our background screening

November 16, 2023 EX-99.1

Chimerix Strengthens Executive Leadership Team with Appointment of Thomas Riga as Chief Operating and Commercial Officer Seasoned Executive Brings More Than 25 Years of Industry Leadership Experience in Oncology Commercialization and Corporate Busine

Exhibit 99.1 Chimerix Strengthens Executive Leadership Team with Appointment of Thomas Riga as Chief Operating and Commercial Officer Seasoned Executive Brings More Than 25 Years of Industry Leadership Experience in Oncology Commercialization and Corporate Business Development DURHAM, N.C., November 16, 2023 (GLOBE NEWSWIRE) — Chimerix (NASDAQ:CMRX), a biopharmaceutical company whose mission is to

November 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 November 16, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 November 16, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Nu

November 2, 2023 EX-99.1

Chimerix Reports Third Quarter 2023 Financial Results and Provides Operational Update – Phase 3 ACTION Study Ongoing with 113 Sites Activated Across 12 Countries; Interim Survival and PFS Data on Track to Report in 2025 – – Actively Recruiting ONC206

Chimerix Reports Third Quarter 2023 Financial Results and Provides Operational Update – Phase 3 ACTION Study Ongoing with 113 Sites Activated Across 12 Countries; Interim Survival and PFS Data on Track to Report in 2025 – – Actively Recruiting ONC206 Dose Escalation Studies; Enrollment on Track to Complete First Half 2024 – – Conference Call at 8:30 a.

November 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 2, 2023 Chimerix, Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 2, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Empl

November 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIME

November 2, 2023 EX-99.2

Chimerix Corporate Presentation November 2, 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties

Chimerix Corporate Presentation November 2, 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

September 29, 2023 SC 13G

CMRX / Chimerix Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* CHIMERIX, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) September 19, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pur

August 3, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Employ

August 3, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

August 3, 2023 EX-99.1

Chimerix Reports Second Quarter 2023 Financial Results and Provides Operational Update – Phase 3 ACTION Study Ongoing with 77 Sites Activated Across 11 Countries; Reiterate First Interim Overall Survival Analysis Expected Early 2025 – – ONC206 Dose E

Chimerix Reports Second Quarter 2023 Financial Results and Provides Operational Update – Phase 3 ACTION Study Ongoing with 77 Sites Activated Across 11 Countries; Reiterate First Interim Overall Survival Analysis Expected Early 2025 – – ONC206 Dose Escalation Completion Expected in First Half 2024 – – Capital Available to Fund Operations is $233 Million as of June 30, 2023 – – Conference Call at 8:30 a.

August 3, 2023 EX-99.2

Chimerix Corporate Presentation August 3, 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties t

cmrx3q23corporatepresent Chimerix Corporate Presentation August 3, 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

June 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 27, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 27, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number

June 27, 2023 EX-99.4

Chimerix, Inc. Non-Employee Director Compensation Policy Last Modified: June 27, 2023

Exhibit 99.4 Chimerix, Inc. Non-Employee Director Compensation Policy Last Modified: June 27, 2023 Each member of the Board of Directors (the “Board”) who is not also serving as an employee of Chimerix, Inc. (“Chimerix”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy for his or her Boar

June 27, 2023 EX-99.3

Mike Andriole

Exhibit 99.3 Mike Andriole 2015 Strathmoor Blvd. Louisville, KY 40205 Dear Mike, Chimerix is pleased to confirm your continued employment in the role of President and Chief Executive Officer, reporting to the Board of Directors. This Amended Offer Letter will be effective on August 1, 2023 (the “Transition Date”). The following are the terms of this offer: Base Salary: Your annual base salary will

June 27, 2023 EX-99.1

Chimerix Announces Promotion of Michael T. Andriole to President and Chief Executive Officer Mike Sherman to Transition to Chair of the Board of Directors Martha Demski to Assume Role of Lead Independent Director

Exhibit 99.1 Chimerix Announces Promotion of Michael T. Andriole to President and Chief Executive Officer Mike Sherman to Transition to Chair of the Board of Directors Martha Demski to Assume Role of Lead Independent Director DURHAM, N.C., June 27, 2023 – Chimerix, Inc. (NASDAQ:CMRX), a biopharmaceutical company whose mission it is to develop medicines that meaningfully improve and extend the live

June 27, 2023 EX-99.2

June 27, 2023

Exhibit 99.2 June 27, 2023 Michael Sherman 1817 Milford Street Carmel, IN 46032 Re: Management Transition Dear Mike: This letter agreement will serve to memorialize our mutual understanding regarding the transition of your employment with Chimerix, Inc. (the “Company”). Effective as of August 1, 2023 (the “Transition Date”), you will retire as Chief Executive Officer of the Company, your employmen

June 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 9, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 9, 2023 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number)

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

May 4, 2023 EX-99.2

Chimerix Corporate Presentation Q2 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that cou

cmrx2q23corporatepresent Chimerix Corporate Presentation Q2 2023 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2023 Chimerix, Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Employer

May 4, 2023 EX-99.1

Chimerix Reports First Quarter 2023 Financial Results and Provides Operational Update – European Union Study Authorization for Phase 3 ACTION Received, Reiterate First Efficacy Data Expected Early 2025 – – Completion of ONC206 Dose Escalation Expecte

Chimerix Reports First Quarter 2023 Financial Results and Provides Operational Update – European Union Study Authorization for Phase 3 ACTION Received, Reiterate First Efficacy Data Expected Early 2025 – – Completion of ONC206 Dose Escalation Expected by First Half 2024 – – Conference Call at 8:30 a.

May 2, 2023 SC 13G

CMRX / Chimerix Inc / Rubric Capital Management LP - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Chimerix, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) April 30, 2023 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which thi

April 28, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

April 28, 2023 DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Numb

March 2, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Chimerix, Inc. (Exact name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Share(2) Maximum Aggregate Offering Price(2) Fee Rate Amount of Registration Fee Fees to be Paid Equity Common Stock, $0.001 par value per share, reser

March 2, 2023 EX-4.2

Description of Common Stock

Exhibit 4.2 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Chimerix, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation, as well as our amended and restated bylaws, and the applicable provisions of the Delaware General Corporation Law. This information is qualified entirely by reference to the applicable pr

March 2, 2023 EX-99.1

Chimerix Reports Fourth Quarter and Year End 2022 Financial Results and Provides Operational Update – Continued Execution and Progress Towards Commercial Approval of Dordaviprone (ONC201) with Global Launch of Phase 3 ACTION Study – – Confirmed Respo

Chimerix Reports Fourth Quarter and Year End 2022 Financial Results and Provides Operational Update – Continued Execution and Progress Towards Commercial Approval of Dordaviprone (ONC201) with Global Launch of Phase 3 ACTION Study – – Confirmed Response in Non-H3 K27M Recurrent Glioblastoma Patient During ONC206 Dose Escalation – – Strong Balance Sheet with $266 Million in Cash at Year-End and No Debt – – Conference Call at 8:30 a.

March 2, 2023 EX-10.21

Employment Offer Letter to Allen Melemed dated May 7, 2020.

[LETTERHEAD OF CHIMERIX INC] May 7, 2020 Allen S. Melemed, M.D., M.B.A. 375 Fox Pond Road Aiken, SC 29801 Dear Allen, Chimerix is pleased to extend an offer of employment to you for the position of Chief Medical Officer. This position reports to Mike Sherman, President and CEO. Our offer of employment is contingent on successful completion of our background screening process including, but not lim

March 2, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 Chimerix, Inc.

March 2, 2023 EX-99.2

Chimerix Corporate Presentation 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause

chimerix1q23corporatepre Chimerix Corporate Presentation 2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected.

March 2, 2023 EX-21.1

Subsidiaries of Chimerix, Inc.

Exhibit 21.1 Subsidiaries of Chimerix, Inc. Oncoceutics, Inc., a Delaware corporation

March 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2023 Chimerix, Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2023 Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of (Commission File Number) (IRS Employe

March 2, 2023 S-8

As filed with the Securities and Exchange Commission on March 2, 2023

S-8 1 a20230302cmrxs-8evergreens.htm S-8 As filed with the Securities and Exchange Commission on March 2, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CHIMERIX, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 33-0903395 (State or Other Jurisdiction of Incorpor

February 14, 2023 SC 13G/A

CMRX / Chimerix Inc / Point72 Asset Management, L.P. - SCHEDULE 13G/A, AMENDMENT #2 Passive Investment

SC 13G/A 1 pt7213gaa.htm SCHEDULE 13G/A, AMENDMENT #2 240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* (Name of Issuer) Chimerix, Inc. (Title of Class

February 14, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 pt7213gab.htm JOINT FILING AGREEMENBT Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behal

February 13, 2023 SC 13G/A

CMRX / Chimerix Inc / Opaleye Management Inc. Passive Investment

SC 13G/A 1 formsc13ga.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* CHIMERIX, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 16934W106 (CUSIP Number) James Silverman, One Boston Place, 26th Floor, Boston, MA 02108, 617-229-5085 (Name, Address and Te

February 13, 2023 SC 13G/A

CMRX / Chimerix Inc / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

January 12, 2023 EX-99.1

Chimerix, Inc 41 st Annual J.P. Morgan Healthcare Conference January 12, 2023

Exhibit 99.1 Chimerix, Inc 41 st Annual J.P. Morgan Healthcare Conference January 12, 2023 2 2 Forward - Looking Statements This presentation contains forward - looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward - looking statemen

January 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 12, 2023 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 12, 2023 Chimerix, Inc.

December 9, 2022 EX-99.2

Chimerix Corporate Presentation

Exhibit 99.2 Chimerix Corporate Presentation 2 2 Forward - Looking Statements This presentation contains forward - looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward - looking statements include those relating to, among other thin

December 9, 2022 EX-99.1

Chimerix Announces Successful Launch of ONC201 Phase 3 ACTION Study at Society for Neuro-Oncology Conference and Provides Operational Update

Exhibit 99.1 Chimerix Announces Successful Launch of ONC201 Phase 3 ACTION Study at Society for Neuro-Oncology Conference and Provides Operational Update – Natural Disease History study indicates median overall survival in recurrent H3 K27M-mutant diffuse glioma of 5.1 months compared to 13.7 months in the prior ONC201 Phase 2 efficacy analysis – – Two external analyses presented at SNO concluded

December 9, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2022 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2022 Chimerix, Inc.

December 9, 2022 EX-3.2

Amended and Restated Bylaws of the Registrant.

Exhibit 3.2 AMended and restated BYLAWS OF Chimerix, Inc. ARTICLE I Offices Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other Offices. The corporation shall also have and maintain an office or principal place of business at such place as may be fixed by the corporation?s Board o

November 10, 2022 SC 13D

CMRX / Chimerix Inc / Rubric Capital Management LP - SC 13D Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Chimerix, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) Rubric Capital Management LP 155 East 44th St, Suite 1630 New York, NY 10017 Attention: Brian Kleinhaus 212-418-1888 (Name, Address and Tele

November 3, 2022 EX-99.2

Chimerix Corporate Presentation

Exhibit 99.2 Chimerix Corporate Presentation 2 2 Forward - Looking Statements This presentation contains forward - looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward - looking statements include those relating to, among other thin

November 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIME

November 3, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2022 Chimerix, Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2022 Chimerix, Inc.

November 3, 2022 EX-10.1

BARDA Agreement, dated August 26, 2022, by and between the Registrant and Biomedical Advanced Research and Development Authority

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.

November 3, 2022 EX-99.1

Chimerix Reports Third Quarter 2022 Financial Results and Provides Operational Update – ONC201 Phase 3 ACTION Study On-Track to Open Enrollment in November – – Meeting with U.S. Food and Drug Administration (FDA) Set for Fourth Quarter – – Strong Fin

Exhibit 99.1 Chimerix Reports Third Quarter 2022 Financial Results and Provides Operational Update – ONC201 Phase 3 ACTION Study On-Track to Open Enrollment in November – – Meeting with U.S. Food and Drug Administration (FDA) Set for Fourth Quarter – – Strong Financial Position with ~$285 Million in Cash at September 30 – – Conference Call at 8:30 a.m. ET Today – DURHAM, N.C., November 3, 2022 – C

November 3, 2022 EX-10.2

Amendment to BARDA Agreement, dated September 9, 2022, by and between the Registrant and Biomedical Advanced Research and Development Authority.

Exhibit 10.2 AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES 1 1 2. AMENDMENT/MODIFICATION NO P00001 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ NO N/A. 5. PROJECT NO (if applicable) 6. ISSUED BY CODE ASPR-BARDA 7. ADMINISTERED BY (if other than line item 6) CODE ASPR-BARDA02 ASPR-BARDA 200 Independence Ave., S.W. Room 640-G Washington DC 20201

September 28, 2022 EX-2.1

First Amendment to Asset Purchase Agreement, dated September 26, 2022, by and between the Registrant, Emergent BioSolutions Inc. and Emergent Biodefense Operations Lansing LLC.

Exhibit 2.1 Execution Version FIRST AMENDMENT TO ASSET PURCHASE AGREEMENT THIS FIRST AMENDMENT TO ASSET PURCHASE AGREEMENT, dated as of September 26, 2022 (this ?Amendment?), is being entered into by and between Chimerix, Inc., a Delaware corporation (the ?Seller?), Emergent BioSolutions Inc., a Delaware corporation (?Emergent?) and Emergent Biodefense Operations Lansing LLC, a Delaware limited li

September 28, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2022 Chimerix, Inc.

September 28, 2022 EX-99.1

CHIMERIX, INC. UNAUDITED PRO FORMA CONSOLIDATED FINANCIAL STATEMENTS

Exhibit 99.1 CHIMERIX, INC. UNAUDITED PRO FORMA CONSOLIDATED FINANCIAL STATEMENTS Sale of TEMBEXA On September 26, 2022 (the ?Closing Date?), Chimerix, Inc. (the ?Company?), completed the previously announced sale of the Company?s exclusive worldwide rights to brincidofovir, including TEMBEXA and related assets (the ?EBS Agreement?) to Emergent BioSolutions, Inc. (?EBS?). Based on the terms of the

August 31, 2022 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 August 26, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer

August 8, 2022 EX-99.1

Chimerix Reports Second Quarter 2022 Financial Results and Provides Operational Update – ONC201 Phase 3 ACTION Study Planned to Initiate This Year – –~$32M in Revenue from International TEMBEXA Agreements Recently Recognized – – U.S. Anti-Trust Clear

Chimerix Reports Second Quarter 2022 Financial Results and Provides Operational Update – ONC201 Phase 3 ACTION Study Planned to Initiate This Year – –~$32M in Revenue from International TEMBEXA Agreements Recently Recognized – – U.

August 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 August 8, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer I

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

August 1, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 July 29, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Id

July 5, 2022 SC 13G

CMRX / Chimerix Inc / Moll Peter Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.J* Chimerix, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 16934W106 (CU SIP Number) June 17, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

June 28, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 23, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Id

June 28, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 June 28, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Id

June 28, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 June 23, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Id

May 18, 2022 EX-2.1

Asset Purchase Agreement, dated May 15, 2022, by and between the Company and Emergent BioSolutions Inc.

Exhibit 2.1 CERTAIN PORTIONS OF THIS EXHIBIT (INDICATED BY ?[***]?) HAVE BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. Execution Version ASSET PURCHASE AGREEMENT between: Chimerix, Inc., a Delaware corporation; and Emergent BioSolutions Inc., a Delaware corporation. Dated as of May 15, 2022 TABLE OF CONTENTS 1. Sale and Purchase of

May 18, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 May 15, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Ide

May 16, 2022 EX-99.2

Chimerix Announces Sale of TEMBEXA to Emergent BioSolutions for up to $337.5 million plus Royalties – $225 Million in Upfront Proceeds Secures Substantial Capital to Fund Operations and Allows for Participation in Future Economics – – Transaction All

Chimerix Announces Sale of TEMBEXA to Emergent BioSolutions for up to $337.5 million plus Royalties ? $225 Million in Upfront Proceeds Secures Substantial Capital to Fund Operations and Allows for Participation in Future Economics ? ? Transaction Allows Focus on Development Pipeline ? ? Positions TEMBEXA with Leading Global Biodefense Partner to Maximize Long Term Value ? DURHAM, N.C., May 16, 202

May 16, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 May 16, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Ide

May 16, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

May 16, 2022 EX-99.1

Chimerix Reports First Quarter 2022 Financial Results and Provides Operational Update Receiving up to $337.5 Million plus Royalties for Sale of Worldwide Rights of TEMBEXA to Emergent BioSolutions – – Initiation of Phase 3 Randomized Study of ONC201

Chimerix Reports First Quarter 2022 Financial Results and Provides Operational Update Receiving up to $337.

May 4, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

May 2, 2022 SC 13G

CMRX / Chimerix Inc / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

April 28, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A 1 chimerixinc-proxystatement.htm DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of t

April 28, 2022 DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 noticecard2022-defa14a.htm DEFA14A SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy Sta

April 18, 2022 EX-10.1

Chimerix, Inc. Officer Severance Benefit Plan, as amended.

Exhibit 10.1 Chimerix, Inc. Officer Severance Benefit Plan Section 1. Introduction. The Chimerix, Inc. Officer Severance Benefit Plan (the ?Plan?) is hereby established effective February 21, 2013 (the ?Effective Date?). The purpose of the Plan is to provide for the payment of severance benefits to eligible officers of Chimerix, Inc. (the ?Company?) in the event that such officers become subject t

April 18, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 13, 2022 Chimerix, Inc.

April 13, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 13, 2022 Chimerix, Inc.

March 1, 2022 EX-10.83

Loan and Security Agreement, dated January 31, 2022, by and between the Registrant and Silicon Valley Bank.

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.

March 1, 2022 POSASR

As filed with the Securities and Exchange Commission on March 1, 2022

As filed with the Securities and Exchange Commission on March 1, 2022 Registration No.

March 1, 2022 EX-4.2

Description of Common Stock

Exhibit 4.2 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Chimerix, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation, as well as our amended and restated bylaws, and the applicable provisions of the Delaware General Corporation Law. This information is qualified entirely by reference to the applicable pr

March 1, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 March 1, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Id

March 1, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Chimerix, Inc. (Exact name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Fees to be Paid Equity Common Stock, $0.001 par value per share - - - - - - Equ

March 1, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 Form 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 Chimerix, Inc.

March 1, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Chimerix, Inc. (Exact name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Fees to be Paid Equity Common Stock, $0.001 par value per share - - - - - - Equ

March 1, 2022 EX-21.1

Subsidiaries of Chimerix, Inc.

Exhibit 21.1 Subsidiaries of Chimerix, Inc. Oncoceutics, Inc., a Delaware corporation

March 1, 2022 POS AM

As filed with the Securities and Exchange Commission on March 1, 2022

As filed with the Securities and Exchange Commission on March 1, 2022 Registration No.

March 1, 2022 EX-99.1

Chimerix Reports Fourth Quarter and Year End 2021 Financial Results and Provides Operational Update – TEMBEXA RFP Response Submitted and Under Review with BARDA – – Pre-Clinical CMX521 Data Accepted for Late Breaking Oral Presentation at Internationa

Chimerix Reports Fourth Quarter and Year End 2021 Financial Results and Provides Operational Update ? TEMBEXA RFP Response Submitted and Under Review with BARDA ? ? Pre-Clinical CMX521 Data Accepted for Late Breaking Oral Presentation at International Conference on Antiviral Research ? ? ONC201 Program Remains on Track ? ? Conference Call at 8:30 a.

March 1, 2022 EX-FILING FEES

Filing Fee Table

EX-FILING FEES 4 ex107-2022sx8.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Chimerix, Inc. (Exact name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Share(2) Maximum Aggregate Offering Price(2) Fee Rate Amount of Registration Fee Fees to be Paid Equi

March 1, 2022 S-8

As filed with the Securities and Exchange Commission on March 1, 2022

S-8 1 a20220301cmrxs-8evergreens.htm S-8 As filed with the Securities and Exchange Commission on March 1, 2022 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 CHIMERIX, INC. (Exact Name of Registrant as Specified in Its Charter) Delaware 33-0903395 (State or Other Jurisdiction of Incorpor

February 14, 2022 SC 13G/A

CMRX / Chimerix Inc / Point72 Asset Management, L.P. - SCHEDULE 13G (AMENDMENT NO. 1) Passive Investment

240.13d-102 Schedule 13G - Information to be included in statements filed pursuant to 240.13d-1(b), (c), and (d) and amendments thereto filed pursuant to 240.13d-2. Securities and Exchange Commission, Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* (Name of Issuer) Chimerix, Inc. (Title of Class of Securities) Common Stock, Par Value $0.001 Per Shar

February 14, 2022 SC 13G

CMRX / Chimerix Inc / Rubric Capital Management LP - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Chimerix, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 16934W106 (CUSIP Number) December 31, 2021 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessi

February 3, 2022 SC 13G/A

CMRX / Chimerix Inc / Cantex Pharmaceuticals, Inc. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Chimerix, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 16934W106 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 1, 2022 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 January 31, 2022 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer

February 1, 2022 SC 13G/A

CMRX / Chimerix Inc / Opaleye Management Inc. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* CHIMERIX, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 16934W106 (CUSIP Number) James Silverman, One Boston Place, 26th Floor, Boston, MA 02108 (Name, Address and Telephone Number of Person Authorized to R

December 23, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 December 22, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employe

November 30, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 November 29, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employe

November 22, 2021 EX-99.1

Post Society for Neuro - Oncology Management Conference Call November 22, 2021 © 2021 Chimerix, Inc

Exhibit 99.1 Post Society for Neuro - Oncology Management Conference Call November 22, 2021 ? 2021 Chimerix, Inc 2 Forward - Looking Statements These slides contains forward - looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward - l

November 22, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 November 22, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Nu

November 4, 2021 EX-99.2

Chimerix Announces Positive Topline Results for ONC201 in Recurrent H3 K27M-mutant Glioma – Blinded Independent Central Review (BICR) of ONC201 Cohort Reported 20.0% Objective Response Rate (ORR) by RANO-HGG Criteria – – Compelling Durability of Resp

Chimerix Announces Positive Topline Results for ONC201 in Recurrent H3 K27M-mutant Glioma ? Blinded Independent Central Review (BICR) of ONC201 Cohort Reported 20.

November 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIME

November 4, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 November 4, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer

November 4, 2021 EX-10.2

Contract modification No. 67, dated September 20, 2021, to the contract by and between the Registrant and the Biomedical Advanced Research and Development Authority of the United States Department of Health and Human Services dated February 16, 2011, as amended.

Exhibit 10.2 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES 1 4 2. AMENDMENT/MODIFICATION NO P00067 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ

November 4, 2021 EX-10.1

Contract modification No. 66, dated May 24, 2021, to the contract by and between the Registrant and the Biomedical Advanced Research and Development Authority of the United States Department of Health and Human Services dated February 16, 2011, as amended.

Exhibit 10.1 AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES 1 2 2. AMENDMENT/MODIFICATION NO P00066 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ NO N/A. 5. PROJECT NO (if applicable) 6. ISSUED BY CODE ASPR-BARDA 7. ADMINISTERED BY (if other than line item 6) CODE ASPR-BARDA02 ASPR-BARDA 200 Independence Ave., S.W. Room 640-G Washington DC 20201

November 4, 2021 EX-99.1

Chimerix Reports Third Quarter 2021 Financial Results and Provides Operational Update – Announced Positive Topline Results from ONC201 in Recurrent H3 K27M-mutant Glioma – – U.S. Food and Drug Administration (FDA) Published Article Summarizing Benefi

Chimerix Reports Third Quarter 2021 Financial Results and Provides Operational Update ? Announced Positive Topline Results from ONC201 in Recurrent H3 K27M-mutant Glioma ? ? U.

August 5, 2021 EX-99.1

Chimerix Reports Second Quarter 2021 Financial Results and Provides Operational Update – Received U.S. Food and Drug Administration (FDA) Approval for TEMBEXA® (brincidofovir) for the Treatment of Smallpox – – Blinded Independent Central Review (BICR

Chimerix Reports Second Quarter 2021 Financial Results and Provides Operational Update ? Received U.

August 5, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

August 5, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 August 5, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer I

June 25, 2021 8-K

Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 June 23, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number

May 6, 2021 EX-99.1

Chimerix Reports First Quarter 2021 Financial Results and Provides Operational Update – BCV PDUFA Date Set for July 7 and ONC201 Blinded Independent Central Review Expected in Second Half of 2021 – – DSTAT COVID 19 Trial Advances to Cohort 3 at Highe

Chimerix Reports First Quarter 2021 Financial Results and Provides Operational Update ? BCV PDUFA Date Set for July 7 and ONC201 Blinded Independent Central Review Expected in Second Half of 2021 ? ? DSTAT COVID 19 Trial Advances to Cohort 3 at Higher Dose ? ? Conference Call at 8:30 a.

May 6, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-35867 CHIMERIX,

May 6, 2021 S-3ASR

- S-3ASR

As filed with the Securities and Exchange Commission on May 6, 2021 Registration No.

May 6, 2021 EX-99.1

Independent Auditor's Report

Exhibit 99.1 Oncoceutics, Inc. Index Page Independent Auditor's Report 2 Financial Statements Balance Sheets 3 Statements of Operations 4 Statements of Changes in Stockholders' Equity 5 Statements of Cash Flows 6 Notes to Financial Statements 7 1 Independent Auditor's Report To the Board of Directors Oncoceutics, Inc. We have audited the accompanying financial statements of Oncoceutics, Inc., whic

May 6, 2021 EX-10.2

Contract modification No. 65, dated April 16, 2021, to the contract by and between the Registrant and the Biomedical Advanced Research and Development Authority of the United States Department of Health and Human Services dated February 16, 2011, as amended.

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES 1 2 2. AMENDMENT/MODIFICATION NO P00065 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ NO N/A. 5. PROJECT NO (if applicable) 6. ISSUED BY CODE ASPR-BARDA 7. ADMINISTERED BY (if other than line item 6) CODE ASPR-BARDA02 ASPR-BARDA 200 Independence Ave., S.W. Room 640-G Washington DC 20201 ASPR-BARDA 33

May 6, 2021 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 May 6, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Number)

May 6, 2021 EX-99.2

CHIMERIX, INC. UNAUDITED PRO FORMA CONSOLIDATED COMBINED FINANCIAL STATEMENTS

Exhibit 99.2 CHIMERIX, INC. UNAUDITED PRO FORMA CONSOLIDATED COMBINED FINANCIAL STATEMENTS On January 7, 2021, Chimerix, Inc., a Delaware corporation (the ?Company?), Ocean Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of the Company (?Merger Sub?), Oncoceutics, Inc., a Delaware corporation (?Oncoceutics?), and Fortis Advisors, LLC solely in its capacity as representative of

May 6, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 May 6, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction (Commission File Number) (IRS Employer Iden

April 28, 2021 DEF 14A

- DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

April 28, 2021 DEFA14A

- DEFA14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 27, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 April 22, 2021 Date of Report (Date of earliest event reported) Chimerix, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35867 33-0903395 (State or other jurisdiction of incorporation) (Commission File Numbe

April 27, 2021 EX-99.1

Chimerix Appoints Vicki Vakiener to Board of Directors

Exhibit 99.1 Chimerix Appoints Vicki Vakiener to Board of Directors DURHAM, N.C., April 26, 2021 (GLOBE NEWSWIRE) - Chimerix (NASDAQ:CMRX), a biopharmaceutical company focused on accelerating the development of medicines to treat cancer and other serious diseases, today announced the appointment of Vicki Vakiener to its Board of Directors, effective immediately. Ms. Vakiener currently serves as Ch

March 25, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 24, 2021 Chimerix, Inc.

February 25, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on February 25, 2021 Registration No.

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