AVEO / AVEO Pharmaceuticals Inc - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

شركة أفيو للأدوية
US ˙ NASDAQ ˙ US0535883070
هذا الرمز لم يعد نشطا

الإحصائيات الأساسية
LEI 529900PLC55DUQO4CR76
CIK 1325879
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to AVEO Pharmaceuticals Inc
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
January 30, 2023 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-34655 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified

January 19, 2023 EX-99.1

LG Chem Completes Acquisition of AVEO Oncology AVEO to Become the U.S. Foundation for LG Chem Life Sciences’ Oncology Division

Exhibit 99.1 LG Chem Completes Acquisition of AVEO Oncology AVEO to Become the U.S. Foundation for LG Chem Life Sciences’ Oncology Division SEOUL, South Korea, January 20, 2023 — LG Chem, Ltd. (“LG Chem”) (KOSPI: 051910) today announced that it has completed its previously announced acquisition of AVEO Oncology (“AVEO”), a commercial stage, oncology-focused biopharmaceutical company committed to d

January 19, 2023 8-K

Regulation FD Disclosure, Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Termination of a Material Definitive Agreement, Material Modification to Rights of Security Holders, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2023 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commis

January 19, 2023 POS AM

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 POS AM

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 EX-3.2

Amended and Restated Bylaws of AVEO Pharmaceuticals, Inc.

Exhibit 3.2 BYLAWS OF AVEO PHARMACEUTICALS, INC. (the “Corporation”) Article I - Stockholders 1. Annual Meeting. The annual meeting of stockholders shall be held for the election of directors each year at such place, date and time as shall be designated by the Board of Directors of the Corporation (the “Board of Directors”). Any other proper business may be transacted at the annual meeting. If no

January 19, 2023 EX-3.1

Amended and Restated Certificate of Incorporation of AVEO Pharmaceuticals, Inc.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF AVEO PHARMACEUTICALS, INC. ARTICLE I The name of the corporation is AVEO Pharmaceuticals, Inc. (the “Corporation”). ARTICLE II The address of the Corporation’s registered office in the State of Delaware is The Corporation Trust Company, 1209 Orange Street, in the City of Wilmington, County of New Castle, Delaware 19801. The name of t

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 POS AM

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 19, 2023 S-8 POS

As filed with the Securities and Exchange Commission on January 19, 2023

As filed with the Securities and Exchange Commission on January 19, 2023 Registration No.

January 18, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 17, 2023 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commis

January 5, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2023 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commiss

January 3, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 23, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 20, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pro

December 2, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

December 2, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2022 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commis

November 25, 2022 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

DEFM14A 1 d407975ddefm14a.htm DEFM14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the C

November 15, 2022 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Transaction Valuation Proposed Maximum Aggregate Value of Transaction Fee Rate Amount of Filing Fee F

Exhibit 107 CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) AVEO Pharmaceuticals, Inc.

November 15, 2022 PREM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

PREM14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 7, 2022 EX-99.1

AVEO Oncology Reports Third Quarter 2022 Financial Results – Total Q3 2022 Net Revenue of $30.4 million, including $30.2 million of FOTIVDA® (tivozanib) U.S. Net Product Revenue – – Announced entering a definitive agreement under which LG Chem will a

AVEO Oncology Reports Third Quarter 2022 Financial Results – Total Q3 2022 Net Revenue of $30.

November 7, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2022 AVEO Pharmaceuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

November 7, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

RL DEFA14A: Additional proxy soliciting materials - definitive.fromPatent rights UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF

November 1, 2022 SC 13D/A

AVEO / AVEO Pharmaceuticals, Inc. / Growth Equity Opportunities Fund IV, LLC - GROWTH EQUITY OPPORTUNITIES FUND IV, LLC -- SCHEDULE 13DAE (#6) Activist Investment

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 6)* Aveo Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $.001 par value (Title of Class of Securities) 053588109 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842

October 20, 2022 SC 13G/A

AVEO / AVEO Pharmaceuticals, Inc. / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 2 Under the Securities Exchange Act of 1934 AVEO PHARMACEUTICALS INC (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) October 16, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

October 18, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 AVEO Pharmaceuti

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Co

October 18, 2022 EX-99.1

LG Chem to Acquire AVEO Oncology for $15.00 Per Share in Cash

Exhibit 99.1 FOR IMMEDIATE RELEASE LG Chem to Acquire AVEO Oncology for $15.00 Per Share in Cash ? Acquisition Provides LG Chem?s Life Sciences Division a Commercial Footprint in the U.S., Diversifies its Pipeline with a Broad Range of Oncology Therapies and Accelerates LG Chem?s Efforts to Deliver Continued Growth ? AVEO Will Have Enhanced Ability to Deliver on its Mission to Improve the Lives of

October 18, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A 1 d410341ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule

October 18, 2022 EX-2.1

Agreement and Plan of Merger, dated as of October 18, 2022, by and among LG Chem, Ltd., Acacia Acquisition Sub, Inc. and the Company*

Execution Version CONFIDENTIAL Exhibit 2.1 AGREEMENT AND PLAN OF MERGER dated as of October 18, 2022 among AVEO PHARMACEUTICALS, INC., LG CHEM, LTD. and ACACIA ACQUISITION SUB, INC. TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions 1 Section 1.02 Other Definitional and Interpretative Provisions 13 ARTICLE 2 THE MERGER 14 Section 2.01 The Merger 14 Section 2.02 Conversion of S

October 18, 2022 EX-3.1

Second Amended and Restated Bylaws of AVEO Pharmaceuticals, Inc, as amended

Exhibit 3.1 SECOND AMENDED AND RESTATED BY-LAWS OF AVEO PHARMACEUTICALS, INC. TABLE OF CONTENTS ARTICLE I STOCKHOLDERS 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meetings 1 1.4 Notice of Meetings 1 1.5 Voting List 1 1.6 Quorum 1 1.7 Adjournments 1 1.8 Voting and Proxies 2 1.9 Action at Meeting. 2 1.10 Nomination of Directors. 2 1.11 Notice of Business at Annual Meetings 4 1.12 Cond

October 18, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 AVEO Pharmaceuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

August 9, 2022 EX-99.1

Passionately pursuing a better life for patients with cancer Corporate Overview August 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litiga

Passionately pursuing a better life for patients with cancer Corporate Overview August 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties.

August 9, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

August 5, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107.1 Calculation of Filing Fee Table FORM S-8 (Form Type) AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Table 1?Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common Stock, $0.001 par

August 5, 2022 S-8

As filed with the Securities and Exchange Commission on August 4, 2022

As filed with the Securities and Exchange Commission on August 4, 2022 Registration No.

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

RL DEFA14A: Additional proxy soliciting materials - definitive.fromPatent rights UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

August 4, 2022 EX-99.1

AVEO Oncology Reports Second Quarter 2022 Financial Results – Total Q2 2022 Net Revenue of $25.3 million including $25.0 million of FOTIVDA® (tivozanib) U.S. Net Product Revenue – – Q2 2022 FOTIVDA U.S. Net Product Revenue Growth of 24% Compared with

AVEO Oncology Reports Second Quarter 2022 Financial Results ? Total Q2 2022 Net Revenue of $25.

August 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

June 8, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission Fil

June 8, 2022 EX-3.1

Certificate of Amendment of Restated Certificate of Incorporation of Registrant

Delaware The First State Page 1 3444819 8100 Authentication: 203615775 SR# 20222645880 Date: 06-07-22 You may verify this certificate online at corp.

May 6, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission File

May 6, 2022 EX-99.1

Passionately pursuing a better life for patients with cancer Corporate Overview May 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigatio

Passionately pursuing a better life for patients with cancer Corporate Overview May 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties.

May 5, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission File

May 5, 2022 EX-99.1

AVEO Oncology Reports First Quarter 2022 Financial Results – Total Q1 2022 Net Revenue of $20.9 Million including $20.1 Million of FOTIVDA® (tivozanib) U.S. Net Product Revenue – – Q1 2022 FOTIVDA Prescriptions Increased by 25% Compared With Q4 2021

AVEO Oncology Reports First Quarter 2022 Financial Results ? Total Q1 2022 Net Revenue of $20.

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

DEFA14A: Additional proxy soliciting materials - definitive.fromPatent rights UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 F

April 26, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A 1 aveoproxydefa14a-2022combi.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permit

April 26, 2022 DEF 14A

Amendment No. 3 to 2019 Equity Incentive Plan (incorporated by reference to Appendix B to the Registrant’s Definitive Proxy Statement on Form DEF-14A filed on April 26, 2022 (File No. 001-34655)).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 14, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 8, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 4, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission Fi

April 8, 2022 EX-99.1

EXECUTION 30 WINTER STREET OFFICE LEASE 2 OFFICE LEASE BETWEEN TFC 30 WINTER LLC, a Massachusetts limited liability company, AS LANDLORD AND AVEO PHARMACEUTICALS, INC., a Delaware corporation, AS TENANT 30 WINTER STREET BOSTON, MASSACHUSETTS TABLE OF

EXECUTION 30 WINTER STREET OFFICE LEASE 2 OFFICE LEASE BETWEEN TFC 30 WINTER LLC, a Massachusetts limited liability company, AS LANDLORD AND AVEO PHARMACEUTICALS, INC.

March 14, 2022 EX-10.39

License Agreement, dated December 18, 2015, by and between the Registrant and EUSA Pharma (UK) Limited

LICENSE AGREEMENT BY AND BETWEEN EUSA PHARMA (UK) LIMITED AND AVEO PHARMACEUTICALS, INC Dated: December 18, 2015 TABLE OF CONTENTS ARTICLE 1.

March 14, 2022 EX-21.1

Subsidiaries of the Registrant

SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization Percentage Ownership AVEO Pharma Limited United Kingdom 100% AVEO Securities Corporation Massachusetts 100% AVEO Pharma (Ireland) Limited Ireland 100%

March 14, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 14, 2022 EX-10.21

Offer Letter by the Registrant to Jebediah Ledell, dated November 12, 2021

November 12, 2021 Jebediah Ledell 36 Village View Rd Westford, MA, 01886 Dear Jeb: It is with great pleasure that we extend you this offer of employment to join AVEO Pharmaceuticals, Inc.

March 14, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2022 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 14, 2022 EX-10.32

Third Amendment to Amended and Restated Loan and Security Agreement, dated March 8, 2022, by and among the Registrant, the several banks and other financial institutions or entities from time to time parties thereto and Hercules Capital, In

Execution Version Conformed ? 3rd Amendment AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (as amended by that certain (i) First Amendment to Amended and Restated Loan and Security Agreement dated as of August 7, 2020 (the ?First Amendment?), (ii) Second Amendment to Amended and Restated Loan and Security Agreement dated as of February 1, 2021 (the ?Second Amendment?) and (iii) Third Amendment to Amended and Restated Loan and Security Agreement dated as of March 8, 2022 (the ?Third Amendment?)) is made and dated as of December 28, 2017 and is entered into by and between AVEO PHARMACEUTICALS, INC.

March 14, 2022 EX-10.48

Revocable Temporary License Agreement, dated November 17, 2021, by and between the Registrant and Commonwealth Care Alliance, Inc.

REVOCABLE TEMPORARY LICENSE AGREEMENT THIS REVOCABLE TEMPORARY LICENSE AGREEMENT (this ?License?) dated as of November 17, 2021 is entered into between TFC 30 Winter LLC, a Massachusetts limited liability company (?Licensor?), and AVEO Pharmaceuticals, Inc.

March 14, 2022 EX-10.24

Form of Non-Competition and Non-Solicitation Agreement, dated March

NON-COMPETITION AND NON-SOLICITATION AGREEMENT This Non-Competition and Non-Solicitation Agreement (the ?Agreement?) is made between AVEO Pharmaceuticals, Inc.

March 14, 2022 EX-99.1

AVEO Oncology Reports Full Year and Fourth Quarter 2021 Financial Results – Total 2021 Net Revenue of $42.3 Million – – FOTIVDA® (tivozanib) U.S. Net Product Revenue of $38.9 Million since March 22, 2021 – – FOTIVDA U.S. Net Product Revenue of $16.8

AVEO Oncology Reports Full Year and Fourth Quarter 2021 Financial Results ? Total 2021 Net Revenue of $42.

March 14, 2022 EX-3.1

Restated Certificate of Incorporation of the Registrant, as amended

Delaware The First State Page 1 3444819 8100X Authentication: 202854145 SR# 20220916489 Date: 03-08-22 You may verify this certificate online at corp.

March 14, 2022 EX-10.19

Offer Letter by the Registrant to Michael Ferraresso, dated April 8, 2021

AVEO Pharmaceuticals, Inc. 30 Winter Street Boston, MA 02108 p. 857.400.0101 April 8, 2021 Michael Ferraresso 84 Naugus Road Marblehead, MA 01945 Dear Mike: It is with great pleasure that we present to you a promotion from your current position of SVP, Commercial Analytics & Business Development to Chief Commercial Officer. Position. Your new position will be Chief Commercial Officer, and you will

March 14, 2022 EX-99.1

Passionately pursuing a better life for patients with cancer Corporate Overview March 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigat

Passionately pursuing a better life for patients with cancer Corporate Overview March 2022 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties.

March 14, 2022 EX-10.20

Severance and Change in Control Agreement, dated March 10, 2021, by and between the Registrant and Michael Ferraresso

SEVERANCE AND CHANGE IN CONTROL AGREEMENT THIS SEVERANCE AND CHANGE IN CONTROL AGREEMENT (the ?Agreement?), made this 10th day of March 2021 (the ?Effective Date?), is entered into by AVEO Pharmaceuticals, Inc.

March 14, 2022 EX-10.22

Severance and Change in Control Agreement, dated December 1, 2021, by and between the Registrant and Jebediah Ledell

SEVERANCE AND CHANGE IN CONTROL AGREEMENT . THIS SEVERANCE AND CHANGE IN CONTROL AGREEMENT (the "Agreement"), made this 15 day of November 2021 (the "Effective Date"), is entered into by AYEO Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 30 Winter Street Boston, MA 02108 (the "Company"), and Jebediah Ledell (the "Employee") with a address at 36 Village View

March 14, 2022 EX-10.23

Executive Severance and Change in Control Plan

AVEO Pharmaceuticals, Inc. Executive Severance and Change in Control Benefits Plan 1.Establishment of Plan. AVEO Pharmaceuticals, Inc., a Delaware corporation, hereby establishes an unfunded severance benefits plan (the ?Plan?) that is intended to be a welfare benefit plan within the meaning of Section 3(1) of ERISA. The Plan is in effect for Covered Employees who experience a Covered Termination

March 14, 2022 EX-10.47

First Amendment to Sublease Agreement, dated November 17, 2021, by and between the Registrant and Commonwealth Care Alliance, Inc.

FIRST AMENDMENT TO SUBLEASE AGREEMENT 30 WINTER STREET Boston, Massachusetts This First Amendment to Sublease Agreement (this ?Agreement?) is dated as of November 17, 2021 (?Effective Date?) by and between Commonwealth Care Alliance, Inc.

March 14, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

fromPatent rights UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2021 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-3

February 11, 2022 SC 13G/A

AVEO / AVEO Pharmaceuticals, Inc. / HIRSCHMAN ORIN Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Amendment No. 1 Under the Securities Exchange Act of 1934 AVEO PHARMACEUTICALS INC (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this

December 1, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

November 8, 2021 10-Q

*9 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents *9 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-34655 AVEO PHARMACEUTICALS, INC.

November 8, 2021 EX-10.2

Amended and Restated License Agreement, dated August 13, 2015, by and between the Registrant and St. Vincent’s Hospital Sydney Limited

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential.

November 8, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

November 8, 2021 EX-99.1

AVEO Oncology Reports Third Quarter 2021 Financial Results and Provides Business – Total Q3 2021 Revenue of $15.2 Million Includes FOTIVDA® (tivozanib) U.S. Net Product Revenue of $14.3 Million – – Enrollment Open for Pivotal Phase 3 TiNivo-2 Clinica

Exhibit 99.1 AVEO Oncology Reports Third Quarter 2021 Financial Results and Provides Business Update ? Total Q3 2021 Revenue of $15.2 Million Includes FOTIVDA? (tivozanib) U.S. Net Product Revenue of $14.3 Million ? ? Enrollment Open for Pivotal Phase 3 TiNivo-2 Clinical Trial of FOTIVDA? (tivozanib) in Combination with OPDIVO? (nivolumab) ? ? Ficlatuzumab and ERBITUX? (cetuximab) Granted Fast Tra

September 15, 2021 SC 13G

AVEO / AVEO Pharmaceuticals, Inc. / HIRSCHMAN ORIN - SCHEDULE FILED TO REPORT ACQUISITION OF BENEFICIAL OWNERSHIP Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 AVEO PHARMACEUTICALS INC (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) September 3, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed ? Rule 13d-1(

August 27, 2021 EX-10.1

Termination, Separation and Release of Claims Agreement, dated August 27, 2021 by and between AVEO Pharmaceuticals, Inc. and Michael Needle, M.D.

Exhibit 10.1 TRANSITION, SEPARATION, AND RELEASE OF CLAIMS AGREEMENT This Transition, Separation, and Release of Claims Agreement (the ?Agreement?) is made as of the Agreement Effective Date (as defined below) by and between Aveo Pharmaceuticals, Inc. (the ?Company?) and Michael N. Needle, M.D. (?Executive?) (together, the ?Parties?). WHEREAS, the Company and Executive are parties to the Severance

August 27, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 25, 2021 AVEO Pharmaceutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 25, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

August 5, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

August 5, 2021 EX-99.1

AVEO Oncology Reports Second Quarter 2021 Financial Results and Provides Business Update – Total 2Q 2021 Revenue of $7.6 Million Includes FOTIVDA® (tivozanib) U.S. Net Product Revenue of $6.7 Million – – Pivotal Phase 3 TiNivo-2 Trial of FOTIVDA in C

EX-99.1 2 aveo-ex9916.htm EX-99.1 Exhibit 99.1 AVEO Oncology Reports Second Quarter 2021 Financial Results and Provides Business Update – Total 2Q 2021 Revenue of $7.6 Million Includes FOTIVDA® (tivozanib) U.S. Net Product Revenue of $6.7 Million – – Pivotal Phase 3 TiNivo-2 Trial of FOTIVDA in Combination with OPDIVO® (nivolumab) on Track to Initiate Enrollment in 3Q 2021 – – COVID-19 Related Man

August 5, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

July 16, 2021 EX-99.1

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, ot

FOTIVDA? (tivozanib) in Renal Cell Carcinoma July 16, 2021 Exhibit 99.1 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are fo

July 16, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 16, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

June 10, 2021 S-8

As filed with the Securities and Exchange Commission on June 10, 2021

As filed with the Securities and Exchange Commission on June 10, 2021 Registration No.

June 9, 2021 8-K/A

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

June 9, 2021 EX-99.1

AMENDMENT NO. 2 TO 2019 EQUITY INCENTIVE PLAN OF AVEO PHARMACEUTICALS, INC.

Exhibit 99.1 AMENDMENT NO. 2 TO 2019 EQUITY INCENTIVE PLAN OF AVEO PHARMACEUTICALS, INC. The 2019 Equity Incentive Plan of Aveo Pharmaceuticals, Inc., as amended (the ?2019 Equity Incentive Plan?) is hereby further amended as follows: 1. Section 4(a)(1)(A) is hereby deleted in its entirety and the following is inserted in lieu thereof: ?4,500,000 shares of Common Stock.? Except as set forth above,

June 9, 2021 EX-99.2

AMENDED AND RESTATED 2010 EMPLOYEE STOCK PURCHASE PLAN AVEO PHARMACEUTICALS, INC. AVEO PHARMACEUTICALS, INC. AMENDED AND RESTATED 2010 EMPLOYEE STOCK PURCHASE PLAN

Exhibit 99.2 AMENDED AND RESTATED 2010 EMPLOYEE STOCK PURCHASE PLAN OF AVEO PHARMACEUTICALS, INC. AVEO PHARMACEUTICALS, INC. AMENDED AND RESTATED 2010 EMPLOYEE STOCK PURCHASE PLAN The purpose of this Plan is to provide eligible employees of AVEO Pharmaceuticals, Inc. (the ?Company?) and certain of its subsidiaries with opportunities to purchase shares of the Company?s common stock, $.001 par value

June 9, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

May 10, 2021 EX-10.2

Clinical Trial Collaboration and Supply Agreement

Exhibit 10.2 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions. EXECUTION VERSION CONFIDENTIAL CLINICAL TRIAL COLLABORATION AND SUPPLY AGREEMENT This CLINICAL TRIAL COLLABORATION AND SUPPLY AGREEMENT (the ?Agreement?) is ma

May 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission Fil

May 10, 2021 EX-99.1

AVEO Oncology Reports First Quarter 2021 Financial Results and Provides Business Update – U.S. Commercial Launch Underway with Fully Deployed Sales Force Following FDA Approval of FOTIVDA® (tivozanib) on March 10, 2021 – – FOTIVDA Net Product Revenue

Exhibit 99.1 AVEO Oncology Reports First Quarter 2021 Financial Results and Provides Business Update ? U.S. Commercial Launch Underway with Fully Deployed Sales Force Following FDA Approval of FOTIVDA? (tivozanib) on March 10, 2021 ? ? FOTIVDA Net Product Revenue of $1.1 Million from Initial Distributor Orders in the Last Week of Q1; All Distributors Have Placed Reorders for Q2 ? ? Entered Clinica

May 10, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

May 10, 2021 EX-10.3

, 2021, by and between the Registrant and Bristol-Myers Squibb Company

Exhibit 10.3 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions. AMENDMENT No. 1 to Clinical Trial Collaboration and Supply Agreement This Amendment No. 1 to Clinical Trial Collaboration and Supply Agreement (this ?Amendment

April 28, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ?Filed by a party other than the Registrant ? Check the appropriate box: ?Preliminary Proxy Statement ?Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ?Definitive Proxy Statement

April 28, 2021 DEF 14A

- DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ?Filed by a party other than the Registrant ? Check the appropriate box: ?Preliminary Proxy Statement ?Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ?Definitive Proxy Statement

April 16, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission F

April 16, 2021 EX-99.1

AVEO Announces Appointment of Kevin Cullen, M.D., to its Board of Directors

EX-99.1 EXHIBIT 99.1 AVEO Announces Appointment of Kevin Cullen, M.D., to its Board of Directors BOSTON, Mass. – April 16, 2021 – AVEO Oncology (Nasdaq: AVEO), a commercial and clinical development stage biopharmaceutical company, today announced the appointment of Kevin J. Cullen, M.D., to the Company’s Board of Directors. A widely recognized clinical oncologist with a specialty in head and neck

April 16, 2021 PRE 14A

- PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ?Filed by a party other than the Registrant ? Check the appropriate box: ?Preliminary Proxy Statement ?Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ?Definitive Proxy Statement

March 24, 2021 424B5

6,000,000 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-249982 PROSPECTUS SUPPLEMENT (To Prospectus dated November 18, 2020) 6,000,000 Shares Common Stock We are offering 6,000,000 shares of our common stock. Our common stock is listed on the Nasdaq Capital Market under the symbol ?AVEO.? The last reported sale price for our common stock on March 23, 2021 was $8.69 per share. This

March 24, 2021 EX-1.1

Underwriting Agreement, dated March 23, 2021, by and among the Company, SVB Leerink LLC and Stifel, Nicolaus & Company, Incorporated.

Exhibit 1.1 AVEO PHARMACEUTICALS, INC. (a Delaware corporation) 6,000,000 Shares of Common Stock UNDERWRITING AGREEMENT March 23, 2021 SVB Leerink LLC Stifel, Nicolaus & Company, Incorporated as Representatives of the several Underwriters c/o SVB Leerink LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 c/o Stifel, Nicolaus & Company, Incorporated 787 Seventh Avenue, 11th Floor New Yo

March 24, 2021 EX-99.1

AVEO Announces Pricing of $48.0 Million Public Offering of Common Stock

EX-99.1 Exhibit 99.1 AVEO Announces Pricing of $48.0 Million Public Offering of Common Stock BOSTON, Mass. – March 23, 2021 — AVEO Oncology (Nasdaq: AVEO) today announced that it has priced its previously announced underwritten public offering of 6,000,000 shares of its common stock at a price to the public of $8.00 per share. The gross proceeds to AVEO from the offering are expected to be $48.0 m

March 24, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 23, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 22, 2021 424B5

SUBJECT TO COMPLETION, DATED MARCH 22, 2021

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-249982 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

March 16, 2021 10-K

Annual Report - 10-K

en UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2020 Or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-34655 AVEO PHARM

March 16, 2021 EX-99.1

AVEO Oncology Reports Full Year 2020 Financial Results and Provides Business Update – FOTIVDA® (tivozanib) Approved for Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma Following Two or More Prior Systemic Therapies; AVEO Plan

Exhibit 99.1 AVEO Oncology Reports Full Year 2020 Financial Results and Provides Business Update – FOTIVDA® (tivozanib) Approved for Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma Following Two or More Prior Systemic Therapies; AVEO Plans to Make FOTIVDA Available to Patients in the U.S. by March 31, 2021 – - Entered Clinical Trial Collaboration and Supply Agreement with

March 16, 2021 EX-10.27

Option and License Agreement, dated as of March 18, 2009, by and between the Registrant and Biogen Idec International GmbH

Execution Copy Exhibit 10.27 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential. Double asterisks denote omissions. OPTION AND LICENSE AGREEMENT BY AND BETWEEN AVEO PHARMACEUTICALS, INC. AND BIOGEN IDEC INTERNATIONAL GMBH OPTION AND LICENSE AGREEMENT This Opt

March 16, 2021 EX-3.1

Restated Certificate of Incorporation of the Registrant, as amended

Exhibit 3.1 Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED ARE TRUE AND CORRECT COPIES OF ALL DOCUMENTS FILED FROM AND INCLUDING THE RESTATED CERTIFICATE OR A MERGER WITH A RESTATED CERTIFICATE ATTACHED OF ?AVEO PHARMACEUTICALS, INC.? AS RECEIVED AND FILED IN THIS OFFICE. THE FOLLOWING DOCUMENTS HAVE BEEN CERTIFIED

March 16, 2021 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization Percentage Ownership AVEO Pharma Limited United Kingdom 100% AVEO Securities Corporation Massachusetts 100% AVEO Pharma (Ireland) Limited Ireland 100%

March 16, 2021 EX-10.28

Amendment No. 1 to Option and License Agreement, dated as of March 18, 2014 by and between the Registrant and Biogen Idec MA Inc.

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type of information that the registrant treats as private or confidential.

March 16, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2021 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 15, 2021 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission Fi

March 10, 2021 EX-99.1

AVEO Oncology Announces U.S. FDA Approval of FOTIVDA® (tivozanib) for the Treatment of Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma - FOTIVDA is the First Therapy Approved for Adult Patients with Relapsed or Refractory Adv

EX-99.1 Exhibit 99.1 AVEO Oncology Announces U.S. FDA Approval of FOTIVDA® (tivozanib) for the Treatment of Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma - FOTIVDA is the First Therapy Approved for Adult Patients with Relapsed or Refractory Advanced Renal Cell Carcinoma Following Two or More Prior Systemic Therapies – - AVEO Plans to Make FOTIVDA Available to Patients in

March 10, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission F

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* AVEO Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which t

February 12, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1) * AVEO

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

February 8, 2021 8-K/A

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commissio

February 2, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 1, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

February 2, 2021 EX-10.1

Second Amendment to Amended and Restated Loan and Security Agreement, dated February 1, 2021, by and among the Registrant, the several banks and other financial institutions or entities from time to time parties thereto and Hercules Capital, Inc.

EX-10.1 Exhibit 10.1 EXECUTION VERSION SECOND AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This SECOND AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Amendment”) is dated as of February 1, 2021 and is entered into by and among (a) AVEO PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”), (b) the several banks and other financial institutions or entitie

January 29, 2021 EX-10.1

Separation and Release of Claims Agreement, dated January 25, 2021, by and between the Registrant and Karuna Rubin

EX-10.1 Exhibit 10.1 SEPARATION AND RELEASE OF CLAIMS AGREEMENT This Separation and Release of Claims Agreement (the “Agreement”) is made as of the Agreement Effective Date (as defined below) by and between Aveo Pharmaceuticals, Inc. (the “Company”) and Karuna Rubin (“Executive”) (together, the “Parties”). WHEREAS, the Company and Executive are parties to the Employment Agreement dated as of June

January 29, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 25, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

January 22, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 21, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

January 12, 2021 EX-99.1

AVEO Oncology Highlights Recent Progress and 2021 Outlook – Commercial Readiness Nearing Completion in Support of Potential Tivozanib U.S. Launch – – Updated IP Strategy Offers Potential for Tivozanib Patent Term Extension to November 2028 – – Corinn

EX-99.1 Exhibit 99.1 AVEO Oncology Highlights Recent Progress and 2021 Outlook – Commercial Readiness Nearing Completion in Support of Potential Tivozanib U.S. Launch – – Updated IP Strategy Offers Potential for Tivozanib Patent Term Extension to November 2028 – – Corinne D. Epperly, MD, MPH, Appointed to Board of Directors – – Phase 2 Open Label Randomized Study of Ficlatuzumab in HNSCC Enrollmen

January 12, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2021 AVEO Pharmaceuticals, Inc. (Exact name of registrant as specified in charter) Delaware 001-34655 04-3581650 (State or other jurisdiction of incorporation) (Commission

November 20, 2020 S-8

- S-8

S-8 As filed with the Securities and Exchange Commission on November 19, 2020 Registration No.

November 16, 2020 CORRESP

-

CORRESP November 16, 2020 VIA EDGAR SUBMISSION Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Tim Buchmiller Re: AVEO Pharmaceuticals, Inc.

November 9, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

November 9, 2020 EX-99.1

AVEO Oncology Reports Third Quarter 2020 Financial Results and Provides Business Update - U.S. Commercial Launch Preparations Underway Supporting the Tivozanib PDUFA Target Action Date of March 31, 2021 – - Ficlatuzumab Worldwide Rights Regained; Fin

Exhibit 99.1 AVEO Oncology Reports Third Quarter 2020 Financial Results and Provides Business Update - U.S. Commercial Launch Preparations Underway Supporting the Tivozanib PDUFA Target Action Date of March 31, 2021 – - Ficlatuzumab Worldwide Rights Regained; Final Results from Open Label Randomized Phase 2 HNSCC Study and Plans for Pivotal Program Expected in the Middle of 2021 – - AV-380 IND Sub

November 9, 2020 S-3

- S-3

Table of Contents As filed with the Securities and Exchange Commission on November 9, 2020 Registration No.

November 9, 2020 EX-4.7

Form of Subordinated Note

Exhibit 4.7 Form of Subordinated Note (FACE OF SECURITY) [Each Global Security shall bear substantially the following legend: UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE REGISTERED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE

November 9, 2020 EX-4.4

Form of Senior Indenture

Exhibit 4.4 AVEO PHARMACEUTICALS, INC. and Trustee INDENTURE Dated as of SENIOR DEBT SECURITIES CROSS-REFERENCE TABLE1 Section of Trust Indenture Act of 1939, as amended Section of Indenture 310(a) 6.09 310(b) 6.08 6.10 310(c) Inapplicable 311(a) 6.13 311(b) 6.13 311(c) Inapplicable 312(a) 4.01 4.04 312(b) 4.04(c) 312(c) 4.04(c) 313(a) 4.03 313(b) 4.03 313(c) 4.03 313(d) 4.03 314(a) 4.02 314(b) In

November 9, 2020 EX-4.6

Form of Senior Note

Exhibit 4.6 Form of Senior Note (FACE OF SECURITY) [Each Global Security shall bear substantially the following legend: UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE REGISTERED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE

November 9, 2020 EX-4.5

Form of Subordinated Indenture

Exhibit 4.5 AVEO PHARMACEUTICALS, INC. and Trustee INDENTURE Dated as of SUBORDINATED DEBT SECURITIES CROSS-REFERENCE TABLE 1 Section of Trust Indenture Act of 1939, as amended Section of Indenture 310(a) 6.09 310(b) 6.08 6.10 310(c) Inapplicable 311(a) 6.13 311(b) 6.13 311(c) Inapplicable 312(a) 4.01 4.04 312(b) 4.04(c) 312(c) 4.04(c) 313(a) 4.03 313(b) 4.03 313(c) 4.03 313(d) 4.03 314(a) 4.02 31

November 9, 2020 EX-1.3

Amendment No.1 to the Sales Agreement dated November 9, 2020, by and between the Registrant and SVB Leerink LLC

Exhibit 1.3 AMENDMENT NO. 1 TO SALES AGREEMENT November 9, 2020 SVB LEERINK LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 Ladies and Gentlemen: This Amendment No. 1 to Sales Agreement (this ?Amendment?) is entered into as of the date first written above by AVEO Pharmaceuticals, Inc., a Delaware corporation (the ?Company?), and SVB Leerink LLC (formerly known as Leerink Partners LL

November 9, 2020 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

September 8, 2020 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

September 8, 2020 EX-99.1

AVEO Oncology Regains Full Global Rights to Ficlatuzumab Announces Decision to Fund Clinical Manufacture of Ficlatuzumab for Potential Phase 3 Study and Update to Biodesix Partnership No Change to AVEO Cash Runway Guidance

EX-99.1 Exhibit 99.1 AVEO Oncology Regains Full Global Rights to Ficlatuzumab Announces Decision to Fund Clinical Manufacture of Ficlatuzumab for Potential Phase 3 Study and Update to Biodesix Partnership No Change to AVEO Cash Runway Guidance BOSTON, Mass. – September 8, 2020 – AVEO Oncology (Nasdaq: AVEO) today announced that it has regained full global rights to ficlatuzumab, AVEO’s potent hepa

August 10, 2020 EX-99.1

AVEO Oncology Reports Second Quarter 2020 Financial Results and Provides Business Update - NDA Filing Accepted by U.S. FDA for Tivozanib as a Treatment of Relapsed or Refractory Renal Cell Carcinoma; Assigned PDUFA Target Action Date of March 31, 202

Exhibit 99.1 AVEO Oncology Reports Second Quarter 2020 Financial Results and Provides Business Update - NDA Filing Accepted by U.S. FDA for Tivozanib as a Treatment of Relapsed or Refractory Renal Cell Carcinoma; Assigned PDUFA Target Action Date of March 31, 2021 – - Preparations Underway to Support Potential Commercial Launch of Tivozanib in the U.S.; New Debt and Equity Financings, Partnership

August 10, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

August 10, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

August 10, 2020 EX-10.1

First Amendment to Amended and Restated Loan and Security Agreement, dated as of August 7, 2020, by and among the registrant, Hercules Capital, Inc. and the other lenders named therein

Exhibit 10.1 Execution Version First AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This First Amendment to Amended and Restated Loan and Security Agreement (this “Amendment”) is dated as of August 7, 2020 and is entered into by and among (a) AVEO PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”), (b) the several banks and other financial institutions or entities from time

July 6, 2020 EX-99.1

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, ot

EX-99.1 Passionately pursuing a better life for patients with cancer July 2020 Pipeline Overview Exhibit 99.1 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts,

July 6, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 6, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

June 29, 2020 SC 13G

AVEO / AVEO Pharmaceuticals, Inc. / Cormorant Asset Management, LLC Passive Investment

SC 13G 1 schedule13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AVEO Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) June 17, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule

June 29, 2020 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of June 29, 2020, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Asset Management, LP and Bihua Chen (collectively, the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13D and/o

June 29, 2020 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of June 29, 2020, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Asset Management, LP and Bihua Chen (collectively, the “Filers”). Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13D and/o

June 29, 2020 SC 13G

AVEO / AVEO Pharmaceuticals, Inc. / Cormorant Asset Management, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AVEO Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) June 17, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this S

June 24, 2020 SC 13D/A

AVEO / AVEO Pharmaceuticals, Inc. / Growth Equity Opportunities IV, LLC - GROWTH EQUITY OPPORTUNITIES FUND IV, LLC -- SCHEDULE 13DA (#5) Activist Investment

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 5)* Aveo Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $.001 par value (Title of Class of Securities) 053588109 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842

June 19, 2020 SC 13G

AVEO / AVEO Pharmaceuticals, Inc. / Flynn James E Passive Investment

SC 13G 1 e619713sc13g-aveo.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. ) * AVEO Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 053588307 (CUSIP Number) June 19, 202

June 17, 2020 424B5

8,500,000 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-221837 PROSPECTUS SUPPLEMENT (To Prospectus dated December 15, 2017) 8,500,000 Shares Common Stock We are offering 8,500,000 shares of our common stock. Our common stock is listed on the Nasdaq Capital Market under the symbol “AVEO.” The last reported sale price for our common stock on June 16, 2020 was $6.25 per share.

June 17, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

June 17, 2020 EX-99.1

AVEO Announces Pricing of $44.6 Million Public Offering of Common Stock

EX-99.1 Exhibit 99.1 AVEO Announces Pricing of $44.6 Million Public Offering of Common Stock BOSTON, Mass. – June 16, 2020 — AVEO Oncology (Nasdaq: AVEO) today announced that it has priced its previously announced underwritten public offering of 8,500,000 shares of its common stock at a price to the public of $5.25 per share. The gross proceeds to AVEO from the offering are expected to be approxim

June 17, 2020 EX-1.1

Underwriting Agreement, dated June 16, 2020, by and among the Company, SVB Leerink LLC and Stifel, Nicolaus & Company, Incorporated.

EX-1.1 Exhibit 1.1 AVEO PHARMACEUTICALS, INC. (a Delaware corporation) 8,500,000 Shares of Common Stock UNDERWRITING AGREEMENT June 16, 2020 SVB Leerink LLC Stifel, Nicolaus & Company, Incorporated as Representatives of the several Underwriters c/o SVB Leerink LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 c/o Stifel, Nicolaus & Company, Incorporated 787 Seventh Avenue, 11th Floor

June 15, 2020 424B5

SUBJECT TO COMPLETION, DATED JUNE 15, 2020

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-221837 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

June 15, 2020 8-K

Results of Operations and Financial Condition, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

June 10, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 10, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

June 10, 2020 EX-99.1

AMENDMENT NO. 1 TO 2019 EQUITY INCENTIVE PLAN OF AVEO PHARMACEUTICALS, INC.

EX-99.1 Exhibit 99.1 AMENDMENT NO. 1 TO 2019 EQUITY INCENTIVE PLAN OF AVEO PHARMACEUTICALS, INC. The 2019 Equity Incentive Plan of Aveo Pharmaceuticals, Inc. (the “2019 Equity Incentive Plan”) is hereby amended as follows: 1. Section 4(a)(1)(A) is hereby deleted in its entirety and the following is inserted in lieu thereof: “2,300,000 shares of Common Stock.” 2. Section 4(b) is hereby deleted in i

June 1, 2020 8-K

Financial Statements and Exhibits, Other Events

8-K 1 d904464d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incor

June 1, 2020 EX-99.1

AVEO Oncology Announces FDA Acceptance for Filing of a New Drug Application for Tivozanib as a Treatment of Relapsed or Refractory Renal Cell Carcinoma - Tivozanib assigned PDUFA target action date of March 31, 2021; FDA indicates that it does not cu

EX-99.1 Exhibit 99.1 AVEO Oncology Announces FDA Acceptance for Filing of a New Drug Application for Tivozanib as a Treatment of Relapsed or Refractory Renal Cell Carcinoma - Tivozanib assigned PDUFA target action date of March 31, 2021; FDA indicates that it does not currently plan to convene an ODAC - BOSTON, Mass. – June 1, 2020 – AVEO Oncology (NASDAQ: AVEO) today announced that the U.S. Food

May 29, 2020 EX-99.3

AVEO Oncology Announces Phase 1b/2 DEDUCTIVE Study of FOTIVDA® (tivozanib) in Combination with IMFINZI® (durvalumab) in Previously Untreated Metastatic Hepatocellular Carcinoma Advances to Phase 2

EX-99.3 Exhibit 99.3 AVEO Oncology Announces Phase 1b/2 DEDUCTIVE Study of FOTIVDA® (tivozanib) in Combination with IMFINZI® (durvalumab) in Previously Untreated Metastatic Hepatocellular Carcinoma Advances to Phase 2 BOSTON, Mass. – May 29, 2020 – AVEO Oncology (NASDAQ: AVEO) today announced that the Phase 1b/2 DEDUCTIVE clinical trial evaluating FOTIVDA® (tivozanib), the Company’s once-daily, po

May 29, 2020 EX-99.2

AVEO Oncology Announces TIVO-3 Final Overall Survival Results Featured at ASCO 2020 Virtual Scientific Program and Submitted to U.S. FDA as Part of NDA Filing - Final OS Hazard Ratio Improves to 0.97 - - Company to Host Conference Call Today at 8:30

EX-99.2 Exhibit 99.2 AVEO Oncology Announces TIVO-3 Final Overall Survival Results Featured at ASCO 2020 Virtual Scientific Program and Submitted to U.S. FDA as Part of NDA Filing - Final OS Hazard Ratio Improves to 0.97 - - Company to Host Conference Call Today at 8:30 am Eastern Time - BOSTON, Mass. – May 29, 2020 – AVEO Oncology (NASDAQ: AVEO) today announced the presentation of results from th

May 29, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

8-K 1 d889663d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incor

May 29, 2020 EX-99.1

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, ot

EX-99.1 Passionately pursuing a better life for patients with cancer TIVO-3 Overall Survival Update Conference Call May 29, 2020 Exhibit 99.1 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than

May 27, 2020 DEFA14A

- DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Pro

May 27, 2020 EX-99.1

AVEO Announces Change to Virtual Annual Meeting of Stockholders

EX-99.1 Exhibit 99.1 AVEO Announces Change to Virtual Annual Meeting of Stockholders BOSTON, Mass. – May 27, 2020 – AVEO Oncology (NASDAQ: AVEO) today announced that due to the public health impact of the novel coronavirus (COVID-19) outbreak and governmental restrictions limiting the number of people who may gather together, and to support the health and well-being of its stockholders, employees

May 27, 2020 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 27, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

April 30, 2020 EX-99.1

AVEO Oncology Reports First Quarter 2020 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Oncology Reports First Quarter 2020 Financial Results and Provides Business Update BOSTON, Mass. – April 30, 2020 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the first quarter ended March 31, 2020 and provided a business update. “Our recent submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking marketing approval

April 30, 2020 EX-10.2

Sublease, dated March 5, 2020, by and between the Registrant and Commonwealth Care Alliance, Inc.

Exhibit 10.2 SUBLEASE AGREEMENT THIS SUBLEASE AGREEMENT made as of the 5th day of March, 2020 (the “Effective Date”) by and between Commonwealth Care Alliance, Inc. a Massachusetts not-for-profit corporation (“Sublandlord”), and AVEO Pharmaceuticals, Inc., a Delaware corporation (“Subtenant”); WHEREAS, Sublandlord is the tenant under that certain Lease dated January 26, 2007 (the “Lease”), as amen

April 30, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

April 30, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

April 28, 2020 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒Definitive Proxy Statemen

April 28, 2020 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐Definitive Proxy Statemen

March 16, 2020 10-K

Form 10-K

en UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-34655 AVEO PHARM

March 16, 2020 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization Percentage Ownership AVEO Pharma Limited United Kingdom 100% AVEO Securities Corporation Massachusetts 100% AVEO Pharma (Ireland) Limited Ireland 100%

March 16, 2020 EX-99.1

AVEO Oncology Reports Full Year 2019 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Oncology Reports Full Year 2019 Financial Results and Provides Business Update CAMBRIDGE, Mass.– March 16, 2020 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the full year ended December 31, 2019 and provided a business update. “The coming months will be an important period for AVEO, with filing of a New Drug Application (NDA) for tivozanib as a treatment fo

March 16, 2020 EX-10.17

Severance and Change in Control Agreement, dated January 6, 2020, by and between the Registrant and Erick Lucera

EXHIBIT 10.17 SEVERANCE AND CHANGE IN CONTROL AGREEMENT THIS SEVERANCE AND CHANGE IN CONTROL AGREEMENT (the “Agreement”), made this 6th day of January 2020 (the “Effective Date”), is entered into by AVEO Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 1 Broadway 14th Floor, Cambridge, MA 02142 (the “Company”), and Erick Lucera (the “Employee”). WHEREAS, the Co

March 16, 2020 EX-4.5

Description of Registered Securities

EXHIBIT 4.5 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT The following description of registered securities of AVEO Pharmaceuticals, Inc. (“us,” “our,” “we” or the “Company”) is intended as a summary only and therefore is not a complete description. This description is based upon, and is qualified by reference to, our restated certificate of incorporation, as amended,

March 16, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 16, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 16, 2020 EX-10.16

Offer Letter by and between the Registrant and Erick Lucera, dated December 12, 2019

AVEO Pharmaceuticals, Inc. 1 Broadway, 14th Floor Cambridge, MA 02142 p. 617.588.1960 EXHIBIT 10.16 December 12, 2019 Erick Lucera [address] [address] Dear Erick: It is with great pleasure that we extend you this offer of employment to join AVEO Pharmaceuticals. The following letter sets forth the proposed terms and conditions of your offer of employment.Position. Your position will be Chief Finan

March 16, 2020 EX-4.1

Specimen Stock Certificate evidencing the shares of common stock

Exhibit 4.1 AVEO ONCOLOGY PO BOX 505006, Louisville, KY 40233-5006 MR A SAMPLE DESIGNATION (IF ANY) ADD 1 ADD 2 ADD 3 ADD 4 CUSIP/IDENTIFIER XXXXXX XX X Holder ID XXXXXXXXXX Insurance Value 1,000,000.00 Number of Shares 123456 DTC 12345678 123456789012345 Certificate Numbers Num/No. Denom. Total 1234567890/1234567890 1 1 1 1234567890/1234567890 2 2 2 1234567890/1234567890 3 3 3 1234567890/12345678

February 19, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 19, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

February 19, 2020 EX-99.1

AVEO Announces Effectiveness of 1-for-10 Reverse Stock Split

EX-99.1 Exhibit 99.1 AVEO Announces Effectiveness of 1-for-10 Reverse Stock Split CAMBRIDGE, Mass. – February 19, 2020 – AVEO Oncology (NASDAQ: AVEO) today announced that it will effect a 1-for-10 reverse stock split of its common stock that will be effective as of 5:00 p.m. Eastern Time today, February 19, 2020. AVEO’s common stock will begin trading on the Nasdaq Capital Market on a split-adjust

February 19, 2020 EX-3.1

Certificate of Amendment of Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K filed on February 19, 2020 (File No. 001-34655)).

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF AVEO PHARMACEUTICALS, INC. AVEO Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), does hereby certify as follows: 1. The current name of the Corporation is

February 13, 2020 8-K

Other Events, Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2020 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

February 4, 2020 DEFA14A

AVEO / AVEO Pharmaceuticals, Inc. DEFA14A - - DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, fo

January 24, 2020 DEFA14A

AVEO / AVEO Pharmaceuticals, Inc. DEFA14A - - DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, fo

January 8, 2020 DEF 14A

AVEO / AVEO Pharmaceuticals, Inc. DEF 14A - - DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒Definitive Proxy Statemen

January 6, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 25, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

December 16, 2019 PRE 14A

AVEO / AVEO Pharmaceuticals, Inc. PRE 14A - - PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐Definitive Proxy Statemen

November 19, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

November 12, 2019 10-Q

AVEO / AVEO Pharmaceuticals, Inc. 10-Q - Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 12, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

November 12, 2019 EX-99.1

AVEO Reports Third Quarter 2019 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Reports Third Quarter 2019 Financial Results and Provides Business Update CAMBRIDGE, Mass. – November 12, 2019 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the third quarter ended September 30, 2019 and provided a business update. “This quarter we have made meaningful progress toward our goal of bringing effective and better tolerated therapies to patients

November 5, 2019 EX-99.1

AVEO Overview November 2019

EX-99.1 AVEO Overview November 2019 Cautionary Note Regarding Forward-Looking Statements Multiple Potential Opportunities for Value Creation Financial Highlights FOTIVDA® (tivozanib) TIVO-3 Pivotal Phase 3 Study Tivozanib: VEGFR 1, 2 and 3 Tyrosine Kinase Inhibitor TIVO-3: Study Design TIVO-3: Superior PFS and ORR* Progression-Free Survival – Key Subgroups* Durable Disease Control with Tivozanib (

November 5, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 d816002d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction

October 3, 2019 EX-99.1

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, ot

EX-99.1 AVEO Overview October 2019 Exhibit 99 .1 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are forward-looking statement

October 3, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 3, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Com

September 27, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 26, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (

September 17, 2019 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 17, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (

September 12, 2019 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (

September 10, 2019 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 10, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (

September 10, 2019 EX-99.2

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, ot

EX-99.2 AVEO Overview September 2019 Exhibit 99.2 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are forward-looking statemen

September 10, 2019 EX-99.1

AVEO Oncology Announces Updated Overall Survival Hazard Ratio of 0.99 in Phase 3 TIVO-3 Trial of Tivozanib in Renal Cell Carcinoma - 20 Patients Remain Progression Free on Tivozanib Arm vs. 2 on Sorafenib Arm - - Company Plans to Discuss Updated Resu

EX-99.1 Exhibit 99.1 AVEO Oncology Announces Updated Overall Survival Hazard Ratio of 0.99 in Phase 3 TIVO-3 Trial of Tivozanib in Renal Cell Carcinoma - 20 Patients Remain Progression Free on Tivozanib Arm vs. 2 on Sorafenib Arm - - Company Plans to Discuss Updated Results with FDA - - AVEO to Host Conference Call Today at 8:00 am Eastern Time - CAMBRIDGE, Mass. – September 10, 2019 – AVEO Oncolo

August 27, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 27, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Com

August 8, 2019 EX-99.1

AVEO Reports Second Quarter 2019 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Reports Second Quarter 2019 Financial Results and Provides Business Update CAMBRIDGE, Mass. – August 8, 2019 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the second quarter ended June 30, 2019 and provided a business update. “As we move toward reporting more mature interim overall survival (OS) results from our TIVO-3 study of tivozanib in advanced kidney c

August 8, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

August 8, 2019 10-Q

AVEO / AVEO Pharmaceuticals, Inc. 10-Q - Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

August 8, 2019 EX-3.1

Restated Certificate of Incorporation of the Registrant, as amended (incorporated by reference to Exhibit 3.1 to the Registrant’s Quarterly Report on Form 10-Q filed on August 8, 2019 (File No. 001-34655)).

Exhibit 3.1 State of Delaware Secretary of State Division of Corporations Delivered 07:50 AM 03/17/2010 FILED 08:00 AM 03/17/2010 SRV 100286912 – 3444819 FILE RESTATED CERTIFICATE OF INCORPORATION OF AVEO PHARMACEUTICALS, INC. (originally incorporated on October 19, 2001 under the name GenPath Pharmaceuticals, Inc.) FIRST: The name of the Corporation is Aveo Pharmaceuticals, Inc. SECOND: The addre

August 1, 2019 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Comm

August 1, 2019 EX-10.1

Amendment to License Agreement, dated as of August 1, 2019, by and between the Registrant and Kyowa Kirin Co., Ltd.

EX-10.1 Exhibit 10.1 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause competitive harm to the Company, if publicly disclosed. Double asterisks denote omissions. AMENDMENT TO LICENSE AGREEMENT THIS AMENDMENT TO the December 21, 2006 LICENSE AGREEMENT (this “Amendment”) is made and entered into this 1st day of August, 2

June 13, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 12, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

June 13, 2019 EX-3.1

Certificate of Amendment to Restated Certificate of Incorporation of AVEO Pharmaceuticals, Inc.

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF AVEO PHARMACEUTICALS, INC. AVEO Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation Law”), does hereby certify as follows: 1. The name of the Corporation is AVEO Ph

May 31, 2019 DEFA14A

AVEO / AVEO Pharmaceuticals, Inc. DEFA14A - - DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, fo

May 9, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission File

May 9, 2019 EX-99.1

AVEO Reports First Quarter 2019 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Reports First Quarter 2019 Financial Results and Provides Business Update CAMBRIDGE, Mass. – May 9, 2019 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the first quarter ended March 31, 2019 and provided a business update. “With a successful recent equity offering, together with the triggering of a FOTIVDA® (tivozanib) milestone from EUSA, AVEO’s strengthened

May 9, 2019 10-Q

AVEO / AVEO Pharmaceuticals, Inc. 10-Q Quarterly Report 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2019 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

April 30, 2019 DEFA14A

AVEO / AVEO Pharmaceuticals, Inc. DEFA14A DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐Definitive Proxy Statemen

April 30, 2019 DEF 14A

2019 Equity Incentive Plan

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒Definitive Proxy Statemen

April 30, 2019 10-K/A

AVEO / AVEO Pharmaceuticals, Inc. 10-K/A Annual Report 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-3

April 30, 2019 EX-10.36

Agreement, dated December 18, 2018, by and between the Registrant and Novartis International Pharmaceutical Ltd.

EXHIBIT 10.36 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause competitive harm to the Company, if publicly disclosed. Double asterisks denote omissions. AGREEMENT Agreement (the “Agreement”), dated December 18, 2018 (the “Agreement Effective Date”), by and between Novartis International Pharmaceutical Ltd. (“Novartis

April 19, 2019 PRE 14A

AVEO / AVEO Pharmaceuticals, Inc. PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☒Preliminary Proxy Statement ☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐Definitive Proxy Statemen

April 17, 2019 SC 13D/A

AVEO / AVEO Pharmaceuticals, Inc. / Growth Equity Opportunities IV, LLC - GROWTH EQUITY OPPORTUNITIES FUND IV, LLC - AVEO PHARMACEUTICALS, INC. -- SCHEDULE 13D/A (AMEND. #4) Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Aveo Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $.001 par value (Title of Class of Securities) 053588109 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842-4000 (Name,

April 4, 2019 EX-99.1

AVEO Pharmaceuticals, Inc. Announces Pricing of $25 Million Underwritten Public Offering

EX-99.1 Exhibit 99.1 AVEO Pharmaceuticals, Inc. Announces Pricing of $25 Million Underwritten Public Offering CAMBRIDGE, Mass. – April 3, 2019 – AVEO Pharmaceuticals, Inc. (Nasdaq: AVEO) (“AVEO” or the “Company”), a biopharmaceutical company seeking to advance targeted medicines for oncology and other unmet medical needs, today announced the pricing of its previously announced underwritten public

April 4, 2019 EX-4.1

Form of Offering Warrant

EX-4.1 Exhibit 4.1 Form of Warrant COMMON STOCK PURCHASE WARRANT AVEO PHARMACEUTICALS, INC. Warrant Shares: Issue Date: , 2019 Initial Exercise Date: , 2019 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time o

April 4, 2019 EX-1.1

Purchase Agreement, dated April 3, 2019, by and between AVEO Pharmaceuticals, Inc. and H.C. Wainwright & Co., LLC.

EX-1.1 Exhibit 1.1 21,739,131 Shares of Common Stock Warrants to Purchase up to 21,739,131 Shares of Common Stock AVEO PHARMACEUTICALS, INC. PURCHASE AGREEMENT April 3, 2019 H.C. Wainwright & Co., LLC 430 Park Avenue New York, New York 10022 Ladies and Gentlemen: AVEO Pharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes to sell to H.C. Wainwright & Co., LLC, as underwriter (the

April 4, 2019 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissio

April 4, 2019 424B5

AVEO PHARMACEUTICALS, INC. 21,739,131 Shares of Common Stock Warrants to Purchase up to 21,739,131 Shares of Common Stock

424B5 Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-221837 Prospectus Supplement (To Prospectus dated December 15, 2017) AVEO PHARMACEUTICALS, INC. 21,739,131 Shares of Common Stock Warrants to Purchase up to 21,739,131 Shares of Common Stock • AVEO Pharmaceuticals, Inc. is offering 21,739,131 shares of common stock and warrants to purchase up to 21,739,131 shares of comm

April 3, 2019 424B5

Subject to completion, dated April 3, 2019

424B5 Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-221837 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the U.S. Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are not an offer to

April 3, 2019 8-K

Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 2, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Comm

March 21, 2019 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commissi

March 14, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission F

March 14, 2019 EX-99.1

AVEO Reports Full Year 2018 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Reports Full Year 2018 Financial Results and Provides Business Update CAMBRIDGE, Mass. – March 14, 2019 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the full year ended December 31, 2018 and provided a business update. “The results of TIVO-3, presented in February at the 2019 ASCO GU Symposium, underscore a unique activity and tolerability profile among VEG

March 14, 2019 EX-10.22

Severance and Change in Control Agreement, dated March 13, 2019, by and between the Registrant and Karuna Rubin

EXHIBIT 10.22 SEVERANCE AND CHANGE IN CONTROL AGREEMENT THIS SEVERANCE AND CHANGE IN CONTROL AGREEMENT (the “Agreement”), made this 13th day of March 2019 (the “Effective Date”), is entered into by AVEO Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 1 Broadway 14th Floor, Cambridge, MA 02142 (the “Company”), and Karuna Rubin (the “Employee”). WHEREAS, the Com

March 14, 2019 EX-10.36

Agreement, dated December 18, 2018, by and between the Registrant and Novartis International Pharmaceutical Ltd.

EXHIBIT 10.36 Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. AGREEMENT Agreement (the “Agreement”), dated December 18, 2018 (the “Agreement Effective Date”), by and between Novartis International Pharmaceutical Ltd. (“Novartis”) and AVEO Pharmaceuticals, Inc. (“AVEO”). Novartis and AVEO are separately referred to

March 14, 2019 EX-10.21

Offer Letter by and between the Registrant and Karuna Rubin dated June 16, 2015

AVEO Pharmaceuticals, Inc. 1 Broadway, 14th Floor Cambridge, MA 02142 p. 617.588.1960 EXHIBIT 10.21 June 16, 2015 Karuna Rubin [address] [address] Dear Karuna: It is with great pleasure that we extend you this offer of employment to join AVEO Pharmaceuticals. The following letter sets forth the proposed terms and conditions of your offer of employment. Position. Your position will be Senior Corpor

March 14, 2019 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT Name Jurisdiction of Organization Percentage Ownership AVEO Pharma Limited United Kingdom 100% AVEO Securities Corporation Massachusetts 100% AVEO Pharma (Ireland) Limited Ireland 100%

March 14, 2019 10-K

AVEO / AVEO Pharmaceuticals, Inc. 10-K (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-34655 AVEO PHARMACE

March 1, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 25, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

February 15, 2019 EX-99.1

Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are

EX-99.1 AVEO Overview February 2019 Exhibit 99.1 Cautionary Note Regarding Forward-Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are forward-looking statements. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,

February 15, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 15, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

February 14, 2019 SC 13G/A

AVEO / AVEO Pharmaceuticals, Inc. / Polar Capital LLP - SCHEDULE 13G HOLDINGS REPORT AMENDMENT Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

February 6, 2019 8-K

Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 5, 2019 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commis

December 19, 2018 8-K

Entry into a Material Definitive Agreement

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 18, 2018 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commi

November 28, 2018 SC 13D/A

AVEO / AVEO Pharmaceuticals, Inc. / Growth Equity Opportunities IV, LLC - GROWTH EQUITY OPPORTUNITIES FUND IV, LLC - AVEO PHARMACEUTICALS, INC. -- SCHEDULE 13D/A (AMEND. #3) Activist Investment

SC 13D/A 1 aveogeo418272.htm GROWTH EQUITY OPPORTUNITIES FUND IV, LLC - AVEO PHARMACEUTICALS, INC. - SCHEDULE 13D/A (AMEND. #3) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Aveo Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $.001 par value (Title of Class of Securities) 053588109 (CUSIP Numb

November 9, 2018 EX-99.1

AVEO Reports Third Quarter 2018 Financial Results and Provides Business Update

Exhibit 99.1 AVEO Reports Third Quarter 2018 Financial Results and Provides Business Update CAMBRIDGE, Mass. – November 9, 2018 – AVEO Oncology (NASDAQ: AVEO) today reported financial results for the third quarter ended September 30, 2018 and provided a business update. “The recent announcement of positive topline results from the Phase 3 TIVO-3 study in renal cell carcinoma is transformative for

November 9, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2018 AVEO Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 001-34655 04-3581650 (State or Other Jurisdiction of Incorporation) (Commission

November 9, 2018 10-Q

AVEO / AVEO Pharmaceuticals, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2018 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to .

November 5, 2018 EX-99.1

Forward-Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are forward-looking statement

EX-99.1 TIVO-3: Phase 3 Pivotal Trial of Tivozanib Meets Primary Endpoint of Improving Progression Free Survival in Renal Cell Carcinoma Exhibit 99.1 Forward-Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this presentation are forward-looking statement

Fintel data has been cited in the following publications:
Daily Mail Fox Business Business Insider Wall Street Journal The Washington Post Bloomberg Financial Times Globe and Mail
NASDAQ.com Reuters The Guardian Associated Press FactCheck.org Snopes Politifact
Federal Register The Intercept Forbes Fortune Magazine TheStreet Time Magazine Canadian Broadcasting Corporation International Business Times
Cambridge University Press Investopedia MarketWatch NY Daily News Entrepreneur Newsweek Barron's El Economista