AMGN / Amgen Inc. - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

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US ˙ NasdaqGS ˙ US0311621009

الإحصائيات الأساسية
LEI 62QBXGPJ34PQ72Z12S66
CIK 318154
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Amgen Inc.
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
August 6, 2025 EX-10.19 3

Letter Agreement, dated May 9, 2025, by and between Amgen Inc. and BeiGene Switzerland GmbH, a wholly owned subsidiary of BeiGene, Ltd.

Exhibit 10.19.3 Amgen Inc. 1 Amgen Center Drive Thousand Oaks, CA 91320 USA (805) 447-1000 amgen.com May 9, 2025 BeiGene Switzerland GmbH Aeschengraben 27 4051 Basel Switzerland Attention: Managing Director BeOne Medicines USA, Inc. 55 Cambridge Parkway, Suite 700W Cambridge, Massachusetts 02142 USA Attention: General Counsel Re: Sales Force FTE Invoicing Methodology Reference is made to that cert

August 6, 2025 EX-10.22 6

Amendment No. 9 to the Collaboration Agreement, dated May 20, 2025, by and between Amgen Inc. and

Exhibit 10.22.6 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMENDMENT NO. 9 TO THE COLLABORATION AGREEMENT This Amendment No. 9 to the Collaboration Agreement (this “Amendment”) is entered into as of the 20th day of May, 2025 (the “Amendme

August 6, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spec

August 5, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 5, 2025 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 5, 2025 EX-99.1

AMGEN REPORTS SECOND QUARTER 2025 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS SECOND QUARTER 2025 FINANCIAL RESULTS THOUSAND OAKS, Calif. (Aug. 5, 2025) - Amgen (NASDAQ:AMGN) today announced financial results for the second quarter of 2025. “We're delivering strong performance and reaching more patients with innovative medicines and biosimilars th

June 12, 2025 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 RETIREMENT AND SAVINGS PLAN FOR AMGEN MANUFACTURING LIMITED LL

June 12, 2025 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 AMGEN RETIREMENT AND SAVINGS PLAN (Full title of the plan) AMG

May 27, 2025 8-K

FORM 8-K Item 5.07. Submission of Matters to a Vote of Security Holders.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2025 Amgen Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-37702 95-3540776 (State or Other Jurisdiction of Incorporation) (Commission File Number) (I

May 2, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spe

May 1, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 1, 2025 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

May 1, 2025 EX-99.1

AMGEN REPORTS FIRST QUARTER 2025 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER 2025 FINANCIAL RESULTS THOUSAND OAKS, Calif. (May 1, 2025) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2025. “Demand for our products was strong globally in the first quarter. Ongoing new product launches and successful

April 29, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ Defin

April 17, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ Defin

April 16, 2025 PX14A6G

Notice of Exempt Solicitation Pursuant to Rule 14a-103

Notice of Exempt Solicitation Pursuant to Rule 14a-103 Name of Registrant: Amgen Inc.

April 9, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ Defin

April 9, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☑ Defin

February 14, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 Amgen Inc. (Exact name of registrant as specified

February 14, 2025 EX-10.3

Form of Restricted Stock Unit Agreement for the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.3 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2025 EX-10.2

Form of Grant of Stock Option Agreement for the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.2 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2025 EX-21

Subsidiaries of the Company.

Exhibit 21 AMGEN INC. The following is a list of subsidiaries of the Company as of December 31, 2024, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary. SUBSIDIARY (Name under which subsidiary does business) STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION Amgen (Europe) GmbH Switzerland Amgen Canada Inc. Canada Amgen Fremont I

February 14, 2025 EX-10.5

Form of Performance Unit Agreement for the Amgen Inc. 2009 Performance Award Program

Exhibit 10.5 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2025 EX-4.32

Description of Amgen Inc.’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.

EXHIBIT 4.32 DESCRIPTION OF AMGEN INC.’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of February 11, 2025, Amgen Inc. has two classes of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): (1) our common stock, par value $0.0001 per share (the “Common Stock”); and (2) our 2.000% Senior Notes due

February 14, 2025 EX-19.1

Amgen Inc. Insider Trading Policy.

Amgen GLOBAL CORPORATE COMPLIANCE POLICY INSIDER TRADING Exhibit 19.1 1. Scope Applicable to all Amgen Inc. and subsidiary or affiliated company staff members, consultants, contract workers, secondees, and temporary staff worldwide as well as non-employee directors of Amgen Inc. (“Covered Persons”). Consultants, contract workers, secondees, temporary staff, and non-employee directors are not Amgen

February 14, 2025 EX-97

Policy Relating to Recovery of Erroneously Awarded Compensation.

Exhibit 97 Amgen Policy on Recovery of Erroneously Awarded Compensation (effective as of October 2, 2023) 1.

February 14, 2025 EX-19.2

Amgen Inc. Securities Transactions Blackout and Pre-Clearance Practices and Procedures.

Exhibit 19.2 Amgen Inc. Securities Transactions Pre-Clearance Practices and Procedures The following practices must be observed whenever any Restricted Individual (a term which includes any member of Amgen’s Board of Directors, any officer of Amgen subject to Section 16 of the Securities Exchange Act of 1934 (the “34 Act”), any non-Section 16 officer of Amgen (“Amgen Officers”), and/or any other A

February 4, 2025 EX-99.1

AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2024 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2024 FINANCIAL RESULTS THOUSAND OAKS, Calif. (Feb. 4, 2025) - Amgen (NASDAQ:AMGN) today announced financial results for the fourth quarter and full year of 2024 versus comparable periods in 2023. “Robust growth in sales and earnings throughou

February 4, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 4, 2025 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

October 31, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as

October 30, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 30, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 30, 2024 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

October 30, 2024 EX-99.1

AMGEN REPORTS THIRD QUARTER 2024 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS THIRD QUARTER 2024 FINANCIAL RESULTS THOUSAND OAKS, Calif. (Oct. 30, 2024) - Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2024. “Strong growth in sales and earnings this quarter reflects the momentum we're building throughout our busines

August 23, 2024 SC 13G/A

NAMS / NewAmsterdam Pharma Company N.V. / AMGEN INC - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* NewAmsterdam Pharma Company N.V. (Name of Issuer) Ordinary Shares, nominal value EUR 0.12 per share (Title of Class of Securities) N62509109 (CUSIP Number) August 22, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropr

August 23, 2024 EX-99.1

Joint Filing Agreement

EX-99.1 2 d856951dex991.htm EX-99.1 Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the com

August 7, 2024 EX-10.7

Form of Restricted Stock Unit Agreement for the Amgen Inc. 2009 Director Equity Incentive Program.

Exhibit 10.7 RESTRICTED STOCK UNIT AGREEMENT (Director Equity Incentive Program) , Amgen Inc. Grantee: On this day of (the “Grant Date”), Amgen Inc., a Delaware corporation (the “Company”), pursuant to its Amgen Inc. 2009 Director Equity Incentive Program (as amended and/or restated from time to time, the “Program”) which implements the Amgen Inc. Second Amended and Restated 2009 Equity Incentive

August 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spec

August 7, 2024 EX-10.4

Amgen Inc. 2009 Performance Award Program.

Exhibit 10.4 AMGEN INC. 2009 PERFORMANCE AWARD PROGRAM (Effective March 3, 2009) As Amended and Restated Through May 31, 2024 ARTICLE I PURPOSE The purpose of this document is to set forth the general terms and conditions applicable to the Amgen Inc. 2009 Performance Award Program (the “Program”) established by the Compensation and Management Development Committee of the Board of Directors of Amge

August 7, 2024 EX-10.8

Form of Cash-Settled Restricted Stock Unit Agreement for the Amgen Inc. 2009 Director Equity Incentive Program.

Exhibit 10.8 CASH-SETTLED RESTRICTED STOCK UNIT AGREEMENT (Director Equity Incentive Program) , Amgen Inc. Grantee: On this day of (the “Grant Date”), Amgen Inc., a Delaware corporation (the “Company”), pursuant to its Amgen Inc. 2009 Director Equity Incentive Program (as amended and/or restated from time to time, the “Program”) has granted to you, the grantee named above, an award (the “Award”) o

August 7, 2024 EX-10.2

Form of Grant of Stock Option Agreement for the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.2 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

August 7, 2024 EX-10.6

Amgen Inc. 2009 Director Equity Incentive Program.

Exhibit 10.6 AMGEN INC. 2009 DIRECTOR EQUITY INCENTIVE PROGRAM (Effective May 31, 2024 (the “Effective Date”)) As Amended and Restated May 31, 2024 ARTICLE I PURPOSE The purpose of this document is to set forth the general terms and conditions of the Amgen Inc. 2009 Director Equity Incentive Program (the “Program”) established by the Board of Directors of Amgen Inc. (the “Company”) including, with

August 7, 2024 EX-10.5

Form of Performance Unit Agreement for the Amgen Inc. 2009 Performance Award Program.

Exhibit 10.5 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

August 7, 2024 EX-10.3

Form of Restricted Stock Unit Agreement for the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.3 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

August 6, 2024 EX-99.1

AMGEN REPORTS SECOND QUARTER 2024 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS SECOND QUARTER 2024 FINANCIAL RESULTS THOUSAND OAKS, Calif. (Aug. 6, 2024) - Amgen (NASDAQ:AMGN) today announced financial results for the second quarter 2024. “With a strong, balanced portfolio of in-market products and a rapidly advancing pipeline of innovative medicin

August 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 6, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 6, 2024 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

June 21, 2024 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 AMGEN RETIREMENT AND SAVINGS PLAN (Full title of the plan) AMG

June 21, 2024 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 THE RETIREMENT AND SAVINGS PLAN FOR AMGEN MANUFACTURING LIMITE

June 12, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1—Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount to be Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common stock, $0.0001 par val

June 12, 2024 S-8

As filed with the Securities and Exchange Commission on June 12, 2024

As filed with the Securities and Exchange Commission on June 12, 2024 Registration No.

June 3, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 31, 2024 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (IR

May 10, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registr

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box:    ☐     Preliminary Proxy Statement ☐  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2))

May 3, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registr

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box:    ☐     Preliminary Proxy Statement ☐  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2))

May 3, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spe

May 2, 2024 EX-99.1

AMGEN REPORTS FIRST QUARTER 2024 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER 2024 FINANCIAL RESULTS THOUSAND OAKS, Calif. (May 2, 2024) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter 2024. “With many of our innovative products delivering strong growth and promising new medicines advancing through our p

May 2, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 2, 2024 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registr

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box:    ☐     Preliminary Proxy Statement ☐  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2))

April 22, 2024 CORRESP

Peter H. Griffith

Peter H. Griffith Executive Vice President and Chief Financial Officer   Amgen Inc. 1 Amgen Center Drive Thousand Oaks, CA 91320 USA (805) 447-1000 Direct Dial: XXX-XXX-XXXX E-mail: [email protected] April 19, 2024 Division of Corporation Finance Office of Life Sciences Securities and Exchange Commission Via email Re: Amgen Inc.   Form 10-K for Fiscal Year Ended December 31, 2023   File No. 001-37702

April 17, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑  Filed by the registrant      ☐  Filed by a party other than the registrant Check the appropriate box:     ☐      Preliminary Proxy Statement ☐   CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E

April 17, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registr

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant      ☐ Filed by a party other than the registrant Check the appropriate box:    ☐     Preliminary Proxy Statement ☐  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2))

February 14, 2024 EX-4.33

Description of Amgen Inc.’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.

EXHIBIT 4.33 DESCRIPTION OF AMGEN INC.’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of February 9, 2024, Amgen Inc. has two classes of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): (1) our common stock, par value $0.0001 per share (the “Common Stock”); and (2) our 2.000% Senior Notes due 2

February 14, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 Amgen Inc. (Exact name of registrant as specified

February 14, 2024 EX-10.14

Agreement between Amgen Inc. and James Bradner, dated December 13, 2023.

Exhibit 10.14 Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 805.447.1000 www.Amgen.com December 12, 2023 Dr. James (Jay) E. Bradner XXXXXXXX XXXXXXXX Dear Jay: Congratulations! You have made an excellent impression on Amgen and I am excited to present you with the attached offer package. As an organization dedicated to improving the lives of patients around the world, Amgen welcom

February 14, 2024 EX-10.2

Form of Grant of Stock Option Agreement for the Amgen Inc

Exhibit 10.2 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2024 EX-10.3

Form of Restricted Stock Unit Agreement

Exhibit 10.3 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2024 EX-21

Subsidiaries of the Company.

Exhibit 21 AMGEN INC. The following is a list of subsidiaries of the Company as of December 31, 2023, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary. SUBSIDIARY (Name under which subsidiary does business) STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION Amgen (Europe) GmbH Switzerland Amgen Australia Pty Ltd Australia Amgen

February 14, 2024 EX-10.9 5

Fifth Amendment to the Amgen Inc. Supplemental Retirement Plan, effective January 1, 2024.

Exhibit 10.9.5 FIFTH AMENDMENT TO THE AMGEN INC. SUPPLEMENTAL RETIREMENT PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Inc. Supplemental Retirement Plan, as Amended and Restated Effective October 16, 2013, and as subsequently amended (the “Plan”), is hereby amended, effective as of the dates below, as follows: 1.Effective January 1, 2024, Section 2.27 is amended by adding the f

February 14, 2024 EX-97

Policy Relating to Recovery of Erroneously Awarded Compensation.

Exhibit 97 Amgen Policy on Recovery of Erroneously Awarded Compensation (effective as of October 2, 2023) 1.

February 14, 2024 EX-10.17 1

Amendment No. 2 to Collaboration and License Agreement, effective November 14, 2016, between Amgen Inc. and Celltech R&D Limited.

Exhibit 10.17.1 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. SUCH EXCLUDED INFORMATION HAS BEEN MARKED WITH “[*]”. Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 805.447.1000 www.Amgen.com November 14, 2016 Via facsimile and overnight courier UCB Cell

February 14, 2024 EX-10.17

and Amendment No. 1, effective June 9, 2003, to Collaboration and License Agreement between Amgen Inc. and Celltech R&D Limited

Exhibit 10.17 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. SUCH EXCLUDED INFORMATION HAS BEEN MARKED WITH “[*]”. COLLABORATION AND LICENCE AGREEMENT Between AMGEN INC. and CELLTECH R&D LIMITED Re BEER BEER COLLABORATION AND LICENCE AGREEMENT I N DE X Article Descript

February 14, 2024 EX-10.22 5

Letter Agreement Regarding the Collaboration Agreement, dated as of December 1, 2023, by and between Amgen Inc. and AstraZeneca Collaboration Ventures, LLC

Exhibit 10.22.5 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT BOTH (I) IS NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. SUCH EXCLUDED INFORMATION HAS BEEN MARKED WITH “[***]”. Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 805.447.1000 www.Amgen.com December 1, 2023 Via Overnight Courier Service AstraZeneca C

February 14, 2024 EX-10.12 4

Fourth Amendment to the Amgen Nonqualified Deferred Compensation Plan, effective January 1, 2024

Exhibit 10.12.4 FOURTH AMENDMENT TO THE AMGEN NONQUALIFIED DEFERRED COMPENSATION PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Nonqualified Deferred Compensation Plan, as Amended and Restated Effective October 16, 2013, and as subsequently amended (the “Plan”), is hereby amended, effective January 1, 2024, as follows: 1.Appendix A is amended by adding the following entity to th

February 14, 2024 EX-10.5

Form of Performance Unit Agreement

Exhibit 10.5 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 14, 2024 EX-10.6

Amgen Inc. 2009 Director Equity Incentive Program. (As Amended and Restated on October 24, 2023.)

Exhibit 10.6 AMGEN INC. 2009 DIRECTOR EQUITY INCENTIVE PROGRAM (Effective January 1, 2024 (the “Effective Date”)) As Amended and Restated October 24, 2023 ARTICLE I PURPOSE The purpose of this document is to set forth the general terms and conditions of the Amgen Inc. 2009 Director Equity Incentive Program (the “Program”) established by the Board of Directors of Amgen Inc. (the “Company”) includin

February 13, 2024 SC 13G/A

AMGN / Amgen Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv0276-amgeninc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 9)* Name of issuer: Amgen Inc Title of Class of Securities: Common Stock CUSIP Number: 031162100 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to designate the rule pursuan

February 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 6, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 6, 2024 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

February 6, 2024 EX-99.1

AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2023 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2023 FINANCIAL RESULTS THOUSAND OAKS, Calif. (Feb. 6, 2024) - Amgen (NASDAQ:AMGN) today announced financial results for the fourth quarter and full year 2023 versus comparable periods in 2022. “2023 was another year of performance and progres

December 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 12, 2023 AMGEN INC. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) December 12, 2023 AMGEN INC.

December 14, 2023 EX-99.1

AMGEN ANNOUNCES EXECUTIVE APPOINTMENTS TO ACCELERATE INNOVATION James Bradner, M.D., Joins as Executive Vice President, Research and Development, and Chief Scientific Officer David M. Reese, M.D., Named Executive Vice President and Chief Technology O

EX-99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com AMGEN ANNOUNCES EXECUTIVE APPOINTMENTS TO ACCELERATE INNOVATION James Bradner, M.D., Joins as Executive Vice President, Research and Development, and Chief Scientific Officer David M. Reese, M.D., Named Executive Vice President and Chief Technology Officer THOUSAND OAKS, Calif. (Dec. 14, 2

October 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 31, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 31, 2023 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

October 31, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as

October 31, 2023 EX-99.1

AMGEN REPORTS THIRD QUARTER FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS THIRD QUARTER FINANCIAL RESULTS THOUSAND OAKS, Calif. (October 31, 2023) - Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 20231. "We are excited about our pipeline progress and our operating performance in the third quarter," said Robert A

October 6, 2023 S-8

As filed with the Securities and Exchange Commission on October 6, 2023

S-8 As filed with the Securities and Exchange Commission on October 6, 2023 Registration No.

October 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 6, 2023 Amgen Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 6, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

October 6, 2023 EX-4.5

Horizon Therapeutics Public Limited Company Amended and Restated 2020 Equity Incentive Plan and 2020 Restricted Stock Unit Award Sub-Plan

EX-4.5 Exhibit 4.5 HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY AMENDED AND RESTATED 2020 EQUITY INCENTIVE PLAN 1. GENERAL. (a) Relationship to Prior Plans. The Plan is the successor to the 2014 Plan. As of the Effective Date, (i) no additional awards may be granted under the 2014 Plan; (ii) the Prior Plans’ Available Reserve plus any Returning Shares will become available for issuance pursuant to

October 6, 2023 EX-99.1

AMGEN COMPLETES ACQUISITION OF HORIZON THERAPEUTICS PLC Advances Amgen’s Mission to Serve Patients With First-in-Class Rare Disease Medicines

EX-99.1 Exhibit 99.1      One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com  News Release AMGEN COMPLETES ACQUISITION OF HORIZON THERAPEUTICS PLC Advances Amgen’s Mission to Serve Patients With First-in-Class Rare Disease Medicines THOUSAND OAKS, Calif. (Oct. 6, 2023) – Amgen (NASDAQ: AMGN) today announced that it has completed its acquisition of Horizon Ther

October 6, 2023 EX-4.3

Horizon Therapeutics Public Limited Company Amended and Restated 2014 Equity Incentive Plan

EX-4.3 Exhibit 4.3 HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY AMENDED AND RESTATED 2014 EQUITY INCENTIVE PLAN 1. GENERAL. (a) Relationship to Prior Plans. This Plan is intended as the successor to the Horizon Pharma, Inc. 2011 Equity Incentive Plan (the “2011 Plan”) with respect to grants to Employees. From and after 12:01 a.m. on the Effective Date, all outstanding stock awards granted under the

October 6, 2023 EX-4.4

Horizon Therapeutics Public Limited Company Amended and Restated 2018 Equity Incentive Plan and 2018 Restricted Stock Unit Award Sub-Plan

EX-4.4 Exhibit 4.4 HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY AMENDED AND RESTATED 2018 EQUITY INCENTIVE PLAN (As Amended and Restated Effective July 29, 2021) 1. PURPOSES OF THE PLAN; ASSUMPTION OF PLAN. The purposes of the Plan are to attract and retain the best available personnel, to provide additional incentives to Employees, Directors and Consultants and to promote the success of the busine

October 6, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit(3) Maximum Aggregate Offering Price(3) Fee Rate Amount of Registration Fee Equity Common Stock, par value $0.0001

October 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 5, 2023 Amgen Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 5, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction (Commission (IRS Employer of incorporation

September 27, 2023 EX-99.3

RBNC THERAPEUTICS, INC.

EX-3 Exhibit 3 RBNC THERAPEUTICS, INC. September 10, 2021 Amgen Inc. One Amgen Center Drive Thousand Oaks, California 91320 Attn: Re: Letter Agreement regarding the acquisition of shares of Series A-2 Preferred Stock by Amgen Inc. (“Amgen”, together with its Affiliates (as defined below), the “Investor”) of RBNC Therapeutics, Inc. (the “Company”) Ladies and Gentlemen: Reference is made to (i) that

September 27, 2023 EX-99.4

September 22, 2022

EX-4 Exhibit 4 September 22, 2022 Neumora Therapeutics, Inc. 65 Grove Street Watertown, Massachusetts 02472 ATTENTION: Chief Executive Officer Re: Amendment to Letter Agreement Ladies and Gentlemen: Reference is made to that certain Letter Agreement, dated as of September 10, 2021, by and between Amgen Inc. (“Amgen”) and Neumora Therapeutics, Inc. (f/k/a RBNC Therapeutics, Inc.; the “Company”), re

September 27, 2023 SC 13D

AMGEN INC - SC 13D

SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Neumora Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 640979100 (CUSIP Number) Jonathan P. Graham Executive Vice President and General Counsel and Secretary One Amgen Center Drive Thousand Oaks, CA 91320-1799 (805)

September 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 11, 2023 Amgen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 11, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numb

September 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Amgen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

September 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Amgen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction (Commission (IRS Employer of incorporati

September 1, 2023 EX-99.1

AMGEN AND HORIZON THERAPEUTICS PLC RESOLVE FTC LAWSUIT, CLEARING PATH TO CLOSE ACQUISITION

EX-99.1 Exhibit 99.1 One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com News Release AMGEN AND HORIZON THERAPEUTICS PLC RESOLVE FTC LAWSUIT, CLEARING PATH TO CLOSE ACQUISITION THOUSAND OAKS, Calif., & DUBLIN (September 1, 2023) – Amgen (NASDAQ:AMGN) and Horizon Therapeutics plc (NASDAQ:HZNP) today announced the entry into a consent order agreement with the Fed

August 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spec

August 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2023 Amgen Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 3, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 3, 2023 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 3, 2023 EX-99.1

AMGEN REPORTS SECOND QUARTER FINANCIAL RESULTS Positive Top-Line Results for Tarlatamab in Small Cell Lung Cancer Positive Top-Line Results for LUMAKRAS® (Sotorasib) Plus Vectibix® (Panitumumab) in Metastatic Colorectal Cancer

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS SECOND QUARTER FINANCIAL RESULTS Positive Top-Line Results for Tarlatamab in Small Cell Lung Cancer Positive Top-Line Results for LUMAKRAS® (Sotorasib) Plus Vectibix® (Panitumumab) in Metastatic Colorectal Cancer THOUSAND OAKS, Calif. (August 3, 2023) - Amgen (NASDAQ:AMG

June 15, 2023 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 AMGEN RETIREMENT AND SAVINGS PLAN (Full title of the plan) AMG

June 15, 2023 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 THE RETIREMENT AND SAVINGS PLAN FOR AMGEN MANUFACTURING, LIMIT

June 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2023 Amgen Inc. (Exact na

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

May 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 19, 2023 Amgen Inc. (Exact nam

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) May 19, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (IR

May 18, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

May 16, 2023 EX-99.1

AMGEN RESPONDS TO FTC ACTION RE: PROPOSED ACQUISITION OF HORIZON THERAPEUTICS

EX-99.1 Exhibit 99.1 One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com News Release AMGEN RESPONDS TO FTC ACTION RE: PROPOSED ACQUISITION OF HORIZON THERAPEUTICS THOUSAND OAKS, Calif. (May 16, 2023) – Amgen (NASDAQ:AMGN) today issued the following statement in response to the U.S. Federal Trade Commission’s (FTC) complaint seeking to block the company’s propo

May 16, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

May 3, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ De

April 28, 2023 EX-10.20 2

Second Amendment to Collaboration Agreement, entered into as of February 26, 2023, by and between Amgen Inc. and BeiGene Switzerland GmbH, and BeiGene, Ltd.

Exhibit 10.20.2 EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. SECOND AMENDMENT TO COLLABORATION AGREEMENT This Second Amendment to the Collaboration Agreement (“Amendment”) is entered into as of February 26, 2023 (the “Seco

April 28, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spe

April 27, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 27, 2023 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

April 27, 2023 EX-99.1

AMGEN REPORTS FIRST QUARTER FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER FINANCIAL RESULTS THOUSAND OAKS, Calif. (April 27, 2023) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2023. "We delivered 14% volume growth driven by the breadth of our portfolio and strong demand for our products globall

April 25, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ Definitive

April 14, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ De

April 6, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ☐ De

April 6, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E

March 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 Amgen Inc. (Exact n

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

March 9, 2023 EX-10.1

Third Amended and Restated Credit Agreement, dated as of March 9, 2023, among Amgen Inc., the Banks therein named, Citibank, N.A., as Administrative Agent, and JPMorgan Chase Bank, N.A., as Syndication Agent.

EX-10.1 Exhibit 10.1 EXECUTION COPY THIRD AMENDED AND RESTATED CREDIT AGREEMENT Dated as of March 9, 2023 among Amgen Inc., The Borrowing Subsidiaries Herein Named, The Banks Herein Named, Citibank, N.A., as Administrative Agent, JPMorgan Chase Bank, N.A., as Syndication Agent, Citibank, N.A. JPMorgan Chase Bank, N.A. BofA Securities, Inc. Goldman Sachs Bank USA and Morgan Stanley Senior Funding,

March 2, 2023 EX-4.2

Officer’s Certificate of the Company, dated as of March 2, 2023, including forms of the Company’s 5.250% Senior Notes due 2025, 5.507% Senior Notes due 2026, 5.150% Senior Notes due 2028, 5.250% Senior Notes due 2030, 5.250% Senior Notes due 2033, 5.600% Senior Notes due 2043, 5.650% Senior Notes due 2053 and 5.750% Senior Notes due 2063.

EX-4.2 Exhibit 4.2 OFFICER’S CERTIFICATE OF AMGEN INC. Dated as of March 2, 2023 The undersigned officer of the Company certifies, pursuant to resolutions duly adopted by the Board of Directors at a meeting duly held on December 9, 2022 and by the Pricing Committee of the Board of Directors of the Company on February 13, 2023 (the “Resolutions”), and in accordance with Sections 2.1, 2.2 and 2.3 of

March 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2023 Amgen Inc. (Exact n

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

February 17, 2023 EX-FILING FEES

Calculation of Filing Fees Tables (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Reg

Exhibit 107 Calculation of Filing Fees Tables 424(b)(2) (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forw

February 17, 2023 424B2

$2,000,000,000 5.250% Senior Notes due 2025 $1,500,000,000 5.507% Senior Notes due 2026 $3,750,000,000 5.150% Senior Notes due 2028 $2,750,000,000 5.250% Senior Notes due 2030 $4,250,000,000 5.250% Senior Notes due 2033 $2,750,000,000 5.600% Senior N

Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No. 333-269670 Prospectus Supplement (To Prospectus Dated February 9, 2023) $2,000,000,000 5.250% Senior Notes due 2025 $1,500,000,000 5.507% Senior Notes due 2026 $3,750,000,000 5.150% Senior Notes due 2028 $2,750,000,000 5.250% Senior Notes due 2030 $4,250,000,000 5.250% Senior Notes due 2033 $2,750,000,000 5.600% Senior Notes due 2

February 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 15, 2023 Amgen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 15, 2023 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

February 16, 2023 EX-1.1

Underwriting Agreement, dated February 15, 2023, by and among the Company and Citigroup Global Markets Inc., BofA Securities, Inc., Goldman Sachs & Co. LLC and Mizuho Securities USA LLC, as representatives of the several underwriters named therein

EX-1.1 Exhibit 1.1 AMGEN INC. $2,000,000,000 5.250% SENIOR NOTES DUE 2025 $1,500,000,000 5.507% SENIOR NOTES DUE 2026 $3,750,000,000 5.150% SENIOR NOTES DUE 2028 $2,750,000,000 5.250% SENIOR NOTES DUE 2030 $4,250,000,000 5.250% SENIOR NOTES DUE 2033 $2,750,000,000 5.600% SENIOR NOTES DUE 2043 $4,250,000,000 5.650% SENIOR NOTES DUE 2053 $2,750,000,000 5.750% SENIOR NOTES DUE 2063 Underwriting Agree

February 16, 2023 FWP

Amgen Inc. PRICING TERM SHEET Dated February 15, 2023 $2,000,000,000 5.250% Senior Notes due 2025 (the “2025 Notes”) $1,500,000,000 5.507% Senior Notes due 2026 (the “2026 Notes”) $3,750,000,000 5.150% Senior Notes due 2028 (the “2028 Notes”) $2,750,

Filed Pursuant to Rule 433 Registration Statement 333-269670 February 15, 2023 Amgen Inc.

February 14, 2023 424B3

Subject to Completion Preliminary Prospectus Supplement, dated February 14, 2023

Table of Contents This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, but is not complete and may be changed.

February 10, 2023 SC 13G/A

US4718711033 / JASPER THERAPEUTICS INC / AMGEN INC - SC 13G/A Passive Investment

SC 13G/A 1 d447460dsc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Jasper Therapeutics, Inc. (Name of Issuer) Voting Common Stock, $0.0001 par value per share (Title of Class of Securities) 471871 103 (CUSIP Number) January 31, 2023 (Date of Event Which Requires Filing of this Stat

February 9, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES 5 d416616dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offeri

February 9, 2023 SC 13G/A

AMGN / Amgen, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv0250-amgeninc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 8)* Name of issuer: Amgen Inc. Title of Class of Securities: Common Stock CUSIP Number: 031162100 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursua

February 9, 2023 EX-4.34

Description of Amgen Inc.’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.

Exhibit 4.34 DESCRIPTION OF AMGEN INC.’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of February 6, 2023, Amgen Inc. has two classes of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”): (1) our common stock, par value $0.0001 per share (the “Common Stock”); and (2) our 2.000% Senior Notes due 2

February 9, 2023 EX-10.5

Form of Restricted Stock Unit Agreement for the Amgen Inc. Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.5 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 9, 2023 EX-25.1

Statement of Eligibility on Form T-1 under the Trust Indenture Act of 1939, as amended, of The Bank of New York Mellon Trust Company, N.A., as Trustee under the Indenture.

EX-25.1 Exhibit 25.1 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE ☐  CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (Exact name of trustee as specified in its charter) Californ

February 9, 2023 EX-21

Subsidiaries of the Company.

Exhibit 21 AMGEN INC. The following is a list of subsidiaries of the Company as of December 31, 2022, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary. SUBSIDIARY STATE OR OTHER JURISDICTION OF (Name under which subsidiary does business) INCORPORATION OR ORGANIZATION Amgen (Europe) GmbH Switzerland Amgen Canada Inc. Canada Amgen Fremont I

February 9, 2023 EX-10.16 1

Amendment No. 1 to the Second Amended and Restated Credit Agreement, dated as of December 29, 2022, between Amgen Inc. and Citibank, N.A., as the Administrative Agent and an Issuing Bank.

Exhibit 10.16.1 AMENDMENT NO. 1 TO THE CREDIT AGREEMENT Dated as of December 29, 2022 AMENDMENT NO. 1 TO THE CREDIT AGREEMENT (this “Amendment”) among Amgen Inc., a Delaware corporation (the “Company”), each financial institution whose name is set forth on the signature pages hereof as a Bank, Citibank, N.A. (“Citibank”), as the Administrative Agent and an Issuing Bank. PRELIMINARY STATEMENTS: (1)

February 9, 2023 EX-10.7

Form of Performance Unit Agreement for the Amgen Inc. 2009 Performance Award Program. (As Amended and Reinstated on December 12, 2022.)

Exhibit 10.7 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 9, 2023 S-3ASR

As filed with the Securities and Exchange Commission on February 9, 2023

Table of Contents As filed with the Securities and Exchange Commission on February 9, 2023 Registration No.

February 9, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 Amgen Inc. (Exact name of registrant as specified

February 9, 2023 EX-10.11 4

Fourth Amendment to the Amgen Inc. Supplemental Retirement Plan, effective October 20, 2022.

Exhibit 10.11.4 FOURTH AMENDMENT TO THE AMGEN INC. SUPPLEMENTAL RETIREMENT PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Inc. Supplemental Retirement Plan, as Amended and Restated Effective October 16, 2013 (the “Plan”), is hereby amended, effective October 20, 2022, as follows: 1.Section 2.27 is amended by adding the following at the end thereof: If you were employed by ChemoC

February 9, 2023 EX-10.4

Form of Grant of Stock Option Agreement for the Amgen Inc. Amended and Restated 2009 Equity Incentive Plan.

Exhibit 10.4 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

January 31, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) January 30, 2023 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

January 31, 2023 EX-99.2

Amgen Inc.

Exhibit 99.2 Amgen Inc. Recast of 2021 Non-GAAP Financial Information As Reported to Reflect Updated Non-GAAP Policy Beginning January 1, 2022, Amgen Inc. (the Company) no longer excludes adjustments for upfront license fees, development milestones and in-process research and development (IPR&D) expenses of pre-approval programs related to licensing, collaboration and asset acquisition transaction

January 31, 2023 EX-10.1

Amendment No. 3 to Share Purchase Agreement, dated January 30, 2023, by and among BeiGene, Ltd. and Amgen Inc.

Exhibit 10.1 AMENDMENT NO. 3 TO SHARE PURCHASE AGREEMENT THIS AMENDMENT NO. 3 (this “Amendment”) to the SHARE PURCHASE AGREEMENT, dated as of October 31, 2019, as amended on December 6, 2019 and September 24, 2020 (the “Agreement”), is made and entered into as of January 30, 2023 (the “Amendment Effective Date”), by and among BeiGene, Ltd., an exempted company incorporated in the Cayman Islands (t

January 31, 2023 EX-99.1

AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2022 FINANCIAL RESULTS AMGEN ALSO PROVIDES 2023 GUIDANCE EXCLUDING ANY CONTRIBUTION FROM THE ANNOUNCED ACQUISITION OF HORIZON THERAPEUTICS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2022 FINANCIAL RESULTS AMGEN ALSO PROVIDES 2023 GUIDANCE EXCLUDING ANY CONTRIBUTION FROM THE ANNOUNCED ACQUISITION OF HORIZON THERAPEUTICS THOUSAND OAKS, Calif. (January 31, 2023) - Amgen (NASDAQ:AMGN) today announced financial results for th

December 22, 2022 EX-10.1

Term Loan Credit Agreement, dated as of December 22, 2022, by and among Amgen Inc., Citibank, N.A., as administrative agent, Bank of America, N.A., as syndication agent, Citibank, N.A., Bank of America, N.A., Goldman Sachs Bank USA and Mizuho Bank, Ltd., as lead arrangers and book runners, Goldman Sachs Bank USA and Mizuho Bank, Ltd. as documentation agents, and the other banks party thereto.

Exhibit 10.1 TERM LOAN CREDIT AGREEMENT Dated as of December 22, 2022 among Amgen Inc., The Banks Herein Named, Citibank, N.A. as Administrative Agent, Bank of America, N.A. as Syndication Agent, Goldman Sachs Bank USA and Mizuho Bank, Ltd. as Documentation Agents, and Citibank, N.A., Bank of America, N.A., Goldman Sachs Bank USA and Mizuho Bank, Ltd. as Joint Lead Arrangers and Joint Bookrunners

December 22, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2022 Amgen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

December 12, 2022 EX-2.1

Transaction Agreement, dated as of December 11, 2022, by and among Amgen Inc., Pillartree Limited and Horizon Therapeutics plc.

EX-2.1 Exhibit 2.1 TRANSACTION AGREEMENT dated as of December 11, 2022 among AMGEN INC. PILLARTREE LIMITED and HORIZON THERAPEUTICS PLC TABLE OF CONTENTS Page SECTION 1. INTERPRETATION 1 1.1 Definitions 1 1.2 Construction 21 SECTION 2. RULE 2.7 ANNOUNCEMENT AND SCHEME DOCUMENT 22 2.1 Rule 2.7 Announcement 22 2.2 The Scheme 22 2.3 Change in Shares 23 2.4 Company Equity Award Holder Proposal 23 SECT

December 12, 2022 EX-10.1

Bridge Credit Agreement, dated as of December 12, 2022, by and among Amgen Inc., Citibank, N.A., as administrative agent, Bank of America, N.A., as syndication agent, Citibank, N.A. and Bank of America, N.A., as lead arrangers and book runners, and the other banks party thereto.

EX-10.1 Exhibit 10.1 BRIDGE CREDIT AGREEMENT Dated as of December 12, 2022 among Amgen Inc., The Banks Herein Named, Citibank, N.A. as Administrative Agent, Bank of America, N.A. as Syndication Agent, Citibank, N.A. and Bank of America, N.A. as Lead Arrangers and Book Runners Table of Contents ARTICLE 1 DEFINITIONS AND ACCOUNTING TERMS 1.1 Defined Terms 1 1.2 Use of Defined Terms 25 1.3 Accounting

December 12, 2022 EX-2.2

Appendix 3 to the Rule 2.7 Announcement, dated as of December 12, 2022 (Conditions Appendix).

EX-2.2 Exhibit 2.2 APPENDIX 3 CONDITIONS OF THE ACQUISITION AND THE SCHEME The Acquisition and the Scheme will comply with the Irish Takeover Rules and, where relevant, the rules and regulations of the U.S. Exchange Act, the Irish Companies Act and the Nasdaq, and are subject to the terms and conditions set out in this Announcement and to be set out in the Scheme Document. The Acquisition and the

December 12, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 11, 2022 Amgen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 11, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

December 12, 2022 EX-99.1

RECOMMENDED CASH OFFER HORIZON THERAPEUTICS PLC Pillartree Limited, a newly formed private limited company wholly owned by Amgen Inc. to be implemented by way of a scheme of arrangement under Chapter 1 of Part 9 of the Companies Act 2014

EX-99.1 Exhibit 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION THIS ANNOUNCEMENT IS BEING MADE PURSUANT TO RULE 2.7 OF THE IRISH TAKEOVER RULES FOR IMMEDIATE RELEASE December 12, 2022 RECOMMENDED CASH OFFER for HORIZON THERAPEUTICS PLC by P

December 2, 2022 SC 13G

AMGEN INC - SC 13G

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* NewAmsterdam Pharma Company N.V. (Name of Issuer) Ordinary Shares, nominal value EUR 0.12 per share (Title of Class of Securities) N62509109 (CUSIP Number) November 22, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropri

December 2, 2022 EX-99.1

Joint Filing Agreement

EX-99.1 Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the

December 2, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 2, 2022 Amgen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 2, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number

December 2, 2022 EX-99.1

Amgen Inc. (“Amgen”) Possible offer for Horizon Therapeutics plc (“Horizon”) Announcement for the purposes of Rule 2.12 of the Irish Takeover Panel Act 1997, Takeover Rules, 2022 (the “Irish Takeover Rules”)

EX-99.1 EXHIBIT 99.1 NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION December 2, 2022 Amgen Inc. (“Amgen”) Possible offer for Horizon Therapeutics plc (“Horizon”) Announcement for the purposes of Rule 2.12 of the Irish Takeover Panel Act

November 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as

November 4, 2022 EX-10.36

Amendment No. 1 to Sourcing and Supply Agreement, dated July 14, 2022, by and between Amgen USA Inc., a wholly owned subsidiary of Amgen Inc., and DaVita Inc

EXHIBIT 10.36 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMENDMENT NO. 1 TO AGREEMENT NO. 00135085 BETWEEN AMGEN USA INC. AND DAVITA INC. This Amendment No. 1 (“Amendment No. 1”) to that certain Sourcing and Supply Agreement No. 00135085

November 3, 2022 EX-99.2

Amgen Inc.

Exhibit 99.2 Amgen Inc. Recast of 2021 Non-GAAP Financial Information As Reported to Reflect Updated Non-GAAP Policy Beginning January 1, 2022, Amgen Inc. (the Company) no longer excludes adjustments for upfront license fees, development milestones and in-process research and development (IPR&D) expenses of pre-approval programs related to licensing, collaboration and asset acquisition transaction

November 3, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 3, 2022 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

November 3, 2022 EX-99.1

AMGEN REPORTS THIRD QUARTER 2022 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS THIRD QUARTER 2022 FINANCIAL RESULTS THOUSAND OAKS, Calif. (November 3, 2022) - Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2022. Key results include: ?Total revenues decreased 1% to $6.7 billion in comparison to the third quarter of 20

October 20, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) October 20, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

October 20, 2022 EX-99.1

AMGEN SUCCESSFULLY COMPLETES ACQUISITION OF CHEMOCENTRYX TAVNEOS® (avacopan), a First-in-Class Medicine for Patients With Severe Active ANCA-Associated Vasculitis, Added to Inflammation Portfolio

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com AMGEN SUCCESSFULLY COMPLETES ACQUISITION OF CHEMOCENTRYX TAVNEOS? (avacopan), a First-in-Class Medicine for Patients With Severe Active ANCA-Associated Vasculitis, Added to Inflammation Portfolio THOUSAND OAKS, Calif., (Oct. 20, 2022) ? Amgen (NASDAQ: AMGN) today announced that it has

August 18, 2022 EX-4.2

Officer’s Certificate of Amgen Inc., dated as of August 18, 2022, including forms of the Company’s 4.050% Senior Notes due 2029, 4.200% Senior Notes due 2033 and 4.875% Senior Notes due 2053.

Exhibit 4.2 OFFICER?S CERTIFICATE OF AMGEN INC. Dated as of August 18, 2022 The undersigned officer of the Company certifies, pursuant to resolutions duly adopted by the Board of Directors at a meeting duly held on August 3, 2022 and by the Pricing Committee of the Board of Directors of the Company on August 12, 2022 (the ?Resolutions?), and in accordance with Sections 2.1, 2.2 and 2.3 of the Inde

August 18, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 15, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 18, 2022 EX-1.1

Underwriting Agreement, dated August 15, 2022, by and among the Company and BofA Securities, Inc., Morgan Stanley & Co. LLC, Credit Suisse Securities (USA) LLC and Deutsche Bank Securities Inc., as representatives of the several underwriters named therein.

EX-1.1 2 d280175dex11.htm EX-1.1 Exhibit 1.1 AMGEN INC. $1,250,000,000 4.050% SENIOR NOTES DUE 2029 $750,000,000 4.200% SENIOR NOTES DUE 2033 $1,000,000,000 4.875% SENIOR NOTES DUE 2053 Underwriting Agreement August 15, 2022 BofA Securities, Inc. Morgan Stanley & Co. LLC Credit Suisse Securities (USA) LLC Deutsche Bank Securities Inc. As representatives of the several Underwriters named in Schedul

August 16, 2022 424B2

$1,250,000,000 4.050% Senior Notes due 2029 $750,000,000 4.200% Senior Notes due 2033 $1,000,000,000 4.875% Senior Notes due 2053

Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No. 333-236351 Prospectus Supplement (To Prospectus Dated February 10, 2020) $1,250,000,000 4.050% Senior Notes due 2029 $750,000,000 4.200% Senior Notes due 2033 $1,000,000,000 4.875% Senior Notes due 2053 We are offering $1,250,000,000 aggregate principal amount of 4.050% Senior Notes due 2029 (the ?2029 notes?), $750,000,000 aggreg

August 16, 2022 EX-FILING FEES

Calculation of Filing Fee Tables (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities

Exhibit 107 Calculation of Filing Fee Tables 424(b)(2) (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forwa

August 15, 2022 FWP

Amgen Inc. PRICING TERM SHEET Dated August 15, 2022 $1,250,000,000 4.050% Senior Notes due 2029 (the “2029 Notes”) $750,000,000 4.200% Senior Notes due 2033 (the “2033 Notes”) $1,000,000,000 4.875% Senior Notes due 2053 (the “2053 Notes”)

FWP 1 d280177dfwp.htm FWP Filed Pursuant to Rule 433 Registration Statement 333-236351 August 15, 2022 Amgen Inc. PRICING TERM SHEET Dated August 15, 2022 $1,250,000,000 4.050% Senior Notes due 2029 (the “2029 Notes”) $750,000,000 4.200% Senior Notes due 2033 (the “2033 Notes”) $1,000,000,000 4.875% Senior Notes due 2053 (the “2053 Notes”) This term sheet relates only to the securities described b

August 15, 2022 424B3

Subject to Completion Preliminary Prospectus Supplement, dated August 15, 2022

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-236351 This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, but is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these sec

August 5, 2022 EX-10.47

Amendment No. 1 to the Collaboration Agreement, dated October 1, 2014, by and among Amgen Inc., AstraZeneca Collaboration Ventures, LLC and AstraZeneca Pharmaceuticals LP

EXHIBIT 10.47 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMENDMENT NO. 1 TO THE COLLABORATION AGREEMENT This Amendment No. 1 to the Collaboration Agreement (this ?Amendment?) is entered into as of the 1st day of October, 2014 (the ?Amendm

August 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spec

August 5, 2022 EX-10.46

Collaboration Agreement dated March 30, 2012 by and between Amgen Inc. and AstraZeneca Collaboration Ventures, LLC, a wholly owned subsidiary of AstraZeneca Pharmaceuticals LP

EXHIBIT 10.46 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Collaboration Agreement by and between Amgen Inc. and AstraZeneca Collaboration Ventures, LLC Table of Contents DEFINITIONS 1 SCOPE AND GOVERNANCE 17 2.1 Purpose of the Collaboratio

August 5, 2022 EX-10.41

First Amendment to Collaboration Agreement, dated April 20, 2022, by and between Amgen Inc. and BeiGene Switzerland GmbH, and BeiGene, Ltd.

EXHIBIT 10.41 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. FIRST AMENDMENT TO COLLABORATION AGREEMENT This Amendment to the Collaboration Agreement (?Amendment?) is entered into as of April 20, 2022 (the ?Amendment Effective Date?) by and a

August 4, 2022 EX-99.1

AMGEN REPORTS SECOND QUARTER 2022 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS SECOND QUARTER 2022 FINANCIAL RESULTS THOUSAND OAKS, Calif. (August 4, 2022) - Amgen (NASDAQ:AMGN) today announced financial results for the second quarter of 2022. Key results include: ?Total revenues increased 1% to $6.6 billion in comparison to the second quarter of 2

August 4, 2022 EX-99.1

AMGEN TO ACQUIRE CHEMOCENTRYX FOR $4 BILLION IN Acquisition Includes TAVNEOS® (avacopan), a First-in-Class Medicine for Patients With Serious Autoimmune Disease Tavneos Adds to Amgen’s Decades-Long Leadership in Inflammation and Nephrology

EX-99.1 Exhibit 99.1 News Release AMGEN TO ACQUIRE CHEMOCENTRYX FOR $4 BILLION IN CASH Acquisition Includes TAVNEOS® (avacopan), a First-in-Class Medicine for Patients With Serious Autoimmune Disease Tavneos Adds to Amgen’s Decades-Long Leadership in Inflammation and Nephrology THOUSAND OAKS, Calif. and SAN CARLOS, Calif., Aug. 4, 2022 – Amgen (NASDAQ: AMGN) and ChemoCentryx, Inc., (NASDAQ: CCXI),

August 4, 2022 EX-99.2

Amgen Inc.

Exhibit 99.2 Amgen Inc. Recast of 2021 Non-GAAP Financial Information As Reported to Reflect Updated Non-GAAP Policy Beginning January 1, 2022, Amgen Inc. (the Company) no longer excludes adjustments for upfront license fees, development milestones and in-process research and development (IPR&D) expenses of pre-approval programs related to licensing, collaboration and asset acquisition transaction

August 4, 2022 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 4, 2022 (August 3, 2022) Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commissi

August 4, 2022 EX-2.1

Agreement and Plan of Merger, dated as of August 3, 2022, among ChemoCentryx, Inc., Amgen Inc. and Carnation Merger Sub, Inc.

Exhibit 2.1 Execution Version AGREEMENT AND PLAN OF MERGER dated as of August 3, 2022 among CHEMOCENTRYX, INC., AMGEN INC. and CARNATION MERGER SUB, INC. TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS Section 1.01. Definitions 1 Section 1.02. Other Definitional and Interpretative Provisions 11 ARTICLE 2 THE MERGER Section 2.01. The Merger 12 Section 2.02. Conversion of Shares 13 Section 2.03. Surren

August 4, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 4, 2022 - Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 3, 2022 EX-99.1

AMGEN APPOINTS MICHAEL V. DRAKE TO BOARD OF DIRECTORS

Exhibit 99.1 One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com News Release AMGEN APPOINTS MICHAEL V. DRAKE TO BOARD OF DIRECTORS THOUSAND OAKS, Calif., Aug. 3, 2022 ? Amgen (NASDAQ: AMGN) today announced the appointment of Michael V. Drake, M.D., to its Board of Directors, effective immediately. Dr. Drake will also serve as a member of the Board?s Corporate

August 3, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

June 24, 2022 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 AMGEN RETIREMENT AND SAVINGS PLAN (Full title of the plan) AMG

June 24, 2022 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

11-K 1 a2021puertoricoplan11-k.htm THE RETIREMENT AND SAVINGS PLAN FOR AMGEN MANUFACTURING, LIMITED UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF

May 18, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2022 AMGEN INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-37702 95-3540776 (State or Other Jurisdiction of Incorporation) (Commission File Number) (I

April 28, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A 1 d142504ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMI

April 28, 2022 EX-10.17

Amgen Inc. Executive Incentive Plan.

EX-10.17 2 amgn-ex10172022331xq1.htm AMGEN INC. EXECUTIVE INCENTIVE PLAN Exhibit 10.17 AMGEN INC. EXECUTIVE INCENTIVE PLAN I. PURPOSE The purpose of the Amgen Inc. Executive Incentive Plan (the "Plan") is to attract and retain highly qualified individuals to Amgen Inc., and its subsidiary companies (collectively, “Amgen” or the “Company”); to obtain from each the best possible performance; to esta

April 28, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spe

April 27, 2022 EX-99.1

AMGEN REPORTS FIRST QUARTER 2022 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER 2022 FINANCIAL RESULTS THOUSAND OAKS, Calif. (April 27, 2022) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2022. Key results include: ?Total revenues increased 6% to $6.2 billion in comparison to the first quarter of 2021

April 27, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 27, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

April 27, 2022 EX-99.2

Amgen Inc.

Exhibit 99.2 Amgen Inc. Recast of 2021 Non-GAAP Financial Information As Reported to Reflect Updated Non-GAAP Policy Beginning January 1, 2022, Amgen Inc. (the Company) no longer excludes adjustments for upfront license fees, development milestones and in-process research and development (IPR&D) expenses of pre-approval programs related to licensing, collaboration and asset acquisition transaction

April 22, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A 1 d261564ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMI

April 13, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A 1 d343008ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMI

April 5, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEFA14A 1 d333563ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMI

April 5, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant C

DEF 14A 1 d234450ddef14a.htm DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMIT

February 25, 2022 EX-10.1

Form of ASR Agreement.

Exhibit 10.1 Form of ASR Agreement [ ], 2022 To: Amgen Inc. 1 Amgen Center Drive Thousand Oaks, CA 91320 Attn: [ ] Telephone: [ ] Email: [ ] From: [Dealer] [] [] Attention: [] Telephone: [] Email: [] Re: Issuer Forward Repurchase Transaction (Dealer Reference Number: ) Ladies and Gentlemen: The purpose of this communication (this ?Confirmation?) is to confirm the terms and conditions of the Transa

February 25, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 24, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number

February 22, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 17, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Numbe

February 22, 2022 EX-1.1

Underwriting Agreement, dated February 17, 2022, by and among the Company and BofA Securities, Inc., Morgan Stanley & Co. LLC, Citigroup Global Markets Inc. and Goldman Sachs & Co. LLC, as representatives of the several underwriters named therein.

Exhibit 1.1 AMGEN INC. $750,000,000 3.000% SENIOR NOTES DUE 2029 $1,000,000,000 3.350% SENIOR NOTES DUE 2032 $1,000,000,000 4.200% SENIOR NOTES DUE 2052 $1,250,000,000 4.400% SENIOR NOTES DUE 2062 Underwriting Agreement February 17, 2022 BofA Securities, Inc. Morgan Stanley & Co. LLC Citigroup Global Markets Inc. Goldman Sachs & Co. LLC As representatives of the several Underwriters named in Sched

February 22, 2022 EX-4.2

Officer’s Certificate of Amgen Inc., dated as of February 22, 2022, including forms of the Company’s 3.000% Senior Notes due 2029, 3.350% Senior Notes due 2032, 4.200% Senior Notes due 2052 and 4.400% Senior Notes due 2062.

Exhibit 4.2 Execution Version OFFICER?S CERTIFICATE OF AMGEN INC. Dated as of February 22, 2022 The undersigned officer of the Company certifies, pursuant to resolutions duly adopted by the Board of Directors at a meeting duly held on February 16, 2022 (the ?Resolutions?), and in accordance with Sections 2.1, 2.2 and 2.3 of the Indenture, dated as of May 22, 2014 (the ?Indenture?; capitalized term

February 18, 2022 EX-FILING FEES

Calculation of Filing Fee Tables (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Regi

EX-FILING FEES 2 d282135dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables 424(b)(2) (Form Type) Amgen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offer

February 18, 2022 424B2

$750,000,000 3.000% Senior Notes due 2029 $1,000,000,000 3.350% Senior Notes due 2032 $1,000,000,000 4.200% Senior Notes due 2052 $1,250,000,000 4.400% Senior Notes due 2062

Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No. 333-236351 Prospectus Supplement (To Prospectus Dated February 10, 2020) $750,000,000 3.000% Senior Notes due 2029 $1,000,000,000 3.350% Senior Notes due 2032 $1,000,000,000 4.200% Senior Notes due 2052 $1,250,000,000 4.400% Senior Notes due 2062 We are offering $750,000,000 aggregate principal amount of 3.000% Senior Notes due 20

February 17, 2022 424B3

Subject to Completion Preliminary Prospectus Supplement, dated February 17, 2022

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-236351 This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, but is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these sec

February 17, 2022 FWP

Amgen Inc. PRICING TERM SHEET Dated February 17, 2022 $750,000,000 3.000% Senior Notes due 2029 (the ?2029 Notes?) $1,000,000,000 3.350% Senior Notes due 2032 (the ?2032 Notes?) $1,000,000,000 4.200% Senior Notes due 2052 (the ?2052 Notes?) $1,250,00

Filed Pursuant to Rule 433 Registration Statement 333-236351 February 17, 2022 Amgen Inc.

February 16, 2022 EX-4.32

Description of Amgen Inc.’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.

EXHIBIT 4.32 DESCRIPTION OF AMGEN INC.?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of February 14, 2022, Amgen Inc. has two classes of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): (1) our common stock, par value $0.0001 per share (the ?Common Stock?); and (2) our 2.000% Senior Notes due

February 16, 2022 EX-10.23

Third Amendment to the Amgen Nonqualified Deferred Compensation Plan, effective January 1, 2022.

EX-10.23 7 amgn-ex102320211231xq4.htm THIRD AMENDMENT TO NONQUALIFIED DEFERRED COMPENSATION PLAN EXHIBIT 10.23 THIRD AMENDMENT TO THE AMGEN NONQUALIFIED DEFERRED COMPENSATION PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Nonqualified Deferred Compensation Plan, as Amended and Restated Effective October 16, 2013 (the “Plan”), is hereby amended, effective January 1, 2022, as foll

February 16, 2022 EX-10.15

Third Amendment to the Amgen Inc. Supplemental Retirement Plan, effective October 20, 2021.

EXHIBIT 10.15 THIRD AMENDMENT TO THE AMGEN INC. SUPPLEMENTAL RETIREMENT PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Inc. Supplemental Retirement Plan, as Amended and Restated Effective October 16, 2013 (the ?Plan?), is hereby amended, effective October 20, 2021, as follows: 1.Section 2.27 is amended by adding the following at the end thereof: If you were employed by Five Prim

February 16, 2022 EX-10.5

Form of Restricted Stock Unit Agreement for the Amgen Inc. Amended and Restated 2009 Equity Incentive Plan. (As Amended

EXHIBIT 10.5 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 16, 2022 EX-10.51

Amendment No. 8 to the Collaboration Agreement, dated November 19, 2021, by and between Amgen Inc. and AstraZeneca Collaboration Ventures, LLC

CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT BOTH (I) IS NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

February 16, 2022 EX-21

Subsidiaries of the Company.

Exhibit 21 AMGEN INC. The following is a list of subsidiaries of the Company as of December 31, 2021, omitting some subsidiaries which, considered in the aggregate, would not constitute a significant subsidiary. SUBSIDIARY STATE OR OTHER JURISDICTION OF (Name under which subsidiary does business) INCORPORATION OR ORGANIZATION Amgen (Europe) GmbH Switzerland Amgen Canada Inc. Canada Amgen Fremont I

February 16, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 Amgen Inc. (Exact name of registrant as specified

February 16, 2022 EX-10.25

Aircraft Time Sharing Agreement, dated December 3, 2021, by and between Amgen Inc. and Robert A. Bradway.

EXHIBIT 10.25 AIRCRAFT TIME SHARING AGREEMENT This Agreement is made and entered into as of December 3, 2021 by and between Amgen Inc. (together with its subsidiaries and affiliates, ?Lessor?), and Robert A. Bradway (?Lessee?). WITNESSETH: WHEREAS, Lessor is the operator and/or registered owner of undivided interests in aircraft bearing the Manufacturer?s Serial Number(s) and the United States Fed

February 16, 2022 EX-10.4

Form of Grant of Stock Option Agreement for the Amgen Inc. Amended and Restated 2009 Equity Incentive Plan. (As Amended

EXHIBIT 10.4 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 16, 2022 EX-10.7

Form of Performance Unit Agreement for the Amgen Inc. 2009 Performance Award Program. (As Amended

EXHIBIT 10.7 Form of Award Notice [The information set forth in this Award Notice will be contained on the related pages on Merrill Lynch Benefits Website (or the website of any successor company to Merrill Lynch Bank & Trust Co., FSB). This Award Notice shall be replaced by the equivalent pages on such website. References to Award Notice in this Agreement shall then refer to the equivalent pages

February 11, 2022 SC 13G/A

AMGN / Amgen, Inc. / Capital Research Global Investors - SEC SCHEDULE 13G Passive Investment

SC 13G/A 1 SEC13GFiling.htm SEC SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9 )* Amgen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 031162100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designat

February 9, 2022 SC 13G/A

AMGN / Amgen, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 7)* Name of issuer: Amgen Inc. Title of Class of Securities: Common Stock CUSIP Number: 031162100 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☒ Rule 13d

February 7, 2022 EX-99.1

AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FOURTH QUARTER AND FULL YEAR 2021 FINANCIAL RESULTS THOUSAND OAKS, Calif. (February 7, 2022) - Amgen (NASDAQ:AMGN) today announced financial results for the fourth quarter and full year 2021 versus comparable periods in 2020. Key results include: ?For the fourth quarter,

February 7, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) February 7, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

February 7, 2022 EX-99.25

EX-99.25

amgn22-form25

January 31, 2022 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) January 31, 2022 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

January 31, 2022 EX-10.1

Amendment No. 3 to the Exclusive License and Collaboration Agreement, dated January 31, 2022, by and between Amgen Inc. and Novartis Pharma AG

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMENDMENT No. 3 to the Exclusive License and Collaboration Agreement between Novartis Pharma AG and Amgen Inc. This Amendment No. 3 (?Amendment?) is entered into as of January 31,

January 12, 2022 SC 13G

VIGL / Vigil Neuroscience Inc / AMGEN INC - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Vigil Neuroscience, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 92673K 108 (CUSIP Number) January 11, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desig

November 3, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as

November 3, 2021 EX-99.4

Third Amendment to the Amgen Nonqualified Deferred Compensation Plan, effective January 1, 2022.

Exhibit 99.4 THIRD AMENDMENT TO THE AMGEN NONQUALIFIED DEFERRED COMPENSATION PLAN AS AMENDED AND RESTATED EFFECTIVE OCTOBER 16, 2013 The Amgen Nonqualified Deferred Compensation Plan, as Amended and Restated Effective October 16, 2013 (the ?Plan?), is hereby amended, effective January 1, 2022, as follows: 1. Section 3.3 (?Delayed Commencement Election?) is amended by adding the following at the en

November 3, 2021 S-8

As filed with the Securities and Exchange Commission on November 3, 2021

As filed with the Securities and Exchange Commission on November 3, 2021 Registration No.

November 3, 2021 S-8

As filed with the Securities and Exchange Commission on November 3, 2021

As filed with the Securities and Exchange Commission on November 3, 2021 Registration No.

November 3, 2021 EX-2.7

Agreement and Plan of Merger, dated July 27, 2021, by and among Amgen Inc., Teneobio, Inc., Tuxedo Merger Sub, Inc., and Fortis Advisors LLC.

Exhibit 2.7 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AGREEMENT AND PLAN OF MERGER dated as of July 27, 2021 by and among AMGEN INC., TUXEDO MERGER SUB, INC., TENEOBIO, INC., and FORTIS ADVISORS LLC, as the Pre-Closing Holders? Represe

November 2, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) November 2, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

November 2, 2021 EX-99.1

AMGEN REPORTS THIRD QUARTER 2021 FINANCIAL RESULTS

EX-99.1 2 amgn-2021930xq3ex991.htm EX-99.1 Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS THIRD QUARTER 2021 FINANCIAL RESULTS THOUSAND OAKS, Calif. (November 2, 2021) - Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2021. Key results include: •Total revenues increased 4% to $6.7 billi

October 1, 2021 SC 13G

AMHC / Amplitude Healthcare Acquisition Corp / AMGEN INC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Jasper Therapeutics, Inc. (Name of Issuer) Voting Common Stock, $0.0001 par value per share (Title of Class of Securities) 471871 103 (CUSIP Number) September 24, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to de

August 9, 2021 EX-4.2

Officer’s Certificate of Amgen Inc., dated as of August 9, 2021, including forms of the Company’s 1.650% Senior Notes due 2028, 2.000% Senior Notes due 2032, 2.800% Senior Notes due 2041 and 3.000% Senior Notes due 2052.

Exhibit 4.2 Execution Version OFFICER?S CERTIFICATE OF AMGEN INC. Dated as of August 9, 2021 The undersigned officer of the Company certifies, pursuant to resolutions duly adopted by the Board of Directors at a meeting duly held on May 18, 2021, and by the Pricing Committee of the Board of Directors of the Company on July 29, 2021 (the ?Resolutions?), and in accordance with Sections 2.1, 2.2 and 2

August 9, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number)

August 9, 2021 EX-1.1

Underwriting Agreement, dated August 5, 2021, by and among the Company and Citigroup Global Markets Inc., Morgan Stanley & Co. LLC, Barclays Capital Inc. and Goldman Sachs & Co. LLC, as representatives of the several underwriters named therein.

Exhibit 1.1 AMGEN INC. $1,250,000,000 1.650% SENIOR NOTES DUE 2028 $1,250,000,000 2.000% SENIOR NOTES DUE 2032 $1,150,000,000 2.800% SENIOR NOTES DUE 2041 $1,350,000,000 3.000% SENIOR NOTES DUE 2052 Underwriting Agreement August 5, 2021 Citigroup Global Markets Inc. Morgan Stanley & Co. LLC Barclays Capital Inc. Goldman Sachs & Co. LLC As representatives of the several Underwriters named in Schedu

August 6, 2021 424B2

CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to Be Registered Amount to be Registered Proposed Maximum Offering Price per Unit Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) 1.650% Senior Notes due 2028 $

424B2 1 d180187d424b2.htm 424B2 Table of Contents Filed Pursuant to Rule 424(b)(2) Registration No. 333-236351 CALCULATION OF REGISTRATION FEE Title of Each Class of Securities to Be Registered Amount to be Registered Proposed Maximum Offering Price per Unit Proposed Maximum Aggregate Offering Price Amount of Registration Fee(1) 1.650% Senior Notes due 2028 $1,250,000,000 99.908% $1,248,850,000 $1

August 6, 2021 FWP

Amgen Inc. PRICING TERM SHEET Dated August 5, 2021 $1,250,000,000 1.650% Senior Notes due 2028 (the “2028 Notes”) $1,250,000,000 2.000% Senior Notes due 2032 (the “2032 Notes”) $1,150,000,000 2.800% Senior Notes due 2041 (the “2041 Notes”) $1,350,000

Filed Pursuant to Rule 433 Registration Statement 333-236351 August 5, 2021 Amgen Inc.

August 5, 2021 424B3

Subject to Completion Preliminary Prospectus Supplement, dated August 5, 2021

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-236351 This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, but is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these sec

August 4, 2021 EX-10.49

License and Collaboration Agreement, dated June 1, 2021, by and between Amgen Inc. and Kyowa Kirin Co., Ltd.

Exhibit 10.49 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMGEN INC. and KYOWA KIRIN CO., LTD. Dated June 1, 2021 LICENSE AND COLLABORATION AGREEMENT CONTENTS Page Article I. Definitions 1 Article II. Scope and Governance 27 Section 2.1

August 4, 2021 EX-10.39

Amended and Restated Collaboration Agreement, dated June 2, 2021, by and between Amgen Inc. and Novartis Pharma AG

Exhibit 10.39 EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Amended and Restated Collaboration Agreement By and Between Amgen Inc. and Novartis Pharma AG Dated June 2, 2021 2017774574-009 2" = "2" "169527475" "" 169527475

August 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spec

August 3, 2021 EX-99.1

AMGEN REPORTS SECOND QUARTER 2021 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS SECOND QUARTER 2021 FINANCIAL RESULTS THOUSAND OAKS, Calif. (August 3, 2021) - Amgen (NASDAQ:AMGN) today announced financial results for the second quarter of 2021. Key results include: ?Total revenues increased 5% to $6.5 billion in comparison to the second quarter of 2

August 3, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) August 3, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

July 30, 2021 EX-99.1

AMGEN APPOINTS S. OMAR ISHRAK TO BOARD OF DIRECTORS

Exhibit 99.1 One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com News Release AMGEN APPOINTS S. OMAR ISHRAK TO BOARD OF DIRECTORS THOUSAND OAKS, Calif. (July 29, 2021) ? Amgen (NASDAQ:AMGN) today announced the appointment of S. Omar Ishrak to its Board of Directors, effective immediately. Dr. Ishrak will also serve as a member of the Board?s Corporate Responsib

July 30, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 29, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

July 27, 2021 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 27, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

July 27, 2021 EX-99.1

AMGEN TO ACQUIRE PRIVATELY HELD TENEOBIO FOR $900 MILLION IN CASH WITH FUTURE CONTINGENT MILESTONE PAYMENTS Acquisition Complements Amgen’s Antibody Research Capabilities Across Therapeutic Areas Acquisition Includes a Portfolio of Early-Stage Oncolo

Exhibit 99.1 News Release AMGEN TO ACQUIRE PRIVATELY HELD TENEOBIO FOR $900 MILLION IN CASH WITH FUTURE CONTINGENT MILESTONE PAYMENTS Acquisition Complements Amgen?s Antibody Research Capabilities Across Therapeutic Areas Acquisition Includes a Portfolio of Early-Stage Oncology Assets, Including a Phase 1 Bispecific Antibody for Patients With Advanced Prostate Cancer THOUSAND OAKS, Calif. and NEWA

June 23, 2021 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

11-K 1 a2020puertoricoplan11-k.htm THE RETIREMENT AND SAVINGS PLAN FOR AMGEN MANUFACTURING, LIMITED UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ý ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF

June 23, 2021 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 11-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37702 AMGEN RETIREMENT AND SAVINGS PLAN (Full title of the plan) AMG

June 1, 2021 EX-99.1

AMGEN AND KYOWA KIRIN TO JOINTLY DEVELOP AND COMMERCIALIZE KHK4083, A PHASE 3-READY, POTENTIAL FIRST-IN-CLASS TREATMENT FOR ATOPIC DERMATITIS Agreement Renews Successful Global Collaboration That led to Several Groundbreaking Therapies in Multiple Di

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.Amgen.com AMGEN AND KYOWA KIRIN TO JOINTLY DEVELOP AND COMMERCIALIZE KHK4083, A PHASE 3-READY, POTENTIAL FIRST-IN-CLASS TREATMENT FOR ATOPIC DERMATITIS Agreement Renews Successful Global Collaboration That led to Several Groundbreaking Therapies in Multiple Disease Areas KHK4083 Depletes OX40-E

June 1, 2021 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (I

May 19, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 18, 2021 AMGEN INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-37702 95-3540776 (State or Other Jurisdiction of Incorporation) (Commission File Number) (I

April 30, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? Filed by the registrant ? Filed by a party other than the registrant Check the appropriate box: ? Preliminary Proxy Statement ? CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY RULE 14A-6(E)(2)) ? Definitive

April 28, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 001-37702 Amgen Inc. (Exact name of registrant as spe

April 28, 2021 DEFA14A

- DEFA14A

DEFA14A 1 d132478ddefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ☑ Filed by the registrant ☐ Filed by a party other than the registrant Check the appropriate box: ☐ Preliminary Proxy Statement ☐ CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMI

April 27, 2021 EX-99.1

AMGEN REPORTS FIRST QUARTER 2021 FINANCIAL RESULTS

Exhibit 99.1 News Release One Amgen Center Drive Thousand Oaks, CA 91320-1799 Telephone 805-447-1000 www.amgen.com AMGEN REPORTS FIRST QUARTER 2021 FINANCIAL RESULTS THOUSAND OAKS, Calif. (April 27, 2021) - Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2021. Key results include: ?Total revenues decreased 4% to $5.9 billion in comparison to the first quarter of 2020

April 27, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported) April 27, 2021 Amgen Inc. (Exact name of registrant as specified in its charter) Delaware 001-37702 95-3540776 (State or other jurisdiction of incorporation) (Commission File Number) (

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