AMAM / Ambrx Biopharma Inc. - تصريحات هيئة الأوراق المالية والبورصات، التقرير السنوي، بيان الوكيل

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الإحصائيات الأساسية
CIK 1836056
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Ambrx Biopharma Inc.
SEC Filings (Chronological Order)
توفر هذه الصفحة قائمة كاملة ومرتبة ترتيبًا زمنيًا لتصريحات هيئة الأوراق المالية والبورصات، باستثناء تصريحات الملكية التي نقدمها في مكان آخر.
February 9, 2024 SC 13G/A

AMAM / Ambrx Biopharma Inc. / Artal International S.C.A. - SC 13G/A Passive Investment

SC 13G/A 1 d620387dsc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* (Amendment No. 2) Ambrx Biopharma Cayman, Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Sta

October 23, 2023 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 1

15-12G OMB Approval OMB Number 3235-0167    Expires: July 31, 2024  Estimated average burden hours per response 1.

October 12, 2023 S-8 POS

As filed with the Securities and Exchange Commission on October 12, 2023

As filed with the Securities and Exchange Commission on October 12, 2023 Registration No.

October 12, 2023 EX-3.2

AMENDED AND RESTATED AMBRX BIOPHARMA, INC. A Delaware Corporation Effective October 11, 2023

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF AMBRX BIOPHARMA, INC. A Delaware Corporation Effective October 11, 2023 TABLE OF CONTENTS Page ARTICLE I OFFICES Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II MEETINGS OF STOCKHOLDERS Section 1. Place of Meetings 1 Section 2. Annual Meetings 2 Section 3. Special Meetings 2 Section 4. Nature of Business at Meetings of Stockholders 2

October 12, 2023 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION NEW AMBRX BIOPHARMA INC. Pursuant to Sections 242 and 245 of the Delaware General Corporation Law

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF NEW AMBRX BIOPHARMA INC. Pursuant to Sections 242 and 245 of the Delaware General Corporation Law New Ambrx Biopharma Inc. (the “Corporation”), a Delaware corporation (the “Corporation”), does hereby further certify as follows: (1) The name of the Corporation is New Ambrx Biopharma Inc. (2) The name under which the Corporation was or

October 12, 2023 S-8 POS

As filed with the Securities and Exchange Commission on October 12, 2023

As filed with the Securities and Exchange Commission on October 12, 2023 Registration No.

October 12, 2023 S-8 POS

As filed with the Securities and Exchange Commission on October 12, 2023

S-8 POS 1 d497403ds8pos.htm S-8 POS As filed with the Securities and Exchange Commission on October 12, 2023 Registration No. 333-271966 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Ambrx Biopharma, Inc. (Exact name of registrant as specified in its charter) Delaware 93-289

October 12, 2023 EX-10.1

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT

Exhibit 10.1 AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT This Amended and Restated Executive Employment Agreement (“Agreement”) amends and restates in its entirety that certain Executive Employment Agreement, dated as of [DATE] (the “Previous Employment Agreement”), by and between Ambrx, Inc., a Delaware corporation (the “Company”) and [NAME] (the “Executive”), and is made effective as of

October 12, 2023 S-8 POS

As filed with the Securities and Exchange Commission on October 12, 2023

As filed with the Securities and Exchange Commission on October 12, 2023 Registration No.

October 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2023 (October 11, 202

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 12, 2023 (October 11, 2023) Ambrx Biopharma Cayman, Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of In

October 10, 2023 SC 13G

AMAM / Ambrx Biopharma Inc - ADR / HOPU Reunion Co Ltd - SC 13G Passive Investment

SC 13G 1 ef20012174sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G INFORMATION TO BE INCLUDED IN STATEMENTS PURSUANT TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share (Title of

October 10, 2023 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 10, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission Fi

October 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 6, 2023 Ambrx Biopharma I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 6, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission Fil

September 25, 2023 SC 13G

AMAM / Ambrx Biopharma Inc - ADR / Paradigm Biocapital Advisors LP - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share** (Title of Class of Securities) 02290A102*** (CUSIP Number) September 14, 2023 (Date of Event Which Requires Filing of this statement) Check the appropriate box to designa

September 25, 2023 8-K

Termination of a Material Definitive Agreement, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2023 (September 18, 2023) Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorp

September 25, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm2326849d2ex-1.htm EXHIBIT 99.1 Exhibit 1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the ordinary shares, par value $0.0001 per share, of Ambrx Biopharma Inc., and fur

September 15, 2023 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2023 (September 11, 2023) Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorp

September 15, 2023 EX-2.1

AGREEMENT AND PLAN OF MERGER

Exhibit 2.1 AGREEMENT AND PLAN OF MERGER This AGREEMENT AND PLAN OF MERGER (this “Agreement”) is made and entered into as of September 11, 2023 (the “Effective Date”), by and among Ambrx Biopharma Inc., a Cayman Islands exempted company (“Ambrx”), New Ambrx Biopharma Inc., a Delaware corporation (“Parent”), and Ambrx Merger Sub Inc., a Cayman Islands exempted company and wholly-owned subsidiary of

September 15, 2023 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defi

September 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Ambrx Biopharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission F

August 25, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 25, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission Fil

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001

August 9, 2023 EX-3.2

www.verify.gov.ky File#: 299705

Exhibit 3.2 Registrar of Companies Government Administration Building 133 Elgin Avenue George Town Grand Cayman Ambrx Biopharma Inc. (ROC#299705) (the "Company") TAKE NOTICE that at an Annual General Meeting of the Company held on 7 June 2023, the following resolution was passed: Approval of an increase in the authorized share capital from US$60,000 divided into 600,000,000 shares of US$0.0001 eac

August 9, 2023 EX-4.4

Ambrx Biopharma Inc. - Ordinary Shares (Incorporated under the laws of the Cayman Islands)

Exhibit 4.4 Ambrx Biopharma Inc. - Ordinary Shares (Incorporated under the laws of the Cayman Islands) Number Shares Share Capital is US$105,000 divided into 1,050,000,000 shares consisting of (i) 950,000,000 Ordinary Shares of a par value of US$0.0001 each; (ii) 100,000,000 undesignated shares of a par value of US$0.0001 each, of such class or classes (however designated) as the board of director

August 9, 2023 EX-4.3

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT

Exhibit 4.3 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT Ambrx Biopharma Inc. (“we,” “us,” and “our”) is a Cayman Islands exempted company incorporated in May 2015 with limited liability and our affairs are governed by our memorandum and articles of association, the Companies Act (as amended) of the Cayman Islands (the “Companies Act”), and the common law by the Cayman

June 28, 2023 EX-99.1

Ambrx Announces Closing of $75 Million Market Priced Registered

Exhibit 99.1 Ambrx Announces Closing of $75 Million Market Priced Registered Offering SAN DIEGO, June 27, 2023 - Ambrx Biopharma Inc., or Ambrx (or the “Company”) (NASDAQ: AMAM), today announced the closing of its previously announced market-priced registered direct offering of approximately $75 million (the “Offering”) of its American Depositary Shares of the Company (“ADS”) at a price of $13.93

June 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2023 Ambrx Biopharma Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission File

June 28, 2023 SC 13D/A

AMAM / Ambrx Biopharma Inc - ADR / Darwin Global Management, Ltd. - AMBRX BIOPHARMA INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 2)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, without par value (Title of Class of Securities) 02290A102** (CUSIP Number) Abhishe

June 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 Ambrx Biopharma Inc. (Exact name of Registrant as Specified in Its Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission File N

May 25, 2023 EX-99.1

Ambrx Announces $75 Million Market Priced Registered Offering

EX-99.1 Exhibit 99.1 Ambrx Announces $75 Million Market Priced Registered Offering SAN DIEGO, May 24, 2023 — Ambrx Biopharma Inc., or Ambrx (or the “Company”) (NASDAQ: AMAM), today announced that it has entered into a securities purchase agreement with clients managed by Darwin Global Management Ltd. (“Darwin”) for the sale of an aggregate of approximately 5.4 million American Depositary Shares of

May 25, 2023 EX-10.1

Securities Purchase Agreement, dated as of May 23, 2023, by and between Ambrx Biopharma Inc. and the Purchasers

EX-10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of May 23, 2023, between Ambrx Biopharma Inc., an exempted company incorporated in the Cayman Islands (the “Company”), and the purchasers named on the signature pages hereto (each a “Purchaser” and together, the “Purchasers”). WHEREAS, subject to the terms and conditions set forth i

May 25, 2023 424B5

American Depositary Shares representing Ordinary Shares

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-271008 PROSPECTUS SUPPLEMENT (to Prospectus dated May 2, 2023) $75,000,000 American Depositary Shares representing Ordinary Shares We have entered into a purchase agreement (the “Purchase Agreement”) directly with the investors named on the signature pages thereto (the “Purchasers”) relating to the sale of American Depos

May 25, 2023 SC 13D/A

AMAM / Ambrx Biopharma Inc - ADR / Darwin Global Management, Ltd. - AMBRX BIOPHARMA INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, without par value (Title of Class of Securities) 02290A102** (CUSIP Number) Abhishe

May 25, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2023 Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2023 Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission File N

May 18, 2023 EX-99.1

Ambrx Appoints Stephen Glover as Chairman of its Board of Directors

EX-99.1 Exhibit 99.1 Ambrx Appoints Stephen Glover as Chairman of its Board of Directors SAN DIEGO, May 18, 2023 – Ambrx Biopharma Inc., or Ambrx (NASDAQ: AMAM), today announced that Stephen Glover has joined the Company’s Board of Directors as Chairman. Mr. Glover has extensive experience building successful biopharmaceutical companies, with a focus on pharmaceutical business strategy, corporate

May 18, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

May 18, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 18, 2023 Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 18, 2023 Ambrx Biopharma Inc. (Exact Name of Registrant as Specified in Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission File Numbe

May 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 15, 2023 Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 15, 2023 Ambrx Biopharma Inc. (Exact Name of Registrant as Specified in Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission File Numbe

May 16, 2023 EX-10.1

Amendment to Executive Employment Agreement by and between the Company and Daniel J. O’Connor, dated May 15, 2023

EX-10.1 Exhibit 10.1 AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT THIS AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (this “Amendment”) is entered into and effective as of May 15, 2023, by and between Ambrx, Inc. (the “Company”) and Daniel J. O’Connor (“Executive”). WHEREAS, the Company and Executive have entered into an employment agreement dated as of November 22, 2022 (the “Employment Agreement”);

May 16, 2023 EX-FILING FEES

Filing Fee Exhibit

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Ambrx Biopharma Inc.

May 16, 2023 S-8

Power of Attorney (included on the signature page of this Form S-8).

S-8 As filed with the Securities and Exchange Commission on May 16, 2023. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands Not Applicable (State or other jurisdiction of incorporation or organization)

May 11, 2023 10-Q

Form 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 00

May 4, 2023 EX-10.1

Employment Agreement between Ambrx Biopharma Inc. and Andrew Aromando, dated April 28, 2023

EX-10.1 Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (“Agreement”) is made effective as of April 28, 2023(“Effective Date”), by and between Ambrx, Inc., a Del

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 28, 2023 Ambrx Biopharma In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 28, 2023 Ambrx Biopharma Inc. (Exact Name of Registrant as Specified in Charter) Cayman Islands 001-40505 N/A (State or Other Jurisdiction of Incorporation) (Commission File Num

April 28, 2023 DEF 14A

SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A Table of Contents SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 28, 2023 CORRESP

Ambrx Biopharma Inc. 10975 North Torrey Pines Road La Jolla, California 92037

Ambrx Biopharma Inc. 10975 North Torrey Pines Road La Jolla, California 92037 VIA EDGAR April 28, 2023 U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Cindy Polynice Re: Ambrx Biopharma Inc. Registration Statement on Form S-3 (File No. 333-271008) Request for Acceleration of Effective Date Ladies and Ge

April 27, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc - ADR / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

April 18, 2023 PRE 14A

SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

PRE 14A Table of Contents SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

April 10, 2023 EX-99.1

Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, are forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statem

EX-99.1 Exhibit 99.1 Corporate Presentation April 2023 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, are forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by the use of words such as “believes,” “expects,” “ hopes,” “may,” “wil

April 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 April 10, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 April 10, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission File

April 3, 2023 DEL AM

AMBRX BIOPHARMA INC. 10975 North Torrey Pines Road La Jolla, CA 92037

DEL AM 1 d494386ddelam.htm DEL AM AMBRX BIOPHARMA INC. 10975 North Torrey Pines Road La Jolla, CA 92037 March 31, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Ambrx Biopharma Inc. Registration Statement on Form S-3 (File No. 333-271008) Ladies and Gentlemen: Reference is made to the Registration Statem

March 30, 2023 EX-10

Ambrx Biopharma Inc. Amended and Restated Non-Employee Director Compensation Policy.

Exhibit 10.4 AMBRX BIOPHARMA Inc. Non-Employee Director Compensation Policy Adopted and Effective: June 17, 2021 Amended and Restated: August 15, 2022 (the “Effective Date”) Each member of the Board of Directors (the “Board”) who is not also serving as an employee of or consultant to Ambrx Biopharma Inc. (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will rec

March 30, 2023 10-K

Form 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-405

March 30, 2023 EX-FILING FEES

Filing Fee Exhibit

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Ambrx Biopharma Inc.

March 30, 2023 S-3

As filed with the Securities and Exchange Commission on March 30, 2023

S-3 Table of Contents As filed with the Securities and Exchange Commission on March 30, 2023 Registration No.

March 30, 2023 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Ambrx Biopharma Inc.

March 30, 2023 EX-21

Subsidiaries of the Registrant.

Exhibit 21.1 SUBSIDIARIES OF AMBRX BIOPHARMA INC. Name of Subsidiary Jurisdiction of Incorporation Shanghai Ambrx Biopharma Company Limited China Biolaxy Pharmaceutical Hong Kong Limited Hong Kong Ambrx Australia Pty Limited Australia Ambrx Inc. Delaware

March 30, 2023 EX-4

Description of Securities Registered Under Section 12 of the Exchange Act.

Exhibit 4.3 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT Ambrx Biopharma Inc. (“we,” “us,” and “our”) is a Cayman Islands exempted company incorporated in May 2015 with limited liability and our affairs are governed by our memorandum and articles of association, the Companies Act (as amended) of the Cayman Islands (the “Companies Act”), and the common law by the Cayman

March 30, 2023 EX-10

Amendment to Executive Employment Agreement by and between the Registrant and Sonja Nelson, dated March 8, 2022.

Exhibit 10.17 Ambrx Biopharma, Inc. 10975 Torrey Pines Road La Jolla, CA 92037 March 8, 2022 Sonja Nelson San Diego, CA Dear Sonja: This letter agreement (this “Amendment”) memorializes certain amendments to your executive employment agreement, dated June 4, 2021 (the “Employment Agreement”), between you and Ambrx Biopharma, Inc. (the “Company”), as set forth below. 1. Section 14(a)(ii) of the Emp

March 30, 2023 EX-10

Executive Employment Agreement by and between the Registrant and Dan O'Connor, dated November 1, 2022.

Exhibit 10.15 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (“Agreement”) is made effective as of November 1, 2022 (“Effective Date”), by and between Ambrx, Inc., a Delawar

March 30, 2023 S-8

As filed with the Securities and Exchange Commission on March 30, 2023

S-8 As filed with the Securities and Exchange Commission on March 30, 2023 Registration No.

March 30, 2023 EX-10

Form of Retention Bonus Agreement by and between the Registrant and Sonja Nelson, dated March 8, 2022.

Exhibit 10.18 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. March 8, 2022 Sonja Nelson RE: Retention Agreement Dear Sonja: As an incentive for you to remain with Ambrx Biopharma Inc. (the “Company”), the Company is offering you the opportu

March 16, 2023 EX-99.1

POWER OF ATTORNEY FOR CERTAIN REGULATORY FILINGS INCLUDING CERTAIN FILINGS UNDER THE SECURITIES EXCHANGE ACT OF 1934 AND THE INVESTMENT ADVISERS ACT OF 1940

Exhibit 1 POWER OF ATTORNEY FOR CERTAIN REGULATORY FILINGS INCLUDING CERTAIN FILINGS UNDER THE SECURITIES EXCHANGE ACT OF 1934 AND THE INVESTMENT ADVISERS ACT OF 1940 I, David E.

March 16, 2023 EX-99.2

POWER OF ATTORNEY FOR CERTAIN REGULATORY FILINGS INCLUDING CERTAIN FILINGS UNDER THE SECURITIES EXCHANGE ACT OF 1934 AND THE INVESTMENT ADVISERS ACT OF 1940

Exhibit 2 POWER OF ATTORNEY FOR CERTAIN REGULATORY FILINGS INCLUDING CERTAIN FILINGS UNDER THE SECURITIES EXCHANGE ACT OF 1934 AND THE INVESTMENT ADVISERS ACT OF 1940 I, David E.

March 16, 2023 EX-99.3

JOINT FILING AGREEMENT

Exhibit 3 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, each of the undersigned Reporting Persons hereby agrees to the joint filing, along with all other such Reporting Persons, on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Ordinary shares, $0.

March 16, 2023 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-40505 Ambrx Biopharma Inc.

25 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-40505 Ambrx Biopharma Inc. New York Stock Exchange (Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or registered) 10975 T

March 16, 2023 SC 13G

AMAM / Ambrx Biopharma Inc - ADR / D. E. SHAW & CO, L.P. - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, $0.0001 par value per share (Title of Class of Securities) 02290A102(1) (CUSIP Number) March 6, 2023 (Date of Event Which Requires Filing of this Statement) Check the following box to designate the rule pursuant to which the Schedul

March 16, 2023 8-A12B/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A/A AMENDMENT NO. 1 FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Ambrx Biopharma Inc. (Exact n

8-A12B/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A/A AMENDMENT NO. 1 FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands N/A (State or other jurisdiction of incorporation or organization) (I.R.S. Empl

March 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 March 13, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 March 13, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission File

March 13, 2023 EX-99.1

Ambrx Raises $78 Million and Completes its ATM Program

EX-99.1 Exhibit 99.1 Ambrx Raises $78 Million and Completes its ATM Program SAN DIEGO, March 13, 2023 – Ambrx Biopharma Inc., or Ambrx (NYSE: AMAM), today announced that it has completed net sales of approximately $78 million of American Depositary Shares (“ADSs”) pursuant to the Company’s at-the-market (“ATM”) program established on Aug 5, 2022, through Cowen and Company LLC (“TD Cowen”), acting

March 13, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc - ADR / Cormorant Asset Management, LP - AMENDMENT NO. 3 Passive Investment

SC 13G/A 1 schedule13g.htm AMENDMENT NO. 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 (CUSIP Number) March 3, 2023 (Date of Event which Requires Filing of this Statement) Ch

March 8, 2023 EX-99.1

JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)

EXHIBIT 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k) In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including additional amendments thereto) with respect to the Ordinary Shares of Ambrx Biopharma Inc.. This Joint Filing Agreement shal

March 8, 2023 SC 13D

AMAM / Ambrx Biopharma Inc - ADR / Darwin Global Management, Ltd. - AMBRX BIOPHARMA INC. Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, without par value (Title of Class of Securities) 02290A102** (CUSIP Number) Abhishek T

March 6, 2023 EX-99.1

Ambrx to Commence Trading on Nasdaq Company to Transfer Stock Exchange Listing from NYSE to Nasdaq Ticker symbol will remain “AMAM”

EX-99.1 Exhibit 99.1 Ambrx to Commence Trading on Nasdaq Company to Transfer Stock Exchange Listing from NYSE to Nasdaq Ticker symbol will remain “AMAM” SAN DIEGO, March 6, 2023 —Ambrx Biopharma Inc. (NYSE: AMAM) (“Ambrx” or “the Company”) today announced that it will voluntarily transfer its stock exchange listing to the Nasdaq Stock Market from the New York Stock Exchange, effective March 16, 20

March 6, 2023 8-K

March 6, 2023 and

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 March 5, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission File N

March 3, 2023 SC 13G

AMAM / Ambrx Biopharma Inc - ADR / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 3, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc - ADR / COMMODORE CAPITAL LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 1, 2023 EX-99.1

ACE-Breast-02 Pivotal Phase 3 Study of Ambrx’s ARX788 for the Treatment of HER2 Positive Metastatic Breast Cancer Achieves Positive Results Interim analysis of the ACE-Breast-02 study being conducted by Ambrx’s partner, NovoCodex Biopharmaceuticals,

EX-99.1 Exhibit 99.1 ACE-Breast-02 Pivotal Phase 3 Study of Ambrx’s ARX788 for the Treatment of HER2 Positive Metastatic Breast Cancer Achieves Positive Results Interim analysis of the ACE-Breast-02 study being conducted by Ambrx’s partner, NovoCodex Biopharmaceuticals, was completed by the Independent Data Monitoring Committee (IDMC) The pivotal Phase 3 ACE-Breast-02 study met its pre-specified i

March 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 March 1, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 March 1, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission File N

February 27, 2023 SC 13G

AMAM / Ambrx Biopharma Inc - ADR / Venrock Healthcare Capital Partners III, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) February 16, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate t

February 24, 2023 EX-99.1

Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, are "forward-looking" statements, within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking stat

EX-99.1 Analyst and Investor Day February 24, 2023 Exhibit 99.1 Forward-Looking Statements Certain statements contained in this presentation, other than statements of historical fact, are "forward-looking" statements, within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by the use of words such as “believes,” “expects,” “hopes,” “

February 24, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 22, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 22, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission Fi

February 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 16, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 16, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission Fi

February 17, 2023 EX-99.1

ARX517, Ambrx’s Proprietary Anti-PSMA ADC, Shows Encouraging Single-Agent Safety and Efficacy Data in Patients with Advanced Prostate Cancer

Exhibit 99.1 ARX517, Ambrx’s Proprietary Anti-PSMA ADC, Shows Encouraging Single-Agent Safety and Efficacy Data in Patients with Advanced Prostate Cancer • First clinical data from ongoing Phase 1 dose escalation trial (APEX-01) shows a prostate-specific antigen (PSA) decrease of > 50% reduction in PSA levels from baseline in 3 of 3 patients with metastatic prostate cancer receiving ARX517 at 2.0

February 14, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / Cormorant Asset Management, LP Passive Investment

SC 13G/A 1 schedule13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appr

February 14, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / HBM Healthcare Investments (Cayman) Ltd. - SC 13G/A Passive Investment

SC 13G/A 1 tm235913d2sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement

February 14, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / Darwin Global Management, Ltd. - AMBRX BIOPHARMA INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pur

February 13, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / Artal International S.C.A. - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* (Amendment No. 1) Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to d

February 9, 2023 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / ADAGE CAPITAL PARTNERS GP, L.L.C. - AMBRX BIOPHARMA INC. Passive Investment

SC 13G/A 1 p23-0670sc13ga.htm AMBRX BIOPHARMA INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 ** (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of This Statement)

February 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 6, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 February 6, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission Fil

January 30, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 January 27, 2023 Date of Report (Date of earliest event reported) Ambrx Biopharma Inc. (Exact name of registrant as specified in its charter) Cayman Islands 001-40505 N/A (State or other jurisdiction of incorporation) (Commission Fil

December 19, 2022 SC 13G

AMAM / Ambrx Biopharma Inc. (each representing seven ) / Darwin Global Management, Ltd. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 9, 2022 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuan

December 16, 2022 EX-99.1

–Receipt of NYSE Non-Compliance Letter Regarding –

Exhibit 99.1 ?Receipt of NYSE Non-Compliance Letter Regarding ? San Diego?Ambrx Biopharma Inc. (Ambrx) (NYSE: AMAM), a clinical stage biopharmaceutical company using its proprietary Engineered Precision Biologics platform to create antibody drug conjugates, announced today that it received a notice (the Notice) on November 23, 2022 from the New York Stock Exchange (NYSE) that it was not in complia

December 16, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 16, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc.

6-K 1 d426111d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 16, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant’s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey P

December 13, 2022 EX-99.2

Poster presentation: ACE-Breast-03: Efficacy and safety of ARX788 in patients with HER2+ metastatic breast cancer previously treated with T-DM1.

EX-99.2 Exhibit 99.2 ACE-Breast-03: Efficacy and safety of ARX788 in patients with HER2+ metastatic breast cancer previously PD18-09 treated with T-DM1 Background Demographics Efficacy Results Key Takeaways Safety Results Characteristic Patients (N = 7) Spider Plot for ACE-Breast-03 Safety profile Amplification of the human epidermal growth • ARX788 provided clinical benefit to patients 50% Age fa

December 13, 2022 EX-99.1

Ambrx Announces Encouraging Preliminary Safety and Efficacy Data Evaluating ARX788 in HER2 Positive Metastatic Breast Cancer Patients Who Progressed Following T-DM1 Treatment San Antonio Breast Cancer Symposium 2022 (SABCS) poster – Data to be discus

EX-99.1 Exhibit 99.1 Ambrx Announces Encouraging Preliminary Safety and Efficacy Data Evaluating ARX788 in HER2 Positive Metastatic Breast Cancer Patients Who Progressed Following T-DM1 Treatment San Antonio Breast Cancer Symposium 2022 (SABCS) poster – Data to be discussed in a Spotlight Poster Presentation at the 2022 San Antonio Breast Cancer Symposium – – Preliminary Phase 2 results from ACE-B

December 13, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 13, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc.

6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 13, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant’s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, C

November 1, 2022 EX-99.1

Ambrx Biopharma Inc. Appoints Daniel O’Connor as Chief Executive Officer

Exhibit 99.1 Ambrx Biopharma Inc. Appoints Daniel O?Connor as Chief Executive Officer SAN DIEGO, Calif., November 1, 2022 ? Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today announced the appointment of Daniel O?Connor as Chief Executive Officer. ?On beha

November 1, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 1, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 1, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

October 18, 2022 EX-99.2

Forward-Looking Statements 2 © 2022 Ambrx Biopharma Inc. All rights reserved Certain statements contained in this presentation, other than statements of historical fact, are "forward-looking" statements, within the meaning of the Private Securities L

Strategic Reprioritization and Corporate Update NYSE: AMAM October 2022 Exhibit 99.

October 18, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 18, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 18, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

October 18, 2022 EX-99.1

Ambrx Biopharma Inc. Announces Strategic Reprioritization and Provides Corporate Update - Company now focused on earlier stage engineered antibody drugs for cancer therapies, including new lead asset ARX517 – - Revised focus and projected cost-reduct

Exhibit 99.1 Ambrx Biopharma Inc. Announces Strategic Reprioritization and Provides Corporate Update - Company now focused on earlier stage engineered antibody drugs for cancer therapies, including new lead asset ARX517 ? - Revised focus and projected cost-reductions expected to extend cash runway into 2025 ? - Ambrx to host a conference call today at 5:00 p.m. EDT / 2:00 p.m. PDT - SAN DIEGO, Cal

August 29, 2022 EX-99.1

Ambrx Biopharma Inc. Reports 1H 2022 Financial Results and Provides Corporate Update - Appointed Kate Hermans as Interim Chief Executive Officer –

Exhibit 99.1 Ambrx Biopharma Inc. Reports 1H 2022 Financial Results and Provides Corporate Update - Appointed Kate Hermans as Interim Chief Executive Officer ? SAN DIEGO, Calif., August 29, 2022 ? Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), today provided

August 29, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 29, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 29, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califor

August 29, 2022 EX-99.1

AMBRX BIOPHARMA INC. INDEX TO CONDENSED CONSOLIDATED FINANCIAL

Table of Contents Table of Contents Exhibit 99.1 AMBRX BIOPHARMA INC. INDEX TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Page Condensed Consolidated Balance Sheets (Unaudited) F- 2 Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) F- 3 Condensed Consolidated Statements of Changes in Shareholders? Equity and of Changes in Redeemable Noncontrolling Interests, Conve

August 29, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 2 9 , 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc.

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 2 9 , 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Ro

August 16, 2022 EX-99.1

Ambrx Biopharma Appoints Kate Hermans as Interim CEO, Replacing Feng Tian - Katrin Rupalla, Ph.D., appointed Chair of Ambrx’s Board of Directors - - Ambrx to conduct strategic pipeline review with focus on commercial opportunity and cash runway exten

Exhibit 99.1 Ambrx Biopharma Appoints Kate Hermans as Interim CEO, Replacing Feng Tian - Katrin Rupalla, Ph.D., appointed Chair of Ambrx?s Board of Directors - - Ambrx to conduct strategic pipeline review with focus on commercial opportunity and cash runway extension - - Dr. Tian will continue to be available to Ambrx in an advisory capacity - SAN DIEGO, Calif., August 16, 2022 ? Ambrx Biopharma I

August 16, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 16, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 August 16, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califor

August 5, 2022 424B5

Up to $80,000,000 American Depositary Shares representing Ordinary Shares

Filed Pursuant to Rule 424(b)(5) Registration No. 333-266404 PROSPECTUS Up to $80,000,000 American Depositary Shares representing Ordinary Shares We have entered into a sales agreement, or the sales agreement, with Cowen and Company LLC, or Cowen, relating to the sale of American Depositary Shares, or ADSs, representing ordinary shares. In accordance with the terms of the sales agreement, we may o

August 3, 2022 CORRESP

Ambrx Biopharma Inc. 10975 North Torrey Pines Road La Jolla, California 92037

CORRESP 1 filename1.htm Ambrx Biopharma Inc. 10975 North Torrey Pines Road La Jolla, California 92037 VIA EDGAR August 3, 2022 U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Tim Buchmiller Re: Ambrx Biopharma Inc. Registration Statement on Form F-3 (File No. 333-266404) Request for Acceleration of Effe

July 29, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form F-3 (Form Type) Ambrx Biopharma Inc.

July 29, 2022 EX-1.2

Sales Agreement, dated as of July 29, 2022, by and between the Registrant and Cowen and Company, LLC.

Exhibit 1.2 AMBRX BIOPHARMA INC. $80,000,000 AMERICAN DEPOSITARY SHARES EACH REPRESENTING 7 ORDINARY SHARES SALES AGREEMENT July 29, 2022 Cowen and Company, LLC 599 Lexington Avenue New York, NY 10022 Ladies and Gentlemen: Ambrx Biopharma Inc. (the ?Company?), confirms its agreement (this ?Agreement?) with Cowen and Company, LLC (?Cowen?), as follows: 1. Issuance and Sale of Shares. The Company ag

July 29, 2022 F-3

As filed with the Securities and Exchange Commission on July 29, 2022.

Table of Contents As filed with the Securities and Exchange Commission on July 29, 2022.

July 5, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 July 5, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Tran

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 July 5, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, California

June 6, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 June 6, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Tran

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 June 6, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, California

May 17, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 May 17, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Tran

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 May 17, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, California

April 26, 2022 20-F

Form 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ? REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 26, 2022 EX-FILING FEES

Filing Fee Exhibit

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Ambrx Biopharma Inc.

April 26, 2022 EX-13.2

Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

EX-13.2 Exhibit 13.2 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), Sonja Nelson, Chief Financial Officer of Ambrx Biopharma Inc. (the “Company”), hereby certifies that, to the best o

April 26, 2022 EX-12.2

Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

EX-12.2 Exhibit 12.2 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Sonja Nelson, certify that: 1. I have reviewed this annual report on Form 20-F of Ambrx Biopharma Inc. (the “Company”); 2. Based on my knowledge, this report does not contain any untrue statement of a materia

April 26, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 April 26, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Tr

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 April 26, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Californ

April 26, 2022 EX-15.1

Consent of Independent Registered Public Accounting Firm Deloitte & Touche LLP.

EX-15.1 Exhibit 15.1 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-257264 on Form S-8 of our report dated April 26, 2022, relating to the financial statements of Ambrx Biopharma Inc. appearing in this Annual Report on Form 20-F for the year ended December 31, 2021. /s/ Deloitte & Touche LLP San Diego, Califor

April 26, 2022 S-8

As filed with the Securities and Exchange Commission on April 26, 2022

As filed with the Securities and Exchange Commission on April 26, 2022 Registration No.

April 26, 2022 EX-99.1

Ambrx Biopharma Inc. Reports Full Year 2021 Financial Results; Provides Corporate Update

Exhibit 99.1 Ambrx Biopharma Inc. Reports Full Year 2021 Financial Results; Provides Corporate Update SAN DIEGO, Calif., April 26, 2022 ? Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics, today provided a corporate update and reported financial results for the full ye

April 26, 2022 EX-13.1

Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

EX-13.1 Exhibit 13.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), Feng Tian, Ph.D., President, Chief Executive Officer and Chairman of the Board of Directors of Ambrx Biopharma Inc.

April 26, 2022 EX-12.1

Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

EX-12.1 Exhibit 12.1 CERTIFICATION PURSUANT TO RULES 13a-14(a) AND 15d-14(a) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Feng Tian, Ph.D., certify that: 1. I have reviewed this annual report on Form 20-F of Ambrx Biopharma Inc. (the “Company”); 2. Based on my knowledge, this report does not contain any untrue statement of a mat

April 26, 2022 EX-2.3

Description Of Securities Registered Under Section 12 of the Exchange Act.

Exhibit 2.3 DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT As of December 31, 2021, Ambrx Biopharma Inc., or ?we,? ?us,? and ?our?, had the following series of securities registered pursuant to Section 12(b) of the Securities Exchange Act, as amended, or Exchange Act: Title of each class Trading symbol Name of each exchange on which registered American Depositary Shares

February 14, 2022 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / Cormorant Asset Management, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate th

February 11, 2022 SC 13G/A

AMAM / Ambrx Biopharma Inc. (each representing seven ) / HBM Healthcare Investments (Cayman) Ltd. - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tm226019d4sc13ga.htm SCHEDULE 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ambrx Biopharma Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Sta

February 8, 2022 SC 13G

AMAM / Ambrx Biopharma Inc. (each representing seven ) / WuXi PharmaTech Healthcare Fund I L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

February 7, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 February 7, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 February 7, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

January 18, 2022 SC 13G

AMAM / Ambrx Biopharma Inc. (each representing seven ) / ADAGE CAPITAL PARTNERS GP, L.L.C. - AMBRX BIOPHARMA INC. Passive Investment

SC 13G 1 p21-2786sc13g.htm AMBRX BIOPHARMA INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 ** (CUSIP Number) January 5, 2022 (Date of Event Which Requires Filing of This Statement) Check t

January 4, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 January 4, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 January 4, 2022 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califor

December 9, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 9, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 December 9, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

November 22, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 22, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 22, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Calif

November 8, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 8, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 November 8, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

November 8, 2021 EX-99.1

Forward-Looking Statements © 2021 Ambrx Biopharma Inc. All rights reserved Certain statements contained in this presentation, other than statements of historical fact, are "forward-looking" statements, within the meaning of the Private Securities Lit

Precision Biologics for Life NYSE: AMAM November 2021 Exhibit 99.1 Forward-Looking Statements ? 2021 Ambrx Biopharma Inc. All rights reserved Certain statements contained in this presentation, other than statements of historical fact, are "forward-looking" statements, within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by the use

October 28, 2021 EX-99.1

Ambrx Biopharma Inc. Reports 1H 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 Ambrx Biopharma Inc. Reports 1H 2021 Financial Results and Provides Corporate Update SAN DIEGO, Calif., October 28, 2021 ? Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to discover and develop Engineered Precision Biologics (EPBs), today provided a corporate update and reported financial resu

October 28, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 28, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 28, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

October 28, 2021 EX-99.1

AMBRX BIOPHARMA INC. INDEX TO CONDENSED CONSOLIDATED FINANCIAL Page Condensed Consolidated Balance Sheets (Unaudited) F-2 Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) F-3 Condensed Consolidated Statements of Chan

Exhibit 99.1 AMBRX BIOPHARMA INC. INDEX TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Page Condensed Consolidated Balance Sheets (Unaudited) F-2 Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) F-3 Condensed Consolidated Statements of Changes in Redeemable Noncontrolling Interests, Convertible Preferred Shares and Shareholders? Equity (Deficit) (Unaudited) F-4 Co

October 28, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 28, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 October 28, 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 Torrey Pines Road La Jolla, Califo

October 4, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the Month of October 2021 (Commission File No. 001-40505) Ambrx Bio

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the Month of October 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant?s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975 North Torrey Pines Ro

July 12, 2021 SC 13G

Artal International S.C.A. - SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* (Amendment No. ) Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) June 22, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

July 12, 2021 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 1 JOINT FILING AGREEMENT The undersigned agree that the statement on Schedule 13G with respect to the Ordinary Shares, par value $0.

July 2, 2021 SC 13G

HBM Healthcare Investments (Cayman) Ltd. - SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma, Inc. (Name of Issuer) Ordinary shares, par value $0.0001 per share (Title of Class of Securities) 02290A102** (CUSIP Number) June 22, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

July 2, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of July 2, 2021, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Private Healthcare Fund III, LP, Cormorant Private Healthcare GP III, LLC, Cormorant Asset Management, LP and Bihua Chen (collectively, the ?Filers?). Each of the Filers may be required to file with th

July 2, 2021 SC 13G

Cormorant Asset Management, LP

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Ambrx Biopharma Inc. (Name of Issuer) Ordinary Shares, par value $0.0001 per share (Title of Class of Securities) 02290A102 (CUSIP Number) June 22, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rul

July 2, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the Month of June 2021 (Commission File No. 001-40505) Ambrx Biopha

6-K 1 d188863d6k.htm 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the Month of June 2021 (Commission File No. 001-40505) Ambrx Biopharma Inc. (Translation of registrant’s name into English) Cayman Islands (Jurisdiction of incorporation or organization) 10975

June 22, 2021 EX-4.4

Deposit Agreement between the Registrant and JPMorgan Chase Bank, N.A., as depositary and holders and beneficial owners of the American Depositary Shares.

Exhibit 4.4 TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposited Securities 2 (i) Direct Registration System 2 (j) Holder 2 (k) Securities Act of 1933 2 (l) Securities Exchange Act of 1934 3 (m) Shares

June 22, 2021 S-8

As filed with the Securities and Exchange Commission on June 22, 2021

As filed with the Securities and Exchange Commission on June 22, 2021 Registration No.

June 22, 2021 EX-4.2

Amended and Restated Memorandum and Articles of Association of the Registrant, as currently in effect.

Exhibit 4.2 THE COMPANIES ACT (AS REVISED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF AMBRX BIOPHARMA INC. (Adopted by a Special Resolution passed on April 1, 2021 and effective immediately prior to the completion of the initial public offering of the Company?s American Depositary Shares representing its Ordinary Shares) 1. The name of the Com

June 21, 2021 424B4

7,000,000 American Depositary Shares Representing 49,000,000 Ordinary Shares

Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-256639 7,000,000 American Depositary Shares Representing 49,000,000 Ordinary Shares This is an initial offering of American depositary shares (ADSs), representing ordinary shares of Ambrx Biopharma Inc. We are offering 7,000,000 ADSs. Each ADS represents seven ordinary shares, $0.0001 par value per share. Prior to this offerin

June 15, 2021 CORRESP

AMBRX BIOPHARMA INC. 10975 North Torrey Pines Road La Jolla, California 92037

AMBRX BIOPHARMA INC. 10975 North Torrey Pines Road La Jolla, California 92037 June 15, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Michael Fay Brian Cascio Margaret Schwartz Laura Crotty Re: Ambrx Biopharma Inc. Registration Statement on Form F-1, as amended (File No. 333-256639) Requ

June 15, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(B) OR (G) OF THE SECURITIES EXCHANGE ACT OF 1934 Ambrx Biopharma Inc.

June 15, 2021 CORRESP

[Signature Page Follows]

June 15, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Ambrx Biopharma Inc. Registration Statement on Form F-1 Registration No. 333-256639 Acceleration Request Requested Date: June 17, 2021 Requested Time: 4:00 PM, Eastern Daylight Time Ladies and Gentlemen: In accordance with Rule 461 under the Securities Act o

June 14, 2021 EX-10.18

Ambrx Biopharma Inc. Non-Employee Director Compensation Policy.

Exhibit 10.18 AMBRX BIOPHARMA INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY Each member of the Board of Directors (the ?Board?) who is not also serving as an employee of or consultant to Ambrx Biopharma Inc. (the ?Company?) or any of its subsidiaries (each such member, an ?Eligible Director?) will receive the compensation described in this Non-Employee Director Compensation Policy for his or her

June 14, 2021 EX-99.A

TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposite

Exhibit (a) TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposited Securities 2 (i) Direct Registration System 2 (j) Holder 2 (k) Securities Act of 1933 2 (l) Securities Exchange Act of 1934 3 (m) Shares

June 14, 2021 EX-10.23

Executive Employment Agreement by and between the Registrant and Sonja Nelson, dated June 4, 2021.

Exhibit 10.23 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of June 4, 2021 (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and SONJA NELSON, CPA (?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of a mutually agreed upon date toward

June 14, 2021 EX-1.1

Form of Underwriting Agreement.

Exhibit 1.1 Ambrx Biopharma Inc. American Depositary Shares Underwriting Agreement [?], 2021 Goldman Sachs & Co. LLC, BofA Securities Inc., Cowen and Company, LLC, As representatives of the several Underwriters named in Schedule I hereto, c/o Goldman Sachs & Co. LLC, 200 West Street, New York, New York 10282-2198 c/o BofA Securities, Inc., One Bryant Park, New York, New York 10036 c/o Cowen and Co

June 14, 2021 EX-10.16

Ambrx Biopharma Inc. 2021 Equity Incentive Plan (including Forms of Option Grant Notice, Option Agreement, Notice of Exercise, Restricted Share Unit Award Notice and Restricted Share Unit Award Agreement thereunder).

Table of Contents Exhibit 10.16 AMBRX BIOPHARMA INC. 2021 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: JUNE 3, 2021 APPROVED BY THE SHAREHOLDERS: JUNE 9, 2021 Table of Contents TABLE OF CONTENTS Page 1. GENERAL. 1 2. SHARES SUBJECT TO THE PLAN. 1 3. ELIGIBILITY AND LIMITATIONS. 2 4. OPTIONS AND SHARE APPRECIATION RIGHTS. 3 5. AWARDS OTHER THAN OPTIONS AND SHARE APPRECIATION RIGHTS. 7 6

June 14, 2021 F-6/A

As filed with the U.S. Securities and Exchange Commission on June 14, 2021

As filed with the U.S. Securities and Exchange Commission on June 14, 2021 Registration No. 333-256765 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6/A PRE-EFFECTIVE AMENDMENT NO. 1 TO REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 For Depositary Shares Evidenced by American Depositary Receipts Ambrx Biopharma Inc. (Exact name of issuer of deposited secur

June 14, 2021 EX-4.4

Shareholders Agreement, dated November 6, 2020, by and among the Registrant and the investors named therein.

EX-4.4 4 d108474dex44.htm EX-4.4 Exhibit 4.4 SHAREHOLDERS AGREEMENT SHAREHOLDERS AGREEMENT THIS SHAREHOLDERS AGREEMENT (this “Agreement”) is made and entered into as of November 6, 2020 by and among: 1. Ambrx Biopharma Inc., an exempted company duly incorporated and validly existing under the laws of the Cayman Islands (the “Company”); 2. The person(s) listed on Schedule I hereto (such person(s),

June 14, 2021 EX-10.17

2021 Employee Share Purchase Plan (incorporated herein by reference to Exhibit 10.17 to the Registration Statement on Form F-1, as amended (File No. 333-256639)).

Exhibit 10.17 AMBRX BIOPHARMA INC. 2021 EMPLOYEE SHARE PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: JUNE 3, 2021 APPROVED BY THE SHAREHOLDERS: JUNE 9, 2021 1. GENERAL; PURPOSE. (a) The Plan provides a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase Ordinary Shares. The Plan permits the Company to grant a serie

June 14, 2021 EX-4.1

Registrant’s Specimen Certificate for Ordinary Shares.

Exhibit 4.1 Ambrx Biopharma Inc. - Ordinary Shares (Incorporated under the laws of the Cayman Islands) Number Shares Share Capital is US$60,000 divided into 600,000,000 shares consisting of (i) 500,000,000 Ordinary Shares of a par value of US$0.0001 each; (ii) 100,000,000 undesignated shares of a par value of US$0.0001 each, of such class or classes (however designated) as the board of directors m

June 14, 2021 F-1/A

As filed with the Securities and Exchange Commission on June 14, 2021.

Table of Contents As filed with the Securities and Exchange Commission on June 14, 2021.

June 14, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Sean M. Clayton T: +1 858 550 6034 [email protected] June 14, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Margaret Schwartz and Laura Crotty Re: Ambrx Biopharma Inc. Amendment No. 1 to F-1 Registration Statement Filed May 28, 2021 File No. 333-256639 Ladies and Gentlemen: On behalf of Ambrx Biopharma Inc. (?Ambrx? o

June 4, 2021 EX-99.D

June 3, 2021

Exhibit (d) Troutman Pepper Hamilton Sanders LLP 875 Third Avenue New York, NY 10022 troutman.

June 4, 2021 EX-99.A

TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposite

Exhibit (a) TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposited Securities 2 (i) Direct Registration System 2 (j) Holder 2 (k) Securities Act of 1933 2 (l) Securities Exchange Act of 1934 3 (m) Shares

June 4, 2021 F-6

As filed with the U.S. Securities and Exchange Commission on June 3, 2021

As filed with the U.S. Securities and Exchange Commission on June 3, 2021 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 For Depositary Shares Evidenced by American Depositary Receipts Ambrx Biopharma Inc. (Exact name of issuer of deposited securities as specified in its charter) n/a (Tr

May 28, 2021 EX-4.4

Shareholders Agreement, dated November 6, 2020, by and among the Registrant and the investors named therein.

Exhibit 4.4 SHAREHOLDERS AGREEMENT SHAREHOLDERS AGREEMENT THIS SHAREHOLDERS AGREEMENT (this ?Agreement?) is made and entered into as of November 6, 2020 by and among: 1. Ambrx Biopharma Inc., an exempted company duly incorporated and validly existing under the laws of the Cayman Islands (the ?Company?); 2. The person(s) listed on Schedule I hereto (such person(s), together with the Management Foun

May 28, 2021 EX-10.14

Executive Employment Agreement, by and between the Registrant and Joy Yan, M.D., Ph.D., dated September 25, 2020, as amended.

Exhibit 10.14 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of September 25, 2020, (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and Jinchun (AKA ?Joy?) Yan, MD, PhD (?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of Octoberl9 ,

May 28, 2021 EX-10.12

Executive Employment Agreement, by and between the Registrant and Feng Tian, Ph.D., dated June 19, 2018.

Exhibit 10.12 EXECUTIVE EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this ?Agreement?) is entered into as of June 19, 2018 by and between Ambrx, Inc., a Delaware corporation (the ?Company?) and Feng Tian (the ?Executive?) (collectively the ?Parties?; individually a ?Party?). WHEREAS, the Company is a wholly-owned subsidiary of Ambrx Biopharma Inc., a Cayman corporation (the ?Parent?); WHEREAS,

May 28, 2021 EX-3.1

Amended and Restated Memorandum and Articles of Association of the Registrant, as currently in effect.

Exhibit 3.1 THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION OF AMBRX BIOPHARMA INC. (Adopted by Special Resolution passed on November 4, 2020 and effective from November 6, 2020) THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF A

May 28, 2021 EX-10.7

Collaborative License Agreement, by and between The California Institute for Biomedical Research and Ambrx, Inc., dated as of August 23, 2013, as amended.

Exhibit 10.7 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [****], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. AMENDED AND RESTATED COLLABORATIVE LICENSE AGREEMENT This Amended and Restated Collaborative License Agreement (the ?Agreement?) is entered into and made effective as of October 1

May 28, 2021 EX-10.2

Exclusive License, by and between the Regents of the University of California and Ambrx, Inc., dated as of December 16, 2009.

Exhibit 10.2 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. UNIVERSITY OF CALIFORNIA, BERKELEY OFFICE OF TECHNOLOGY LICENSING EXCLUSIVE LICENSE AGREEMENT FOR CYCLOADDITIONS IN BIOLOGICAL SYSTEMS PROMOTED BY STRAINED II-BONDS UC Case No.: B0

May 28, 2021 EX-10.10

Co-Development and License Agreement, by and between Sino Biopharmaceutical Co, Ltd. and Ambrx, Inc., dated as of January 13, 2020.

Exhibit 10.10 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. CO-DEVELOPMENT AND LICENSE AGREEMENT between SINO BIOPHARMACEUTICAL CO., LTD. and AMBRX, INC. Dated as of January 13, 2020 1 This CO-DEVELOPMENT AND LICENSE AGREEMENT (this ?Agree

May 28, 2021 EX-10.1

License Agreement, by and between The Scripps Research Institute and Ambrx, Inc., dated as of August 26, 2003, as amended.

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. LICENSE AGREEMENT This License Agreement is entered into and made effective as of this 26th day of August, 2003 (the ?Effective Date?), by and between THE SCRIPPS RESEARCH INSTITUT

May 28, 2021 EX-10.19

Lease Agreement, by and between Ambrx, Inc. and ARE-10933 North Torrey Pines, LLC, dated March 15, 2005.

Exhibit 10.19 LEASE AGREEMENT THIS LEASE AGREEMENT is made this 15th day of March, 2005, between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). Address: 10975 North Torrey Pines Road, La Jolla, California Premises: That portion of the Building (as defined below), containing approximately 36,058 rentable squa

May 28, 2021 EX-10.20

First Amendment to Lease Agreement, by and between Ambrx, Inc. and ARE-10933 North Torrey Pines, LLC, dated May 19, 2005.

Exhibit 10.20 FIRST AMENDMENT TO LEASE AGREEMENT THIS FIRST AMENDMENT TO LEASE AGREEMENT (this ?First Amendment?) is made as of May 19, 2005, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated as of March 15, 2005 (t

May 28, 2021 EX-10.21

Second Amendment to Lease Agreement, by and between Ambrx, Inc. and ARE-10933 North Torrey Pines, LLC, dated December 1, 2011.

Exhibit 10.21 SECOND AMENDMENT TO LEASE THIS SECOND AMENDMENT TO LEASE (this ?Second Amendment?) is made as of December 1, 2011, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated as of March 15, 2005, as amended by

May 28, 2021 EX-10.3

Collaboration and License Agreement, by and between Bristol-Myers Squibb Company and Ambrx, Inc., dated as of September 21, 2011.

Exhibit 10.3 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. COLLABORATION AND LICENSE AGREEMENT (Relaxin) This Collaboration and License Agreement (the ?Agreement?) is made and entered into effective as of September 21, 2011 (the ?Effective

May 28, 2021 EX-10.9

Co-Development and License Agreement, by and between Novocodex Biopharmaceuticals Ltd. and Ambrx, Inc., dated as of October 22, 2019.

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. CO-DEVELOPMENT AND LICENSE AGREEMENT among NOVOCODEX BIOPHARMACEUTICALS LTD. and AMBRX, INC. Dated as of 22 October, 2019 1 This CO-DEVELOPMENT AND LICENSE AGREEMENT (this ?Agreeme

May 28, 2021 EX-4.2

Form of American Depositary Receipt evidencing American Depositary Shares (included in Exhibit 4.2).

Exhibit 4.2 TABLE OF CONTENTS Page PARTIES 1 RECITALS 1 Section 1. Certain Definitions (a) ADR Register 1 (b) ADRs; Direct Registration ADRs 1 (c) ADS 1 (d) Beneficial Owner 1 (e) Custodian 2 (f) Deliver, execute, issue et al. 2 (g) Delivery Order 2 (h) Deposited Securities 2 (i) Direct Registration System 2 (j) Holder 2 (k) Securities Act of 1933 2 (l) Securities Exchange Act of 1934 3 (m) Shares

May 28, 2021 EX-10.15

Ambrx Biopharma Inc. Amended and Restated Share Incentive Plan (including notice of grant, notice of exercise and option purchase agreement).

Exhibit 10.15 AMBRX BIOPHARMA SHARE INCENTIVE PLAN (As Amended and Restated effective August 2, 2019, and further amended November 6, 2020 and February 7, 2021) ARTICLE 1. PURPOSE The purpose of the Ambrx Biopharma Share Incentive Plan (the ?Plan?) is to enable Ambrx Biopharma, Inc., a Cayman Island company (the ?Company?) to attract and retain the services of employees, consultants and members of

May 28, 2021 EX-10.4

Collaboration and License Agreement, by and between Bristol-Myers Squibb Company and Ambrx, Inc., dated as of September 21, 2011.

Exhibit 10.4 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. COLLABORATION AND LICENSE AGREEMENT (FGF21) THIS COLLABORATION AND LICENSE AGREEMENT (the ?Agreement?) is made and entered into effective as of September 21, 2011 (the ?Effective D

May 28, 2021 EX-10.6

Co-Development and License Agreement, by and between Zhejiang Medicine Co, Ltd. and Ambrx, Inc., dated as of June 14, 2013.

Exhibit 10.6 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. CO-DEVELOPMENT AND LICENSE AGREEMENT Between Zhejiang Medical Corporation and AMBRX, INC. Dated as of June 14, 2013 CO-DEVELOPMENT AND LICENSE AGREEMENT This CO-DEVELOPMENT AND LIC

May 28, 2021 F-1

Form F-1

Table of Contents As filed with the Securities and Exchange Commission on May 28, 2021.

May 28, 2021 EX-10.8

Collaboration and Exclusive License Agreement, by and between BeiGene, Ltd. and Ambrx, Inc., dated as of March 4, 2019.

Exhibit 10.8 CONFIDENTIAL EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT THIS COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT (this ?Agreement?) is made and entered into effectiv

May 28, 2021 EX-10.5

Research Collaboration and Exclusive License Agreement, by and between Agensys, Inc. and Ambrx, Inc., dated as of April 1, 2013.

Exhibit 10.5 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT THIS RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT (this ?Agreement?), effective as of April 1, 2013 (the ?Effective

May 28, 2021 EX-10.11

Form of Indemnification Agreement, by and between the Registrant and each of its executive officers and directors.

Exhibit 10.11 AMBRX BIOPHARMA INC. INDEMNIFICATION AGREEMENT This Indemnification Agreement (this ?Agreement?) is made as of , by and between Ambrx Biopharma Inc., an exempted company incorporated and existing under the laws of the Cayman Islands (the ?Company?), and [Name of Director/Officer] ([US passport/ID]:[*]) WHEREAS, the Indemnitee has agreed to serve as a director or officer of the Compan

May 28, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Sean M. Clayton T: +1 858 550 6034 [email protected] May 28, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Margaret Schwartz and Laura Crotty Re: Ambrx Biopharma Inc. Amendment No. 1 to Draft Registration Statement on Form F-1 Filed March 15, 2021 File No. 0001836056 Ladies and Gentlemen: On behalf of Ambrx Biopharma

May 28, 2021 EX-10.13

Executive Employment Agreement, by and between the Registrant and Simon Allen, dated March 20, 2019.

Exhibit 10.13 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of 20 March, 2019 (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and Simon Allen (?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of March 29, 2019 (the ?Employment Commen

May 28, 2021 EX-3.2

Amended and Restated Memorandum and Articles of Association of the Registrant, as currently in effect.

Exhibit 3.2 THE COMPANIES ACT (AS REVISED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF AMBRX BIOPHARMA INC. (Adopted by a Special Resolution passed on 2021 and effective immediately prior to the completion of the initial public offering of the Company?s American Depositary Shares representing its Ordinary Shares) 1. The name of the Company is A

May 28, 2021 EX-21.1

Subsidiaries of the Registrant.

Exhibit 21.1 SUBSIDIARIES OF AMBRX BIOPHARMA INC. Name of Subsidiary Jurisdiction of Incorporation Shanghai Ambrx Biomedical Co., Ltd. Biolaxy Pharmaceutical Hong Kong Limited Ambrx Australia Pty Limited Ambrx Inc. China Honk Kong Australia Delaware

May 28, 2021 EX-10.22

Third Amendment to Lease Agreement, by and between Ambrx, Inc. and ARE-10933 North Torrey Pines, LLC, dated July 28, 2016.

Exhibit 10.22 THIRD AMENDMENT TO LEASE THIS THIRD AMENDMENT TO LEASE (this ?Third Amendment?) is made as of July 28, 2016 (?Effective Date?), by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated March 15, 2005, as amen

March 15, 2021 EX-10.5

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT

Exhibit 10.5 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT THIS RESEARCH COLLABORATION AND EXCLUSIVE LICENSE AGREEMENT (this ?Agreement?), effective as of April 1, 2013 (the ?Effective Date?), by a

March 15, 2021 EX-10.3

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. COLLABORATION AND LICENSE AGREEMENT (Relaxin)

Exhibit 10.3 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. COLLABORATION AND LICENSE AGREEMENT (Relaxin) This Collaboration and License Agreement (the ?Agreement?) is made and entered into effective as of September 21, 2011 (the ?Effective Date?) by an

March 15, 2021 EX-10.1

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. LICENSE AGREEMENT

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. LICENSE AGREEMENT This License Agreement is entered into and made effective as of this 26th day of August, 2003 (the ?Effective Date?), by and between THE SCRIPPS RESEARCH INSTITUTE, a Californ

March 15, 2021 EX-10.6

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. CO-DEVELOPMENT AND LICENSE AGREEMENT Zhejiang Medical Co

Exhibit 10.6 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. CO-DEVELOPMENT AND LICENSE AGREEMENT Between Zhejiang Medical Corporation and AMBRX, INC. Dated as of June 14, 2013 CO-DEVELOPMENT AND LICENSE AGREEMENT This CO-DEVELOPMENT AND LICENSE AGREEMEN

March 15, 2021 EX-10.7

AMENDED AND RESTATED COLLABORATIVE LICENSE AGREEMENT

Exhibit 10.7 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [****], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. AMENDED AND RESTATED COLLABORATIVE LICENSE AGREEMENT This Amended and Restated Collaborative License Agreement (the ?Agreement?) is entered into and made effective as of October 10, 2014 (the

March 15, 2021 EX-10.4

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. COLLABORATION AND LICENSE AGREEMENT (FGF21)

Exhibit 10.4 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. COLLABORATION AND LICENSE AGREEMENT (FGF21) THIS COLLABORATION AND LICENSE AGREEMENT (the ?Agreement?) is made and entered into effective as of September 21, 2011 (the ?Effective Date?) by and

March 15, 2021 EX-10.9

CO-DEVELOPMENT AND LICENSE AGREEMENT NOVOCODEX BIOPHARMACEUTICALS LTD. AMBRX, INC. Dated as of 22 October, 2019

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. CO-DEVELOPMENT AND LICENSE AGREEMENT among NOVOCODEX BIOPHARMACEUTICALS LTD. and AMBRX, INC. Dated as of 22 October, 2019 1 This CO-DEVELOPMENT AND LICENSE AGREEMENT (this ?Agreement?), effecti

March 15, 2021 DRS/A

As confidentially submitted to the Securities and Exchange Commission on March 12, 2021 as Amendment No. 1 to the confidentially submitted draft registration statement. This draft registration statement has not been publicly filed with the Securities

Table of Contents As confidentially submitted to the Securities and Exchange Commission on March 12, 2021 as Amendment No.

March 12, 2021 DRSLTR

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Sean M. Clayton T: +1 858 550 6034 [email protected] March 12, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Michael Fay and Brian Cascio Re: Ambrx Biopharma Inc. Draft Registration Statement on Form F-1 Filed February 3, 2021 File No. 0001836056 Ladies and Gentlemen: On behalf of Ambrx Biopharma Inc. (“Ambrx” or the

February 3, 2021 EX-3.1

THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION AMBRX BIOPHARMA INC. (Adopted by Special Resolution passed on November 4, 2020 and effective from November 6, 2

Exhibit 3.1 THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM AND ARTICLES OF ASSOCIATION OF AMBRX BIOPHARMA INC. (Adopted by Special Resolution passed on November 4, 2020 and effective from November 6, 2020) THE COMPANIES LAW (AS AMENDED) OF THE CAYMAN ISLANDS COMPANY LIMITED BY SHARES AMENDED AND RESTATED MEMORANDUM OF ASSOCIATION OF A

February 3, 2021 EX-10.20

LEASE AGREEMENT

Exhibit 10.20 LEASE AGREEMENT THIS LEASE AGREEMENT is made this 15th day of March, 2005, between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). Address: 10975 North Torrey Pines Road, La Jolla, California Premises: That portion of the Building (as defined below), containing approximately 36,058 rentable squa

February 3, 2021 EX-10.14

EXECUTIVE EMPLOYMENT AGREEMENT

Exhibit 10.14 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of September 25, 2020, (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and Jinchun (AKA ?Joy?) Yan, MD, PhD (?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of Octoberl9 ,

February 3, 2021 EX-10.22

SECOND AMENDMENT TO LEASE

Exhibit 10.22 SECOND AMENDMENT TO LEASE THIS SECOND AMENDMENT TO LEASE (this ?Second Amendment?) is made as of December 1, 2011, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated as of March 15, 2005, as amended by

February 3, 2021 EX-10.13

EXECUTIVE EMPLOYMENT AGREEMENT

Exhibit 10.13 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of 20 March, 2019 (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and Simon Allen (?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of March 29, 2019 (the ?Employment Commen

February 3, 2021 EX-10.12

EXECUTIVE EMPLOYMENT AGREEMENT

Exhibit 10.12 EXECUTIVE EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this ?Agreement?) is entered into as of June 19, 2018 by and between Ambrx, Inc., a Delaware corporation (the ?Company?) and Feng Tian (the ?Executive?) (collectively the ?Parties?; individually a ?Party?). WHEREAS, the Company is a wholly-owned subsidiary of Ambrx Biopharma Inc., a Cayman corporation (the ?Parent?); WHEREAS,

February 3, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on February 3, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confident

Table of Contents As confidentially submitted to the Securities and Exchange Commission on February 3, 2021.

February 3, 2021 EX-10.23

THIRD AMENDMENT TO LEASE

Exhibit 10.23 THIRD AMENDMENT TO LEASE THIS THIRD AMENDMENT TO LEASE (this ?Third Amendment?) is made as of July 28, 2016 (?Effective Date?), by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated March 15, 2005, as amen

February 3, 2021 EX-4.4

SHAREHOLDERS AGREEMENT

Exhibit 4.4 SHAREHOLDERS AGREEMENT SHAREHOLDERS AGREEMENT THIS SHAREHOLDERS AGREEMENT (this ?Agreement?) is made and entered into as of November 6, 2020 by and among: 1. Ambrx Biopharma Inc., an exempted company duly incorporated and validly existing under the laws of the Cayman Islands (the ?Company?); 2. The person(s) listed on Schedule I hereto (such person(s), together with the Management Foun

February 3, 2021 EX-10.15

EXECUTIVE EMPLOYMENT AGREEMENT

Exhibit 10.15 EXECUTIVE EMPLOYMENT AGREEMENT This Executive Employment Agreement (?Agreement?) is made effective as of December 16, 2020 (?Effective Date?), by and between Ambrx, Inc., a Delaware corporation (the ?Company?), and GARY YEUNG, MBA, CFA(?Executive?). The parties agree as follows: 1. Employment. The Company hereby employs Executive commencing effective as of December 16, 2020 (the ?Emp

February 3, 2021 EX-10.21

FIRST AMENDMENT TO LEASE AGREEMENT

Exhibit 10.21 FIRST AMENDMENT TO LEASE AGREEMENT THIS FIRST AMENDMENT TO LEASE AGREEMENT (this ?First Amendment?) is made as of May 19, 2005, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and AMBRX, INC., a Delaware corporation (?Tenant?). RECITALS A. Landlord and Tenant are parties to that certain Lease Agreement dated as of March 15, 2005 (t

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