Market Value1,818,287,000
Total Holdings314
File Date2016-02-16
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
AGIO / Agios Pharmaceuticals, Inc. Call
AGIO / Agios Pharmaceuticals, Inc.
AGIO / Agios Pharmaceuticals, Inc. Put
NURO / NeuroMetrix, Inc.
ALBO / Albireo Pharma Inc Put
ALBO / Albireo Pharma Inc
ADVM / Adverum Biotechnologies, Inc.
GWP / GW Pharmaceuticals plc
NVAX / Novavax, Inc. Put
/ Ceres, Inc.
PRGO / Perrigo Company plc Call
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated Put
SCON / Superconductor Technologies Inc.
WINT / Windtree Therapeutics, Inc.
EXEL / Exelixis, Inc. Put
PBYI / Puma Biotechnology, Inc. Call
PRSN / Perseon Corporation
MTEM / Molecular Templates, Inc. Call
IDRA / Idera Pharmaceuticals, Inc.
ISEE / IVERIC bio Inc Call
CSLT / Castlight Health Inc - Class B
CYTR / LadRx Corp Call
CYTR / LadRx Corp
NLTX / Neoleukin Therapeutics, Inc.
SPDR SERIES TRUST / S&P BIOTECH Put (78464A950)
NDRM / NeuroDerm Ltd. Put
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
FOLD / Amicus Therapeutics, Inc.
CYTX / Cytori Therapeutics, Inc.
NTRA / Natera, Inc.
WGBS / WaferGen Bio-Systems, Inc.
NUVA / Nuvasive Inc
ITCI / Intra-Cellular Therapies, Inc. Put
MGNX / MacroGenics, Inc. Put
DERM / Journey Medical Corporation
OEF / iShares Trust - iShares S&P 100 ETF Put
ABUS / Arbutus Biopharma Corporation
UTHR / United Therapeutics Corporation Call
UTHR / United Therapeutics Corporation Put
BDSI / Biodelivery Sciences International
BDSI / Biodelivery Sciences International Put
ACER / Acer Therapeutics Inc
CSLT / Castlight Health Inc - Class B Call
NVRO / Nevro Corp. Put
SKY / Champion Homes, Inc.
THMO / ThermoGenesis Holdings, Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
RLYP / Relypsa, Inc.
APDNW / Applied DNA Sciences, Inc., Warrants
US0153511094 / Alexion Pharmaceuticals, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc. Call
US0153511094 / Alexion Pharmaceuticals, Inc. Put
LUMO / Lumos Pharma, Inc.
LUMO / Lumos Pharma, Inc. Put
ADVM / Adverum Biotechnologies, Inc. Call
ADVM / Adverum Biotechnologies, Inc. Put
CYH / Community Health Systems, Inc.
TROV / TrovaGene, Inc. Call
OPK / OPKO Health, Inc.
OPK / OPKO Health, Inc. Call
ENDP / Endo International plc Put
032420101 / Anacor Pharmaceuticals, Inc.
032420101 / Anacor Pharmaceuticals, Inc. Put
SESN / Sesen Bio Inc.
RPTP / Raptor Pharmaceutical Corp. Call
RPTP / Raptor Pharmaceutical Corp. Put
IDRA / Idera Pharmaceuticals, Inc. Call
IDRA / Idera Pharmaceuticals, Inc. Put
607355906 / China Mobile Ltd. Call
ZSAN / Zosano Pharma Corp
SIOX / Sio Gene Therapies Inc.
CASI / CASI Pharmaceuticals, Inc.
ENDP / Endo International plc
BMRN / BioMarin Pharmaceutical Inc. Call
BMRN / BioMarin Pharmaceutical Inc. Put
ZSPH / ZS Pharma, Inc.
ZSPH / ZS Pharma, Inc. Put
ZSPH / ZS Pharma, Inc. Call
INO / Inovio Pharmaceuticals, Inc. Call
MDGN.WS / Medgenics, Inc., Warrant
FGEN / FibroGen, Inc.
ACRX / Talphera, Inc. Call
ADXS / Ayala Pharmaceuticals, Inc.
CYTK / Cytokinetics, Incorporated Call
ONCS / OncoSec Medical Inc
PCRX / Pacira BioSciences, Inc.
PCRX / Pacira BioSciences, Inc. Call
RNVA / Rennova Health, Inc.
CLDX / Celldex Therapeutics, Inc. Call
CLDX / Celldex Therapeutics, Inc. Put
FOLD / Amicus Therapeutics, Inc. Call
FOLD / Amicus Therapeutics, Inc. Put
MDCO / Medicines Company Call
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
0PP / Portola Pharmaceuticals Inc Put
032420101 / Anacor Pharmaceuticals, Inc. Call
ACAD / ACADIA Pharmaceuticals Inc.
MBLY / Mobileye Global Inc.
MBLY / Mobileye Global Inc. Call
MBLY / Mobileye Global Inc. Put
AVDL / Avadel Pharmaceuticals plc Put
ITCI / Intra-Cellular Therapies, Inc. Call
IOC / InterOil Corporation
ALPN / Alpine Immune Sciences, Inc.
NVRO / Nevro Corp. Call
/ Zephyr Energy PLC
ABUS / Arbutus Biopharma Corporation Call
NDRM / NeuroDerm Ltd.
DERM / Journey Medical Corporation Put
PVCT / Provectus Biopharmaceuticals, Inc.
ECYT / Endocyte, Inc.
MNOV / MediciNova, Inc.
NONOF / Novo Nordisk A/S Call
91911K102 / Bausch Health Companies Put
ONCE / Spark Therapeutics, Inc. Put
HTWR / Heartware International Inc. Put
CEMP / Cempra, Inc. Call
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019
US88165N2045 / Tetraphase Pharmaceuticals, Inc.
OASM / Oasmia Pharmaceutical AB
ATRS / Antares Pharma Inc
MTEM / Molecular Templates, Inc.
ONCE / Spark Therapeutics, Inc. Call
SPNC / Spectranetics Corp. (The) Call
NUROW / NeuroMetrix, Inc. Warrants
LJPC / La Jolla Pharmaceutical Co.
PRSNW / Perseon Corporation Warrants
KITE / Kite Pharma, Inc. Put
PHG / Koninklijke Philips N.V. - Depositary Receipt (Common Stock) Call
ASRT / Assertio Holdings, Inc. Put
US00C4U1L353 / Mylan N.V.
US60877T1007 / Momenta Pharmaceuticals, Inc.
US60877T1007 / Momenta Pharmaceuticals, Inc. Call
PSDV / pSivida Corp. Put
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
HZNP / Horizon Therapeutics Plc
HZNP / Horizon Therapeutics Plc Put
KERX / Keryx Biopharmaceuticals, Inc. Put
ZLTQ / ZELTIQ Aesthetics, Inc.
BMRN / BioMarin Pharmaceutical Inc.
BIIB / Biogen Inc.
BIIB / Biogen Inc. Put
BIIB / Biogen Inc. Call
ZGNX / Zogenix Inc Call
MLNT / Melinta Therapeutics, Inc.
584688AC9 / Medicines Company 1.375% Bond due 2017-06-01
RGNX / REGENXBIO Inc.
FWP / Forward Pharma A/S - ADR
US00C4U1L353 / Mylan N.V. Call
AVDL / Avadel Pharmaceuticals plc
91911K102 / Bausch Health Companies
GMED / Globus Medical, Inc.
IMDZ / Immune Design Corp.
NONOF / Novo Nordisk A/S Put
MACK / Merrimack Pharmaceuticals, Inc. Call
NSPH / Nanosphere, Inc.
BNTCW / Benitec Biopharma Ltd
OCAT / Ocata Therapeutics, Inc. Put
THC / Tenet Healthcare Corporation
49803V115 / Kitov Pharamceuticals Holdings Ltd.
RENNOVA HEALTH INC. WARRANTS / *W (759757115)
CNAT / Conatus Pharmaceuticals Inc.
BIOL / BIOLASE, Inc.
AOXG / Aoxing Pharmaceutical Company, Inc.
ARCT / Arcturus Therapeutics Holdings Inc.
AERI / Aerie Pharmaceuticals Inc Call
RLYP / Relypsa, Inc. Call
LUMO / Lumos Pharma, Inc. Call
IOVA / Iovance Biotherapeutics, Inc. Call
CEMP / Cempra, Inc. Put
09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018
US00484MAA45 / Acorda Therapeutics, Inc. Bond 1.750% 6/1
RGLS / Regulus Therapeutics Inc. Put
FOMX / Foamix Pharmaceuticals Ltd.
DXTR / Dextera Surgical Inc.
ACERW / Acer Therapeutics Inc. Warrant
OCRX / Ocera Therapeutics, Inc.
ADHD / Alcobra Ltd. Call
ATRS / Antares Pharma Inc Call
TROV / TrovaGene, Inc.
FLDM / Standard BioTools Inc
KITE / Kite Pharma, Inc.
VASC / Vascular Solutions, Inc.
POZN / Pozen, Inc.
US00C4U1L353 / Mylan N.V. Put
HTWR / Heartware International Inc.
REEMF / Rare Element Resources Ltd.
ANTH / Anthera Pharmaceuticals, Inc. Call
EXEL / Exelixis, Inc. Call
FLDM / Standard BioTools Inc Call
THC / Tenet Healthcare Corporation Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
CYNA / Cynapsus Therapeutics Inc.
TTHI / Transition Therapeutics Inc.
QRHC / Quest Resource Holding Corporation
IOVA / Iovance Biotherapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Call
ZLTQ / ZELTIQ Aesthetics, Inc. Call
BDSI / Biodelivery Sciences International Call
GMED / Globus Medical, Inc. Put
76028H209 / Repros Therapeutics, Inc. Put
RGLS / Regulus Therapeutics Inc. Call
COLLABRX ORD SHS / (19422J108)
CSBR / Champions Oncology, Inc.
RGLS / Regulus Therapeutics Inc.
NVRO / Nevro Corp.
HALO / Halozyme Therapeutics, Inc. Call
HALO / Halozyme Therapeutics, Inc. Put
PGNX / Progenics Pharmaceuticals, Inc. Call
QURE / uniQure N.V.
IOC / InterOil Corporation Put
US29266S3040 / Endologix, Inc.
UTHR / United Therapeutics Corporation
EXAS / Exact Sciences Corporation Put
EXAS / Exact Sciences Corporation
MGNX / MacroGenics, Inc. Call
APEN / Apollo Endosurgery Inc
451731103 / Ignyta, Inc.
PRTK / Paratek Pharmaceuticals Inc.
REGN / Regeneron Pharmaceuticals, Inc.
REGN / Regeneron Pharmaceuticals, Inc. Put
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RDUS / Radius Recycling, Inc.
RDUS / Radius Recycling, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc.
BLCM / Bellicum Pharmaceuticals, Inc. Put
RMTI / Rockwell Medical, Inc.
RMTI / Rockwell Medical, Inc. Put
NUVA / Nuvasive Inc Call
LLY / Eli Lilly and Company Call
LLY / Eli Lilly and Company Put
OTLC / Oncotelic Therapeutics, Inc.
PXD / Pioneer Natural Resources Company Put
ADAP / Adaptimmune Therapeutics plc - Depositary Receipt (Common Stock)
09074D103 / Biotie Therapies Corp.
OCUL / Ocular Therapeutix, Inc.
OCUL / Ocular Therapeutix, Inc. Call
QURE / uniQure N.V. Call
QURE / uniQure N.V. Put
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Call
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Put
FEIC / FEI Company Call
ASRT / Assertio Holdings, Inc. Call
ASRT / Assertio Holdings, Inc.
VASC / Vascular Solutions, Inc. Put
LCI / Lannett Co., Inc. Call
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
GALT / Galectin Therapeutics Inc.
PATI / Patriot Transportation Holding, Inc.
BCLI / Brainstorm Cell Therapeutics Inc.
CAPR / Capricor Therapeutics, Inc.
RIBT / RiceBran Technologies
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
BNTC / Benitec Biopharma Inc.
CYCC / Cyclacel Pharmaceuticals, Inc.
DYAX / Dyax Corp.
DYAX / Dyax Corp. Put
ALDX / Aldeyra Therapeutics, Inc.
TBRA / Tobira Therapeutics, Inc.
INO / Inovio Pharmaceuticals, Inc.
ALKS / Alkermes plc Put
IPCI / Intellipharmaceutics International Inc. Put
PXD / Pioneer Natural Resources Company
ABEO / Abeona Therapeutics Inc.
TPST / Tempest Therapeutics, Inc. Put
TPST / Tempest Therapeutics, Inc. Call
AGTC / Applied Genetic Technologies Corp
MCRB / Seres Therapeutics, Inc.
MCRB / Seres Therapeutics, Inc. Call
ASXC / Asensus Surgical, Inc.
CELG / Celgene Corp. Call
LRMR / Larimar Therapeutics, Inc. Call
LRMR / Larimar Therapeutics, Inc. Put
HCMC / Healthier Choices Management Corp.
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
IONS / Ionis Pharmaceuticals, Inc. Call
PIRS / Pieris Pharmaceuticals, Inc.
GNCA / Genocea Biosciences Inc
ADMS / Adamas Pharmaceuticals Inc Call
ADMS / Adamas Pharmaceuticals Inc
IMUC / EOM Pharmaceuticals Holdings, Inc.
BCS / Barclays PLC - Depositary Receipt (Common Stock) Call
ENDP / Endo International plc Call
TXMD / TherapeuticsMD, Inc. Call
TXMD / TherapeuticsMD, Inc. Put
CDTX / Cidara Therapeutics, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Put
AEZS / COSCIENS Biopharma Inc.
VRTX / Vertex Pharmaceuticals Incorporated
VRTX / Vertex Pharmaceuticals Incorporated Call
MEIP / MEI Pharma, Inc.
0PP / Portola Pharmaceuticals Inc
0PP / Portola Pharmaceuticals Inc Call
XOMA / XOMA Royalty Corporation Call
CBPO / China Biologic Products Holdings Inc
INFI / Infinity Pharmaceuticals Inc.
INFI / Infinity Pharmaceuticals Inc. Call
INFI / Infinity Pharmaceuticals Inc. Put
PGEN / Precigen, Inc. Call
ORMP / Oramed Pharmaceuticals Inc.
CYTK / Cytokinetics, Incorporated Put
US0325111070 / Anadarko Petroleum Corp.
US0325111070 / Anadarko Petroleum Corp. Put
NVAX / Novavax, Inc.
BCRX / BioCryst Pharmaceuticals, Inc.
BCRX / BioCryst Pharmaceuticals, Inc. Put
GILD / Gilead Sciences, Inc.
ASXC / Asensus Surgical, Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc.
BLCM / Bellicum Pharmaceuticals, Inc. Call
ADXS / Ayala Pharmaceuticals, Inc. Put
EW / Edwards Lifesciences Corporation
TNXP / Tonix Pharmaceuticals Holding Corp.
PBYI / Puma Biotechnology, Inc.
PBYI / Puma Biotechnology, Inc. Put
TSRO / TESARO, Inc.
TSRO / TESARO, Inc. Put
VYNT / Vyant Bio, Inc.
PGEN / Precigen, Inc. Put
GILD / Gilead Sciences, Inc. Call
GILD / Gilead Sciences, Inc. Put
DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock)
HCA / HCA Healthcare, Inc. Call
EW / Edwards Lifesciences Corporation Put
PGEN / Precigen, Inc.
OCGN / Ocugen, Inc.
CLVS / Clovis Oncology Inc
CLVS / Clovis Oncology Inc Call
GBT / Global Blood Therapeutics Inc.
ALQA / Alliqua, Inc.
ABBV / AbbVie Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
CLSN / Imunon Inc
PSTI / Pluristem Therapeutics Inc
POAI / Predictive Oncology Inc.
ACUR / Acura Pharmaceuticals, Inc.
NVAX / Novavax, Inc. Call
NHWK / NightHawk Biosciences, Inc.
THC / Tenet Healthcare Corporation Put
PTCT / PTC Therapeutics, Inc.
MRTX / Mirati Therapeutics, Inc.
IL0011177958 / Intec Pharma Ltd
SKBI / Skystar Bio-Pharmaceutical Company
CTIC / CTI BioPharma Corp
CTIC / CTI BioPharma Corp Call
TTOO / T2 Biosystems, Inc.
OPK / OPKO Health, Inc. Put
CJJD / China Jo-Jo Drugstores, Inc.
HCMC / Healthier Choices Management Corp.
NVIV / InVivo Therapeutics Holdings Corp. Call
IMUX / Immunic, Inc. Call
IMUX / Immunic, Inc.
IMUX / Immunic, Inc. Put
PRQR / ProQR Therapeutics N.V.
CLSN / Imunon Inc Put
AAPL / Apple Inc. Call
AAPL / Apple Inc. Put
OMER / Omeros Corporation
OMER / Omeros Corporation Call
LXRX / Lexicon Pharmaceuticals, Inc.
LXRX / Lexicon Pharmaceuticals, Inc. Call
LXRX / Lexicon Pharmaceuticals, Inc. Put
NSPR / InspireMD, Inc.
VTVT / vTv Therapeutics Inc.
ACRX / Talphera, Inc.
RSLS / ReShape Lifesciences Inc.
BLUE / bluebird bio, Inc. Put
BLUE / bluebird bio, Inc.
BLUE / bluebird bio, Inc. Call
PSTI / Pluristem Therapeutics Inc Put
MBOT / Microbot Medical Inc.
ADXS / Ayala Pharmaceuticals, Inc. Call
RVNC / Revance Therapeutics, Inc. Call
BPTH / Bio-Path Holdings, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp. Call
FNCX / Function(x) Inc.
TENX / Tenax Therapeutics, Inc.
CYH / Community Health Systems, Inc. Put
HRTX / Heron Therapeutics, Inc.
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
NWBO / Northwest Biotherapeutics, Inc.
CDMO / Avid Bioservices, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
RCKT / Rocket Pharmaceuticals, Inc.
BPMC / Blueprint Medicines Corporation
BPMC / Blueprint Medicines Corporation Call
SAGE / Sage Therapeutics, Inc.
SAGE / Sage Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Call
PTCT / PTC Therapeutics, Inc. Put
CBAY / CymaBay Therapeutics, Inc.
ATNM / Actinium Pharmaceuticals, Inc.
ALKS / Alkermes plc
ALKS / Alkermes plc Call
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
ELDN / Eledon Pharmaceuticals, Inc.
SSKN / STRATA Skin Sciences, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
AFMD / Affimed N.V.
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
NWBO / Northwest Biotherapeutics, Inc. Put
LPCN / Lipocine Inc.
LPCN / Lipocine Inc. Call
DVAX / Dynavax Technologies Corporation Put
DVAX / Dynavax Technologies Corporation
DVAX / Dynavax Technologies Corporation Call
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
PEGY / Pineapple Energy Inc. Call
SPY / SPDR S&P 500 ETF Put
TPST / Tempest Therapeutics, Inc.
SEEL / Seelos Therapeutics, Inc. Put
ESPR / Esperion Therapeutics, Inc.
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
GEVO * / Gevo, Inc.
KPRX / Kiora Pharmaceuticals, Inc.
KPRX / Kiora Pharmaceuticals, Inc.
SEEL / Seelos Therapeutics, Inc.
SRNE / Sorrento Therapeutics, Inc. Call
SRNE / Sorrento Therapeutics, Inc.
ACRX / Talphera, Inc. Put
IWM / iShares Trust - iShares Russell 2000 ETF