Market Value2,740,914,000
Total Holdings318
File Date2015-08-14
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price
Prev
Shares
Current
Shares
Change
(Percent)
Prev Value
(USD x1000)
Current Value
(USD x1000)
Change
(Percent)
ESPR / Esperion Therapeutics, Inc.
ESPR / Esperion Therapeutics, Inc. Put
GWP / GW Pharmaceuticals plc
IONS / Ionis Pharmaceuticals, Inc. Put
IONS / Ionis Pharmaceuticals, Inc. Call
AGIO / Agios Pharmaceuticals, Inc.
AGIO / Agios Pharmaceuticals, Inc. Call
AGIO / Agios Pharmaceuticals, Inc. Put
PRQR / ProQR Therapeutics N.V.
ADVM / Adverum Biotechnologies, Inc.
ADVM / Adverum Biotechnologies, Inc. Call
ALBO / Albireo Pharma Inc
NWBO / Northwest Biotherapeutics, Inc.
NWBO / Northwest Biotherapeutics, Inc. Put
TSRO / TESARO, Inc. Put
NVAX / Novavax, Inc. Put
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated Put
ATHX / Athersys, Inc. Put
06740C519 / Barclays Bank iPath S&P 500 VIX Mid-Term Futures ETN due 1/30/2019
ONVO / Organovo Holdings, Inc.
SCON / Superconductor Technologies Inc.
SCON / Superconductor Technologies Inc. Put
EXEL / Exelixis, Inc. Call
PBYI / Puma Biotechnology, Inc. Put
MNKKQ / Mallinckrodt Plc
CYTR / LadRx Corp Put
GEVA / Synageva Biopharma Corp
GEVA / Synageva Biopharma Corp Put
CYTX / Cytori Therapeutics, Inc. Put
DARA / DARA Biosciences, Inc.
CTSO / Cytosorbents Corporation Put
OCAT / Ocata Therapeutics, Inc.
885175307 / Thoratec Call
SNOA / Sonoma Pharmaceuticals, Inc.
THC / Tenet Healthcare Corporation Call
US0153511094 / Alexion Pharmaceuticals, Inc. Put
G0083B108 / Actavis Call
NUVA / Nuvasive Inc Call
CNAT / Conatus Pharmaceuticals Inc.
ABUS / Arbutus Biopharma Corporation
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
UTHR / United Therapeutics Corporation Call
BDSI / Biodelivery Sciences International Put
BLPH / Bellerophon Therapeutics, Inc.
PGNX / Progenics Pharmaceuticals, Inc. Put
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
ABEO / Abeona Therapeutics Inc.
FEIC / FEI Company Call
THMO / ThermoGenesis Holdings, Inc.
US0153511094 / Alexion Pharmaceuticals, Inc.
LUMO / Lumos Pharma, Inc. Call
LUMO / Lumos Pharma, Inc. Put
MEIP / MEI Pharma, Inc. Call
INCY / Incyte Corporation Call
CASC / Cascadian Therapeutics, Inc.
OPK / OPKO Health, Inc.
IMUC / EOM Pharmaceuticals Holdings, Inc.
TROV / TrovaGene, Inc.
HUM / Humana Inc. Call
RPTP / Raptor Pharmaceutical Corp. Call
RPTP / Raptor Pharmaceutical Corp. Put
IDRA / Idera Pharmaceuticals, Inc.
IDRA / Idera Pharmaceuticals, Inc. Call
IDRA / Idera Pharmaceuticals, Inc. Put
607355906 / China Mobile Ltd. Call
ZSAN / Zosano Pharma Corp
BIIB / Biogen Inc. Call
CASI / CASI Pharmaceuticals, Inc.
ENDP / Endo International plc
HALO / Halozyme Therapeutics, Inc. Put
BMRN / BioMarin Pharmaceutical Inc. Call
INO / Inovio Pharmaceuticals, Inc.
MDGN.WS / Medgenics, Inc., Warrant
CERN / Cerner Corp. Call
NURO / NeuroMetrix, Inc.
PFE / Pfizer Inc. Put
CLDX / Celldex Therapeutics, Inc. Call
CLDX / Celldex Therapeutics, Inc. Put
APDNW / Applied DNA Sciences, Inc., Warrants
FOLD / Amicus Therapeutics, Inc. Call
FOLD / Amicus Therapeutics, Inc. Put
MDCO / Medicines Company Put
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
VNDA / Vanda Pharmaceuticals Inc. Call
RMTI / Rockwell Medical, Inc. Call
ONCS / OncoSec Medical Inc
IPCI / Intellipharmaceutics International Inc. Put
ACRX / Talphera, Inc. Call
ACRX / Talphera, Inc. Put
MBLY / Mobileye Global Inc.
MBLY / Mobileye Global Inc. Call
TLT / iShares Trust - iShares 20+ Year Treasury Bond ETF
ITCI / Intra-Cellular Therapies, Inc.
RCPT / Receptos, Inc. Put
INCY / Incyte Corporation Put
91911K102 / Bausch Health Companies Put
PGNX / Progenics Pharmaceuticals, Inc. Call
09061GAE1 / BioMarin Pharmaceutical Inc. Bond 0.75% 10/15/2018
KITE / Kite Pharma, Inc.
EXEL / Exelixis, Inc. Put
ARROWHEAD RESEARCH CORP / (042797209)
ALPN / Alpine Immune Sciences, Inc.
PRGO / Perrigo Company plc Call
ABUS / Arbutus Biopharma Corporation Call
ALDR / Alder BioPharmaceuticals, Inc.
G0083B108 / Actavis
MBLY / Mobileye Global Inc. Put
QURE / uniQure N.V. Call
ACHC / Acadia Healthcare Company, Inc. Call
TENX / Tenax Therapeutics, Inc. Call
CAPR / Capricor Therapeutics, Inc.
ACHC / Acadia Healthcare Company, Inc. Put
PVCT / Provectus Biopharmaceuticals, Inc.
RGLS / Regulus Therapeutics Inc. Call
TSRO / TESARO, Inc. Call
ACERW / Acer Therapeutics Inc. Warrant
ELDN / Eledon Pharmaceuticals, Inc.
REPH / Societal CDMO Inc
NXTM / NxStage Medical, Inc. Call
KERX / Keryx Biopharmaceuticals, Inc.
KITE / Kite Pharma, Inc. Put
BDSI / Biodelivery Sciences International Call
CLLS / Cellectis S.A. - Depositary Receipt (Common Stock)
ASND / Ascendis Pharma A/S - Depositary Receipt (Common Stock)
ZSPH / ZS Pharma, Inc.
CSLT / Castlight Health Inc - Class B
IOC / InterOil Corporation
584688AC9 / Medicines Company 1.375% Bond due 2017-06-01
NXTM / NxStage Medical, Inc.
RGLS / Regulus Therapeutics Inc.
US00C4U1L353 / Mylan N.V. Put
CYTX / Cytori Therapeutics, Inc.
COLLABRX INC / (19422J108)
30161QAC8 / Exelixis, Inc. Bond
EIGR / Eiger BioPharmaceuticals, Inc. Call
ONCE / Spark Therapeutics, Inc. Call
ACHC / Acadia Healthcare Company, Inc.
FLDM / Standard BioTools Inc
JUNO / Juno Therapeutics, Inc.
BLCM / Bellicum Pharmaceuticals, Inc. Put
NONOF / Novo Nordisk A/S Call
HTWR / Heartware International Inc. Call
TRUP / Trupanion, Inc.
CHRS / Coherus Oncology, Inc.
JUNO / Juno Therapeutics, Inc. Put
US00C4U1L353 / Mylan N.V. Call
CYNA / Cynapsus Therapeutics Inc.
US00C4U1L353 / Mylan N.V.
CVMW / CEL-SCI Corp. Warrants
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
HZNP / Horizon Therapeutics Plc Call
KERX / Keryx Biopharmaceuticals, Inc. Put
NSPH / Nanosphere, Inc.
/ Immunomedics, Inc.
ZGNX / Zogenix Inc Call
ZGNX / Zogenix Inc
MLNT / Melinta Therapeutics, Inc.
HTWR / Heartware International Inc. Put
SLXP / Salix Therapeuticals, Inc. Call
CERS / Cerus Corporation
FWP / Forward Pharma A/S - ADR
ONCE / Spark Therapeutics, Inc. Put
RCPT / Receptos, Inc. Call
XNPT / XenoPort, Inc. Call
REEMF / Rare Element Resources Ltd.
PMAH / PlasmaTech, Inc.
IOVA / Iovance Biotherapeutics, Inc.
SPDR S&P BIOTECH ETF / ETF Put (78464A950)
XLB / The Select Sector SPDR Trust - The Materials Select Sector SPDR Fund Put
VNDA / Vanda Pharmaceuticals Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
ANIP / ANI Pharmaceuticals, Inc. Call
KYTH / Kythera Biopharma Put
EPZM / Epizyme Inc
US0325111070 / Anadarko Petroleum Corp.
AXGN / Axogen, Inc.
NONOF / Novo Nordisk A/S Put
BDSI / Biodelivery Sciences International
PGNX / Progenics Pharmaceuticals, Inc.
BMRN / BioMarin Pharmaceutical Inc. Put
CSLT / Castlight Health Inc - Class B Call
DXTR / Dextera Surgical Inc.
TTHI / Transition Therapeutics Inc.
AM / Antero Midstream Corporation Call
QRHC / Quest Resource Holding Corporation
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock)
FOMX / Foamix Pharmaceuticals Ltd.
ITCI / Intra-Cellular Therapies, Inc. Call
AR / Antero Resources Corporation
US0325111070 / Anadarko Petroleum Corp. Call
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
MDCO / Medicines Company Call
CEMP / Cempra, Inc. Call
CEMP / Cempra, Inc. Put
ARROWHEAD RESEARCH CORP / Put (042797959)
ZSPH / ZS Pharma, Inc. Put
AMG / Affiliated Managers Group, Inc. Put
ARROWHEAD RESEARCH CORP / Call (042797909)
RMTI / Rockwell Medical, Inc.
G0083B108 / Actavis Put
PLASMATECH BIOPHARMACEUTICALS / *W (72754H117)
HALO / Halozyme Therapeutics, Inc.
HALO / Halozyme Therapeutics, Inc. Call
IOC / InterOil Corporation Put
OCRX / Ocera Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Call
76028H209 / Repros Therapeutics, Inc. Put
EXAS / Exact Sciences Corporation Call
EXAS / Exact Sciences Corporation Put
032420101 / Anacor Pharmaceuticals, Inc. Call
APEN / Apollo Endosurgery Inc
451731103 / Ignyta, Inc.
PVCT / Provectus Biopharmaceuticals, Inc.
PRTK / Paratek Pharmaceuticals Inc.
REGN / Regeneron Pharmaceuticals, Inc. Call
REGN / Regeneron Pharmaceuticals, Inc. Put
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RMTI / Rockwell Medical, Inc. Put
885175307 / Thoratec Put
PXD / Pioneer Natural Resources Company
PXD / Pioneer Natural Resources Company Put
VXX / iPath Series B S&P 500 VIX Short-Term Futures ETN
VXX / iPath Series B S&P 500 VIX Short-Term Futures ETN Call
LRMR / Larimar Therapeutics, Inc. Call
OCUL / Ocular Therapeutix, Inc.
FLDM / Standard BioTools Inc Call
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Put
MNKKQ / Mallinckrodt Plc Call
/ GW Pharmaceuticals Plc. Put
/ GW Pharmaceuticals Plc. Call
FGEN / FibroGen, Inc.
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
MNKKQ / Mallinckrodt Plc Put
A / Agilent Technologies, Inc. Put
BCLI / Brainstorm Cell Therapeutics Inc.
ICPT / Intercept Pharmaceuticals Inc Call
ICPT / Intercept Pharmaceuticals Inc Put
RIBT / RiceBran Technologies
SRPT / Sarepta Therapeutics, Inc. Put
DYAX / Dyax Corp. Put
DYAX / Dyax Corp. Call
TXMD / TherapeuticsMD, Inc. Call
ALDX / Aldeyra Therapeutics, Inc.
TTOO / T2 Biosystems, Inc.
DERM / Journey Medical Corporation
ALKS / Alkermes plc Put
IPCI / Intellipharmaceutics International Inc.
XOM / Exxon Mobil Corporation
XOM / Exxon Mobil Corporation Put
TPST / Tempest Therapeutics, Inc. Call
TPST / Tempest Therapeutics, Inc. Put
ABBV / AbbVie Inc. Put
PGEN / Precigen, Inc. Call
HIFR / InfraREIT, Inc. Call
CELG / Celgene Corp. Put
CELG / Celgene Corp.
ACRX / Talphera, Inc.
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
VIRX / Viracta Therapeutics, Inc. Call
LLY / Eli Lilly and Company Put
LLY / Eli Lilly and Company Call
GNCA / Genocea Biosciences Inc
PFE / Pfizer Inc. Call
ENDP / Endo International plc Call
ENDP / Endo International plc Put
BCS / Barclays PLC - Depositary Receipt (Common Stock) Call
TXMD / TherapeuticsMD, Inc.
A / Agilent Technologies, Inc. Call
CDTX / Cidara Therapeutics, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Put
VRTX / Vertex Pharmaceuticals Incorporated Call
DHR / Danaher Corporation Call
DHR / Danaher Corporation
DHR / Danaher Corporation Put
MEIP / MEI Pharma, Inc.
XOMA / XOMA Royalty Corporation Call
XOMA / XOMA Royalty Corporation Put
CBPO / China Biologic Products Holdings Inc
ALBO / Albireo Pharma Inc Put
SLS / SELLAS Life Sciences Group, Inc.
ASXC / Asensus Surgical, Inc.
CYTK / Cytokinetics, Incorporated Put
US0325111070 / Anadarko Petroleum Corp. Put
NVAX / Novavax, Inc. Call
BCRX / BioCryst Pharmaceuticals, Inc. Call
BCRX / BioCryst Pharmaceuticals, Inc. Put
INFI / Infinity Pharmaceuticals Inc. Call
INFI / Infinity Pharmaceuticals Inc. Put
CNAT / Conatus Pharmaceuticals Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc.
BLCM / Bellicum Pharmaceuticals, Inc. Call
EW / Edwards Lifesciences Corporation
TNXP / Tonix Pharmaceuticals Holding Corp.
PBYI / Puma Biotechnology, Inc.
PBYI / Puma Biotechnology, Inc. Call
CERN / Cerner Corp. Put
PGEN / Precigen, Inc. Put
GILD / Gilead Sciences, Inc. Call
GILD / Gilead Sciences, Inc. Put
HCA / HCA Healthcare, Inc. Call
HCA / HCA Healthcare, Inc. Put
EW / Edwards Lifesciences Corporation Put
SKBI / Skystar Bio-Pharmaceutical Company
ITP / IT Tech Packaging, Inc. Put
BIIB / Biogen Inc. Put
OCGN / Ocugen, Inc.
ATHX / Athersys, Inc. Call
ABBV / AbbVie Inc. Call
PSTI / Pluristem Therapeutics Inc
AGTC / Applied Genetic Technologies Corp
ALQA / Alliqua, Inc.
THC / Tenet Healthcare Corporation
THC / Tenet Healthcare Corporation Put
PCYC / Pharmacyclics Call
PCYC / Pharmacyclics Put
OTLC / Oncotelic Therapeutics, Inc.
NSPR / InspireMD, Inc.
CTIC / CTI BioPharma Corp
CTIC / CTI BioPharma Corp Call
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
ORMP / Oramed Pharmaceuticals Inc.
IMUX / Immunic, Inc. Put
NHWK / NightHawk Biosciences, Inc.
CLSN / Imunon Inc Put
OMER / Omeros Corporation Call
OMER / Omeros Corporation Put
LXRX / Lexicon Pharmaceuticals, Inc.
ARDX / Ardelyx, Inc.
FNCX / Function(x) Inc.
CLBS / Caladrius Biosciences Inc
US00448Q2012 / Achillion Pharmaceuticals, Inc.
RSLS / ReShape Lifesciences Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
BLUE / bluebird bio, Inc. Put
BLUE / bluebird bio, Inc. Call
PSTI / Pluristem Therapeutics Inc Put
RVNC / Revance Therapeutics, Inc.
RVNC / Revance Therapeutics, Inc. Call
BPTH / Bio-Path Holdings, Inc.
NBSE / NeuBase Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc. Call
NBSE / NeuBase Therapeutics, Inc. Put
TENX / Tenax Therapeutics, Inc.
CYH / Community Health Systems, Inc.
CYH / Community Health Systems, Inc. Call
CYH / Community Health Systems, Inc. Put
HRTX / Heron Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
BIOL / BIOLASE, Inc.
MDGL / Madrigal Pharmaceuticals, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
CDMO / Avid Bioservices, Inc.
BPMC / Blueprint Medicines Corporation
PTCT / PTC Therapeutics, Inc. Put
SAGE / Sage Therapeutics, Inc.
PTCT / PTC Therapeutics, Inc. Call
CBAY / CymaBay Therapeutics, Inc.
ALKS / Alkermes plc Call
VIRX / Viracta Therapeutics, Inc.
VIRX / Viracta Therapeutics, Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
ABIO / ARCA biopharma, Inc.
SSKN / STRATA Skin Sciences, Inc.
LRMR / Larimar Therapeutics, Inc. Put
CYCC / Cyclacel Pharmaceuticals, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
LPCN / Lipocine Inc.
DVAX / Dynavax Technologies Corporation Put
DVAX / Dynavax Technologies Corporation
DVAX / Dynavax Technologies Corporation Call
XTLB / XTL Biopharmaceuticals Ltd. - Depositary Receipt (Common Stock)
SEEL / Seelos Therapeutics, Inc.
SEEL / Seelos Therapeutics, Inc. Put
MBOT / Microbot Medical Inc.
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
APDN / Applied DNA Sciences, Inc.
TPST / Tempest Therapeutics, Inc.
NURO / NeuroMetrix, Inc.
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
CLSN / Imunon Inc
GBSN / Great Basin Scientific, Inc.
GBSN / Great Basin Scientific, Inc.
ADXS / Ayala Pharmaceuticals, Inc. Put
OEF / iShares Trust - iShares S&P 100 ETF Put
IWM / iShares Trust - iShares Russell 2000 ETF
GEVO * / Gevo, Inc.
SPY / SPDR S&P 500 ETF Put
OEF / iShares Trust - iShares S&P 100 ETF Put