Market Value3,165,760,000
Total Holdings234
File Date2015-02-17
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price		 Prev
Shares		 Current
Shares		 Change
(Percent)		 Prev Value
(USD x1000)		 Current Value
(USD x1000)		 Change
(Percent)
PRQR / ProQR Therapeutics N.V.
AGIO / Agios Pharmaceuticals, Inc. Put
NURO / NeuroMetrix, Inc.
CYTR / LadRx Corp Put
ADVM / Adverum Biotechnologies, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp. Put
ALBO / Albireo Pharma Inc Put
TSRO / TESARO, Inc. Call
INSM / Insmed Incorporated Call
INSM / Insmed Incorporated
TSLA / Tesla, Inc. Put
EXEL / Exelixis, Inc.
EXEL / Exelixis, Inc. Call
EXEL / Exelixis, Inc. Put
PBYI / Puma Biotechnology, Inc. Put
ATHX / Athersys, Inc. Call
IDRA / Idera Pharmaceuticals, Inc.
GEVA / Synageva Biopharma Corp
GEVA / Synageva Biopharma Corp Put
IRWD / Ironwood Pharmaceuticals, Inc. Call
CEMP / Cempra, Inc. Call
KERX / Keryx Biopharmaceuticals, Inc. Put
REGADO BIOSCIENCE INC / (75874Q107)
DXTR / Dextera Surgical Inc.
ACHC / Acadia Healthcare Company, Inc. Call
DARA / DARA Biosciences, Inc.
REPH / Societal CDMO Inc
ABUS / Arbutus Biopharma Corporation Call
ABUS / Arbutus Biopharma Corporation Put
NPSP / NPS Pharmaceuticals Inc
NPSP / NPS Pharmaceuticals Inc Put
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
UTHR / United Therapeutics Corporation Call
OCGN / Ocugen, Inc.
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Call
INCY / Incyte Corporation
INCY / Incyte Corporation Call
INCY / Incyte Corporation Put
THC / Tenet Healthcare Corporation Put
THMO / ThermoGenesis Holdings, Inc.
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
NWBO / Northwest Biotherapeutics, Inc. Put
CASC / Cascadian Therapeutics, Inc.
NKTR / Nektar Therapeutics Call
IPCI / Intellipharmaceutics International Inc.
IPCI / Intellipharmaceutics International Inc. Put
TROV / TrovaGene, Inc.
AMT.PRB / American Tower Corp Call
OPK / OPKO Health, Inc. Call
OPK / OPKO Health, Inc. Put
LRMR / Larimar Therapeutics, Inc.
15117F112 / Cellectar Biosciences, Inc. Series A Warrants
SESN / Sesen Bio Inc.
GERN / Geron Corporation Call
GERN / Geron Corporation Put
COVIDIEN PLC / SHS Put (G2554F953)
RGLS / Regulus Therapeutics Inc. Call
IDRA / Idera Pharmaceuticals, Inc. Call
CASI / CASI Pharmaceuticals, Inc.
ARNA / Arena Pharmaceuticals Inc Call
ARNA / Arena Pharmaceuticals Inc Put
ECYT / Endocyte, Inc.
ECYT / Endocyte, Inc. Call
ANTH / Anthera Pharmaceuticals, Inc. Call
MDGN.WS / Medgenics, Inc., Warrant
GWP / GW Pharmaceuticals plc Call
MDCO / Medicines Company Put
ALNY / Alnylam Pharmaceuticals, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Put
RMTI / Rockwell Medical, Inc. Call
MBLY / Mobileye Global Inc. Call
MBLY / Mobileye Global Inc. Put
VNDA / Vanda Pharmaceuticals Inc. Call
ALTO / Alto Ingredients, Inc.
ALTO / Alto Ingredients, Inc. Put
MDVN / Medivation, Inc. Put
MDVN / Medivation, Inc. Call
CNAT / Conatus Pharmaceuticals Inc.
ACAD / ACADIA Pharmaceuticals Inc.
SLS / SELLAS Life Sciences Group, Inc.
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock)
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Put
AAPL / Apple Inc. Call
DERM / Journey Medical Corporation
COV /
ASPX / Auspex Pharmaceuticals, Inc.
PRGO / Perrigo Company plc Call
HTWR / Heartware International Inc. Put
BAXS / Baxano Surgical, Inc.
NEOSTEM INC / Put (640650954)
ARROWHEAD RESEARCH CORP / (042797209)
CVMW / CEL-SCI Corp. Warrants
AMT.PRB / American Tower Corp Put
ACHC / Acadia Healthcare Company, Inc. Put
AASTROM BIOSCIENCES INC / (00253U404)
ADHD / Alcobra Ltd. Call
ENTA / Enanta Pharmaceuticals, Inc. Call
G0083B108 / Actavis Call
RCPT / Receptos, Inc. Call
881569AA5 / TESARO, Inc. Bond 3.000%10/0
SHPG / Shire Plc.
ALXA / Alexza Pharmaceuticals, Inc. Call
CYTX / Cytori Therapeutics, Inc.
FOLD / Amicus Therapeutics, Inc. Put
CORI / Corium International, Inc.
AMPE / Ampio Pharmaceuticals, Inc.
ARROWHEAD RESEARCH CORP / Put (042797959)
PLASMATECH BIOPHARMACEU-CW19 / *W (72754H117)
SHPG / Shire Plc. Put
G0083B108 / Actavis Put
VCEL / Vericel Corporation
NEOSTEM INC / (640650404)
MDGN / Medgenics, Inc. Put
ABBV / AbbVie Inc. Put
ECYT / Endocyte, Inc. Put
CGEN / Compugen Ltd.
PSDV / pSivida Corp.
PSDV / pSivida Corp. Put
AEGR / Aegerion Pharmaceuticals, Inc. Call
HZNP / Horizon Therapeutics Plc Call
HZNP / Horizon Therapeutics Plc Put
ONTY / Oncothyreon, Inc. Call
ATHX / Athersys, Inc. Put
ALIM / Alimera Sciences, Inc.
ALIM / Alimera Sciences, Inc. Call
ALIM / Alimera Sciences, Inc. Put
MLNT / Melinta Therapeutics, Inc.
G0083B108 / Actavis
KERX / Keryx Biopharmaceuticals, Inc. Call
/ Ceres, Inc.
XNCR / Xencor, Inc.
ADHD / Alcobra Ltd. Put
PATI / Patriot Transportation Holding, Inc.
PGNX / Progenics Pharmaceuticals, Inc.
NEOSTEM INC / Call (640650904)
EIGR / Eiger BioPharmaceuticals, Inc.
CBST / Call
VNDA / Vanda Pharmaceuticals Inc.
SGYPW / Synergy Pharmaceuticals, Inc., Warrants
G0083B108 / Actavis Call
ACHC / Acadia Healthcare Company, Inc.
AMPE / Ampio Pharmaceuticals, Inc. Put
CEMP / Cempra, Inc. Put
BSTG / Biostage Inc
RGLS / Regulus Therapeutics Inc.
SLXP / Salix Therapeuticals, Inc.
FOLD / Amicus Therapeutics, Inc.
TRUP / Trupanion, Inc.
WGBS / WaferGen Bio-Systems, Inc.
QRHC / Quest Resource Holding Corporation
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) Put
SPDR S&P BIOTECH ETF SHS / S&P BIOTECH Put (78464A950)
FOLD / Amicus Therapeutics, Inc. Call
PMAH / PlasmaTech, Inc.
ACHV / Achieve Life Sciences, Inc.
DRNA / Dicerna Pharmaceuticals Inc
FOMX / Foamix Pharmaceuticals Ltd.
PSDV / pSivida Corp. Call
ICPT / Intercept Pharmaceuticals Inc Call
ARNA / Arena Pharmaceuticals Inc
SLXP / Salix Therapeuticals, Inc. Call
QURE / uniQure N.V.
IOC / InterOil Corporation
IOC / InterOil Corporation Put
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
BMYMP / Bristol-Myers Squibb Company - Preferred Security Put
SMLR / Semler Scientific, Inc.
OCRX / Ocera Therapeutics, Inc.
AVNR / Avanir Pharmaceuticals Inc Call
AUXL / Auxilium Pharmaceuticals Inc Call
76028H209 / Repros Therapeutics, Inc.
76028H209 / Repros Therapeutics, Inc. Call
76028H209 / Repros Therapeutics, Inc. Put
CLTX / Celsus Therapeutics
BMRN / BioMarin Pharmaceutical Inc.
BMRN / BioMarin Pharmaceutical Inc. Call
NSPH / Nanosphere, Inc.
EXAS / Exact Sciences Corporation
EXAS / Exact Sciences Corporation Put
APEN / Apollo Endosurgery Inc
BLUE / bluebird bio, Inc.
451731103 / Ignyta, Inc.
WINT / Windtree Therapeutics, Inc.
WINT / Windtree Therapeutics, Inc. Call
CLSN / Imunon Inc
REGN / Regeneron Pharmaceuticals, Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Call
ACAD / ACADIA Pharmaceuticals Inc. Put
RMTI / Rockwell Medical, Inc.
RMTI / Rockwell Medical, Inc. Put
OTLC / Oncotelic Therapeutics, Inc.
885175307 / Thoratec Call
GILD / Gilead Sciences, Inc. Put
OCUL / Ocular Therapeutix, Inc.
LLY / Eli Lilly and Company Call
ALBO / Albireo Pharma Inc
NPSP / NPS Pharmaceuticals Inc Call
NVAX / Novavax, Inc. Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
OTLC / Oncotelic Therapeutics, Inc. Call
OTLC / Oncotelic Therapeutics, Inc. Put
KEYS / Keysight Technologies, Inc.
A / Agilent Technologies, Inc. Call
US249908AA20 / DepoMed, Inc. 2.5% Bond Due 9/1/2021
GALT / Galectin Therapeutics Inc.
VRTX / Vertex Pharmaceuticals Incorporated Put
RIBT / RiceBran Technologies
TXMD / TherapeuticsMD, Inc. Call
SRPT / Sarepta Therapeutics, Inc.
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
AMGN / Amgen Inc. Call
CVM / CEL-SCI Corporation
A / Agilent Technologies, Inc. Put
DYAX / Dyax Corp. Call
AMGN / Amgen Inc. Put
MSTX / Tidal Trust II - Defiance Daily Target 2X Long MSTR ETF
TNXP / Tonix Pharmaceuticals Holding Corp. Call
XOMA / XOMA Royalty Corporation
XOMA / XOMA Royalty Corporation Call
GEVO / Gevo, Inc.
TNXP / Tonix Pharmaceuticals Holding Corp.
TTOO / T2 Biosystems, Inc.
PGEN / Precigen, Inc. Call
SGEN / Seagen Inc
SGEN / Seagen Inc Call
SGEN / Seagen Inc Put
CELG / Celgene Corp. Call
CELG / Celgene Corp. Put
CBLI / Cytocom Inc
ITP / IT Tech Packaging, Inc.
IONS / Ionis Pharmaceuticals, Inc. Call
IMUC / EOM Pharmaceuticals Holdings, Inc. Put
BIIB / Biogen Inc. Put
PFE / Pfizer Inc. Call
PFE / Pfizer Inc.
PFE / Pfizer Inc. Put
ENDP / Endo International plc Call
TXMD / TherapeuticsMD, Inc.
A / Agilent Technologies, Inc.
ARIA / ARIAD Pharmaceuticals, Inc.
ARIA / ARIAD Pharmaceuticals, Inc. Put
ARIA / ARIAD Pharmaceuticals, Inc. Call
VRTX / Vertex Pharmaceuticals Incorporated Call
DHR / Danaher Corporation
DHR / Danaher Corporation Call
DHR / Danaher Corporation Put
MEIP / MEI Pharma, Inc.
018490100 / Allergan plc Call
XOMA / XOMA Royalty Corporation Put
INFI / Infinity Pharmaceuticals Inc. Call
PGEN / Precigen, Inc.
INFI / Infinity Pharmaceuticals Inc.
INFI / Infinity Pharmaceuticals Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Call
CNAT / Conatus Pharmaceuticals Inc. Call
BLCM / Bellicum Pharmaceuticals, Inc.
PBYI / Puma Biotechnology, Inc.
PBYI / Puma Biotechnology, Inc. Call
PGEN / Precigen, Inc. Put
GILD / Gilead Sciences, Inc. Call
HCA / HCA Healthcare, Inc. Call
BIIB / Biogen Inc. Call
GILD / Gilead Sciences, Inc.
TSLA / Tesla, Inc.
ABBV / AbbVie Inc. Call
PSTI / Pluristem Therapeutics Inc
PSTI / Pluristem Therapeutics Inc Put
THC / Tenet Healthcare Corporation Call
PCYC / Pharmacyclics Put
NSPR / InspireMD, Inc.
CTIC / CTI BioPharma Corp
CTIC / CTI BioPharma Corp Call
CTIC / CTI BioPharma Corp Put
SKBI / Skystar Bio-Pharmaceutical Company
OEF / iShares Trust - iShares S&P 100 ETF Put
ALT / Altimmune, Inc. Call
AAPL / Apple Inc. Put
LXRX / Lexicon Pharmaceuticals, Inc.
TVTX / Travere Therapeutics, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
BLUE / bluebird bio, Inc. Call
MBOT / Microbot Medical Inc.
RVNC / Revance Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc.
NBSE / NeuBase Therapeutics, Inc. Call
TENX / Tenax Therapeutics, Inc.
CYH / Community Health Systems, Inc.
CYH / Community Health Systems, Inc. Call
CYH / Community Health Systems, Inc. Put
HRTX / Heron Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
SEEL / Seelos Therapeutics, Inc. Put
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
CDMO / Avid Bioservices, Inc.
CBAY / CymaBay Therapeutics, Inc.
ALKS / Alkermes plc
ALKS / Alkermes plc Call
ALKS / Alkermes plc Put
ESPR / Esperion Therapeutics, Inc. Call
VIRX / Viracta Therapeutics, Inc. Call
VIRX / Viracta Therapeutics, Inc. Put
SLS / SELLAS Life Sciences Group, Inc. Put
CLRB / Cellectar Biosciences, Inc.
SSKN / STRATA Skin Sciences, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Call
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
NBIX / Neurocrine Biosciences, Inc. Call
NBIX / Neurocrine Biosciences, Inc. Put
BLRX / BioLineRx Ltd. - Depositary Receipt (Common Stock)
BCLI / Brainstorm Cell Therapeutics Inc.
SEEL / Seelos Therapeutics, Inc.
CLSN / Imunon Inc Put
SPY / SPDR S&P 500 ETF Put